Abstract: The present invention concerns a novel process using controlled cooling for obtaining d.sub.4 T polymorphic Form I from a mixture containing one or more of polymorphic Forms I, II and III. Compound d.sub.4 T has been approved for use in the treatment of AIDS.

Abstract: The present invention relates to a novel method useful for the conversion of amino acids to halomethylketones, which are then converted to amino acid epoxides. Such epoxides are important intermediates for the synthesis of inhibitors of renin and HIV protease, which are particularly useful in the treatment and/or prevention of HIV infection (AIDS).

Abstract: Addition of certain tryptophan analogs to the culture medium during fermentation of a rebeccamycin-producing strain of Saccharothrix aerocolonigenes results in production of new rebeccamycin analogs having advantageous antitumor properties.

Abstract: Etoposide phosphate is prepared by coupling dibenzyl 4'-demethyl-4-epipodophyllotoxin-4'-phosphate with 2,3-di-O-benzyl-4,6-O-ethylidene-.alpha.,.beta.-D-glucopyranose in a solvent and subsequently removing the protecting groups. The tetra-benzyl protected etoposide phosphate is recrystallized from methanol or directly crystallized from acetonitrile by adding methanol to yield substantially the pure C-1"-.beta. form. The benzyl protecting groups are simultaneously removed by hydrogenation to produce etoposide phosphate in high yields. In a further embodiment, etoposide phosphate is treated with a phosphatase enzyme to yield etoposide.

Abstract: This invention relates to novel elsamicin A derivatives wherein the 2"-amino group is selectively modified by acylation or alkylation, a process for producing said elsamicin A derivatives, an antitumor composition containing the same as the active ingredient, and a method for therapy using said compositions.

Abstract: An ultrasonic cleaner for domestic use includes a high-power circuit for driving an ultrasonic transducer and a low-power safety switch which enables the high-power circuit only when a cover is in place over the cleaner. The safety switch is a magnetically actuated reed switch, the contacts of which are closed by a magnet on the cover.

Abstract: A portable, battery-operated manicuring machine is disclosed in which the batteries and the final output shaft are aligned substantially coaxially. The motor and actuating switch are positioned within the housing intermediate the battery chamber and the final drive unit with the motor being radially offset from the axis of alignment of the drive unit, batteries and housing and the switch being positioned diametrically opposite the motor. The drive between the motor and the final output shaft includes a gear reduction train comprising a pinion gear on the motor output shaft, a cluster gear having it's larger-diameter gear in meshing relationship with the pinion gear and its smaller gear in meshing relationship with an internally-toothed gear and the output shaft.The motor and gear-reduction train are mounted on opposite sides of a bulkhead which is mounted transversely within the forward part of the machine housing.

Abstract: This invention relates to drain cleaning compositions characterized by a pelletized form. Each pellet formed comprises aluminum; potassium or sodium nitrate; a binding material having a melting point of from about 37.degree. C. to about 67.degree. C. selected from the group consisting of polymers of polyethylene glycol, having a molecular weight of from about 3000 to about 20,000; polymers of ethylene oxide, having a molecular weight of from about 400,000 to about 2,000,000; aliphatic oxyethylated straight chain fatty alcohols having a molecular weight of about 260 to about 265 and containing about 80%, by weight, ethylene oxide; fatty acids having a carbon chain length of from about 10 to about 18 carbon atoms; alkali metal salts of gluconic acid; and mixtures thereof; at least about 1%, by weight, of an alkali metal hydroxide; and a sufficient amount of an additional compatible alkaline ingredient, whereby the total alkaline concentration present, expressed as sodium oxide, is at least about 11%, by weight.

Abstract: A foot massager and bath is disclosed in which either a massage or a heated bath or both are optionally available to the user. The bath is maintained in temperature by an element protruded through the wall of the unit to provide a metal-to-bath heat exchange and is shielded from the user's feet by a grille portion of the unit. A vibrating massage is provided by an electrical vibrator mounted on a plane above the plane of the deck upon which the feet are rested and which is coupled to the deck at a point substantially below the foot plane to provide a variable-direction motion of the foot plane area and a consequent variation in the vibrations imparted to the feet. A variable-capacity mount is disclosed which supports the unit on a surface by means of a variable-contoured elastomeric support under differing weight circumstances to provide increased stiffness in the support to accommodate an increased load from within the unit.

