Patents Represented by Law Firm Saliwanchik & Saliwanchik
  • Process for preparing high purity protein A preparation
    Patent number: 5314993
    Abstract: The invention concerns a process for purifying protein A preparations to high purity with high product yield. Where the protein A is obtained from a Gram-negative recombinant microbe hosting a vehicle containing a gene encoding protein A, the protein A is purified to high purity, and, advantageously, to very low levels of endotoxin. The protein A preparations made via the invention process are useful in therapeutic application, e.g., therapeutic plasma exchange, as well as for other well-known uses of protein A.
    Type: Grant
    Filed: February 10, 1992
    Date of Patent: May 24, 1994
    Assignee: Repligen Corporation
    Inventors: Richard N. Love, Albert T. Profy
  • Coleopteran-active Bacillus thuringiensis isolates and genes encoding coleopteran-active toxins
    Patent number: 5306494
    Abstract: Certain known and available strains of Bacillus thuringiensis (B.t.) have been found to have activity against coleopteran pests. Previously, these strains were not known to have any insecticidal properties. The B.t. strains can be used in various environments to control coleopteran pests, e.g., the Colorado Potato Beetle.
    Type: Grant
    Filed: September 7, 1993
    Date of Patent: April 26, 1994
    Assignee: Mycogen Corporation
    Inventor: Jewel M. Payne
  • Bacillus thuringiensis isolates active against cockroaches and genes encoding cockroach-active toxins
    Patent number: 5302387
    Abstract: The subject invention concerns a novel microbe and genes encoding novel toxin proteins with activity against cockroaches. Cockroaches are common house pests, and they create problems in hospitals, the food industry and in agriculture. The novel Bacillus thuringiensis microbe of the invention is referred to as B.t. PS185L8. The subject invention also concerns the use of PS201T6 to control cockroaches. The spores or crystals of these microbes, or variants thereof, are useful to control cockroaches in various environments. The genes of the invention can be used to transform various hosts wherein the novel toxic proteins can be expressed.
    Type: Grant
    Filed: October 19, 1992
    Date of Patent: April 12, 1994
    Assignee: Mycogen Corporation
    Inventors: Jewel M. Payne, M. Keith Kennedy, John B. Randall, David O. Brower
  • Bacillus thuringiensis isolates active against dipteran pests
    Patent number: 5298245
    Abstract: Bacillus thuringiensis cultures deposited as NRRL B-18747, NRRL B-18749 and NRRL B-18750 have dipteran activity. Thus, these cultures, or mutants thereof, can be used to control such insect pests. Further, genes encoding novel .delta.-endotoxins can be removed from these cultures and transferred to other host microbes, or plants. Expression of the .delta.-endotoxins in such hosts results in the control of susceptible insect pests in the environment of such hosts.
    Type: Grant
    Filed: August 21, 1991
    Date of Patent: March 29, 1994
    Assignee: Mycogen Corporation
    Inventors: Jewel M. Payne, Kendrick A. Uyeda, Christine J. Stalder, Tracy E. Michaels
  • Method for treating transplant patients using mycalamide compounds
    Patent number: 5298523
    Abstract: Mycalamide compounds are derived from marine sponges of the genus Mycale or prepared by synthetic methods. These compounds, and pharmaceutical compositions containing them as active ingredients, are useful as immunomodulatory agents.
    Type: Grant
    Filed: December 14, 1992
    Date of Patent: March 29, 1994
    Assignee: Harbor Branch Oceanographic Institution, Inc.
    Inventors: Ross E. Longley, Glynn T. Faircloth
  • Bacillus thuringiensis isolate denoted B.t. PS81F, active against lepidopteran pests, and a gene encoding a lepidopteran-active toxin
    Patent number: 5296368
    Abstract: A novel B.t. toxin gene toxic to lepidopteran insects has been cloned from a novel lepidopteran-active B. thuringiensis microbe. The DNA encoding the B.t. toxin can be used to transform various prokaryotic and eukaryotic microbes to express the B.t. toxin. These recombinant microbes can be used to control lepidopteran insects in various environments.
    Type: Grant
    Filed: November 19, 1992
    Date of Patent: March 22, 1994
    Assignee: Mycogen Corporation
    Inventors: Jewel Payne, August J. Sick
  • Use for topsentin compounds and pharmaceutical compositions containing same
    Patent number: 5290777
    Abstract: A novel use for the class of biologically active bis-indole alkaloid compounds, which have been named topsentins, nortopsentins, or dragmacidins, pharmaceutical compositions containing them, methods of producing the compounds, and methods of using the compounds are disclosed. Specifically, the novel utility pertains to the anti-inflammatory properties exhibited by the bis-indole compounds and their analogs.
