Abstract: Novel 10-imidoylphenoxazines and 10-imidoylacridans are prepared by reacting a phenoxazine or acridan having optional substituents selected from the group consisting of trifluoromethyl, halogen, dihalogen, alkyl or alkoxy with an imidoyl halide prepared in situ from amides and lactams. Illustrative embodiments are 10-(5-methyl-1-pyrrolin-2-yl)phenoxazine and 9,9-dimethyl-10-(5-methyl-1-pyrrolin-2-yl)acridan. The imidoylphenoxazine and imidoylacridan products are generally useful as smooth muscle relaxants.

Abstract: An improved polyglycerol ester emulsifier is prepared by heating a polyglycerol ester having 3 to 10 glycerol units and 1 to 2 saturated fatty acyl ester groups each having 16-20 carbon atoms, glycerol and water at a temperature of from 125.degree.F. to 135.degree.F. until a homogeneous paste-like consistency is imparted thereto.

Abstract: This invention relates to a series of 1-iminomethylindolines which are analeptic agents capable of counteracting central nervous system depressant effects of pentobarbital and chloral hydrate. They also exhibit analgesic effects. This invention also relates to a process for the preparation of 1-iminomethylindolines which comprises reaction of an indoline with carboxamides selected from the group consisting of amides, lactams, symmetrical or unsymmetrical ureas and hydrazides. Typical examples of 1-iminomethylindoline derivatives are 5-acetyl-1-[2-(1-pyrrolinyl)]indoline and 1-[2-(5,5-dimethyl-1-pyrrolinyl)]indoline.

Abstract: Topical administration of 4-[2-(isopropylamino)ethyl]pyrocatechol to the mammalian eye reduces intraocular pressure without side effects generally associated with adrenergic activation such as tachycardia, mydriasis, hypertension and hypotension.