Abstract: This invention provides 5-HT.sub.1F agonists of Formula I; ##STR1## where A-B, X, and R are as defined in the specification. The invention also encompasses pharmaceutical formulations employing compounds of Formula I as well as methods of treating conditions associated with 5-HT.sub.1F activation employing these compounds or compositions. The invention also provides intermediates useful for the preparation of the compounds of Formula I.
Type:
Grant
Filed:
July 9, 1998
Date of Patent:
December 7, 1999
Assignee:
Eli Lilly and Company
Inventors:
Sandra Ann Filla, Kirk W. Johnson, Lee A. Phebus, John Mehnert Schaus
Abstract: This invention provides novel 5-HT.sub.1F agonists of Formula I ##STR1## where A--B, R,R.sup.1 and X are as defined in the specification, which are useful for the treatment of migraine and associated disorders.
Type:
Grant
Filed:
November 24, 1997
Date of Patent:
October 5, 1999
Assignee:
Eli Lilly and Company
Inventors:
James Edmund Audia, Bruce Anthony Dressman, James Joseph Droste, James Erwin Fritz, Stephen Warren Kaldor, Daniel James Koch, Joseph Herman Krushinski, Jr., Jeffrey Scott Nissen, Vincent Patrick Rocco, John Mehnert Schaus, Dennis Charles Thompson
Abstract: This invention provides methods for the treatment or amelioration of the symptoms of the common cold or allergic rhinitis which comprises administering to a mammal in need thereof a serotonin 5-HT.sub.1F agonist.
Abstract: The availability of serotonin, norepinephrine and dopamine in the brain is increased by administering a serotonin reuptake inhibitor with a serotonin 1A antagonist and L-tryptophan or 5-hydroxy-L-tryptophan.
Abstract: The invention provides novel 5-HT.sub.1f agonists of formula (I) where X, R.sup.1, R.sup.2, and R.sup.3 are defined in the specification, which are useful for the treatment of migraine and associate disorders.
Type:
Grant
Filed:
March 13, 1998
Date of Patent:
August 24, 1999
Assignee:
Eli Lilly and Company
Inventors:
James E Fritz, Patric J Hahn, Stephen W Kaldor, Miles G Siegel, Yao-Chang Xu
Abstract: The invention provides substituted-2-amino-1,2,3,4-tetrahydrodibenzofurans and 2-aminocyclohepta?b!benzo-furans useful as 5-HT.sub.1F agonists.
Type:
Grant
Filed:
June 3, 1998
Date of Patent:
August 10, 1999
Assignee:
Eli Lilly and Company
Inventors:
Michael E. Flaugh, Anton D. Kiefer, Jr.
Abstract: The invention provides substituted-2-amino-1,2,3,4-tetrahydrodibenzofurans and 2-aminocyclohepta?b!benzo-furans useful as 5-HT.sub.1F agonists.
Type:
Grant
Filed:
June 3, 1998
Date of Patent:
August 3, 1999
Assignee:
Eli Lilly and Company
Inventors:
Michael E. Flaugh, Anton D. Kiefer, Jr.
Abstract: A pharmaceutical compound having the formula: ##STR1## in which n is 1 or 2, m is 1 or 2, p is 1 to 6, q is 0 or 1 to 3,R.sup.1 and R.sup.2 are each hydrogen or C.sub.1-4 alkyl,R.sup.3, R.sup.4 and R.sup.5 are each hydrogen, C.sub.1-4 alkyl, optionally substituted phenyl or optionally substituted phenyl-C.sub.1-4 alkyl, or R.sup.3 and R.sup.4 together form an alkylene link of formula --(CH.sub.2).sub.3 -- or --(CH.sub.2).sub.4 --, or R.sup.4 and R.sup.5 together with the carbon atom to which they are attached form a C.sub.3-6 cycloalkyl group,R.sup.6 is C.sub.1-4 alkyl, C.sub.1-4 alkoxy, carboxy, hydroxy, cyano, halo, trifluoromethyl, nitro or amino,the dotted line represents an optional double bond, andthe fluorine atom is attached at the 6 or 7-position;and salts and esters thereof.
