Patents Represented by Law Firm Saliwanchik & Saliwanchik
  • Coleopteran-active Bacillus thuringiensis toxin
    Patent number: 5457179
    Abstract: The subject invention concerns a novel microbe and gene encoding a novel toxin protein with activity against insect pests of the order Coleoptera. Pests in the order Coleoptera do heavy damage to crops, e.g., corn. The novel Bacillus thuringiensis microbe of the invention is referred to as B.t. PS50C. The spores or crystals of this microbe, or mutants thereof, are useful to control coleopteran pests in various environments. The novel gene of the invention can be used to transform various hosts wherein the novel toxic protein can be expressed.
    Type: Grant
    Filed: December 29, 1993
    Date of Patent: October 10, 1995
    Assignee: Mycogen Corporation
    Inventors: Luis Foncerrada, August J. Sick, Jewel M. Payne
  • Liquid crystal optical shutter
    Patent number: 5455083
    Abstract: A liquid crystal optical shutter is disclosed.The liquid crystal optical shutter comprises two sheets of transparent, conductive substrates; a light-adjusting layer supported between the sheets, which comprises a transparent, thin film of polymer prepared by photopolymerizing prepolymers containing approximately 20 to approximately 60% by weight of urethaneacrylate; and a liquid crystal component selected from the group consisting of a cholesteric liquid crystal, a chiral smectic liquid crystal and the mixture thereof, said liquid crystal being encapsulated within said thin film.Superior in operating voltage, transmissivity and response time, the liquid crystal optical shutter is characterized by specifying a concentration range of the nematic liquid crystal, the base liquid crystal and introducing a flexible polytetramethylene chain with intermediate sizes into the polymer.
    Type: Grant
    Filed: June 27, 1994
    Date of Patent: October 3, 1995
    Assignee: Samsung Electron Devices Co., Ltd.
    Inventors: Chang H. Noh, T. Asada
  • Non-nucleoside 1,3-diol reagents for labeling synthetic oligonucleotides
    Patent number: 5451463
    Abstract: A trifunctional reagent possessing a primary hydroxyl, a secondary hydroxyl, and a primary amino group. This reagent is useful in solid phase oligonucleotide synthesis for the convenient labeling of the 3'-terminus. The secondary hydroxyl may be an phosphoramidite derivative permitting the attachment to the solid phase support. The reporter molecule may be attached to the trifunctional molecule prior to the completion of the oligonucleotide synthesis or after the oligonucleotide is cleaved from the support. A preferred species of this trifunctional molecule is shown below.
    Type: Grant
    Filed: June 3, 1993
    Date of Patent: September 19, 1995
    Assignee: Clontech Laboratories, Inc.
    Inventors: Paul S. Nelson, Mark A. Kent
  • Heat shock promoter and gene
    Patent number: 5447858
    Abstract: A plant heat shock promoter has been isolated from soybean, sequenced and shown to induce gene expression in response to a temporary heat shock. This invention utilizes the disclosed plant heat shock promoters for the construction of promoter/structural gene chimeras which are expressible in plant cells in response to heat shock. The reporter gene .beta.-galactosidase was expressed transiently in response to a heat shock signal. Further, this invention permits application of heat shock inducible chimeras as a detection method for successful transformation of plant cells.
    Type: Grant
    Filed: April 13, 1984
    Date of Patent: September 5, 1995
    Assignee: Mycogen Plant Sciences, Inc.
    Inventors: Joe L. Key, William B. Gurley, Ronald T. Nagao, Friedrich Schoeffl, Eva Czarnecka
  • A1 adenosine receptor agonists and antagonists as diuretics
    Patent number: 5446046
    Abstract: Adenosine and xanthine derivatives, and compositions comprising those compounds, are potent selective agonists and antagonists of adenosine receptors. The derivatives and composition are used to treat conditions, including certain cardiac arrhythmias.
