Abstract: The present invention is directed to a system and method for raising financing and/or revenue by artist for a project, where the project may be a creative work of the artist. The method including registering, by at least one artist, with a centralized database, at least one or more projects, offering, by the at least one artist, an entitlement related to the artist in exchange for capital for the project of the artist. The method and system may also include searching, by an interested party, the centralized database, for the least one artist, registering, by the interested party, with the centralized database and accepting the offer by the interested party for the entitlement related to the project. The capital may then be forwarded to the artist and the entitlement provided to the interested party.

Abstract: Method for assessing the patency of a patient's blood vessel, advantageously during or after treatment of that vessel by an invasive procedure, comprising administering a fluorescent dye to the patient; obtaining at least one angiographic image of the vessel portion; and evaluating the at least one angiographic image to assess the patency of the vessel portion. Other related methods are contemplated, including methods for assessing perfusion in selected body tissue, methods for evaluating the potential of vessels for use in creation of AV fistulas, methods for determining the diameter of a vessel, and methods for locating a vessel located below the surface of a tissue.

Abstract: The present invention provides a method for stabilizing a protein in a desired conformation by introducing at least one disulfide bond into the polypeptide. Computational design is used to identify positions where cysteine residues can be introduced to form a disulfide bond in only one protein conformation, and therefore lock the protein in a given conformation. Accordingly, antibody and small molecule therapeutics are selected that are specific for the desired conformation. The invention also provides modified integrin I-domain polypeptides that are stabilized in a desired conformation. The invention further provides screening assays and therapeutic methods utilizing the modified integrin I-domains of the invention.

Abstract: This application relates to a plasma torch assembly comprising a plurality of tubes; a collar integral with at least one tube comprising a first abutment surface; a base for holding the tubes during operation of the torch comprising a portion for receiving the collar and a second abutment; and co-operating interlocking portions for removably urging the first and second abutment surfaces together by relative rotation of the interlocking portions wherein the first and second abutment surfaces comprise a complimentary taper for aligning the collar in concentric formation with at least one other tube on the base by co-operation of the interlocking portions.

Abstract: Stents with coatings comprising a combination of a restenosis inhibitor comprising an HMG-CoA reductase inhibitor and a carrier. Also provided are methods of coating stents with a combination of an HMG-CoA reductase inhibitor and a carrier. A preferred example of a restenosis inhibitor is cerivastatin. The stent coatings have been shown to release restenosis inhibitors in their active forms.

Abstract: Methods for treating multiple myeloma with inhibitors of CXCR4 are described. The decreased expression of CXCR4 on multiple myeloma cells according to the invention results in decreased homing of the cells to the bone marrow and a reduction in the development of the disease. Also disclosed are pharmaceutical compositions incorporating such inhibitors for use in the therapeutic treatment of multiple myeloma. The treatment methods described herein can be used independently, or in conjunction with, other therapies for the treatment of multiple myeloma.

Abstract: An exercise device includes one or more foot supports movable along an arcuate path defined around a point of rotation. The arcuate path is divisible into machine defined user selectable arc segments and the movement of the foot support(s) is limited to the machine defined user selected arc segment. The exercise device can include a frame, a linkage movably engaged with the frame, a foot support movably engaged with the linkage, a crank arm movably engaged with the frame, a motor operative to move the crank arm location with respect to the frame, and a drive linkage movably engaging the linkage.

Abstract: A guidewire stop is disclosed which can be positioned and frictionally locked to a bare guidewire at a user-defined location. The guidewire stop can be used to stop and/or lock a medical device, such as an embolic filter, at a treatment site inside a body lumen. The medical device may be attached to the guidewire stop.

Abstract: Apparatus and method for harvesting energy from the environment and/or other external sources and converting it to useful electrical energy. The harvester does not contain a permanent magnet or other local field source but instead relies on the earth's magnetic field of another source of a magnetic field that is external to the sensing device. One advantage of these new harvesters is that they can be made smaller and lighter than energy harvesters that contain a magnet and/or an inertial mass.

