Patents Represented by Attorney Robert H. Brink

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  • Chemical compounds
    Patent number: 8344155
    Abstract: Disclosed are compounds of Formula III. Also disclosed are salts of the compounds, pharmaceutical composition comprising the compounds or salts, and methods for treating HCV infection by administration of the compounds or salts.
    Type: Grant
    Filed: August 26, 2010
    Date of Patent: January 1, 2013
    Assignee: GlaxoSmith Kline LLC
    Inventors: Pingyun Chen, Ricky Couch, Maosheng Duan, Beth Adams Norton
  • Processes for preparing benzimidazole thiophenes
    Patent number: 8236954
    Abstract: A process for preparing benzimidazole thiophenes including 5-{6-[(4-methylpiperazin-1-yl)methyl]-1H-benzimidazol-1-yl}-3-{(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy}thiophene-2-carboxamide.
    Type: Grant
    Filed: June 23, 2008
    Date of Patent: August 7, 2012
    Assignee: GlaxoSmithKline LLC
    Inventors: Amanda Caroline Lucas, Robert M. Harris, Christopher James Nichols, Andrew Jonathan Whitehead
  • Farnesoid X receptor agonists
    Patent number: 8158665
    Abstract: The present invention provides novel substituted isoxazole compounds, pharmaceutical compositions, therapeutic uses and processes for preparing the same.
    Type: Grant
    Filed: March 9, 2010
    Date of Patent: April 17, 2012
    Assignee: GlaxoSmithKline LLC
    Inventors: Richard Caldwell, David Norman Deaton, Robert Blount McFadyen, Frank Navas, III, Paul Kenneth Spearing
  • IL-8 receptor antagonists
    Patent number: 8097626
    Abstract: This invention relates to novel compounds and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (Il-8).
    Type: Grant
    Filed: April 20, 2007
    Date of Patent: January 17, 2012
    Assignee: GlaxoSmithKline LLC
    Inventor: Jakob Busch-Petersen
  • Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones
    Patent number: 8071592
    Abstract: Bicyclic nitrogen containing compounds and their use as antibacterials.
    Type: Grant
    Filed: July 18, 2007
    Date of Patent: December 6, 2011
    Assignee: Glaxo Group Limited
    Inventors: Lluis Ballell, David Barros, Gerald Brooks, Julia Castro Pichel, Steven Dabbs, Robert A Daines, David Thomas Davies, Jose Maria Fiandor Roman, Israil Pendrak, Modesto J Remuiñan Blanco, Jason Anthony Rossi, Ilaria Giordano, Alan Joseph Hennessy, James B Hoffman, Graham Elgin Jones, Timothy James Miles, Neil David Pearson, Lihua(lily) Zhang
  • Urea-compounds active as vanilloid receptor antagonists for the treatment of pain
    Patent number: 8063078
    Abstract: Certain compounds of formula (I), or a pharmaceutically acceptable salt thereof, or a solvate thereof, wherein R1, R2, P, P?, n, p, q, r and s are as defined in the specification, a process for preparing such compounds, a pharmaceutical composition comprising such compounds and the use of such compounds and composition in medicine.
    Type: Grant
    Filed: September 13, 2002
    Date of Patent: November 22, 2011
    Assignee: GlaxoSmithKline LLC
    Inventors: Harshad Kantilal Rami, Mervyn Thompson
  • IL-8 receptor antagonists
    Patent number: 8044075
    Abstract: This invention relates to novel compounds, compositions and combinations thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
    Type: Grant
    Filed: December 5, 2007
    Date of Patent: October 25, 2011
    Assignee: GlaxoSmithKline
    Inventors: Gregory L. Adams, James A. Brackley, III, Jakob Busch-Petersen, Jianghe Deng, Wei Fu, Huijie Li, Jack J. Taggart, Feng Wang, Yonghui Wang, Katherine Louisa Widdowson, Hongyi Yu
  • Anthranilamide inhibitors of aurora kinase
    Patent number: 7884098
    Abstract: The present invention relates to a compound represented by the following formula: or a pharmaceutically acceptable salt thereof; wherein R1, R1? R2, R3, R4, R5, r and s are as defined herein. Compounds of the present invention are useful in the treatment of diseases associated with Aurora kinase activity such as cancer.