    Type: Grant
    Filed: October 28, 1993
    Date of Patent: August 29, 1995
    Assignee: University of Florida Research Foundation
    Inventors: Luiz Belardinelli, Ray Olsson, Stephen Baker, Peter J. Scammells
  • Compound for treatment of cardiac arrhythmia, synthesis, and methods of use
    Patent number: 5440054
    Abstract: Described is a novel compound and method, useful for treatment of cardiac arrhythmias, especially useful in patients with congestive heart failure (CHF). A process for synthesizing the novel compound is also described.
    Type: Grant
    Filed: June 16, 1994
    Date of Patent: August 8, 1995
    Assignee: Advanced Therapies, Inc.
    Inventor: Pascal Druzgala
  • Gene encoding nematode-active toxin PS63B cloned from Bacillus thuringiensis isolate
    Patent number: 5439881
    Abstract: This invention concerns genes or gene fragments which have been cloned from novel Bacillus thuringiensis isolates which have nematicidal activity. These genes or gene fragments can be used to transform suitable hosts for controlling nematodes.
    Type: Grant
    Filed: April 19, 1993
    Date of Patent: August 8, 1995
    Assignee: Mycogen Corporation
    Inventors: Kenneth E. Narva, George E. Schwab, Jewel M. Payne
  • Process for fractionating wheat flours to obtain protein concentrates and prime starch
    Patent number: 5439526
    Abstract: Disclosed and claimed is a rapid, simple process for fractionating wheat flour into components comprising protein concentrates and prime starch. The claimed method utilizes minimal water and produces a low waste water load. Flour and liquid are mixed to form a dough. Additional liquid is added to the dough and the dough and liquid are vigorously dispersed. The dispersion is centrifuged and forms distinct fractions-layers that are separated for the recovery of vital gluten and prime starch.
    Type: Grant
    Filed: October 1, 1993
    Date of Patent: August 8, 1995
    Assignee: Washington State University Research Foundation
    Inventors: Zuzanna Czuchajowska, Yeshajahu Pomeranz
  • DNA encoding peptide hormone that inhibits digestion in insects
    Patent number: 5439821
    Abstract: The subject invention concerns novel peptides which have the property of interfering with the biosynthesis of the enzyme trypsin. This property enables the use of these peptides to, for example, inhibit the formation of progeny in blood-ingesting insects, since trypsin is an essential enzyme for food digestion which provides the essential building blocks for egg development in such insects.
    Type: Grant
    Filed: July 7, 1994
    Date of Patent: August 8, 1995
    Assignees: University of Florida Research Foundation, The United States of America as represented by the United States Department of Agriculture
    Inventors: Dov Borovsky, David A. Carlson
  • Device and method for hip protection and stabilization
    Patent number: 5437618
    Abstract: A novel joint protection device is disclosed having a rigid outer shell and at least one cushioned pad on its inner face. The device is placed next to the joint area being protected. The cushioned pad is a cushioning foam material, or inflatable, or gel-filled for deflection or absorption of the forces encountered upon an impact. The device can be used for a novel method for prevention of joint injury, especially injuries sustained by the elderly due to falls. The novel device is also provided with a belt and a gluteus medius pad for advantageously stabilizing the hip joint.
    Type: Grant
    Filed: September 14, 1994
    Date of Patent: August 1, 1995
    Assignee: Homeostatics Design Group, Inc.
    Inventor: W. David Sikes
  • Bacillus thuringiensisisolate PS201T6 toxin
    Patent number: 5436002
    Abstract: Disclosed and claimed are toxins produced by novel Bacillus thuringiensis isolates designated B.t. PS92J, B.t. PS196S1, B.t. PS201L1, and B.t. PS201T6, which have dipteran and/or corn rootworm activity. Thus, the isolates, or mutants thereof, can be used to control such pests. Further, claimed are novel genes encoding these .delta.-endotoxins, which can be expressed in other hosts. Expression of the .delta.-endotoxins in such hosts results in the control of susceptible insect pests in the environment of such hosts.
