Patents Represented by Attorney Samuel J. DuBoff

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  • Neurotrophic difluoroamide agents
    Patent number: 6239146
    Abstract: The present invention relates to the design, synthesis, and the peptidyl-prolyl isomerase (PPIase or rotamase) inhibitory activity of novel &agr;,&agr;-difluoroacetamido compounds that are neurotrophic agents (i.e. compounds capable of stimulating growth or proliferation of nervous tissue) and that bind to immunophilins such as FKBP12 and inhibit their rotamase activity. This invention also relates to pharmaceutical compositions comprising these compounds.
    Type: Grant
    Filed: June 9, 2000
    Date of Patent: May 29, 2001
    Assignee: Bristol-Myers Squibb Company
    Inventors: Vivekananda M. Vrudhula, Gene M. Dubowchik, Bireshwar Dasgupta, Dolatrai M. Vyas
  • Neurotrophic diamide and carbamate agents
    Patent number: 6228872
    Abstract: The present invention relates to the design, synthesis, and the peptidyl-prolyl isomerase (PPIase or rotamase) inhibitory activity of novel pyrrolidinemethyl diamide and carbamate compounds that are neurotrophic agents (i.e. compounds capable of stimulating growth or proliferation of nervous tissue) and that bind to immunophilins such as FKBP12 and inhibit their rotamase activity. This invention also relates to pharmaceutical compositions comprising these compounds.
    Type: Grant
    Filed: November 8, 1999
    Date of Patent: May 8, 2001
    Assignee: Bristol-Myers Squibb Company
    Inventors: Gene M. Dubowchik, Jonathan L. Ditta, David P. Provencal, Derek J. Denhart
  • Nocathiacin antibiotics
    Patent number: 6218398
    Abstract: Novel thiazolyl peptide antibiotic compounds, including nocathiacin I, II and III, are disclosed. Also, novel microorganism ATCC-202099 is disclosed.
    Type: Grant
    Filed: July 13, 1999
    Date of Patent: April 17, 2001
    Assignee: Bristol-Myers Squibb Company
    Inventors: John E. Leet, Helen A. Ax, Donald R. Gustavson, Daniel M. Brown, Laura Turner, Kimberly Brown, Wenying Li, Kin S. Lam
  • 7-0-ethers of taxane derivatives
    Patent number: 6201140
    Abstract: The present invention concerns novel 7-ethers of taxane derivatives, their use as antitumor agents and pharmaceutical compositions containing the novel compounds.
    Type: Grant
    Filed: July 28, 1994
    Date of Patent: March 13, 2001
    Assignee: Bristol-Myers Squibb Company
    Inventors: Henry Wong, Mark D. Wittman
  • Neurotrophic difluoroamide agents
    Patent number: 6096762
    Abstract: The present invention relates to the design, synthesis, and the peptidyl-prolyl isomerase (PPIase or rotamase) inhibitory activity of novel .alpha.,.alpha.-difluoroacetamido compounds that are neurotrophic agents (i.e. compounds capable of stimulating growth or proliferation of nervous tissue) and that bind to immunophilins such as FKBP12 and inhibit their rotamase activity. This invention also relates to pharmaceutical compositions comprising these compounds.
    Type: Grant
    Filed: May 21, 1999
    Date of Patent: August 1, 2000
    Assignee: Bristol-Myers Squibb Company
    Inventors: Vivekananda M. Vrudhula, Gene M. Dubowchik, Bireshwar Dasgupta, Dolatrai M. Vyas
  • Cefadroxil monohydrate tablet formulation
    Patent number: 6080427
    Abstract: This invention relates to uncoated direct compression tablets containing cefadroxil monohydrate as the active ingredient, which are capable of oral administration to human beings by swallowing, chewing or disintegrating in water resulting in a drinkable dispersion.
    Type: Grant
    Filed: March 17, 1998
    Date of Patent: June 27, 2000
    Assignee: Bristol-Myers Squibb Company
    Inventor: Jean Paul Louis Auguste Remon
  • 7-sulfur substituted paclitaxels
    Patent number: 6017935
    Abstract: The present invention relates to novel taxane derivatives wherein, the taxol ring is substituted by sulfur groups on the C-7, their use as antitumor agents and pharmaceutical formulations.
    Type: Grant
    Filed: April 14, 1998
    Date of Patent: January 25, 2000
    Assignee: Bristol-Myers Squibb Company
    Inventors: Harold Mastalerz, John F. Kadow
  • N-substituted 2-azetidinones
    Patent number: 6008347
    Abstract: The present invention provides novel cis-N-iminomethyl-3,4-disubstituted-2-azetidinones, and their use in the preparation of N-acyl-2-azetidinones, intermediates in the semi-synthesis of taxol and taxol derivatives.
    Type: Grant
    Filed: January 10, 1995
    Date of Patent: December 28, 1999
    Assignee: Bristol-Myers Squibb Company
    Inventors: Allan W. Rey, Purushotham Vemishetti, Roberto Droghini
  • 6-thio-substituted paclitaxels
    Patent number: 5977386
    Abstract: The present invention concerns novel paclitaxel derivatives, their use as antitumor agents, and pharmaceutical formulations.
    Type: Grant
    Filed: November 26, 1997
    Date of Patent: November 2, 1999
    Assignee: Bristol-Myers Squibb Company
    Inventors: Andrew J. Staab, John F. Kadow, Dolatrai M. Vyas, Mark D. Wittman, Harold A. Mastalerz
  • 6-halo-or nitrate-substituted paclitaxels
    Patent number: 5912264
    Abstract: The present invention concerns novel taxane derivatives, their use as antitumor agents, and pharmaceutical formulations.
