Patents Represented by Attorney Ronald A. Daignault

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  • Method of treating senile cognitive decline with N'-substituted aminopyridine adrenergic agents
    Patent number: 4855308
    Abstract: A method is disclosed for the treatment or amelioration of the symptoms of cerebral insufficiency characterized by decreased central adrenergic and/or cholinergic function employing certain N-substituted aminopyridines.
    Type: Grant
    Filed: December 4, 1987
    Date of Patent: August 8, 1989
    Assignee: Warner-Lambert Company
    Inventors: Jeffrey A. Kester, Walter H. Moos, Anthony J. Thomas
  • 1,2-diamino-4,5-dimethoxycyclohexyl amide analgesic compounds
    Patent number: 4855316
    Abstract: Certain 1,2-diamino-4,5-dimethoxycyclohexane amide derivatives have analgesic activity, and bind selectively to the kappa opioid receptor site. Pharmaceutical compositions containing these compounds, and a method of alleviating pain in mammals are also disclosed.
    Type: Grant
    Filed: February 18, 1988
    Date of Patent: August 8, 1989
    Assignee: Warner-Lambert Company
    Inventors: David C. Horwell, Stephen J. Johnson
  • Method for treating non-small cell lung cancer, head and neck cancers and breast cancer
    Patent number: 4853221
    Abstract: 5-Methyl-6-[[(3,4,5-trimethoxyphenyl)amino]-methyl]-2,4-quinazolinediamine (trimetrexate) has been shown to possess clinical activity against non-small cell lung cancer, head and neck squamous cancers, and breast cancer. The compound also demonstrates therapeutic synergy with several known antineoplastic agents. Methods of treating non-small cell lung cancer, head and neck cancers, and breast cancer by administering trimetrexate alone or in combination with other neoplastic agents is disclosed.
    Type: Grant
    Filed: October 23, 1987
    Date of Patent: August 1, 1989
    Assignee: Warner-Lambert Company
    Inventors: Edward F. Elslager, Wilbur R. Leopold, III
  • Process for producing a fish food
    Patent number: 4853242
    Abstract: A process for producing a fish food is disclosed wherein a mixture containing 30% to 50% by weight crude protein, 5% to 15% fat and 0.5% to 10% crude fiber is extruded by means of a twin-screw conveyor at a speed of 200-250 rpm at a temperature of from 50.degree. C. to 90.degree. C. with the addition of 20 to 40 liters of water per hour and a throughput of 100-150 kg/hr to yield feed sticks with a length of from 10-25 mm and a diameter of 5-15 mm.
    Type: Grant
    Filed: February 17, 1988
    Date of Patent: August 1, 1989
    Assignee: Warner-Lambert Company
    Inventor: Klaus-Jurgen V. Poeppinghausen
  • Sustained release formulations
    Patent number: 4851233
    Abstract: A new drug delivery system, which gives sustained release properties is made by combining certain cellulosic polymers with cellulose in a binder system.
    Type: Grant
    Filed: October 6, 1986
    Date of Patent: July 25, 1989
    Assignee: Warner-Lambert Company
    Inventors: Sadath U. Khan, Reginald Phillips
  • Naphthyridine antibacterial agents containing an .alpha.-amino acid in the side chain of the 7-substituent
    Patent number: 4851418
    Abstract: Novel quinolone and naphthyridine antibacterial agents are herein described having improved in vivo activity both orally and subcutaneously where the 7-side chain of such compounds contain an .alpha.-amino acid; also described are its corresponding optical isomers, methods of preparation as well as compositions and methods of treating infections diseases.
    Type: Grant
    Filed: July 20, 1988
    Date of Patent: July 25, 1989
    Assignee: Warner-Lambert Company
    Inventor: Joseph P. Sanchez
  • Drug compositions stabilized against oxidation
    Patent number: 4830853
    Abstract: The oxidation--and color-stability of certain ace inhibitors is optimized when they are formulated with a stabilizer and at least one lubricant and/or excipient.