    Type: Grant
    Filed: January 25, 2008
    Date of Patent: February 8, 2011
    Assignee: GlaxoSmithKline LLC
    Inventors: Jeffrey Michael Axten, Deborah L. Bryan, David Harold Drewry, Thomas H Faitg, Timothy Francis Gallagher, Neil W Johnson, Jiri Kasparec, Jeffrey M Ralph, Domingos J. Silva
  • Pyrrolidinone anilines as progesterone receptor modulators
    Patent number: 7816395
    Abstract: The present invention relates to a compound represented by the following formula: or a pharmaceutically acceptable salt thereof, or a solvate thereof, or a combination thereof, wherein R1, R2, and X are as defined herein. Compounds of the present invention are useful as progesterone receptor modulators.
    Type: Grant
    Filed: August 7, 2007
    Date of Patent: October 19, 2010
    Assignee: GlaxoSmithKline LLC
    Inventors: David G. Washburn, Tram H. Hoang
  • Benzimidazole thiophene compounds
    Patent number: 7786127
    Abstract: The present invention provides benzimidazole thiophene compounds, pharmaceutical compositions containing the same, and their use as pharmaceutical agents.
    Type: Grant
    Filed: August 28, 2006
    Date of Patent: August 31, 2010
    Assignee: Glaxo SmithKline LLC
    Inventors: Mui Cheung, Kyle Allen Emmitte, James Michael Salovich
  • Medicaments
    Patent number: 7767682
    Abstract: Methods of prevention or treatment of renal diseases or conditions associated with abnormal ion flux, in particular autosomal dominant polycystic kidney disease, with a modulator of human peroxisome proliferator activated receptor gamma.
    Type: Grant
    Filed: March 1, 2006
    Date of Patent: August 3, 2010
    Assignee: GlaxoSmithKline LLC
    Inventors: Kathleen Keating Brown, Bonnie Blazer-Yost
  • N-(6-membered aromatic ring)-amido anti-viral compounds
    Patent number: 7629340
    Abstract: Disclosed are compounds having Formula (I) and the compositions and methods relating to these compounds, for treating or preventing a viral infection mediated at least in part by a virus in the Flaviviridae family of viruses, wherein A, R2, m, R, V, W, T, Z, R1, Y, and p are disclosed herein.
    Type: Grant
    Filed: December 12, 2006
    Date of Patent: December 8, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: Franz Ulrich Schmitz, Christopher Don Roberts, Ali Dehghani Mohammad Abadi, Ronald Conrad Griffith, Martin Robert Leivers
  • Benzimidazole thiophene compounds
    Patent number: 7615643
    Abstract: The present invention provides benzimidazole thiophene compounds pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.
    Type: Grant
    Filed: May 29, 2007
    Date of Patent: November 10, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: Kevin Kuntz, Kyle Allen Emmitte, Tara Renae Rheault, Stephon Smith, Keith Hornberger, Hamilton Dickson, Mui Cheung
  • Benzimidazole thiophene compounds
    Patent number: 7595330
    Abstract: The present invention provides benzimidazole thiophene compounds pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.
    Type: Grant
    Filed: August 28, 2006
    Date of Patent: September 29, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: Mui Cheung, Kyle Allen Emmitte, James M. Salovich
  • Thiazole and oxazole derivatives as activators of human peroxisome proliferator activated receptors
    Patent number: 7449468
    Abstract: The present invention provides a compound of formula (I): wherein R1-R5, R25, R26, Y, y, and X2are as defined herein. The compounds activate human peroxisome proliferater activated receptors (hPPARs) and are useful for the treatment of associated disorders such as dyslipidemia, syndrome X, hypercholesteremia, type II diabetes mellitus, type I diabetes, insulin resistance, hyperlipidemia, and obesity.
