Patents Represented by Attorney Robert C. Hall

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  • Chroman derivatives and uses thereof
    Patent number: 7528250
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, p, q, Ar, R1, R2, R3 and R4 are as defined herein. Also provided are methods for preparing, compositions comprising, and methods for using compounds of formula I.
    Type: Grant
    Filed: December 21, 2005
    Date of Patent: May 5, 2009
    Assignee: Roche Palo Alto LLC
    Inventors: Nancy Elisabeth Krauss, Shu-Hai Zhao
  • p38 MAP kinase inhibitors and methods for using the same
    Patent number: 7517901
    Abstract: Compounds of formula Ia or Ib: wherein X and Y are nitrogen or CRe, and R1, R2, R3, R4 and R5 are as defined herein. Also disclosed are methods of making the subject compounds and methods of using the compounds for treatment of p38-mediated diseases.
    Type: Grant
    Filed: August 23, 2006
    Date of Patent: April 14, 2009
    Assignee: Roche Palo Alto LLC
    Inventors: Tobias Gabriel, Michael Soth
  • Indazole derivatives and methods for using the same
    Patent number: 7495015
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein m, k, B, R1, R2 and R3 are those defined herein, and compositions comprising the same. Also provided are methods for preparing compounds of formula I and using the same in treating p38 mediated disorders in a patient.
    Type: Grant
    Filed: February 25, 2005
    Date of Patent: February 24, 2009
    Assignee: Roche Palo Alto LLC
    Inventors: Nidhi Arora, Tobias Gabriel, David Michael Goldstein, Teresa Alejandra Trejo-Martin
  • Quinolinone derivatives and uses thereof
    Patent number: 7476675
    Abstract: The invention provides compounds of the formula: and pharmaceutically acceptable salts or prodrugs thereof, wherein m, p, q, r, A, E, X, Y, R1, R4, R5, R6, R7, R8, R9 and are as defined herein. The invention also provides methods for preparing, compositions comprising, and methods for using compounds of formula I.
    Type: Grant
    Filed: July 27, 2005
    Date of Patent: January 13, 2009
    Assignee: Roche Palo Alto LLC
    Inventors: David Bruce Repke, Russell Stephen Stabler, Ralph New Harris, III
  • Tetralin and indane derivatives and uses thereof
    Patent number: 7473690
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, p, q, Ar, R1 and R2 are as defined herein. Also provided are methods for preparing, compositions comprising, and methods for using compounds of formula I.
    Type: Grant
    Filed: December 21, 2005
    Date of Patent: January 6, 2009
    Assignee: Roche Palo Alto LLC
    Inventors: Ralph New Harris, III, Nancy Elisabeth Krauss, James M. Kress, David Bruce Repke, Russell Stephen Stabler
  • Substituted pyrazolo [3,4-d] pyrimidines and methods of using the same
    Patent number: 7452880
    Abstract: Compounds of the formula I: where A, B, X, Y, Z, k, R1, R2 and R3 are those defined herein, and compositions comprising the same. The present invention also provides methods for preparing compounds of formula I and using the same in treating p38 mediated disorders in a patient.
    Type: Grant
    Filed: February 25, 2005
    Date of Patent: November 18, 2008
    Inventors: Nidhi Arora, Roland Joseph Billedeau, Nolan James Dewdney, Tobias Gabriel, David Michael Goldstein, Teresa Alejandra Trejo-Martin
  • 6-Substituted pyrido-pyrimidines
    Patent number: 7449581
    Abstract: The present invention provides compounds of the Formula I and II: wherein R1, R3, W, Z, X1, X2, Ar1, R8 and R9 are as defined herein, and methods and intermediates for their preparation and uses thereof.
