Patents Represented by Attorney Robert H. Uloth

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  • Thiazolidinylalkylene piperazine derivatives
    Patent number: 4367335
    Abstract: Piperazinyl derivatives containing a 3-alkylene-2,4-thiazolidinedione heterocyclic component with relatively selective psychotropic properties are disclosed. The compound 3-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-2,4-thiazolidinedione which has selective anxiolytic activity constitutes a typical embodiment of the invention.
    Type: Grant
    Filed: August 3, 1981
    Date of Patent: January 4, 1983
    Assignee: Mead Johnson & Company
    Inventors: Davis L. Temple, Jr., Richard E. Yeager
  • Antiallergic methods using diazaheterocyclopurines
    Patent number: 4366156
    Abstract: Imidazopyrimidinones and other diazaheterocyclopyrimidinones having an additional fused imidazole or triazole ring have utility as bronchodilators, mediator release inhibitors, phosphodiesterase inhibitors, and peripheral vasodilators. They are orally active and useful in the prophylaxis and treatment of asthma. A preferred compound is 4-[(4-chlorophenyl)methyl]-6,7-dihydro-3H-imidazo[1,2-a]purin-9(4H)-one.
    Type: Grant
    Filed: November 24, 1980
    Date of Patent: December 28, 1982
    Assignee: Mead Johnson & Company
    Inventor: Davis L. Temple, Jr.
  • 2-[4-[(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyridines
    Patent number: 4361565
    Abstract: 1-[4-(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]piperazines with 2-2-(3-cyano)pyridyl substituents in the 4- position have been synthesized and demonstrate useful psychotropic properties.
    Type: Grant
    Filed: December 28, 1981
    Date of Patent: November 30, 1982
    Assignee: Mead Johnson & Company
    Inventors: Davis L. Temple, Jr., Joseph P. Yevich, Walter G. Lobeck, Jr.
  • Spiro-quaternary ammonium halides and N-(2-pyrimidinyl)piperazinylalkylazaspiroalkanedione process
    Patent number: 4351939
    Abstract: Novel spiro-quaternary ammonium halides are disclosed. The new compounds are particularly valuable as intermediates in preparation of N-(2-pyrimidinyl)piperazinylalkyl derivatives of azaspiroalkanediones such as the psychopharmacologic agent 8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dio ne.
    Type: Grant
    Filed: October 16, 1980
    Date of Patent: September 28, 1982
    Assignee: Mead Johnson & Company
    Inventors: Jack C. Simms, deceased, Old National Bank in Evansville, administrator
  • Anti-tumor quinazoline compounds
    Patent number: 4343940
    Abstract: 4-Ethyl-6-methoxy-7-(oxiranylmethoxy)quinazoline and its isomer 4-ethyl-7-methoxy-6-(oxiranylmethoxy)quinazoline have potent anti-tumor activity in animals.
    Type: Grant
    Filed: March 6, 1981
    Date of Patent: August 10, 1982
    Assignee: Mead Johnson & Company
    Inventors: William E. Kreighbaum, William T. Comer
  • Phenoxyethyl-1,2,4,-triazol-3-one antidepressants
    Patent number: 4338317
    Abstract: Phenoxyethyl substituted-1,2,4,-triazolones having antidepressant properties typified by 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-4-(2-phenoxyethyl)- 2H-1,2,4-triazol-3(4H)-one are disclosed.
    Type: Grant
    Filed: March 16, 1981
    Date of Patent: July 6, 1982
    Assignee: Mead Johnson & Company
    Inventors: Davis L. Temple, Jr., Walter G. Lobeck, Jr.
  • 2-Alkynyl-5-indanyloxyacetic acids
    Patent number: 4334088
    Abstract: Indanyloxy compounds having 2-alkynyl substituents which exhibit diuretic, saluretic, and uricosuric activity are described. The compounds are obtained according to a process involving selective etherification of a 5-hydroxyindanone followed by alkynylation with a silylated alkynyl bromide to provide novel silylated intermediates which are hydrolyzed to indanyloxy compounds such as (6,7-dichloro-1-oxo-2-phenyl-2-propargyl-5-indanyloxy)acetic acid.
    Type: Grant
    Filed: May 21, 1981
    Date of Patent: June 8, 1982
    Assignee: Mead Johnson & Company
    Inventors: Porter C. Johnson, William L. Matier
  • Benzanilide derivative
    Patent number: 4332803
    Abstract: 4-Hydroxy-3-methoxy-N-[2-[2-(1-methyl-2-piperidinyl)ethyl]-phenyl]benzamide is an antiarrhythmic agent having relatively low toxicity and increased duration of action.