    Type: Grant
    Filed: May 25, 2007
    Date of Patent: November 11, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Pierette Banker, Rodolfo Cadilla, Millard Hurst Lambert, III, Stephen William Rafferty, Daniel David Sternbach, Marcos Luis Sznaidman
  • Thiazole derivatives for treating PPAR related disorders
    Patent number: 7439259
    Abstract: The present invention provides combinations of compounds of formula (I) and other therapeutic agents for the treatment of PPAR related diseases.
    Type: Grant
    Filed: August 17, 2006
    Date of Patent: October 21, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Rodolfo Cadilla, Romain Luc Marie Gosmini, Millard Hurst Lambert, III, Michael Lawrence Sierra
  • Imidazoline derivatives as alpha-1A adrenoceptor ligands
    Patent number: 6884801
    Abstract: Compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof are disclosed. Such compounds are useful in the treatment of Alpha-1A mediated diseases or conditions such as urinary incontinence.
    Type: Grant
    Filed: April 28, 2000
    Date of Patent: April 26, 2005
    Assignee: SmithKline Beecham Corporation
    Inventors: Eric Cleveland Bigham, Michael Joseph Bishop, David Harold Drewry, Deanna Trojan Garrison, Stephen Joseph Hodson, Frank Navas, III, Jason D. Speake
  • Thiazole or oxazole derivatives which are useful in the treatment of cardiovascular and related diseases
    Patent number: 6867225
    Abstract: A compound of formula (I) and pharmaceutically acceptable salts, solvates and hydrolysable esters thereof Wherein R1 and R2 are independently H or C1-3 alkyl or R1 and R2 which are bonded to the same carbon atom may together with the carbon atom to which they are bonded form a 3-5 membered cycloalkyl ring; X1 represents O or S; Each R3, R4, R8 and R9 independently represents H, halogen, —CH3 and —OCH3; R5 represents H or C1-6 alkyl or R4 and R5 together form a 3-6 membered cycloalkyl ring. X2 represents NH, NCH3 or O; One of Y and Z is N, and the other is O or S; R6 represents phenyl or pyridyl (wherein the N is in position 2 or 3) and is optionally substituted by one or more halogen, CF3, C1-6 straight or branched alkyl (optionally substituted by halogen), with the provision that when R6 is pyridyl, the N is unsubstituted.
    Type: Grant
    Filed: May 29, 2002
    Date of Patent: March 15, 2005
    Assignee: SmithKline Beecham Corporation
    Inventors: Bernard Andre Dumaitre, Romain Luc Gosmini
  • Substituted indoles, pharmaceutical compounds containing such indoles and their use as PPAR-&ggr; binding agents
    Patent number: 6787651
    Abstract: Disclosed are substituted indoles, pharmaceutical compositions containing such indoles, and their use in treating or preventing PPAR-&ggr; mediated diseases or conditions, such as osteopenia, osteoporosis, cancer, diabetes and atherosclerosis.
    Type: Grant
    Filed: October 9, 2001
    Date of Patent: September 7, 2004
    Assignee: SmithKline Beecham Corporation
    Inventors: Andreas Stolle, Jacques P. Dumas, William Carley, Philip D. G. Coish, Steven R. Magnuson, Yamin Wang, Dhanapalan Nagarathnam, Derek B. Lowe, Ning Su, William H. Bullock, Ann-Marie Campbell, Ning Qi, Jeremy L. Baryza, James H. Cook
  • Activator of PPAR delta
    Patent number: 6723740
    Abstract: Compounds of Formula (I) are disclosed. These compounds selected activators of human PPAR delta.
    Type: Grant
    Filed: March 6, 2003
    Date of Patent: April 20, 2004
    Assignee: SmithKline Beecham Corporation
    Inventors: Esther Yu-Hsuan Chao, Curt Dale Haffner, Millard Hurst Lambert, III, Patrick Reed Maloney, Michael Lawrence Sierra, Daniel David Sternbach, Marcos Luis Sznaidman, Timothy Mark Willson, Huaqiang Eric Xu