Patents Represented by Attorney, Agent or Law Firm Robert D. Titus
  • Serotonerbic tetrahydropyridoindoles
    Patent number: 5563147
    Abstract: This invention provides novel, optionally substituted tetrahydropyridoindoles which are useful serotonergic agents for the treatment of central nervous system disorders.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: October 8, 1996
    Assignee: Eli Lilly and Company
    Inventors: Jeremy Gilmore, Peter T. Gallagher, Martin V. Miles, William M. Owton, Colin W. Smith
  • Ring-substituted 2-amino-1,2,3,4-tetra-hydronaphthalenes, 3-aminochromanes, and 3-aminothiochromanes
    Patent number: 5552444
    Abstract: The present invention provides novel ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes, 3-aminochromanes, and 3-aminothiochromanes, including their corresponding sulfoxides and sulfones, which ring-substituted compounds exhibit agonist activity at the serotonin 1A receptor.
    Type: Grant
    Filed: March 14, 1995
    Date of Patent: September 3, 1996
    Assignee: Eli Lilly and Company
    Inventors: John M. Schaus, Craig S. Hoechstetter, Diane Huser, Charles J. Paget, Robert D. Titus
  • Antitumor compositions and methods of treatment
    Patent number: 5529999
    Abstract: This invention provides certain sulfonamidoquinoxaline derivatives and methods for using them in the treatment of susceptible neoplasms in mammals. Also provided are certain novel pharmaceutical formulations employing these sulfonamidoquinoxaline derivatives, in combination with a carrier, diluent or excipient.
    Type: Grant
    Filed: March 4, 1994
    Date of Patent: June 25, 1996
    Assignee: Eli Lilly and Company
    Inventors: James E. Ray, John E. Toth
  • 5-HT.sub.1F agonists for the treatment of migraine
    Patent number: 5521196
    Abstract: This invention provides novel 5-HT.sub.1F agonists which are useful for the treatment of migraine and associated disorders.
    Type: Grant
    Filed: October 5, 1994
    Date of Patent: May 28, 1996
    Assignee: Eli Lilly and Company
    Inventors: James E. Audia, Jeffrey S. Nissen
  • 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT.sub.1F agonists
    Patent number: 5521197
    Abstract: This invention provides novel 5-HT.sub.1F agonists which are useful for the treatment of migraine and associated disorders having the following formula: ##STR1## wherein A, B, X, Y, Ar and n are defined in the specification.
    Type: Grant
    Filed: December 1, 1994
    Date of Patent: May 28, 1996
    Assignee: Eli Lilly and Company
    Inventor: James E. Audia
  • Intermediate useful for the asymmetric synthesis of duloxetine
    Patent number: 5491243
    Abstract: This invention provides a stereospecific process for the synthesis of (S)-(+)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine, a key intermediate in the synthesis of duloxetine.
    Type: Grant
    Filed: July 18, 1994
    Date of Patent: February 13, 1996
    Assignee: Eli Lilly and Company
    Inventor: Richard A. Berglund