Patents Represented by Attorney Scott J. Meyer

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  • Derivatives of 1,4-dideoxy-1,4-imino-D-mannitol and a process for their preparation
    Patent number: 4996329
    Abstract: Novel derivatives of 1,4-dideoxy-1,4-imino-D-mannitol and method for their synthesis from 4,5-anhydro-1-azido-1-deoxy-2,3-O-isopropylidene-D-talitol or its triflate derivative are disclosed. The novel derivatives, 6-fluoro-1,4-imino-1,4,6-trideoxy-D-mannitol and the N-butyl and N-benzyl derivatives of 1,4-dideoxy-1,4-amino-D-mannitol, have useful mannosidase inhibitory activity.
    Type: Grant
    Filed: January 8, 1990
    Date of Patent: February 26, 1991
    Assignee: Monsanto Company
    Inventors: George W. J. Fleet, Bryan Winchester, Neil M. Carpenter
  • Synthesis of nojirimycin derivatives
    Patent number: 4994572
    Abstract: Nojirimycin .delta.-lactam and deoxynojirimycin are each synthesized from 5,6-anhydro-3-O-benzyl-1,2-O-isopropylidene-L-idofuranose as a divergent intermediate by a method which comprises formation of the piperidine ring by connection of nitrogen between C-1 and C-5 with inversion of configuration at C-5 to form nojirimycin .delta.-lactam or between C-2 and C-6 with inversion of configuration at C-2.
    Type: Grant
    Filed: October 12, 1989
    Date of Patent: February 19, 1991
    Assignee: Monsanto Company
    Inventor: George W. J. Fleet
  • Bicyclic tetrahydroxylated pyrrolizidines
    Patent number: 4992460
    Abstract: Novel bicyclic tetrahydroxylated pyrrolizidines are disclosed which are inhibitors of glycosidase enzymes. A preferred inhibitor is 1.alpha., 2.alpha., 6.alpha., 7.alpha., 7.alpha..beta.-1,2,6,7-tetrahydroxypyrrolizidine. It is synthesized from D-glycero-D-gulo-heptono-1,4-lactone.Novel Intermediate compounds prepared during this synthesis are 7-O-tert-butyldiphenylsilyl-2,3:5,6-di-O-isopropylidene-D-glycero-D-gulo-h ept ono-1,4-lactone and 1.alpha., 2.alpha., 6.alpha., 7.alpha., 7.alpha..beta.-1,2:6,7-di-O-isopropylidene-1,2,6,7-tetrahydroxypyrrolizidi ne.
    Type: Grant
    Filed: September 8, 1989
    Date of Patent: February 12, 1991
    Assignee: Monsanto Company
    Inventor: George W. J. Fleet
  • Thienyl peptide mimetic compounds which are useful in inhibiting platelet aggregation
    Patent number: 4992463
    Abstract: Novel peptide mimetic compounds are provided which have useful activity as inhibitors of platelet aggregation. These compounds have the chemical structure ##STR1## wherein x=6 to 10,y=0 to 4,Z=H, COOH, CONH.sub.2 or C.sub.1-6 alkyl,Ar=phenyl, biphenyl or napthyl, each substituted with 1 to 3 methoxy groups, or an unsubstituted phenyl, biphenyl, napthyl, pyridyl or thienyl group, andAsp=aspartic acid residue.
    Type: Grant
    Filed: August 18, 1989
    Date of Patent: February 12, 1991
    Assignee: Monsanto Company
    Inventors: Foe S. Tjoeng, Steven P. Adams
  • cDNA encoding 92-kDA type IV collagenase
    Patent number: 4992537
    Abstract: A novel 92-kDa type IV collagenase has been purified to homogeneity from SV-40 transformed fetal lung fibroblasts, its primary structure determined and characterized and a cDNA clone representing the full size protein has been developed.
    Type: Grant
    Filed: May 15, 1989
    Date of Patent: February 12, 1991
    Assignee: Washington University
    Inventors: Gregory I. Goldberg, Arthur Z. Eisen
  • Antiviral compounds and a method of use thereas
    Patent number: 4973602
    Abstract: Novel N-aryl derivatives of 1,4-dideoxy-1,4-imino-L-arabinitol and their acylated derivatives are disclosed. These compounds have useful antiviral activity.
    Type: Grant
    Filed: September 26, 1989
    Date of Patent: November 27, 1990
    Assignee: G. D. Searle & Co.