    Type: Grant
    Filed: January 9, 2007
    Date of Patent: November 11, 2008
    Assignee: Poche Palo Alto LLC
    Inventors: Jian Jeffrey Chen, James Patrick Dunn, David Michael Goldstein, Christoph Martin Stahl
  • 3-amino-1-arylpropyl indoles and aza-substituted indoles and uses thereof
    Patent number: 7446118
    Abstract: The present invention provides compounds of the formula: or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein p, Ar, R1, R2, R3, Ra, Rb, Rc, Rd and Re are defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the compounds.
    Type: Grant
    Filed: November 29, 2006
    Date of Patent: November 4, 2008
    Assignee: Roche Palo Alto LLC
    Inventors: Pravin Iyer, Matthew C. Lucas, Ryan Craig Schoenfeld, Marzia Villa, Robert James Weikert
  • Substituted pyrazolo[3,4-d]pyrimadines and methods of using the same
    Patent number: 7435731
    Abstract: Compounds of the formula Ia or Ib: wherein A, B, X, Y, Z, W, k, R1, R2, R3, R4 and R5 are those defined herein, and compositions comprising the same. The present invention also provides methods for preparing compounds of formula I and using the same in treating p38 mediated disorders in a subject.
    Type: Grant
    Filed: February 25, 2005
    Date of Patent: October 14, 2008
    Assignee: Roche Palo Alto LLC
    Inventors: Nidhi Arora, Roland Joseph Billedeau, Nolan James Dewdney, Tobias Gabriel, David Michael Goldstein, Counde O'Yang, Michael Soth
  • Pyrazolyl and imidazolyl pyrimidines as CRF antagonists
    Patent number: 7414059
    Abstract: Compounds of the formula (I): and pharmaceutically acceptable salts or prodrugs thereof, wherein X, Y, Z and R1 are as defined herein. The invention also provides methods for preparing, compositions comprising, and methods for using compounds of formula I.
    Type: Grant
    Filed: November 24, 2004
    Date of Patent: August 19, 2008
    Assignee: Roche Palo Alto LLC
    Inventors: Alam Jahangir, Counde O'Yang
  • Imidazolinylmethyl aralkylsulfonamides
    Patent number: 7407980
    Abstract: Compounds of the Formula: where R1-R6 are those defined herein and methods for producing the same. Also provided are pharmaceutical compositions comprising a Compound of Formula I and methods for their use as therapeutic agents.
    Type: Grant
    Filed: April 13, 2004
    Date of Patent: August 5, 2008
    Assignee: Roche Palo Alto LLC
    Inventors: Michael Patrick Dillon, Clara Jeou Jen Lin, Counde O'Yang, Xiaoming Zhang
  • 2,4-substituted indoles and methods of use
    Patent number: 7381739
    Abstract: The present invention provides a compound of the formula: a pharmaceutically acceptable salt or a prodrug thereof, where R1, R2, R3, R4, p and n are those defined herein. The present invention also provides compositions comprising, methods for using, and methods for preparing Compound of Formula I.
    Type: Grant
    Filed: September 16, 2003
    Date of Patent: June 3, 2008
    Assignee: Roche Palo Alto LLC
    Inventors: Ann Marie Madera, Robert James Weikert
  • Benzoxazine and quinoxaline derivatives and uses thereof
    Patent number: 7378415
    Abstract: Compounds of the formula I: or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein k, m, n, p, q, X, Y, Z, Ar, R1, R2, R3 and R4 are as defined herein. Also provided are methods for preparing, compositions comprising, and methods for using compounds of formula I.
    Type: Grant
    Filed: September 30, 2005
    Date of Patent: May 27, 2008
    Assignee: Roche Palo Alto LLC
    Inventors: Steven Sethofer, Li Zhang, Shu-Hai Zhao
  • Arylsulfonyl benzodioxanes, benzoxazines and benzothiazines as 5-HT6 antagonists
    Patent number: 7368567
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein m, n, p, Ar, X, R1, R2, R3, R4, R5 and R6 are as defined herein. Also provided are compositions comprising, methods of preparing, and methods of using the subject compounds.