    Type: Grant
    Filed: September 30, 1993
    Date of Patent: July 25, 1995
    Assignee: Mycogen Corporation
    Inventors: Jewel Payne, Kenneth E. Narva, Kendrick A. Uyeda, Christine J. Stalder, Tracy E. Michaels
  • Method for selecting mutants of legume-nodulating bacteria enhanced in competition
    Patent number: 5432079
    Abstract: Methods for the isolation of mutant rhizobial strains with improved competition of nodulation (Comp.sup.+) is presented. Mutants are selected for constitutive expression of inducible nod genes (in the absence of inducer) and screened for hyperinduction of nod genes in the presence of inducer. Mutants which are defective in nodulation or in symbiotic nitrogen fixation are eliminated from further testing. Selections for constitutive nod expression and for hyperinduction of nod genes are facilitated by the use of plasmid carrying a selectable marker fused to an inducible nod gene and a plasmid carrying a reporter gene fused downstream of an inducible nod gene. The methods exemplified are particularly useful for the isolation and identification of Comp.sup.+ mutants of Bradyrhizobium japonicum.
    Type: Grant
    Filed: March 11, 1988
    Date of Patent: July 11, 1995
    Assignee: Mycogen Plant Science, Inc.
    Inventors: Eric Johansen, Edward R. Appelbaum
  • High-Tc superconducting ceramic oxide products and macroscopic and microscopic methods of making the same
    Patent number: 5432150
    Abstract: High-Tc superconducting ceramic oxide products and macroscopic and microscopic methods for making such high-Tc superconducting products. Completely sealed high-Tc superconducting ceramic oxide products are made by a macroscopic process including the steps of pressing a superconducting ceramic oxide powder into a hollow body of a material inert to oxygen; heat treating the superconducting ceramic oxide powder packed body under conditions sufficient to sinter the ceramic oxide powder; and then sealing any openings of the body. Optionally, a waveform or multiple pulses of alternate magnetic field can be applied during the heat treatment.
    Type: Grant
    Filed: June 14, 1993
    Date of Patent: July 11, 1995
    Inventor: Dawei Zhou
  • Probes for the identification of Bacillus thuringiensis endotoxin genes
    Patent number: 5430137
    Abstract: This invention concerns novel gene probes which can be used to identify DNA from Bacillus thuringiensis microbes which encode protein endotoxins. The invention probes greatly facilitate the search for useful microbes hosting genes which encode toxins.
    Type: Grant
    Filed: October 30, 1992
    Date of Patent: July 4, 1995
    Assignee: Mycogen Corporation
    Inventors: Frank H. Gaertner, August J. Sick, Mark Thompson, H. Ernest Schnepf, George E. Schwab, Kenneth E. Narva
  • Octopine T-DNA promoters
    Patent number: 5428147
    Abstract: The sequence of the T-DNA of the octopine-type Ti plasmid found in Agrobacterium tumefaciens ATCC 15955 is disclosed. Fourteen open reading frames bounded by eukaryotic promoters, ribosome binding sites, and polyadenylation sites were found. The use of promoters and polyadenylation sites from pTi15955 to control expression of foreign structural genes is taught, using as examples the structural genes for the Phaseolus vulgaris storage protein phaseolin, P. vulgaris lectin, thaumatin, and Bacillus thuringiensis crystal protein. Vectors useful for manipulation of sequences of the structural genes and T-DNA are also provided.
    Type: Grant
    Filed: July 13, 1993
    Date of Patent: June 27, 1995
    Assignee: Mycogen Plant Science, Inc.
