Patents Represented by Attorney Robert C. Hall

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  • Hydroxyalkyl substituted pyrido-7-pyrimidin-7-ones
    Patent number: 7750016
    Abstract: Compounds of the Formula: where X1, Ar1, R1, and R2 are as defined herein, and compositions comprising the same. Also provided are methods for using compounds of Formula I in treating p38 mediated disorders in a patient.
    Type: Grant
    Filed: November 19, 2007
    Date of Patent: July 6, 2010
    Assignee: Roche Palo Alto LLC
    Inventor: David Michael Goldstein
  • Indole and benzofuran 2-carboxamide derivatives and uses thereof
    Patent number: 7741326
    Abstract: Compounds of formula I or formula II: or pharmaceutically acceptable salts thereof, wherein m, n, p, Ar R1, R2, R4, and R5 are as defined herein. The invention also provides methods for preparing, compositions comprising, and methods for using compounds.
    Type: Grant
    Filed: November 8, 2007
    Date of Patent: June 22, 2010
    Assignee: Roche Palo Alto LLC
    Inventors: Joe Timothy Bamberg, Counde O'Yang, Meng Sui, Shu-Hai Zhao
  • Process for synthesis of phenoxy diaminopyrimidine derivatives
    Patent number: 7741484
    Abstract: A method for preparing a compound of formula I the method comprising treating a compound of formula d with an iodination reagent, to form the compound of formula I, wherein R1, R2 and R3 are as defined herein.
    Type: Grant
    Filed: August 25, 2006
    Date of Patent: June 22, 2010
    Assignee: Roche Palo Alto LLC
    Inventors: Anton Constantinescu, Keena Lynn Green, Eric Roy Humphreys, Gary R. Lee, Patrick Finbar McGarry
  • Cyclopropyl aryl amide derivatives and uses thereof
    Patent number: 7723391
    Abstract: Compounds of the formula: wherein Ar1, Ar2, R1 and R2 are as defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the subject compounds.
    Type: Grant
    Filed: October 2, 2008
    Date of Patent: May 25, 2010
    Assignee: Roche Palo Alto LLC
    Inventors: Daisy Joe Du Bois, David Garrett Loughhead, Hans Maag, Jason Manka, David Bernard Smith, David Nigel Hurst
  • Tetralin and indane derivatives and uses thereof
    Patent number: 7671235
    Abstract: Compounds of the formula I, II or III: or pharmaceutically acceptable salts thereof, wherein m, n, q, Ar, R1, R2, R3, R4 and R5 are as defined herein. Also provided are methods for preparing, compositions comprising, and methods for using compounds of formulas I-III.
    Type: Grant
    Filed: June 20, 2007
    Date of Patent: March 2, 2010
    Assignee: Roche Palo Alto LLC
    Inventors: Ralph New Harris, III, James M. Kress, David Bruce Repke, Russell Stephen Stabler
  • Kinase inhibitors and methods for using the same
    Patent number: 7645764
    Abstract: Compounds of formula I: wherein R1, R2, R3 and R4 are as defined herein. Also disclosed are methods of making the compounds, pharmaceutical compositions, methods of using the compounds for treatment of p38 MAP kinase-mediated diseases, and methods of using the compounds for treatment of Raf kinase-mediated diseases.
    Type: Grant
    Filed: November 8, 2007
    Date of Patent: January 12, 2010
    Assignee: Roche Palo Alto LLC
    Inventors: Tobias Gabriel, Joel McIntosh, Kin-Chun Thomas Luk
  • 3-Amino-1-arylpropyl azaindoles and uses thereof
    Patent number: 7638517
    Abstract: The present invention provides compounds of the formula: or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein p, Ar, R1, R2, R3, Ra, Rb, Rc, Rd and Re are defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the compounds.