    Type: Grant
    Filed: September 18, 1980
    Date of Patent: June 1, 1982
    Assignee: Mead Johnson & Company
    Inventors: Robert F. Mayol, Richard E. Gammans
  • Bran tablet composition and process
    Patent number: 4328217
    Abstract: A bran tablet unit dosage form composition employing comminuted bran useful as a bulk cathartic agent is provided. The bran tablet compositions have suitable characteristics with respect to handling and packaging procedures and are substantially more palatable than whole bran.
    Type: Grant
    Filed: April 2, 1975
    Date of Patent: May 4, 1982
    Assignee: Mead Johnson & Company
    Inventors: John L. Gabby, Gerald K. Ashby, Dennis W. Cameron, Richard C. Theuer
  • Quaternary piperidinium halides
    Patent number: 4321386
    Abstract: 2-[2-[2-[(4-Methoxybenzoyl)amino]phenyl]ethyl]-1-methyl-1-alkylpiperidinium halides and 2-[2-[2-[(4-methoxybenzoyl)amino]phenyl]ethyl]-1-methyl-1-benzylpiperidini um halides are antiarrhythmic agents having reduced toxicity relative to the corresponding piperidine compound.
    Type: Grant
    Filed: January 28, 1981
    Date of Patent: March 23, 1982
    Assignee: Mead Johnson & Company
    Inventor: John E. Lawson
  • Thienyl and benzothienyl-tertiary butylaminophenoxypropanols
    Patent number: 4321398
    Abstract: Substituted 1-phenoxy-3-(thienyl-tert.-butylamino)-2-propanols and related 3-benzothienyl compounds are selective .beta.-receptor blocking agents. Preferred compounds bear an ortho-substituent on the phenoxy ring.
    Type: Grant
    Filed: May 7, 1981
    Date of Patent: March 23, 1982
    Assignee: Mead Johnson & Company
    Inventors: William L. Matier, William E. Kreighbaum
  • N-[(4-Phenyl-1,2,3,6-tetrahydropyridin-1-yl)alkylene]azaspiro alkanediones and N-[(4-hydroxy-4-phenylpiperidin-1-yl)alkylene]azaspiroalkanediones
    Patent number: 4320131
    Abstract: N-[(4-Phenyl-1,2,3,6-tetrahydropyridin-1-yl)alkylene]azaspiroalkanediones having substituents in the phenyl ring have been synthesized and demonstrate useful tranquilizing properties. N-[(4-Hydroxy-4-phenylpiperidin-1-yl)alkylene]azaspiroalkanediones are intermediates in their synthesis.
    Type: Grant
    Filed: March 16, 1981
    Date of Patent: March 16, 1982
    Assignee: Mead Johnson & Company
    Inventors: Davis L. Temple, Jr., Joseph P. Yevich, Walter G. Lobeck, Jr.
  • Encainide assay method
    Patent number: 4318899
    Abstract: A reliable and sensitive immunoassay for encainide in biological fluids including a novel hapten required for antigen synthesis and an immunologically homologous labeled tracer is provided.
    Type: Grant
    Filed: June 2, 1980
    Date of Patent: March 9, 1982
    Assignee: Mead Johnson & Company
    Inventor: Robert F. Mayol
  • Heterocyclic substituted aryloxy 3-indolyl-tertiary butylaminopropanols
    Patent number: 4314943
    Abstract: 1-Aryloxy-3-[(3-indolyl)-tert.-butyl]amino-2-propanols having a heterocyclic aryl-attached substituent or aryl-fused heterocyclic ring are antihypertensive agents having vasodilator and adrenergic .beta.-receptor blocking action.
    Type: Grant
    Filed: February 13, 1979
    Date of Patent: February 9, 1982
    Assignee: Mead Johnson & Company
    Inventors: William E. Kreighbaum, William T. Comer
  • N-[(4-[3-cyano substituted pyridyl]piperazino)alkyl]-azaspirodecanediones
    Patent number: 4305944
    Abstract: 2-[4-[4-(7,9-Dioxo-8-azaspiro[4.5]decan-8-yl)butyl]-1-piperazinyl]pyridine- 3-carbonitrile, 2-[4-[4-(7,9-dioxo-8-azaspiro-[4.5]decan-8-yl)butyl]-3-methyl-1-piperaziny l]pyridine-3-carbonitrile and 8-[4-[4-(3-methoxy-2-pyridinyl)-1-piperazinyl]butyl]-8-azaspiro-[4.5]decan e-7,9-dione are psychotropic compounds.
