Patents Represented by Attorney Richard H. Shear
  • Patent number: 5880275
    Abstract: A method for modifying structural gene sequences to enhance the expression of the protein product is disclosed. Also disclosed are novel structural genes which encode insecticidal proteins of B.t.k. HD-1, and B.t.k. HD-73.
    Type: Grant
    Filed: April 29, 1997
    Date of Patent: March 9, 1999
    Assignee: Monsanto Company
    Inventors: David A. Fischhoff, Frederick J. Perlak
  • Patent number: 5866775
    Abstract: Glyphosate-tolerant 5-enolpyruvyl-3-phosphoshikimate (EPSP) synthases, DNA encoding glyphsate-tolerant EPSP synthases, plant genes encoding the glyphosate-tolerant enzymes, plant transformation vectors containing the genes, transformed plant cells and differentiated transformed plants containing the plant genes are disclosed. The glyphosate-tolerant EPSP synthases are prepared by substituting an alanine residue for a glycine residue in a first conserved sequence found between positions 80 and 120, and a threonine residue for an alanine residue in a second conserved sequence found between positions 170 and 210 in the mature wild type EPSP synthase.
    Type: Grant
    Filed: September 28, 1990
    Date of Patent: February 2, 1999
    Assignee: Monsanto Company
    Inventors: David Alan Eichholtz, Charles Scott Gasser, Ganesh Murthy Kishore
  • Patent number: 5659122
    Abstract: This invention provides DNA molecules which comprise 5' non-translated leader sequences derived from genes coding for heat shock proteins that enhance gene expression in plants when present in a chimeric gene. Plant cells and plants containing same are also provided herewith. Further provided is a method for enhancing gene expression in plants.
    Type: Grant
    Filed: July 25, 1994
    Date of Patent: August 19, 1997
    Assignee: Monsanto Company
    Inventor: Glenn Douglas Austin
  • Patent number: 5654490
    Abstract: The present invention relates to novel 4-halo-2-fluoro-5-alkylbenzoyl compounds and their methods of manufacture. These compounds are useful for the preparation of agricultural chemicals and medicines, particularly as intermediates for an active class of aryl-haloalkylpyrazole and aryl alkylsulfonylpyrazole herbicides.
    Type: Grant
    Filed: May 1, 1995
    Date of Patent: August 5, 1997
    Assignee: Monsanto Company
    Inventors: Bruce C. Hamper, Kindrick L. Leschinsky
  • Patent number: 5536700
    Abstract: Herbicidal compositions of glyphosate, its salts, diquat, or paraquat in combination with a compound of the following formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, and n are as defined. Preferred are combinations of glyphosate, its salts, diquat, or paraquat with 2-chloro-5-(4-bromo-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-4-fluoro benzoic acid, 1-methylethyl ester.
    Type: Grant
    Filed: December 20, 1993
    Date of Patent: July 16, 1996
    Assignee: Monsanto Company
    Inventors: Scott S. Woodard, Bruce C. Hamper, Kurt Moedritzer, Michael D. Rogers, Deborah A. Mischke, Gerard A. Dutra
  • Patent number: 5530196
    Abstract: In one aspect the present invention relates to the use of viral promoters in the expression of chimeric genes in plant cells. In another aspect this invention relates to chimeric genes which are capable of being expressed in plant cells, which utilize promoter regions derived from viruses which are capable of infecting plant cells. One such virus comprises the cauliflower mosaic virux (CaMV). Two different promoter regions have been derived from the CaMV genome and ligated to heterologous coding sequences to form chimeric genes. These chimeric genes have been shown to be expressed in plant cells. This invention also relates to plant cells, plant tissue, and differentiated plants which contain and express the chimeric genes of this invention.
    Type: Grant
    Filed: September 2, 1994
    Date of Patent: June 25, 1996
    Assignee: Monsanto Company
    Inventors: Robert T. Fraley, Robert B. Horsch, Stephen G. Rogers
  • Patent number: 5516671
    Abstract: Plants can be transformed to express glucose oxidase from Aspergillus sp. and be made resistant to bacterial and fungal pathogens. Optionally, the plants may also express invertase to increase the available glucose as a substrate for enzymatic activity.