    Type: Grant
    Filed: November 29, 2006
    Date of Patent: December 29, 2009
    Assignee: Roche Palo Alto LLC
    Inventors: Robert Greenhouse, Saul Jaime-Figueroa, Stephen M. Lynch, Lubica Raptova, Karin Ann Stein, Robert James Weikert
  • Benzazepine derivatives and uses thereof
    Patent number: 7622462
    Abstract: Compounds of the formula: or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ar, R1 and R2 are defined herein. Also provided are pharmaceutical compositions, methods of preparing the compounds, and method of using the compounds for treatment of monoamine reuptake inhibitor-mediated diseases.
    Type: Grant
    Filed: May 31, 2007
    Date of Patent: November 24, 2009
    Assignee: Roche Palo Alto LLC
    Inventors: Ryan Craig Schoenfeld, Robert James Weikert
  • Substituted pyrazolo[3,4-D]pyrimidines as p38 MAP kinase inhibitors
    Patent number: 7608603
    Abstract: Compounds of formula Ia, Ib, Ic, Id, Ie, If, Ig or Ih: wherein X and Y are nitrogen or one of X and Y is nitrogen and the other is CRg, and W, D, E, R4, R5, R6 and Rg are as defined herein. Also disclosed are methods of making the subject compounds and methods of using the compounds in the treatment of p38 MAP kinase-mediated diseases.
    Type: Grant
    Filed: August 23, 2006
    Date of Patent: October 27, 2009
    Assignee: Roche Palo Alto LLC
    Inventors: Nolan James Dewdney, Tobias Gabriel, Kristen Lynn McCaleb
  • Substituted pyrazolo[3,4-d]pyrimidines as p38 MAP kinase inhibitors
    Patent number: 7601726
    Abstract: Compounds of formula Ia or Ib: wherein A, W, X, Y, R1, R2, R3 and R4 are as defined herein. Also disclosed are methods of making the compounds and methods of using the compounds for treatment of p38 MAP kinase-mediated diseases.
    Type: Grant
    Filed: August 23, 2006
    Date of Patent: October 13, 2009
    Assignee: Roche Palo Alto LLC
    Inventors: Nidhi Arora, Nolan James Dewdney, Tobias Gabriel, Kristen Lynn McCaleb, Michael Soth
  • Methods for synthesis of 3-amino-1-arylpropyl indoles
    Patent number: 7598399
    Abstract: A method comprising: hydrogenating an indole propionamide compound of formula h with vitride, to form an aminopropyl indole compound of formula i wherein m, Ar, R1 and R2 are as defined herein. The compounds prepared by the method of the invention are useful as monoamine reuptake inhibitors useful for treatment of CNS indications.
    Type: Grant
    Filed: November 29, 2006
    Date of Patent: October 6, 2009
    Assignee: Roche Palo Alto LLC
    Inventors: Terrence Joseph Connolly, Robert P. Farrell, Eric Roy Humphreys, Stephen M. Lynch, Keshab Sarma
  • Tetrazole-substituted arylamides as P2Xand P2Xantagonists
    Patent number: 7595405
    Abstract: Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted tetrazolyl, R2 is optionally substituted phenyl, optionally substituted pyridinyl or optionally substituted thienyl, and R3, R4, R5 and R6 are as defined herein. Also provided are methods of using the compounds for treating diseases associated with the P2X3 and/or a P2X2/3 receptor antagonist and methods of making the compounds.
    Type: Grant
    Filed: June 28, 2007
    Date of Patent: September 29, 2009
    Assignee: Roche Palo Alto LLC
    Inventors: Michael Patrick Dillon, Ronald Charles Hawley, Li Chen, Lichun Feng, Minmin Yang
  • Diaminopyrimidines as P2Xand P2Xmodulators
    Patent number: 7589090
    Abstract: Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the compounds being of formula (I): wherein R1, R2, R3 and R4 are as defined herein.