    Type: Grant
    Filed: October 20, 1986
    Date of Patent: May 16, 1989
    Assignee: Warner-Lambert Company
    Inventors: Kuchi S. Murthy, Michael R. Harris, Gerard C. Hokanson, Robert G. Reisch, Jr., Mahdi B. Fawzi, Frank Waldman
  • Sustained release formulations
    Patent number: 4816264
    Abstract: Drug delivery systems which exhibit sustained release properties when administered are produced using a "dual control" system which employs polymeric agents in core and membrane portions.
    Type: Grant
    Filed: June 6, 1986
    Date of Patent: March 28, 1989
    Assignee: Warner-Lambert Company
    Inventors: Reginald Phillips, Krishnayya Bikkina, Sadath U. Khan
  • N-phenylbenzamide derivatives
    Patent number: 4816485
    Abstract: N-phenylbenzamide derivatives of the general formula I ##STR1## wherein the radicals R.sup.1, R.sup.2, and R.sup.3, which can be the same or different, are a hydrogen atom or a methyl radical, as well as the pharmacologically acceptable salts thereof for controlling malignant, proliferative and auto-immune diseases and for immunosuppressive therapy upon grafting are described.
    Type: Grant
    Filed: March 30, 1987
    Date of Patent: March 28, 1989
    Assignee: Warner-Lambert Company
    Inventors: Gerhard Satzinger, Manfred Herrmann, Edgar Fritschi, Ute Weiershausen
  • Lipid regulating agents
    Patent number: 4814354
    Abstract: Cholestyramine can be administered orally along with one or more other lipid regulating agent(s) and/or other beneficial agent(s) in compositions in which the cholestyramine has been suitably pretreated.
    Type: Grant
    Filed: September 26, 1986
    Date of Patent: March 21, 1989
    Assignee: Warner-Lambert Company
    Inventors: Isaac Ghebre-Sellassie, Robert H. Gordon, Mahdi B. Fawzi
  • Sustained release pharmaceutical preparations
    Patent number: 4810501
    Abstract: Sustained release solid dosage forms--i.e., tablets, pellets, granules, and powders--can be made using a combination of polymeric and ionic particulate materials to modify release profiles, permeability and processability.
    Type: Grant
    Filed: June 17, 1986
    Date of Patent: March 7, 1989
    Assignee: Warner-Lambert Company
    Inventors: Isaac Ghebre-Sellassie, Russell U. Nesbitt, Jr., Uma Iyer, Mahdi B. Fawzi
  • Trans-6-[2-(N-heteroaryl-3,5-disubstituted)pyrazol-4-yl)-ethyl]- or ethenyl]tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis
    Patent number: 4808621
    Abstract: Certain trans-6-[2-(N-heteroaryl-3,5-disubstituted)pyrazol-4-yl)ethyl]- or ethenyl]tetrahydro-4-hydroxy-2H-pyran-2-ones and the corresponding ring-opened acids derived therefrom which are potent inhibitors of the enzyme 3-hydroxy-3-methylglutarylcoenzyme A reductase (HMG CoA reductase) and are thus useful hypolipidemic or hypocholesterolemic agents. Pharmaceutical compositions containing such compounds, and a method of inhibiting the biosynthesis of cholesterol employing such pharmaceutical compositions are also disclosed.
    Type: Grant
    Filed: May 18, 1987
    Date of Patent: February 28, 1989
    Assignee: Warner-Lambert Company
    Inventors: Bruce D. Roth, Drago R. Sliskovic
  • Phenyl and heterocyclic piperazinyl alkoxy-benzheterocyclic compounds as antipsychotic agents
    Patent number: 4803203
    Abstract: Novel phenyl and heterocyclic tetrahydropyridyl and piperazinyl alkoxy benzheterocyclic compounds are described which have valuable neuroleptic properties by virture of their dopamine autoreceptor agonist activity. Methods of preparation, pharmeceutical compositions, and methods for treating psychoses, such a schizophrenia, are also described.