Abstract: A method of generating a change in a cellular process of a target cell is disclosed. The method comprises contacting the target cell with a solid buffer, so as to alter an intracellular pH value in at least a portion of the cell, thereby generating the change in a cellular process of a target cell of a multicellular organism. The method may be used to kill either eukaryotic or prokaryotic cells. Pharmaceutical compositions and devices are also enclosed.

Abstract: An organic light-emitting device, comprising: a substrate; a first conductive layer formed over the substrate; at least one layer of a light-emissive organic material formed over the first conductive layer; a barrier layer formed over the at least one organic layer which acts to protect the at least one layer of organic material; and a second conductive layer, preferably a patterned sputtered layer, formed over the barrier layer.

Abstract: An electrical power distribution system comprising: a first housing having an outside surface, configured to receive electrical power from a source; a current limiting and splitting mechanism disposed within the first housing, configured to receive the electrical power and output a plurality of separate current limited electrical circuits; a first housing connector having a first shape, mounted on or to the outside surface of the first housing, having a first plurality of contacts mounted in a first contact arrangement, each contact being connected to one circuit of the plurality of separate current limited electrical circuits and each contact selected to conduct at least one of an elevated current and an elevated voltage.

Abstract: A method for the production of nano- or microcapsules having a diameter of from 20 nm to 40 ?m is suggested, wherein template particles are supplied in an aqueous medium, electrically recharged with a polyelectrolyte, re-recharged without separation or washing steps using a second polyelectrolyte having a complementary charge with respect to the first polyelectrolyte, and said process is optionally continued with alternately charged polyelectrolytes.

Abstract: A process comprises the phases of: activating a pusher, which exerts a push force on a plunger of a syringe containing the infusion liquid; measuring the push force by means of a load cell; comparing the push force with a maximum threshold; halting the pusher when the maximum threshold is exceeded; after a predetermined pause, restarting the pusher and emitting a consent signal indicating correct loading of the syringe if, within a certain time from the restart, the push force again exceeds the maximum threshold. The infusion device serves to inject an anticoagulant into an extracorporeal blood circuit. The control process guarantees against loss of infusion due to an incorrect initial loading of the syringe.

Abstract: An excimer laser cavity is disclosed which includes at least one grating-prism (grism) and a wavelength-selective diffraction grating arranged in sequence. The grism grating surface faces the gain medium and produces an expanded beam which is diffracted on the same side of the prism grating surface normal as the incident beam. The expanded diffracted beam is transmitted through a second surface of the grism either to another grating surface of an additional grism or to a wavelength-selective diffraction grating operating in Littrow configuration. The laser produces a laser output beam with a narrow spectral linewidth which is suitable, in particular, for lithography applications.

Abstract: The present invention relates to a cell-occlusive membrane, obtainable by reaction of at least two precursors in the presence of water. The first precursor A comprises a core and n chains each having a conjugated unsaturated group or a conjugated unsaturated bond, and the second precursor B comprises a core and m chains each having a thiol group, wherein m is greater than or equal to 2, n is greater than or equal to 2, and m+n is greater than or equal 5. The reaction forms a three dimensional network with crosslinking-points. The adjacent crosslinking-points are connected by a chain having less than 600 atoms.

Abstract: A leg press exercise machine that provides translational and rotational motion of the user support structure by translating the user support structure along two intersecting non-orthogonal linear paths. A front portion of the user support structure travels along an inclining linear path and a rear portion of the user support structure travels along a declining linear path. The translation of the user support structure along the inclining and declining linear paths results in the user support structure exhibiting a rational motion, defining an arcuate path.

Abstract: A fluorescence endoscopy video system includes a multimode light source that produces light for color and fluorescence imaging modes. Light from the light source is transmitted through an endoscope to the tissue under observation. The system also includes a compact camera for color and fluorescence imaging. Images obtained through the endoscope are optically divided and projected onto one or more image sensors by a fixed beam splitter in the camera. The fixed beam splitter eliminates the need for inserting a movable mirror into the light path between the endoscope and the image sensors. Image signals from the camera are processed in the system processor/controller where a contrast enhancement function can be applied. The contrast enhancement function increases the color contrast between normal tissue and tissue suspicious for early cancer. Finally, the system also includes a calibration feature whereby the system performance can be maintained when used with different endoscopes.