    Type: Grant
    Filed: February 24, 1993
    Date of Patent: March 1, 1994
    Assignees: Regents of the Univ. of California, Harbor Branch Oceanographic Inst. Inc.
    Inventors: Oliver J. McConnell, Gabriel Saucy, Robert Jacobs
  • Hybrid diphtheria-B.t. pesticidal toxins
    Patent number: 5290914
    Abstract: The invention concerns novel hybrid pesticidal toxins. These toxins are expressed as the fusion protein of a chimeric gene. Specifically exemplified is a novel B.t. hybrid toxin. These novel toxins have increased toxicity against target pests. The invention also concerns a process for preparing a hybrid virus having an altered insect host range.
    Type: Grant
    Filed: April 28, 1988
    Date of Patent: March 1, 1994
    Assignee: Mycogen Corporation
    Inventors: Edward Wilcox, David L. Edwards, George E. Schwab, Mark Thompson, Paul Culver
  • Process for controlling lepidopteran pests
    Patent number: 5286485
    Abstract: The subject disclosure concerns Bacillus thuringiensis strains which can be used to control lepidopteran pests. The strains were previously known to control coleopteran pests. The discovery of lepidopteran activity was totally unexpected.These B.t. strains can be formulated using standard lepidopteran formulation procedures. Means of administration are also standard.The genes encoding lepidopteran-active toxins can be isolated from the B.t. isolates and used to transform other microbes for use to control lepidopteran pests.
    Type: Grant
    Filed: September 12, 1991
    Date of Patent: February 15, 1994
    Assignee: Mycogen Corporation
    Inventors: Kendrick A. Uyeda, Luis Foncerrada, Jewel M. Payne, Kenneth E. Narva, George E. Schwab, Gregory A. Bradfisch, August J. Sick
  • Process for microencapsulating cells
    Patent number: 5286495
    Abstract: Oxalate-degrading enzymes and bacteria were encapsulated for both enteric and intraperitoneal administration. We have shown that via alginate microencapsulation of Oxalobacter formigenes, enzymatic activity was retained for several months. A new process was developed which strengthened the alginate microcapsules and their tolerance to citrate treatment. Much smaller (30-50 .mu.m) alginate microcapsules were made for injection as means of implantation. For oral administration, multi-encapsulated microspheres of cellulose acetate phthalate in poly-2-vinylpyridine (pKa=3.5) were prepared to protect the enzymes from gastric juices.
    Type: Grant
    Filed: May 11, 1992
    Date of Patent: February 15, 1994
    Assignee: University of Florida
    Inventors: Chris Batich, Farid Vaghefi
  • Interleukin-1 muteins, their preparation and method of use to inhibit interleukin-1 activity
    Patent number: 5286847
    Abstract: Disclosed are novel muteins of IL-1 compounds which can be used to regulate excess IL-1 produced in various diseases in humans and animals. The IL-1 muteins can be prepared by site-directed mutagenesis whereby a positively charged residue is replaced with a negatively charged or neutral residue at a designated position in the molecule. The resulting IL-1 muteins have reduced biological activity but retain receptor binding affinity.
    Type: Grant
    Filed: May 19, 1992
    Date of Patent: February 15, 1994
    Assignees: New England Medical Center Hospitals, Inc., Massachusetts Institute of Technology
    Inventors: Lee Gehrke, Philip E. Auron, Lanny Rosenwasser
  • Coleopteran-active bacillus thuringiensis isolates and genes encoding coleopteran-active toxins
    Patent number: 5286486
    Abstract: Certain known and available strains of Bacillus thuringiensis (B.t.) have been found to have activity against coleopteran pests. Previously, these strains were not known to have any insecticidal properties. The B.t. strains can be used in various environments to control coleopteran pests, e.g., the Colorado Potato Beetle. Also described are novel toxins, and genes coding for these toxins, which have coleopteran activity.
    Type: Grant
    Filed: November 6, 1992
    Date of Patent: February 15, 1994
    Assignee: Mycogen Corporation
    Inventors: Jewel M. Payne, Jenny M. Fu
  • Herbicidally-active glycol esters of fatty acids
    Patent number: 5284819
    Abstract: The subject invention pertains to novel methods and compositions utilizing novel fatty acid esters which exhibit excellent herbicidal activity in controlling unwanted vegetation. The novel compositions and methods described here facilitate effective weed control using a wide range of fatty acids.
    Type: Grant
    Filed: May 1, 1992
    Date of Patent: February 8, 1994
    Assignee: Mycogen Corporation
    Inventors: Paul S. Zorner, Yasuko Tsujino, Osamu Kamioka
  • Systemic treatment of metastatic cancer with platelet factor 4
    Patent number: 5284827
    Abstract: The subject invention concerns a novel treatment for cancer. Specifically, the invention concerns the systemic administration of recombinant Platelet Factor Four (rPF4) to inhibit tumor growth in a mammal having metastatic cancer.
