Abstract: A method of manufacturing an electroluminescent device which has an anode and a cathode and arranged between the anode and the cathode a light emissive layer, also includes an anode protection layer which protects the anode against the effects of converting a precursor polymer to a semiconductive conjugated polymer which constitutes the light emissive layer. This has been found to increase the brightness and half-life of devices.

Abstract: A discrete powder which includes particles in which a biliquid foam has been entrapped within a matrix of a polymeric material. A process for the preparation of these discrete powders includes the steps of: i) preparing a biliquid foam, ii) forming a dispersion of the biliquid foam in an aqueous solution, suspension or dispersion of a polymeric material, and iii) subjecting the dispersion to drying under conditions such that a discrete powder is formed.

Abstract: Abutment of a dental implant system, having at the top a support region intended for receiving a prosthetic build-up construction and at the bottom an implant contact region intended for insertion into a receiving hole of an implant, and wherein the abutment has between the support region and the implant contact region a soft tissue contact surface. The soft tissue contact surface is at least partially hydroxylated or silanated.

Abstract: A low-concentration formulation of an active enamel substance, such as an enamel matrix, enamel matrix derivative and/or an enamel matrix protein, is intended to be used as a therapeutic, as a prophylactic and/or as a cosmetic agent. The active enamel substance is incorporated into a polymeric matrix, which is either suitable for cellular in-growth, or is cell-occlusive, so that it is released by degradation of the polymeric matrix, by enzymatic action and/or by diffusion. A new pharmaceutical and/or cosmetic formulation of an active enamel substance is provided at a lower total concentration within the formulation, wherein a spatial and/or selective regulation of release of said active enamel substance permits a greater percentage of the active enamel substance to be released at the time of appropriate cellular activity.

Abstract: Apparatus and method for simulating a back and forth leg or foot movement, the apparatus comprising: a pair of pivotable support mechanisms supported on a frame, a pair of foot pedals mounted on the support mechanisms for back and forth movement along an arcuate path of translation movement, the foot pedals being adjustable to a selected segment of an overall arcuate path of translation movement. The apparatus includes handles or arms interconnected or interlinked to the foot pedals for upper body pushing or pulling energy input. The handles or arms pivot together with and in the same back or forth direction as the pedals to which they are interlinked.

Abstract: A method for manufacturing one or several dental prostheses, comprising the steps of: performing a rapid prototyping method for manufacturing one or several dental prostheses and subsequent working, such as reworking, of the one or several dental prostheses with a machining method, such as a milling method. In addition, a method for creating a data record which can be used for a rapid prototyping method for manufacturing a dental prosthesis wherein an end data record is obtained from a starting data record, so that in at least one area of a dental prosthesis manufactured with the end data record excess material is provided, compared to a dental prosthesis manufactured with the starting data record.

Abstract: Method and apparatus for sequentially delivering multiple shots of polymer material to a plurality of mold cavities to form multilayer articles. A first shot of greater than 50% of the total article weight of a first polymer material is simultaneously delivered to a plurality of mold cavities using, at each cavity, a chamber of predetermined volume that is prefilled with the first polymer material. A second shot of no greater than 10% of the total article weight of a second material is simultaneously delivered to all of the cavities beginning subsequent to the step of delivering the start of the first shot delivery step. The second shot of second material is delivered through a manifold channel that fluidly communicates with each cavity, and is injected to all cavities under pressure exerted by a source of the second material that is common to all of the plurality of cavities.

Abstract: Molded preform for blow molding a plastic container for pressurized applications, the preform having a base with a multilayer wall for forming a delamination and crack resistant multilayer footed container base. The preform base forming region has an end cap portion with a non-spherical inner wall, including a flattened central section joined by arcuate corner sections to a generally cylindrical outer section. The inner wall sections provide a varying end cap thickness profile which enhances orientation in select portions of the footed container base for improved performance and/or lightweighting of the container base.

Abstract: A light-emissive device comprising: a light-emissive region (12); a first electrode (10) located on a viewing side of the light-emissive region for injecting charge carriers of a first type: and a second-electrode (11) located on a non-viewing side of the light-emissive region for injecting charge carriers of a second type; and wherein there is a reflectivity-influencing structure (13) located on the non-viewing side of the light-emissive region and including a light absorbent layer comprising graphite and/or a fluoride or oxide of a low work function metal.