    Type: Grant
    Filed: November 3, 1994
    Date of Patent: May 14, 1996
    Assignee: Monsanto Company
    Inventors: Ellen B. Lawrence, Elaine B. Levine, Dilip M. Shah
  • Patent number: 5514717
    Abstract: Novel 3,4,4-trifluorobutenoic acid derivatives of the formula ##STR1## wherein Q is --(C.dbd.W)--R.sub.2 wherein W is O or S, and R.sub.2 is an aliphatic or aromatic group when W.dbd.O; --OR.sub.50 ; --SR.sub.50 ; or --NR.sub.50 R.sub.60 wherein R.sub.60 is hydrogen or R.sub.50 ; NR.sub.7 R.sub.8 ; a heterocyclic group; phenyl substituted by alkyl; or any agronomically acceptable salt thereof having usefulness as nematocides, insecticides and acaricides.
    Type: Grant
    Filed: October 26, 1994
    Date of Patent: May 7, 1996
    Assignee: Monsanto Company
    Inventors: Dennis P. Phillion, Gopichand Yalamanchili, Peter G. Ruminski
  • Patent number: 5512466
    Abstract: A method for controlling the ripening of fruits and vegetables as well as a method for controlling senescence of plant tissue is described. The method generally embraces the expression of an ACC metabolizing enzyme in the fruit or other desired plant tissue to inhibit the production of ethylene in the fruit or plant tissue. The use of the ACC metabolizing enzyme ACC deaminase is described in detail. The ripening or senescence process in the fruit or plant tissue is inhibited by the expression of the ACC deaminase gene such that the shelf-life and marketability of the fruit or plant is enhanced. The ACC metabolizing enzyme may be used in combination with other methods for reducing ethylene production in transformed plants to further reduce the production of ethylene in the fruit or plant. DNA constructs containing the ACC deaminase gene are also described.
    Type: Grant
    Filed: December 17, 1991
    Date of Patent: April 30, 1996
    Assignee: Monsanto Company
    Inventors: Harry J. Klee, Ganesh M. Kishore
  • Patent number: 5510253
    Abstract: An isolated DNA sequence which codes for a PLRV replicase gene is disclosed herein. A method for providing resistance to infection by a virus by expressing a replicase gene in plants is also disclosed, as are transgenic potato plants and tubers containing the replicase gene.
    Type: Grant
    Filed: October 20, 1994
    Date of Patent: April 23, 1996
    Assignee: Monsanto Company
    Inventors: Timothy A. Mitsky, Cynthia L. Hemenway, Nilgun E. Tumer
  • Patent number: 5503999
    Abstract: An isolated DNA sequence which codes for a potyvirus replicase gene is disclosed herein. A method for providing resistance to infection by a virus by expressing a replicase gene in plants is also disclosed. Transgenic potato plants and tubers containing the replicase gene are also disclosed.
    Type: Grant
    Filed: January 3, 1995
    Date of Patent: April 2, 1996
    Assignee: Monsanto Company
    Inventors: Joseph M. Jilka, Nilgun E. Tumer
  • Patent number: 5502025
    Abstract: The disclosure herein relates to the safening of crops from injury by herbicidal pyrazolosulfonylureas alone or combined with co-herbicides from various classes of chemistry, using various antidotal compounds known in the art.
    Type: Grant
    Filed: April 25, 1995
    Date of Patent: March 26, 1996
    Assignee: Monsanto Company
    Inventor: Brett H. Bussler
  • Patent number: 5500365
    Abstract: A method for modifying structural gene sequences to enhance the expression of the protein product is disclosed. Also disclosed are novel structural genes which encode insecticidal proteins of B.t.k. HD-1, B.t.k. HD-73, B.t. tenebrionis, B.t. entomocidus, 2 protein of B.t.k. HD-1, and the coat protein of potato leaf roll virus.
    Type: Grant
    Filed: October 9, 1992
    Date of Patent: March 19, 1996
    Assignee: Monsanto Company
    Inventors: David A. Fischhoff, Frederick J. Perlak
  • Patent number: 5498830
    Abstract: Promoters for enhanced expression of ADPglucose pyrophosphorylase in potato tubers and fruits such as tomato; methods of using them; DNA molecules, plant cells and plants containing them. A method of decreasing the oil content of seeds by expression of ADPglucose pyrophosphorylase.
    Type: Grant
    Filed: July 12, 1993
    Date of Patent: March 12, 1996
    Assignee: Monsanto Company
    Inventors: Gerard F. Barry, Ganesh M. Kishore, David M. Stark
  • Patent number: 5498624
    Abstract: Novel azolyl derivatives, ie 2'-(substituted)cycloalkyl carboxanilides, useful as fungicides, methods of using said compounds and mixtures containing them.