    Type: Grant
    Filed: October 19, 1990
    Date of Patent: February 8, 1994
    Assignee: Repligen Corporation
    Inventors: Theodore Maione, Richard J. Sharpe
  • Biological process for enhanced manganese and silver recovery from refractory manganiferous silver ore
    Patent number: 5283192
    Abstract: Disclosed is an efficient biological process for recovering silver and manganese from refractory manganiferous silver ore. The process utilizes manganese reducing Bacillus sp. Specifically exemplified is a novel microbe designated Bacillus MBX 69, or mutants thereol Further, gene(s) encoding the enzyme(s) obtainable from the said bacteria can be used by placing such gene(s) on a suitable vector and transforming a competent host. The transformed host then can be used to recover silver and manganese from refractory manganiferous silver ore.
    Type: Grant
    Filed: December 9, 1992
    Date of Patent: February 1, 1994
    Assignee: Metallurgical and Biological Extraction Systems, Inc.
    Inventor: Patricia A. Rusin
  • Pseudomas hosts transformed with bacillus endotoxin genes
    Patent number: 5281532
    Abstract: Novel biological pesticides are prepared by introducing into a microorganism the genetic capability to produce a heterologous pesticide, wherein the microorganism is capable of proliferating in the rhizosphere or phylloplane in competition with wild-type microorganisms. A gene capable of expressing a polypeptide is introduced into the microorganism under conditions which allow for stable maintenance and expression of the gene, without significantly diminishing the ability of the microorganism to compete in the environment. Preferred microorganisms provide for the maintenance and protection from degradation of the polypeptide pesticide.
    Type: Grant
    Filed: November 23, 1992
    Date of Patent: January 25, 1994
    Assignee: Mycogen Corporation
    Inventors: David H. Rammler, Frank H. Gaertner, David L. Edwards
  • Genes encoding nematode-active toxins cloned from bacillus thuringiensis isolate PS17
    Patent number: 5281530
    Abstract: Nematicidal .delta.-endotoxin encoding genes have been cloned from a novel Bacillus thuringiensis isolate known as B.t. PS17. These novel genes, designated B.t. PS17a, B.t. PS17b, Bt. PS17d, and B.t. PS17e, can be transferred to various microbial and plant hosts via known techniques. In the microbial or plant host, one or more of the genes of the invention can be used to express the novel nematicidal toxins to control susceptible nematodes.
    Type: Grant
    Filed: July 24, 1990
    Date of Patent: January 25, 1994
    Assignee: Mycogen Corporation
    Inventors: August J. Sick, George E. Schwab, Jewel M. Payne
  • Coleopteran-active bacillus thuringiensis isolate
    Patent number: 5277905
    Abstract: The subject invention concerns a novel microbe and gene encoding a novel toxin protein with activity against insect pests of the order Coleoptera. Pests in the order Coleoptera do heavy damage to crops, e.g., corn. The novel Bacillus thuringiensis microbe of the invention is referred to as B.t. PS50C. The spores or crystals of this microbe, or mutants thereof, are useful to control coleopteran pests in various environments. The novel gene of the invention can be used to transform various hosts wherein the novel toxic protein can be expressed.
    Type: Grant
    Filed: January 16, 1991
    Date of Patent: January 11, 1994
    Assignee: Mycogen Corporation
    Inventors: Luis Foncerrada, August J. Sick, Jewel M. Payne
  • Bacillus thuringiensio NRRL B-18721 active against dipteran pests
    Patent number: 5275815
    Abstract: Disclosed and claimed is a novel Bacillus thuringiensis isolate designated B.t. NRRL B-18721 which has activity against dipteran insect pests. Thus, this isolate, or mutants thereof, can be used to control such insect pests. Further, genes encoding novel .delta.-endotoxins can be removed from the isolate and transferred to other host microbes, or plants. Expression of the .delta.-endotoxins in such hosts results in the control of susceptible insect pests in the environment of such hosts.
    Type: Grant
    Filed: February 22, 1993
    Date of Patent: January 4, 1994
    Assignee: Mycogen Corporation
    Inventor: Jewel M. Payne
  • Caladium cultivar `Florida Sweetheart`
    Patent number: PP8526
    Abstract: Description and specifications of a new and distinct caladium variety which originated from a cross between `Candidum Junior` and `Red Frill` are provided. The new caladium variety is distinct from all others by its color, improved leaf shape, and production of large tubers.
    Type: Grant
    Filed: July 27, 1992
    Date of Patent: December 28, 1993
    Assignee: University of Florida
    Inventor: Gary J. Wilfret