    Inventors: Francis J. Koszyk, Richard A. Partis, Richard A. Mueller
  • DNA clone of human tissue factor inhibitor
    Patent number: 4966852
    Abstract: A cDNA clone having a base sequence for human tissue factor inhibitor (TFI) has been developed and characterized and the amino acid sequence of the TFI has been determined.
    Type: Grant
    Filed: November 23, 1987
    Date of Patent: October 30, 1990
    Assignees: Monsanto Company, Washington University
    Inventors: Tze-Chein Wun, Kuniko K. Kretzmer, George J. Broze, Jr.
  • Tissue plasminogen activator modified by the substitution of Arg for Cys at position 73, methods and pharmaceutical compositions therefor
    Patent number: 4963357
    Abstract: A modified tissue plasminogen activator having an improved in vivo half-life characterized in that the normal protein moiety of 527 amino acids is mutated at the site Cys73.fwdarw.Arg.
    Type: Grant
    Filed: January 29, 1988
    Date of Patent: October 16, 1990
    Assignee: Monsanto Company
    Inventors: Leslie D. Bell, Ernest J. Mayer, Mark O. Palmier, H. Eser Tolunay, Thomas G. Warren, Tze-Chein Wun
  • Method of increasing yield of t-PA in cell culture
    Patent number: 4957863
    Abstract: A method is disclosed for increasing the yield of t-PA in culture of mammalian cells comprising introducing antibodies to the t-PA of said cells into the cell culture nutrient medium, allowing the cells to grow, and then recovering t-PA from the t-PA-antibody complex thus found in the conditioned medium by exchanging antibody in the complex for t-PA antibody immobilized on an inert support.
    Type: Grant
    Filed: January 26, 1988
    Date of Patent: September 18, 1990
    Assignee: Monsanto Company
    Inventors: Michael A. Sanzo, Medora M. Hardy, Joseph Feder
  • Method of treating herpesviruses
    Patent number: 4957926
    Abstract: A method is disclosed for the treatment of herpesvirus infections comprising treating the infected host with an effective amount of an N-alkyl derivative of deoxynojirimycin in which the alkyl group contains from one to about six carbon atoms, and preferably is butyl.
    Type: Grant
    Filed: December 22, 1988
    Date of Patent: September 18, 1990
    Assignee: Monsanto Company
    Inventors: Gary S. Jacob, A. Stanley Tyms, Thomas W. Rademacher, Raymond A. Dwek
  • Intermediates for antiviral compounds
    Patent number: 4937357
    Abstract: N-alkyl, N-hydroxylalkyl and N-alkanoyl derivatives of 1,4-dideoxy-1,4-imino-L-arabinitol are disclosed in which the alkyl group has from 4 to about 9 carbon atoms, the hydroxyalkyl group has from 2 to about 5 carbon atoms and the alkanoyl group has from 3 to about 12 carbon atoms. These compounds are useful intermediates for the preparation of acylated derivatives thereof which have antiviral activity.
    Type: Grant
    Filed: September 26, 1989
    Date of Patent: June 26, 1990
    Assignee: G. D. Searle & Co.
    Inventors: Francis J. Koszyk, Richard A. Partis, Richard A. Mueller
  • Method of determining the number of cells in cell culture
    Patent number: 4933278
    Abstract: A method is disclosed for determining the number of cells in cell culture which comprises lysing the cells and incubating the cell lysate with p-nitrophenyl phosphate for a predetermined period of time at acid pH and at 35.degree.-38.degree. C., and then measuring the color development at 400 to 420 nanometers and comparing with a control. The method is accurate, sensitive, and well-suited for automation, and thereby provides for the rapid sampling of large numbers of cell culture where the cells are grown under very sparse conditions.
    Type: Grant
    Filed: January 28, 1987
    Date of Patent: June 12, 1990
    Assignee: Monsanto Company
    Inventor: Daniel T. Connolly
  • Tissue plasminogen activator from normal human colon cells
    Patent number: 4927630
    Abstract: Normal human colon fibroblast tissue plasminogen activator is separated by lysine-Sepharose affinity chromatography into Types I and II glycoforms and characterized with respect to the relative incidence of each type of oligosaccharide comprising the respective Types I and II glycoforms.