Abstract: Apparatus for controlling the rate of flow of fluid material from an injection molding machine to a mold cavity, the apparatus comprising: a manifold receiving the injected fluid material and having a delivery channel that delivers the fluid material to the mold cavity; a bushing or insert or plug mounted in an aperture in the manifold having a rate flow control channel communicating with the delivery channel of the manifold; a pin having a flow control member; the pin being adapted for back and forth axial movement within the rate flow control channel wherein a surface of the flow control member is controllably engageable or sealable against an interior surface area portion of the rate flow control channel of the bushing or insert or plug.

Abstract: Apparatus and method for making a molded plastic article having a stretched and crystallized neck finish. In one embodiment, a series of platforms are carried by a conveying apparatus for transporting a series of molded plastic articles along a predetermined path of travel through one or more treatment stations. At a finish widening station, the molded article, having a relatively wide and thin-walled blow-molded body portion, and a relatively narrow and thick-walled unexpanded neck finish portion, is positioned to enable insertion of a mandrel into an open top aperture of the finish portion to widen the finish. The mandrel may include a lower heated tapered portion for expanding the finish, and an upper cooled body portion on which the expanded finish may be cooled. The article may then be sent to a finish crystallizing station having a heating device that heats the widened finish portion for a time and temperature selected to crystallize at least a portion of the widened finish.

Abstract: An apparatus including storage means containing methanol and a peroxide, a housing containing a catalyst comprising at least one group 7, 8, 9, 10 or 11 transition metal, and means for introducing the methanol and the peroxide into the housing.

Abstract: A polyaphron dispersion comprising an external phase and polyaphrons having an internal phase, the internal phase comprising (i) a first phase which is liquid and (ii) a second phase which is liquid or gaseous.

Abstract: The invention relates to substrates containing polyphosphazene with a forming surface as matrices for producing biological materials that can be implanted in a mammal. The invention also relates to a method for producing said substrates and substrates containing polyphosphazene with a microstructured surface.

Abstract: A rotor having variable volumes adapted for collecting and centrifuging biological fluids including an impermeable flexible body having a cylindrical shape with stretchable vertical walls and semi pliant base and a rigid circular member seamlessly joined to the top of the flexible body.

Abstract: A method of enhancing an immune response to an antigen is provided. The method involves augmenting the level of a TAP molecule in a target cell bearing the antigen. Preferably, the TAP molecules enhanced by administering a nucleic acid sequence encoding a TAP-1 and/or TAP-2 molecule. The method is useful in treating infectious diseases and cancer.

Abstract: A method for direct therapeutic treatment of myocardial tissue in a localized region of a heart having a pathological condition. The method includes identifying a target region of the myocardium and applying material directly and substantially only to at least a portion of the myocardial tissue of the target region. The material applied results in a physically modification the mechanical properties, including stiffness, of said tissue. Various devices and modes of practicing the method are disclosed for stiffening, restraining and constraining myocardial tissue for the treatment of conditions including myocardial infarction or mitral valve regurgitation.

Abstract: The present invention relates to a new and improved low-concentration formulation of an active enamel substance, such as an enamel matrix, enamel matrix derivative and/or an enamel matrix protein, intended to be used as therapeutic, as propylacetic and/or as cosmetic agent. In the present invention, said active enamel substance is incorporated into a polymeric matrix, which is either suitable for cellular in-growth, or cell-occlusive. The active enamel substance can be incorporated into the polymeric matrix so that it is released by degradation of the polymeric matrix, by enzymatic action and/or by diffusion. Comprised in the invention is thus in particular a new pharmaceutical and/or cosmetic formulation of an active enamel substance at a lower total concentration within the formulation, wherein a spatial and/or selective regulation of release of said active enamel substance permits a greater percentage of the active enamel substance to be released at the time of appropriate cellular activity.

Abstract: A vaccine composition for combating Pox viridae viral infections in living organisms such as mammals (including humans) comprises TAP-1 and/or TAP-2 to augment the antigen processing capability of infected cells and hence their immunogenicity. The composition may be used alone or, preferably, as an immunogenicity-enhancing adjuvant with a pox antigen-based vaccine, especially in the treatment or prophylaxis of viral infections such as smallpox.

Abstract: The present invention provides a method for stabilizing a protein in a desired conformation by introducing at least one disulfide bond into the polypeptide. Computational design is used to identify positions where cysteine residues can be introduced to form a disulfide bond in only one protein conformation, and therefore lock the protein in a given conformation. Accordingly, antibody and small molecule therapeutics are selected that are specific for the desired protein conformation. The invention also provides modified integrin I-domain polypeptides that are stabilized in a desired conformation. The invention further provides screening assays and therapeutic methods utilizing the modified integrin I-domains of the invention.