    Type: Grant
    Filed: May 4, 2005
    Date of Patent: May 6, 2008
    Assignee: Roche Palo Alto LLC
    Inventors: Jacob Berger, Shu-Hai Zhao
  • Quinazolinone and benzoxazinone derivatives and uses thereof
    Patent number: 7365063
    Abstract: Compounds of the formula I: and pharmaceutically acceptable salts thereof wherein X is N, Y is S, Z is —(CRaRb)r—, A is —NR3, m is 2, n is 1, q is 2, R2 is optioinally substituted aryl or optionally substituted heteroaryl, and p, R1, R3, R4, R5, R6, R7, R8, R9, and R10, are as defined herein. The invention also provides methods for preparing, compositions comprising, and methods for using compounds of formula I for treatment of central nervous system diseases.
    Type: Grant
    Filed: February 7, 2007
    Date of Patent: April 29, 2008
    Assignee: Roche Palo Alto LLC
    Inventors: Nancy Elisabeth Krauss, Meng Sui, Shu-Hai Zhao
  • Cathepsin K inhibitors
    Patent number: 7358373
    Abstract: The present invention provides a compound of the Formula: a pharmaceutically acceptable salt, a solvate, or a prodrug thereof, wherein m, n, Ar1, R1, R2, R3, R4, and R5 are those defined herein. The present invention also provides methods for using and preparing compounds of Formula I.
    Type: Grant
    Filed: July 25, 2006
    Date of Patent: April 15, 2008
    Assignee: Roche Palo Alto LLC
    Inventors: Joe Timothy Bamberg, Tobias Gabriel
  • Hydroxyalkyl substituted pyrido-7-pyrimidin-7-ones
    Patent number: 7348331
    Abstract: Compounds of the Formula: where X1, Ar1, R1, and R2 are as defined herein, and compositions comprising the same. Also provided are methods for using compounds of Formula I in treating p38 mediated disorders in a patient.
    Type: Grant
    Filed: November 12, 2004
    Date of Patent: March 25, 2008
    Assignee: Roche Palo Alto LLC
    Inventor: David Michael Goldstein
  • Tetralin and indane derivatives and uses thereof
    Patent number: 7312359
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, p, q, Ar, R1 and R2 are as defined herein. Also provided are methods for preparing, compositions comprising, and methods for using compounds of formula I.
    Type: Grant
    Filed: December 21, 2005
    Date of Patent: December 25, 2007
    Assignee: Roche Palo Alto LLC
    Inventors: Robert Greenhouse, Ralph New Harris, III, Saul Jaime-Figueroa, James M. Kress, David Bruce Repke, Russell Stephen Stabler
  • Carboxylic acid derivatives as IP antagonists
    Patent number: 7312230
    Abstract: This invention relates to compounds which are generally IP receptor antagonists and which are represented by Formula I: wherein: R1, R2, and R3 are each independently in each occurrence aryl or heteroaryl; R4 is —COOH or tetrazolyl; A, B, m, n, and r are as defined in the specification; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and processes for their preparation.
    Type: Grant
    Filed: September 30, 2005
    Date of Patent: December 25, 2007
    Assignee: Roche Palo Alto LLC
    Inventors: Richard Leo Cournoyer, Paul Francis Keitz, Lee Edwin Lowrie, Jr., Alexander Victor Muehldorf, Counde O'Yang, Dennis Mitsugu Yasuda
  • Aryloxy quinolines and uses thereof
    Patent number: 7307089
    Abstract: Compounds of Formula 1 and pharmaceutically acceptable salts thereof, wherein m, Ar, R1, R2, and R3 are as defined herein. The invention also provides methods for preparing, coompositions comprising, and methods for using compounds of Formula 1 for treatment of central nervous system disorders.
    Type: Grant
    Filed: July 25, 2006
    Date of Patent: December 11, 2007
    Assignee: Roche Palo Alto LLC
    Inventors: Ralph New Harris, III, James M. Kress, David Bruce Repke, Russell Stephen Stabler