Patents Represented by Attorney Scott J. Meyer

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  • Novel platelet-aggregation inhibitors
    Patent number: 4879313
    Abstract: Novel peptide mimetic compounds are provided which have useful activity as inhibitors of platelet aggregation. These compounds have the chemical structure ##STR1## wherein x=6 to 10,y=0 to 4,Z=H, COOH, CONH.sub.2 or C.sub.1-6 alkyl,Ar=phenyl, biphenyl or napthyl, each substituted with 1 to 3 methoxy groups, or an unsubstituted phenyl, biphenyl, napthyl, pyridyl or thienyl group, andAsp=aspartic acid residue.
    Type: Grant
    Filed: July 20, 1988
    Date of Patent: November 7, 1989
    Assignee: Mosanto Company
    Inventors: Foe S. Tjoeng, Steven P. Adams
  • Antiviral compounds and use thereof
    Patent number: 4876268
    Abstract: Acylated derivatives of 1,4-dideoxy-1,4-imino-L-arabinitol and their N-alkyl and N-hydroxyalkyl derivatives in which all the free hydroxyl groups are acylated with acyl groups having from one to six carbon atoms and in which the N-alkyl substituents in the N-alkyl and N-hydroxyalkyl derivatives contain from one to fourteen carbon atoms are disclosed.
    Type: Grant
    Filed: November 3, 1988
    Date of Patent: October 24, 1989
    Assignee: G. D. Searle & Co.
    Inventors: Francis J. Koszyk, Richard A. Partis, Richard A. Mueller
  • Method for synthesis of deoxymannojirimycin
    Patent number: 4861892
    Abstract: A method is disclosed for the chemical synthesis of 1,5-dideoxy-1,5-imino-D-mannitol or 1,5-dideoxy-1,5-imino-L-mannitol from, respectively, 2,3-O-isopropylidene-L-gulono-.gamma.-lactone or 2,3-O-isopropylidene-D-gulono-.gamma.-lactone which comprises carrying out interconversion between the L-gulono and D-mannono forms or between the D-gulono and L-mannono forms, respectively, and connecting of C-1 to C-5 by nitrogen.
    Type: Grant
    Filed: September 26, 1988
    Date of Patent: August 29, 1989
    Assignee: G. D. Searle & Co.
    Inventor: George W. J. Fleet
  • Novel antithrombin peptide
    Patent number: 4861865
    Abstract: A novel synthetic peptide with potent antithrombin activity is provided which has the following amino acid sequence: ##STR1##
    Type: Grant
    Filed: January 23, 1989
    Date of Patent: August 29, 1989
    Assignee: Washington University
    Inventor: Glen L. Hortin
  • Novel platelet-aggregation inhibitor peptide derivatives
    Patent number: 4857508
    Abstract: Novel tetrapeptide derivatives are provided which have useful activity as inhibitors of platelet aggregation. These compounds have the sequence X-Gly-Asp-Y wherein X is illustrated by arginine and Y is illustrated by O-methyltyrosine amide.
    Type: Grant
    Filed: December 3, 1987
    Date of Patent: August 15, 1989
    Assignees: Monsanto Company, G. D. Searle & Co.
    Inventors: Steven P. Adams, Larry P. Feigen, Masateru Miyano
  • Method of enhancing the solubility of tissue plasminogen activator
    Patent number: 4857320
    Abstract: The solubility of tissue plasminogen activator in aqueous solution is enhanced by incorporating therein arginine or a non-toxic salt of arginine in an amount effective to increase the solubility of the t-PA without substantially inhibiting its potential biological activity upon administration.
    Type: Grant
    Filed: February 19, 1987
    Date of Patent: August 15, 1989
    Assignee: Monsanto Company
    Inventor: Arthur J. Wittwer
  • Tumor diagnostic method
    Patent number: 4855241
    Abstract: An in vitro diagnostic method for determining the presence of nerve growth factor receptor bearing tumors is disclosed which comprises determining the presence of an elevated level of a truncated nerve growth factor receptor in a sample of a body fluid from a patient afflicted with such tumor.
    Type: Grant
    Filed: May 26, 1988
    Date of Patent: August 8, 1989
    Assignee: Washington University
    Inventor: Eugene M. Johnson, Jr.