    Type: Grant
    Filed: September 8, 1980
    Date of Patent: December 15, 1981
    Assignee: Mead Johnson & Company
    Inventors: Davis L. Temple, Jr., Joseph P. Yevich, Walter G. Lobeck, Jr.
  • Encainide N-oxide
    Patent number: 4306069
    Abstract: 4-Methoxy-N-[2-[2-(1-methyl-2-piperidyl)ethyl]phenyl]-benzamide N-oxide is an antiarrhythmic agent having reduced toxicity and increased water solubility relative to the corresponding tertiary amine.
    Type: Grant
    Filed: June 19, 1980
    Date of Patent: December 15, 1981
    Assignee: Mead Johnson & Company
    Inventor: John E. Lawson
  • Diazaheterocyclopurines and triazolopyrimidines
    Patent number: 4298734
    Abstract: Imidazopyrimidinones and other diazaheterocyclopyrimidinones having an additional fused imidazole or triazole ring have utility as bronchodilators, mediator release inhibitors, phosphodiesterase inhibitors, and peripheral vasodilators. They are orally active and useful in the prophylaxis and treatment of asthma. A preferred compound is 4-[(4-chlorophenyl)methyl]-6,7-dihydro-3H-imidazo[1,2-a]-purin-9(4H)-one.
    Type: Grant
    Filed: March 5, 1979
    Date of Patent: November 3, 1981
    Assignee: Mead Johnson & Company
    Inventor: Davis L. Temple, Jr.
  • 4-Tertiary-amino-2,6-diaminopyridine 1-oxides
    Patent number: 4297498
    Abstract: A series of 2,6-diamino-4-tertiary-amino-pyridine 1-oxides is disclosed. Substituents in the 4-position include diethylamino, pyrrolidinyl, piperidino, morpholino, thiomorpholino, and N-methylpiperazino. Novel oxadiazolones such as 5-amino-7-(1-piperidinyl)-2H-[1,2,4]oxadiazolo[2,3-a]pyridine-2-one which are useful in the preparation of the pyridine 1-oxides are also disclosed. The compounds of this invention lower blood pressure in normotensive and hypertensive mammals and are particularly useful in the treatment of hypertensive conditions in mammals. 2,6-Diamino-4-(1-piperidinyl)pyridine 1-oxide is a representative embodiment of the invention.
    Type: Grant
    Filed: August 23, 1979
    Date of Patent: October 27, 1981
    Assignee: Mead Johnson & Company
    Inventors: John E. Lawson, Ronald D. Dennis
  • Substituted piperidines therapeutic process and compositions
    Patent number: RE30811
    Abstract: The compounds are of the heterocyclic class of 2-phenethylpiperidines having an amido substituent in the ortho position of the phenethyl moiety. Substituents in the ortho position include formamido, benzamido, cinnamamido, 2-thiophenecarboxamido, alkanesulfonamido and alkanoylamido. They are useful as antiarrhythmic and/or antiserotonin agents. The novel compounds are prepared by reaction of appropriately substituted o-aminophenethylpiperidines and the carbonyl or sulfonyl halides or anhydrides. Typical embodiments of this invention are 4-methoxy-2'-[2-(1-methyl-2-piperidyl)ethyl]benzanilide and 2'-[2-(1-methyl-2-piperidyl)ethyl]cinnamanilide.
    Type: Grant
    Filed: November 28, 1979
    Date of Patent: December 1, 1981
    Assignee: Mead Johnson & Company
    Inventors: Stanley J. Dykstra, Joseph L. Minielli
  • Substituted piperidines therapeutic process and compositions
    Patent number: RE30812
    Abstract: The compounds are of the heterocyclic class of 2-phenethylpiperidines having an amido substituent in the ortho position of the phenethyl moiety. Substituents in the ortho position include formamido, benzamido, cinnamamido, 2-thiophenecarboxamido, alkanesulfonamido and alkanoylamido. They are useful as antiarrhythmic and/or antiserotonin agents. The novel compounds are prepared by reaction of appropriately substituted o-aminophenethylpiperidines and the carbonyl or sulfonyl halides or anhydrides. Typical embodiments of this invention are 4-methoxy-2'-[2-(1-methyl-2-piperidyl)ethyl]benzanilide and 2'-[2-(1-methyl-2-piperidyl)ethyl]cinnamanilide.
    Type: Grant
    Filed: November 28, 1979
    Date of Patent: December 1, 1981
    Assignee: Mead Johnson & Company
    Inventors: Stanley J. Dykstra, Joseph L. Minielli