Abstract: This invention provides 5-HT.sub.1F agonists of Formula I: ##STR1## where A-B, X, and R are as defined in the specification. The invention also encompasses pharmaceutical formulations employing compounds of Formula I as well as methods of treating conditions associated with 5-HT.sub.1F activation employing these compounds or compositions. The invention also provides intermediates useful for the preparation of the compounds of Formula I.
Type:
Grant
Filed:
July 9, 1998
Date of Patent:
July 6, 1999
Assignee:
Eli Lilly and Company
Inventors:
Sandra Ann Filla, Kirk W. Johnson, Lee A. Phebus, John Mehnert Schaus
Abstract: A superior enteric formulation of the antidepressant drug, fluoxetine, is in the form of enteric pellets of which the enteric layer comprises hydroxypropylmethylcellulose acetate succinate.
Type:
Grant
Filed:
May 29, 1997
Date of Patent:
June 8, 1999
Assignee:
Eli Lilly and Company
Inventors:
Neil R. Anderson, Roger G. Harrison, Daniel F. Lynch, Peter L. Oren
Abstract: This invention provides 5-HT.sub.1F agonists of Formula: ##STR1## where A-B, X, and R are as defined in the specification. The invention also encompasses pharmaceutical formulations employing the compounds or the invention as well as methods of treating conditions associated with 5-HT.sub.1F activation employing these compounds or compositions.
Type:
Grant
Filed:
November 14, 1997
Date of Patent:
May 18, 1999
Assignee:
Eli Lilly and Company
Inventors:
Sandra A. Filla, Brian M. Mathes, John M. Schaus
Abstract: The present invention provides a method for altering mammalian central and peripheral physiological and pathological functioning which is mediated by serotonin binding to the 5-HT.sub.7 receptor. Specifically, the invention provides a method for antagonizing serotonin binding to the 5-HT.sub.7 receptor.
Abstract: This invention provides novel 5-HT.sub.1F agonists of the Formula ##STR1## in which X, Y, E, R, A, B, and n are as defined in the specification, which are useful for the treatment of migraine and associated disorders.
Type:
Grant
Filed:
April 14, 1998
Date of Patent:
February 23, 1999
Assignee:
Eli Lilly and Company
Inventors:
Sandra A. Filla, Joseph H. Krushinski, Jr., John Mehnert Schaus
Abstract: The invention provides substituted-2-amino-1,2,3,4-tetrahydrodibenzofurans and 2-aminocyclohepta?b!benzo-furans useful as 5-HT.sub.1F agonists.
Type:
Grant
Filed:
August 25, 1997
Date of Patent:
December 8, 1998
Assignee:
Eli Lilly and Company
Inventors:
Michael E. Flaugh, Anton D. Kiefer, Jr.
Abstract: This invention provides 5-HT.sub.1F agonists of Formula I: ##STR1## where A--B, X, and R are as defined in the specification. The invention also encompasses pharmaceutical formulations employing compounds of Formula I as well as methods of treating conditions associated with 5-HT.sub.1F activation employing these compounds or compositions. The invention also provides intermediates useful for the preparation of the compounds of Formula I.
Type:
Grant
Filed:
November 14, 1997
Date of Patent:
October 6, 1998
Assignee:
Eli Lilly and Company
Inventors:
Sandra Ann Filla, Kirk W. Johnson, Lee A. Phebus, John Mehnert Schaus
Abstract: Indazolecarboxamides are used as antagonists and partial agonists for the serotonin receptor 5-HT.sub.4 and provide therapeutic methods for treatment of disorders caused by or affected by dysfunction of the 5-HT.sub.4 receptor.
Type:
Grant
Filed:
January 10, 1997
Date of Patent:
October 6, 1998
Assignee:
Eli Lilly and Company
Inventors:
John T. Catlow, Marlene L. Cohen, Michael O. Martinelli, John M. Schaus, Steven Swanson, Dennis C. Thompson, Thomas M. Wilson
Abstract: This invention provides novel 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta?7,6-b!indoles. These compounds are 5-HT.sub.1F agonists which are useful for the treatment of migraine and associated disorders.
Type:
Grant
Filed:
December 17, 1997
Date of Patent:
September 29, 1998
Assignee:
Eli Lilly and Company
Inventors:
Michael Edward Flaugh, Anton Daniel Kiefer, Jr., Clint Duane Walker, Yao-Chang Xu