Patents Represented by Attorney Ronald A. Daignault

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  • Transdermal matrix system
    Patent number: 4789547
    Abstract: A composition for the transmembranal, including transdermal, administration of a pharmaceutical preparation comprising cross-linked carboxymethylcellulose, an alcohol soluble poly (2-hydroxyethyl) methacrylate), a permeation enhancer, such as a mixture of linoleic acid and propylene glycol, and a biologically active material, as well as a device for administering the aforementioned composition to mammals, and also a method for administering transdermally to a mammal an effective amount of the aforementioned composition.
    Type: Grant
    Filed: June 17, 1987
    Date of Patent: December 6, 1988
    Assignee: Warner-Lambert Company
    Inventors: Suk-Zu Song, Surendra C. Mehta, Zahra A. Rashidbaigi, Russell U. Nesbitt, Mahdi B. Fawzi
  • Transdermal delivery system
    Patent number: 4788064
    Abstract: The administration of a bronchodilator to a subject can be carried out using a new transdermal delivery system, a multilayer laminate where the drug is mixed in a gel which must pass through a barrier membrane prior to administration on the skin.
    Type: Grant
    Filed: July 31, 1987
    Date of Patent: November 29, 1988
    Assignee: Warner-Lambert Company
    Inventors: Niranjan M. Patel, Mohan B. Kabadi, Susan C. Moniot
  • Coated dosage forms
    Patent number: 4786508
    Abstract: Aqueous solutions of certain cationic (meth)acrylic ester copolymers can be used to coat dosage forms to taste- and odor-mask bio-active agents therein. Pellets are highly preferred dosage forms.
    Type: Grant
    Filed: May 30, 1986
    Date of Patent: November 22, 1988
    Assignee: Warner-Lambert Company
    Inventors: Isaac Ghebre-Sellassie, Robert Gordon, Maryann Mench, Russell U. Nesbitt, Jr., Mary E. Trapold
  • Use of commercial lecithin as skin penetration enhancer
    Patent number: 4783450
    Abstract: A method of enhancing penetration of a drug through the skin or other biological membranes using lecithin is herein described along with pharmaceutical compositions containing effective amounts of lecithin as a penetration enhancer.
    Type: Grant
    Filed: April 13, 1987
    Date of Patent: November 8, 1988
    Assignee: Warner-Lambert Company
    Inventors: Mahdi B. Fawzi, Uma R. Iyer, Majid Mahjour
  • Process for tetrafluorobenzoic acid
    Patent number: 4782180
    Abstract: An improved process for the preparation of 2,3,4,5-tetrafluorobenzoic acid is described which involves decarboxylation of tetrafluorophthalic acid in the presence of a base catalyst. Also described is an improved method for preparing tetrafluorophthalic acid and, in turn, a one-pot process for tetrafluorobenzoic acid using the combination of the two improvements.
    Type: Grant
    Filed: May 7, 1986
    Date of Patent: November 1, 1988
    Assignee: Warner-Lambert Company
    Inventors: James N. Wemple, Timothy P. Puls, James Vande Vusse
  • Tetrasubstituted urea cholinergic agents
    Patent number: 4782071
    Abstract: Certain tetrasubstituted alkyl, aryl, pyridinyl, piperidinyl, and piperazinyl urea compounds stimulate the release of acetylcholine and are thus useful analgesic agents for alleviating pain or as cholinergic agents which are useful for the amelioration of the symptoms of cognitive decline in the elderly.These compounds have the general formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.4 are phenyl or substituted phenyl, and R.sub.3 is pyridinyl.Pharmaceutical compositions including these compounds as well as methods for the preparation of the compounds are also disclosed.
    Type: Grant
    Filed: November 3, 1986
    Date of Patent: November 1, 1988
    Assignee: Warner-Lambert Company
    Inventors: Donald E. Butler, David M. Lustgarten, Walter H. Moos, Anthony J. Thomas
  • Antibacterial agents
    Patent number: 4777175
    Abstract: Novel naphthyridine-, quinoline- and benzoxazine-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufacture of the antibacterial agents.
    Type: Grant
    Filed: September 15, 1986
    Date of Patent: October 11, 1988
    Assignee: Warner-Lambert Company
    Inventors: Townley P. Culbertson, John M. Doma, Thomas F. Mich, Jeffrey B. Nichols
  • Method of treating fungal infections with trans-6-[2-substitutedpyrrol-1-yl)alkyl]-4-hydroxypyran-2-ones
    Patent number: 4775681
    Abstract: A method of treating fungal infections comprises administering an antifungally effective amount of a trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-4-hydroxypyran-2-one compound or a .beta.,.delta.-hydroxyheptanoic acid corresponding thereto.
    Type: Grant
    Filed: June 18, 1987
    Date of Patent: October 4, 1988
    Assignee: Warner-Lambert Company
    Inventor: Carl L. Heifetz
  • Process for quinoline-3-carboxylic acid antibacterial agents
    Patent number: 4772706
    Abstract: An improved process for the preparation of 7-substituted amino-1-alkyl- or cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids is described where tetrafluorobenzoyl chloride is converted in three operations via 1-alkyl or 1-cycloalkyl-1,4-dihydro-6,7,8-trifluoro-4-oxoquinoline-3-carbonitrile which in a separate step or in situ is displaced and hydrolyzed to the desired product.
    Type: Grant
    Filed: January 13, 1986
    Date of Patent: September 20, 1988
    Assignee: Warner-Lambert Company
    Inventors: James N. Wemple, James R. Zeller, John M. Domagala
  • Antibacterial agents
    Patent number: 4771054
    Abstract: Novel quinoline-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufacture of the antibacterial agents.