Abstract: Drain cleaning compositions, especially effective in dissolving soap curd, are provided which comprise in aqueous solution an ammonium, alkylamine, hydroxy-alkylamine, or mixtures thereof, salt of nitrilotriacetic acid, N-2-hydroxyethylimino diacetic acid, an alkylene polyamine polycarboxylic acid, or mixtures thereof, and an ammonium, alkylamine, hydroxy-alkylamine, or mixtures thereof, salt of one or more anionic surfactants, wherein the alkylamine and hydroxy-alkylamine have a chain length of from 1 to 5 carbon atoms, the composition is substantially free of alkali metal ions, and the alkylene polyamine polycarboxylic acid has the formula(HOOCCH.sub.2).sub.2 N--[(CH.sub.2).sub.x NCH.sub.2 COOH].sub.Y --CH.sub.2 COOHwherein x and y may each independently be from 1 to 4.

Abstract: Aqueous cleaning compositions, especially effective in dissolving soap curd, are provided which comprise in aqueous solution an ammonium, alkylamine or hydroxy-alkylamine salt of nitrilotriacetic acid, an alkylene polyamine polycarboxylic acid, or mixtures thereof, and one or more nonionic surfactants, wherein the alkylamine and hydroxy-alkylamine have a chain length of from 1 to 5 carbon atoms, the composition is substantially free of alkali metal ions, and the alkylene polyamine polycarboxylic acid has the formula(HOOCCH.sub.2).sub.2 N[(CH.sub.2).sub.x NCH.sub.2 COOH].sub.y CH.sub.2 COOHwherein x and y may each independently be from 1 to 4.

Abstract: A combination of corrosion inhibitors which act synergistically to prevent corrosion in compositions containing a chlorinated hydrocarbon and a substantially large amount of water.

Abstract: A bottle packing system including an oscillating grid for transferring bottle groups from a grouping station to a carton-filling station, the grid including tensioned resilient means for engaging and retaining bottles in the grid during its oscillation, and a positive-ejection member rockable into the grid for ejecting the bottles from the grid at the carton-filling station.

Abstract: Terpenes and their derivatives provide improved stability to aqueous solutions containing hydrogen peroxide as well as to aerosol co-dispensing hair coloring systems containing oxidation dye compositions.

Abstract: A granular drain cleaning composition which remains physically separated in two parts until utilization in the presence of water, useful for freeing a clogged drain of grease, hair, oils, and other debris is disclosed. One part contains an alkali metal hydroxide which is either sodium hydroxide or potassium hydroxide, the other part contains one or more ingredients that are chemically incompatible in the dry state with the alkali metal hydroxide, the ingredients including an acidic agent which is sodium bisulfate or citric acid, and an oxidizing agent. The oxidizing agent is preferably sodium carbonate peroxide, sodium perborate monohydrate or monopotassium peroxymonosulfate. Optionally, an anionic or nonionic surfactant foaming agent can be included.

Abstract: Drain cleaning compositions, especially effective in dissolving soap curd, are provided which comprise in aqueous solution a potassium salt of nitrilotriacetic acid, N-2-hydroxyethylimino diacetic acid, an alkylene polyamine polycarboxylic acid, or mixtures thereof, and potassium hydroxide, wherein the compositions are substantially free of other alkali metal ions and the alkylene polyamine polycarboxylic acid has the formula(HOOCCH.sub.2).sub.2 N[(CH.sub.2).sub.x NCH.sub.2 COOH].sub.y CH.sub.2 COOHwhere x and y may each independently be from 1 to 4.

Abstract: Phosphate derivatives of 4'-demethylepipodophyllotoxin glucosides are novel antitumor agents and the salts thereof offer the pharmaceutical advantage of high water solubility.