    Type: Grant
    Filed: March 11, 1988
    Date of Patent: May 22, 1990
    Assignee: Monsanto Company
    Inventors: Joseph Feder, Susan C. Howard, Arthur J. Wittwer, Thomas W. Rademacher, Raj B. Parekh, Raymond A. Dwek
  • DNA clone of human type IV collagenase
    Patent number: 4923818
    Abstract: The cDNA clone representing the full size human type IV collagenase (gelatinase) is disclosed.
    Type: Grant
    Filed: May 15, 1989
    Date of Patent: May 8, 1990
    Assignee: Washington University
    Inventors: Gregory I. Goldberg, Arthur Z. Eisen
  • DNA clone of human thrombomodulin and portions thereof
    Patent number: 4912207
    Abstract: A cDNA having a base sequence for human thrombomodulin has been cloned and characterized and the amino acid sequence of the human thrombomodulin has been determined.
    Type: Grant
    Filed: May 6, 1987
    Date of Patent: March 27, 1990
    Assignee: Washington University
    Inventors: Philip W. Majerus, J. Evan Sadler
  • Synthesis of N-substituted 1,5-dideoxy-1,5-imino-L-fucitol derivatives
    Patent number: 4910310
    Abstract: Novel intermediates and method for the chemical synthesis of N-substituted 1,5-dideoxy-1,5-imino-L-fucitol derivatives are provided. A preferred intermediate is 1,5-dideoxy-1,5-imino-3, 4-O-isopropylidene-L-fucitol which is used to prepare the HIV inhibitor 1,5-dideoxy-1,5-imino-[N-.omega.-methyl caproate]-L-fucitol. These compounds are prepared in a short synthesis from the known compound 2,3-O-isopropylidene-D-lyxono-1,4-lactone or in a multi-step synthesis from D-galactose.
    Type: Grant
    Filed: October 3, 1988
    Date of Patent: March 20, 1990
    Assignee: G. D. Searle & Co.
    Inventors: Arthur L. Campbell, James R. Behling, Kevin A. Babiak, John S. Ng, Richard A. Mueller, George W. J. Fleet
  • Glycosidase inhibitors and use thereof
    Patent number: 4894388
    Abstract: The specificity of glycosidase inhibitory activity of the novel 1,4-dideoxy-1,4-imino-L-allitol is substantially changed by substituting the ring nitrogen with an alkyl or benzyl substituent.
    Type: Grant
    Filed: December 22, 1988
    Date of Patent: January 16, 1990
    Assignee: Monsanto Company
    Inventor: George W. J. Fleet
  • Monoclonal antibody specific for human colon fibroblast-derived t-PA
    Patent number: 4891312
    Abstract: A monoclonal antibody is disclosed which is specific for human colon fibroblast-derived tissue plasminogen activator (t-PA), and which is useful for immunoaffinity chromatography purification of t-PA and determination of t-PA in a biological sample.
    Type: Grant
    Filed: January 6, 1989
    Date of Patent: January 2, 1990
    Assignee: Monsanto Company
    Inventors: Jon P. Schaumann, Jitka V. Olander, Nicholaos K. Harakas, Joseph Feder
  • Monoclonal antibody specific for human colon fibroblast-derived T-PA
    Patent number: 4889922
    Abstract: A monoclonal antibody is disclosed which is specific for human colon fibroblast-derived tissue plasminogen activator (t-PA), and which is useful for immunoaffinity chromatography purification of t-PA and determination of t-PA in a biological sample.
    Type: Grant
    Filed: January 6, 1989
    Date of Patent: December 26, 1989
    Assignee: Monsanto Co.
    Inventors: Jon P. Schaumann, Jitka V. Olander, Nicholaos K. Hrakas, Joseph Feder
  • Large DNA cloning system based on yeast artificial chromosomes
    Patent number: 4889806
    Abstract: A large DNA cloning system is disclosed which is based on yeast artificial chromosomes. Cloning vectors are disclosed which allow the cloning of large segments of greater than 50 kb of exogenous DNA. The cloning vector comprises DNA sequences of an autonomous replication sequence, a centromere, a selectable yeast marker, two sequences that seed telomere function in vivo, and a cloning site within an interruptible yeast gene for insertion of the exogenous DNA segments.
    Type: Grant
    Filed: April 15, 1987
    Date of Patent: December 26, 1989
    Assignee: Washington University
    Inventors: Maynard V. Olson, David T. Burke