    Type: Grant
    Filed: May 3, 1995
    Date of Patent: March 12, 1996
    Assignee: Monsanto Company
    Inventors: Jim I. McLoughlin, Deborah A. Mischke, Marla J. Williams, Suzanne Metz
  • Patent number: 5498630
    Abstract: A method of controlling Take-All disease of plants by applying a fungicide of the formula ##STR1## wherein Z1 and Z2 are C and are part of an aromatic ring which is benzothiophene; andA is selected from --C(X)-amine wherein the amine is an unsubstituted, monosubstituted or disubstituted amino radical, --C(O)--SR.sub.3, --NH--C(X)R.sub.4, and --C(.dbd.NR.sub.3)--XR.sub.7 ;B is --W.sub.m --Q(R.sub.2).sub.3 or selected from O-tolyl, 1-naphthyl, 2-naphthyl, and 9-phenanthryl, each optionally substituted with halogen or R.sub.4 ;Q is C, Si, Ge, or Sn;W is --C(R.sub.3).sub.p H.sub.(2-p) --; or when Q is C, W is selected from --C(R.sub.3).sub.p H(.sub.2-p), --N(R.sub.3).sub.m H(.sub.1-m)--, --S(O)p--, and --O--;X is 0 or S;n is 0, 1, 2, or 3;m is 0 or 1;p is 0, 1, or 2;each R and R.sub.2 is independently defined herein;R.sub.3 is C.sub.1 -C.sub.4 alkyl;R.sub.4 is C.sub.1 -C.sub.4 alkyl, haloalkyl, alkoxy, alkylthio, alkylamino, or dialkylamino; andR.sub.7 is C.sub.1 -C.sub.
    Type: Grant
    Filed: November 16, 1994
    Date of Patent: March 12, 1996
    Assignee: Monsanto Company
    Inventors: Dennis P. Phillion, Diane S. Braccolino, Matthew J. Graneto, Wendell G. Phillips, Karey A. Van Sant, Daniel M. Walker, Sai C. Wong
  • Patent number: 5496956
    Abstract: The invention herein relates to certain substituted-arylpyrazole compounds, herbicidal compositions containing same, herbicidal methods of use and processes for preparing said compounds.
    Type: Grant
    Filed: April 4, 1995
    Date of Patent: March 5, 1996
    Assignee: Monsanto Company
    Inventors: Scott S. Woodard, Bruce C. Hamper, Kurt Moedritzer, Michael D. Rogers, Deborah A. Mischke, Gerard A. Dutra
  • Patent number: 5495071
    Abstract: A method for producing genetically transformed plants exhibiting toxicity to Coleopteran insects is disclosed. In another aspect, the present invention embraces chimeric plant genes, genetically transformed cells and differentiated plants which exhibit toxicity to Coleopteran insects. In yet another aspect, the present invention embraces bacterial cells and plant transformation vectors comprising a chimeric plant gene encoding a Coleopteran toxin protein of Bacillus thuringiensis.
    Type: Grant
    Filed: June 4, 1993
    Date of Patent: February 27, 1996
    Assignee: Monsanto Company
    Inventors: David A. Fischhoff, Roy L. Fuchs, Paul B. Lavrik, Sylvia A. McPherson, Frederick J. Perlak
  • Patent number: 5489571
    Abstract: The invention herein relates to certain substituted-arylpyrazole compounds, herbicidal compositions containing same, herbicidal methods of use and processes for preparing said compounds.
    Type: Grant
    Filed: November 2, 1993
    Date of Patent: February 6, 1996
    Assignee: Monsanto Company
    Inventors: Scott S. Woodard, Bruce C. Hamper, Kurt Moedritzer, Michael D. Rogers, Deborah A. Mischke, Gerard A. Dutra
  • Patent number: 5484760
    Abstract: The disclosure herein relates to means for combatting the adverse phytotoxic action to crops arising from the interaction of various herbicidal compounds and biocidal compounds, e.g., insecticidal and/or fungicidal compounds. The means employed to reduce said interaction involves the safening action of various antidotal compounds.
    Type: Grant
    Filed: December 20, 1991
    Date of Patent: January 16, 1996
    Assignee: Monsanto Company
    Inventors: Brett H. Bussler, Harrison R. Hakes, David J. Mayonado