    Type: Grant
    Filed: February 27, 2008
    Date of Patent: September 15, 2009
    Assignee: Roche Palo Alto LLC
    Inventors: Michael Patrick Dillon, Alam Jahangir
  • Benzimidazolone and dihydroindolone derivatives and uses thereof
    Patent number: 7582760
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof wherein m, n, X, Ar, R1, R2, R3, R4 and R5 are as defined herein. Also provided are methods for preparing, compositions comprising, and methods for using compounds of formula I.
    Type: Grant
    Filed: July 12, 2006
    Date of Patent: September 1, 2009
    Assignee: Roche Palo Alto LLC
    Inventors: Timothy Owens, Steven Sethofer, Keith Adrian Walker, Shu Hai Zhao
  • Tetralin and indane derivatives and uses thereof
    Patent number: 7576103
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, p, q, Ar, R1 and R2 are as defined herein. Also provided are methods for preparing, compositions comprising, and methods for using compounds of formula I.
    Type: Grant
    Filed: December 21, 2005
    Date of Patent: August 18, 2009
    Assignee: Roche Palo Alto LLC
    Inventors: Ralph New Harris, III, Nancy Elisabeth Krauss, James M. Kress, David Bruce Repke, Russell Stephen Stabler
  • Substituted pyrazolo{3,4-D}pyrimidines as p38 map kinase inhibitors
    Patent number: 7566708
    Abstract: Compounds effective as p38 MAP kinase inhibitors, methods of making the compounds, and methods of using the compounds for treatment of p38 MAP kinase-mediated diseases.
    Type: Grant
    Filed: August 23, 2006
    Date of Patent: July 28, 2009
    Assignee: Roche Palo Alto LLC
    Inventors: Nidhi Arora, Roland Joseph Billedeau, Nolan James Dewdney, Tobias Gabriel, David Michael Goldstein, Counde O'Yang, Michael Soth, Teresa Alejandra Trejo-Martin
  • Substituted pyrazolo[3,4-D]pyrimidines as p38 map kinase inhibitors
    Patent number: 7563799
    Abstract: Compounds of the formula Ia or Ib: wherein X and Y are N or one of X and Y is N and the other is CRg, and A, D, E, G, W, R1, R2, R3, R4 and R5 are as defined herein. Also disclosed are methods of making the subject compounds and methods of using the compounds for treatment of p38 MAP kinase-mediated diseases.
    Type: Grant
    Filed: August 23, 2006
    Date of Patent: July 21, 2009
    Assignee: Roche Palo Alto LLC
    Inventors: Roland Joseph Billedeau, Nolan James Dewdney, Tobias Gabriel
  • Substituted pyrazolo[3,4-D]pyrimidines as p38 map kinase inhibitors
    Patent number: 7563800
    Abstract: Compounds of formula Ia or Ib: wherein R1, R2, R3 and R4 are as defined herein. Also disclosed are methods of making the compounds and methods of using the compounds for treatment of p38 MAP kinase-mediated diseases.
    Type: Grant
    Filed: December 18, 2007
    Date of Patent: July 21, 2009
    Assignee: Roche Palo Alto LLC
    Inventors: Tobias Gabriel, Yan Lou
  • Arylsulfonamidyl tetralin derivatives and uses thereof
    Patent number: 7531577
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein Ar, X, m, R1, R2 are as defined herein. Also provided are methods for preparing, compositions comprising, and methods for using compounds of formula I for treatment of 5-HT6-mediated diseases.
    Type: Grant
    Filed: June 20, 2007
    Date of Patent: May 12, 2009
    Assignee: Roche Palo Alto LLC
    Inventors: Ralph New Harris, III, James M. Kress, David Bruce Repke, Russell Stephen Stabler
  • Diaminopyrimidines as P2Xand P2Xmodulators
    Patent number: 7531547
    Abstract: Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): wherein D, X, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.
    Type: Grant
    Filed: August 25, 2006
    Date of Patent: May 12, 2009
    Assignee: Roche Palo Alto LLC
    Inventors: Michael Patrick Dillon, Alam Jahangir, Amy Geraldine Moore, Paul J. Wagner