    Type: Grant
    Filed: February 2, 1998
    Date of Patent: June 15, 1999
    Assignee: Bristol-Myers Squibb Company
    Inventors: Mark D. Wittman, John F. Kadow
  • 7-methylthiooxomethyl and 7-methylthiodioxomethyl paclitaxels
    Patent number: 5902822
    Abstract: The present invention concerns novel paclitaxel derivatives, their use as antitumor agents, and pharmaceutical formulations.
    Type: Grant
    Filed: February 18, 1998
    Date of Patent: May 11, 1999
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jerzy Golik, Dolatrai M. Vyas
  • C4 methoxy ether derivatives of paclitaxel
    Patent number: 5840929
    Abstract: The present invention concerns novel paclitaxel derivatives, their use as antitumor agents, and pharmaceutical formulations.
    Type: Grant
    Filed: September 9, 1996
    Date of Patent: November 24, 1998
    Assignee: Bristol-Myers Squibb Company
    Inventor: Shu-Hui Chen
  • 7-deoxy-6-substituted paclitaxels
    Patent number: 5773461
    Abstract: The present invention concerns novel paclitaxel derivatives, their use as antitumor agents, and pharmaceutical formulations.
    Type: Grant
    Filed: June 4, 1997
    Date of Patent: June 30, 1998
    Assignees: Bristol-Myers Squibb Company, Virginia Tech Intellectual Properties, Inc.
    Inventors: Mark D. Wittman, Thomas J. Altstadt, John F. Kadow, David G. I. Kingston, Xian Liang
  • C-10 epoxy taxanes
    Patent number: 5773464
    Abstract: The present invention concerns novel paclitaxel derivatives, their use as antitumor agents, and pharmaceutical formulations.
    Type: Grant
    Filed: August 29, 1997
    Date of Patent: June 30, 1998
    Assignee: Bristol-Myers Squibb Company
    Inventors: Michael A. Walker, John F. Kadow
  • Compositions and methods of treating HIV with d4T, 5-fluorouracil/tegafur, and uracil
    Patent number: 5719132
    Abstract: The present invention is directed to the use of pharmaceutical compositions containing anti-retroviral effective amounts of (a) d4T and (b) 5-fluorouracil or a prodrug, or salt thereof.
    Type: Grant
    Filed: June 27, 1996
    Date of Patent: February 17, 1998
    Assignee: Bristol-Myers Squibb Company
    Inventors: Pin-Fang Lin, Yi-Fei Gong
  • Stable injectable formulation of BMY-25067
    Patent number: 5703111
    Abstract: This invention relates to a stable, easy to constitute, injectable formulation of anticancer agent BMY-25067. More specifically, the present invention concerns a formulation of BMY-25067 obtained from lyophilizing a solution comprising up to 4 mg of BMY-25067 per mL of 65% t-butanol/water, further comprising about 2% PVP (K-12 or K-17), optionally comprising pharmaceutically acceptable carrier(s).
    Type: Grant
    Filed: December 4, 1996
    Date of Patent: December 30, 1997
    Assignee: Bristol-Myers Squibb Company
    Inventors: Uday S. Gogate, Shreeram N. Agharkar, Lawan Phusanti
  • 6,7-modified paclitaxels
    Patent number: 5693666
    Abstract: The present invention provides paclitaxel derivatives of formula I ##STR1## and pharmaceutical compositions.
    Type: Grant
    Filed: January 3, 1996
    Date of Patent: December 2, 1997
    Assignee: Bristol-Myers Squibb Company
    Inventors: Shu-Hui Chen, Vittorio Farina, Gregory Roth, John Kadow
  • Process of preparing etoposide phosphate and etoposide
    Patent number: 5688926
    Abstract: Etoposide phosphate is prepared by coupling dibenzyl 4'-demethyl-4-epipodophyllotoxin-4'-phosphate with 2,3-di-O-benzyl-4,6-O-ethylidene-.alpha.,.beta.-D-glucopyranose in a solvent and subsequently removing the protecting groups. The tetra-benzyl protected etoposide phosphate is recrystallized from methanol or directly crystallized from acetonitrile by adding methanol to yield substantially the pure C-1"-.beta. form. The benzyl protecting groups are simultaneously removed by hydrogenation to produce etoposide phosphate in high yields. In a further embodiment, etoposide phosphate is treated with a phosphatase enzyme to yield etoposide.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 18, 1997
    Assignee: Bristol-Myers Squibb Company
    Inventors: Lee J. Silverberg, Purushotham Vemishetti, John L. Dillon, Jr., John J. Usher
  • Phosphonooxymethyl ethers of taxane derivatives
    Patent number: 5646176
    Abstract: The present invention concerns antitumor compounds. More particularly, the invention provides novel taxane derivatives, pharmaceutical compositions thereof, and their use as antitumor agents.
    Type: Grant
    Filed: May 19, 1995
    Date of Patent: July 8, 1997
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jerzy Golik, Dolatrai Vyas, John J. Wright, Henry Wong, John F. Kadow, John K. Thottathil, Wen-Sen Li, Murray A. Kaplan, Robert K. Perrone, Mark D. Wittman
  • 3'-aminocarbonyloxy paclitaxels
    Patent number: 5635531
    Abstract: The present invention concerns novel paclitaxel derivatives, their use as antitumor agents, and pharmaceutical formulations.
    Type: Grant
    Filed: July 8, 1996
    Date of Patent: June 3, 1997
    Assignee: Bristol-Myers Squibb Company
    Inventor: Shu-Hui Chen