    Type: Grant
    Filed: August 15, 1986
    Date of Patent: September 13, 1988
    Assignee: Warner-Lambert Company
    Inventors: John M. Domagala, Thomas F. Mich, Jeffrey B. Nichols
  • 7-[[3-(aminomethyl)-3-alkyl]-1-pyrrolidinyl]-quinoline-carboxylic acids
    Patent number: 4771055
    Abstract: Novel, orally active antibacterial agents are described and characterized as 7-[[3-(aminomethyl)-3-alkyl]-1-pyrrolidinyl]-6-fluoro-1,4-dihydro-4-oxo -3-quinoline carboxylic acids or corresponding 1,8-naphthyridine derivatives as well as methods for their manufacture.
    Type: Grant
    Filed: April 21, 1987
    Date of Patent: September 13, 1988
    Assignee: Warner-Lambert Company
    Inventors: John M. Domagala, Susan E. Hagen, Joseph P. Sanchez
  • Hetero [f] fused carbocyclic pyridines as dopaminergic agents
    Patent number: 4762843
    Abstract: Hetero [f] fused carbocyclic pyridines are described, as well as methods for the preparation and pharmaceutical compositions of same, which are useful as dopamine agonists with selectivity for the presynaptic dopamine receptor and are useful as dopaminergic, antipsychotic and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
    Type: Grant
    Filed: July 17, 1987
    Date of Patent: August 9, 1988
    Assignee: Warner-Lambert Company
    Inventors: Bradley W. Caprathe, Juan C. Jaen, Lawrence D. Wise
  • Stabilized compositions
    Patent number: 4743450
    Abstract: The cyclization, hydrolysis, and coloration of certain ACE inhibitors is minimized when they are formulated with a metal-containing stabilizer and a saccharide.
    Type: Grant
    Filed: February 24, 1987
    Date of Patent: May 10, 1988
    Assignee: Warner-Lambert Company
    Inventors: Michael Harris, Gerard Hokanson, Kuchi Murthy, Robert Reisch, Frank Waldman
  • Adenosine receptor assay and kit
    Patent number: 4705758
    Abstract: Certain substituted adenosines have been found to selectively occupy A.sub.1 adenosine receptors found in animal brain tissues.
    Type: Grant
    Filed: June 19, 1984
    Date of Patent: November 10, 1987
    Assignee: Warner-Lambert Company
    Inventor: Robert F. Bruns
  • Phenyl and heterocyclic tetrahydropyridyl alkoxy-benzheterocyclic compounds as antipsychotic agents
    Patent number: 4704390
    Abstract: Novel phenyl and heterocyclic tetrahydropyridyl and piperazinyl alkoxy benzheterocyclic compounds are described which have valuable neuroleptic properties by virtue of their dopamine autoreceptor agonist activity. Methods of preparation, pharmaceutical compositions, and methods for treating psychoses, such as schizophrenia, are also described.
    Type: Grant
    Filed: November 5, 1986
    Date of Patent: November 3, 1987
    Assignee: Warner-Lambert Company
    Inventors: Bradley W. Caprathe, Horace A. DeWald, Juan C. Jaen, Lawrence D. Wise
  • Parenteral phenytoin compositions
    Patent number: 4696814
    Abstract: Stable, aqueous solutions of phenytoin sodium can be made using polyvinylpyrrolidone with or without an alcoholic solvent system.
    Type: Grant
    Filed: August 21, 1985
    Date of Patent: September 29, 1987
    Assignee: Warner-Lambert Company
    Inventors: Shui-Hsi Kao, Allen I. Kay, Karla Sampson
  • Thrombin preparations
    Patent number: 4696812
    Abstract: Thrombin solutions can be rendered storage stable using stabilizing quantities of an anti-autolytic buffer in combination with low levels of saline and glycerol to prevent denaturation.
    Type: Grant
    Filed: October 28, 1985
    Date of Patent: September 29, 1987
    Assignee: Warner-Lambert Company
    Inventors: Steven B. Silbering, Russell U. Nesbitt, Mahdi B. Fawzi
  • Transdermal delivery system for administration of nitroglycerin
    Patent number: 4696821
    Abstract: A transdermal delivery system for the administration of nitroglycerin for the treatment of heart disease comprising a nitroglycerin water-soluble polyvinylpyrrolidone polymer film coated on one surface of aluminum foil, the uncoated side of said aluminum foil mounted on the adhesive side of adhesive tape having dimensions larger than said aluminum foil is described.
    Type: Grant
    Filed: October 11, 1983
    Date of Patent: September 29, 1987
    Assignee: Warner-Lambert Company
    Inventor: Susan C. Belsole
  • Stabilized compositions
    Patent number: 4696912
    Abstract: The antimicrobial agent CL-1565-A can be effectively stabilized for up to about two years using certain salts or esters of carboxylic acids or their precursors as stabilizing additives.
    Type: Grant
    Filed: January 10, 1986
    Date of Patent: September 29, 1987
    Assignee: Warner-Lambert Company
    Inventors: Allen I. Kay, Gerard C. Hokanson
  • Opthalmic use of quinolone antibiotics
    Patent number: 4692454
    Abstract: Certain quinolone and naphthyridine antibiotics are useful for treating ocular infections by topical administration.
    Type: Grant
    Filed: February 3, 1986
    Date of Patent: September 8, 1987
    Assignee: Warner-Lambert Company
    Inventors: Thomas F. Mich, Carl L. Heifetz