    Type: Grant
    Filed: June 16, 1987
    Date of Patent: February 7, 1989
    Assignee: Warner-Lambert Company
    Inventors: Bradley W. Caprathe, Horace A. DeWald, Juan C. Jaen, Lawrence D. Wise
  • Process for preparing diaminopyrimido(4,5-d)pyrimidine glycoside and glycotide
    Patent number: 4801698
    Abstract: The aminoglycoside and aminoglycotide N.sup.4 -(2,3,5-tri-O-acetyl-.beta.-D-ribofuranosyl)pyrimido[4,5-d]pyrimidine-4,8- diamine and N.sup.4 -(5-O-phosphono-.beta.-D-ribofuranosyl-pyrimido[4,5-d]pyrimidine-4,8-diami ne exhibit antiviral activity as well as cytotoxic activity against the L1210 and mammary 16/C tumor cell lines.An improved method for their production involves the production of a sylilated intermediate and reaction of the intermediate with tetra-O-acetyl-.beta.-D-ribofuranose in the presence of the specific catalyst trimethylsilyltrifluoromethanesulfonate.
    Type: Grant
    Filed: August 15, 1986
    Date of Patent: January 31, 1989
    Assignee: Warner-Lambert Company
    Inventors: Phillip D. Cook, David A. Berry
  • Tetrahydropyridine oxime cholinergic agents and method of treatment
    Patent number: 4798841
    Abstract: Certain N-substituted 1-(1,2,3,6-tetrahydro-3-pyridinyl)oximes and N-substituted 1-(1,2,3,6-tetrahydro-4-pyridinyl)oximes are useful as analgesic agents or agents for the teatment or amelioration of the symptoms of cerebral insufficiency characterized by decreased central acetylcholine production or release.
    Type: Grant
    Filed: March 31, 1987
    Date of Patent: January 17, 1989
    Assignee: Warner-Lambert Company
    Inventors: David A. Downs, Walter H. Moos, David W. Moreland, Haile Tecle
  • Method of treating the symptoms of senile cognitive decline employing di- or trisubstituted urea cholinergic agents
    Patent number: 4797419
    Abstract: Certain trisubstituted alkyl, aryl, pyridinyl, piperidinyl, and piperazinyl urea compounds stimulate the release of acetylcholine and are thus useful agents for the treatment of senile cognitive decline characterized by decreased cerebral acetylcholine production or release.A method for treating the symptoms of senile cognitive decline is disclosed.
    Type: Grant
    Filed: November 3, 1986
    Date of Patent: January 10, 1989
    Assignee: Warner-Lambert Company
    Inventors: Walter H. Moos, Anthony J. Thomas
  • 2-nitroimidazole derivatives useful as radiosensitizers for hypoxic tumor cells
    Patent number: 4797397
    Abstract: Certain .alpha.-[(2-nitro-1H-imidazol-1-yl)methyl]-aziridinylethanols and the corresponding aziridine-ring opened analogs are useful as radiation sensitizers for X-irradiation therapy of tumors.
    Type: Grant
    Filed: July 31, 1987
    Date of Patent: January 10, 1989
    Assignee: Warner-Lambert Company
    Inventors: Mark J. Suto, Leslie M. Werbel
  • Stabilized drug compositions
    Patent number: 4793998
    Abstract: The cyclization and hydrolysis of certain ACE inhibitors is minimized when they are formulated with a stabilizer and at least one lubricant and/or excipient.
    Type: Grant
    Filed: October 20, 1986
    Date of Patent: December 27, 1988
    Assignee: Warner-Lambert Company
    Inventors: Kuchi S. Murthy, Michael R. Harris, Gerard C. Hokanson, Robert G. Reisch, Jr., Frank Waldman, Mahdi B. Fawzi
  • Trans-benzopyran-(4,3-b)-1,4-oxazine derivatives, intermediates and pharmaceutical use
    Patent number: 4792548
    Abstract: trans-Benzopyran-4,3b-1,4-oxazines are described as well as methods of preparation. The compounds are presynaptic dopamine agonists and may be used in pharmaceutical composition form for treating psychoses, e.g., schizophrenia.
    Type: Grant
    Filed: May 21, 1986
    Date of Patent: December 20, 1988
    Assignee: Warner-Lambert Company
    Inventors: Horace A. DeWald, Lawrence D. Wise
  • Tablet
    Patent number: D302481
    Type: Grant
    Filed: October 21, 1987
    Date of Patent: July 25, 1989
    Assignee: Warner-Lambert Company
    Inventors: Henry A. Miller, Michael R. Harris, Frank Goodhart, Mahdi B. Fawzi