    Inventors: Richard F. Barker, John D. Kemp
  • Bacillus thuringiensis isolates selectively active against certain coleopteran pests
    Patent number: 5427786
    Abstract: The subject invention concerns Bacillus thuringiensis microbes with activity against select coleopteran pests e.g., Diabrotica sp., Hypera sp., and various flea beetles. For example, the B.t. isolates of the invention are active against alfalfa weevils--AW (Hypera brunneipennis), rape flea beetles--RFB (Phyllotreta cruciferae) and corn rootworms--CRW (Diabrotica undecimpunctata undecimpunctata). Thus, these microbes can be used to control these pests. Further, genes encoding toxins active against these pests can be isolated from the B.t. isolates and used to transform other microbes. The transformed microbes then can be used to control susceptible coleopteran pests.
    Type: Grant
    Filed: August 4, 1993
    Date of Patent: June 27, 1995
    Assignee: Mycogen Corporation
    Inventors: Jewel M. Payne, Tracy E. Michaels
  • Compositions and methods for detection and treatment of human osteoarthritis
    Patent number: 5427954
    Abstract: The subject invention concerns novel materials and methods for the detection, treatment, and prevention of human osteoarthritis. Specifically, the cleavage site where aggrecanase cleaves aggrecan has been identified. Identification of this site, as well as the nature of the enzyme, facilitates specific treatments which block or diminish the activity of the enzyme. A further aspect of the invention concerns methods for detecting evidence of osteoarthritis.
    Type: Grant
    Filed: April 29, 1992
    Date of Patent: June 27, 1995
    Assignee: Shriner's Hospitals for Crippled Children
    Inventors: John D. Sandy, Carl R. Flannery, Peter J. Neame, L. Stefan Lohmander
  • Methods for detection and prevention of concrete cracking and spalling associated with embedded metal corrosion
    Patent number: 5426973
    Abstract: Applicant has discovered a new mechanism which induces the cracking and spalling of metal-reinforced concrete. Methods and compositions for preventing such cracking and spalling are provided. Methods of testing compositions or admixtures for effectiveness in preventing cracking and spalling are also provided.
    Type: Grant
    Filed: April 24, 1992
    Date of Patent: June 27, 1995
    Assignee: Florida Atlantic University
    Inventor: William H. Hartt
  • PS176 gene encoding nematode-active toxin cloned from a bacillus thuringiensis isolate
    Patent number: 5426049
    Abstract: Nematicidal .delta.-endotoxin encoding genes have been cloned from a novel Bacillus thuringiensis isolate known as B.t. PS17. These novel genes, designated B.t. PS17a, B.t. PS17b, B.t. PS17d, and B.t. PS17e, can be transferred to various microbial and plant hosts via known techniques. In the microbial or plant host, one or more of the genes of the invention can be used to express the novel nematicidal toxins to control susceptible nematodes.
    Type: Grant
    Filed: October 6, 1993
    Date of Patent: June 20, 1995
    Assignee: Mycogen Corporation
    Inventors: August J. Sick, George E. Schwab, Jewel M. Payne
  • Bacillus thuringiensis isolates for controlling acarides
    Patent number: 5424410
    Abstract: Disclosed and claimed are Bacillus thuringiensis isolates designated B.t. PS50C, B.t. PS86A1, B.t. PS69D1, B.t. PS72L1, B.t. PS75J1, B.t. PS83E5, B.t. PS45B1, B.t.. PS24J, B.t. PS94R3, B.t. PS17, B.t. PS62B1 and B.t. PS74G1 which are active against acaride pests. Thus, these isolates, or mutants thereof, can be used to control such pests. Further, genes encoding novel .delta.-endotoxins can be removed from these isolates and transferred to other host microbes, or plants. Expression of the .delta.-endotoxins in microbe hosts results in the control of acaride pests, whereas transformed plants become resistant to acaride pests.
    Type: Grant
    Filed: November 3, 1993
    Date of Patent: June 13, 1995
    Assignee: Mycogen Corporation
    Inventors: Jewel M. Payne, Raymond J. C. Cannon, Angela L. Bagley