  • Tissue plasminogen activator oligosaccharide from normal human colon cells
    Patent number: 4851517
    Abstract: Glycosylated plasminogen activator (t-PA) having a glycosylation pattern significantly different than exhibited by t-PA from Bowes melanoma cells is obtained from cultured normal human colon fibroblast cells (CCD-18Co).
    Type: Grant
    Filed: February 24, 1988
    Date of Patent: July 25, 1989
    Assignee: Monsanto Company
    Inventors: Joseph Feder, William R. Tolbert, Thomas W. Rademacher, Raj B. Parekh, Raymond A. Dwek
  • Method of inhibiting virus
    Patent number: 4849430
    Abstract: A method of inhibiting human immunodeficiency virus is disclosed which comprises administering to a patient infected with said virus a virally inhibitory effective amount of the N-butyl derivative of deoxynojirimycin or a pharmaceutically acceptable salt derivative thereof.
    Type: Grant
    Filed: September 23, 1988
    Date of Patent: July 18, 1989
    Assignee: Monsanto Company
    Inventors: George W. J. Fleet, Thomas W. Rademacher, Raymond A. Dwek
  • Monoclonal antibody specific for human colon fibroblast-derived t-PA
    Patent number: 4833085
    Abstract: A monoclonal antibody is disclosed which is specific for human colon fibroblast-derived tissue plasminogen activator (t-PA), and which is useful for immunoaffinity chromatography purification of t-PA and determination of t-PA in a biological sample.
    Type: Grant
    Filed: August 13, 1986
    Date of Patent: May 23, 1989
    Assignee: Monsanto Company
    Inventors: Jon P. Schaumann, Jitka V. Olander, Nicholaos K. Harakas, Joseph Feder
  • Novel inhibitor peptides II
    Patent number: 4778877
    Abstract: An octapeptide inhibitor of myristoylating enzymes is disclosed having an amino acid sequence as follows or a physiologically acceptable amide or salt derivative thereof: ##STR1##
    Type: Grant
    Filed: September 30, 1987
    Date of Patent: October 18, 1988
    Assignee: Washington University
    Inventors: Steven P. Adams, Dwight A. Towler, Jeffrey I. Gordon
  • Novel inhibitor peptides I
    Patent number: 4778878
    Abstract: An octapeptide inhibitor of myristoylating enzymes is disclosed having an amino acid sequence as follows or a physiologically acceptable amide or salt derivative thereof: ##STR1##
    Type: Grant
    Filed: September 30, 1987
    Date of Patent: October 18, 1988
    Assignee: Washington University
    Inventors: Steven P. Adams, Dwight A. Towler, Jeffrey I. Gordon
  • DNA clone of human skin fibroblast collagenase enzyme
    Patent number: 4772557
    Abstract: A cDNA having a base sequence for human skin fibroblast collagenase has been cloned and characterized and the amino acid sequence of the human skin fibroblast protein has been determined.
    Type: Grant
    Filed: November 12, 1985
    Date of Patent: September 20, 1988
    Assignee: Washington University
    Inventors: Arthur Z. Eisen, Gregory I. Goldberg, Eugene A. Bauer
  • Human soluble immune response suppressor
    Patent number: 4771125
    Abstract: Human soluble immune response suppressor (SIRS) having a molecular weight of about 10,000 to 15,000, an isoelectric point of about 7 and a defined amino acid composition distinctly different from murine SIRS is produced from a culture of MOLT-4 cells.
    Type: Grant
    Filed: April 10, 1986
    Date of Patent: September 13, 1988
    Inventors: H. William Schnaper, Thomas M. Aune
  • Immunostimulating method
    Patent number: 4755382
    Abstract: A method is disclosed for stimulating the immune system of a warm-blooded animal by the production of antibodies by administering an effective amount of Cytophaga allerginae lipopolysaccharide endotoxin.
    Type: Grant
    Filed: June 13, 1985
    Date of Patent: July 5, 1988
    Assignee: Monsanto Company
    Inventor: Dennis K. Flaherty
  • Collagenase inducing factor
    Patent number: 4752578
    Abstract: A method for the production of collagenase inducing factor is disclosed which comprises growing the human liver adenocarcinoma cell line SK-HEP-1 in nutrient culture medium at 35.degree.-38.degree. C. and recovering the resulting collagenase inducing factor from the spent cells or conditioned medium.
    Type: Grant
    Filed: April 11, 1986
    Date of Patent: June 21, 1988
    Assignee: Monsanto Company
    Inventors: William M. Moore, Curtis A. Spilburg
  • Tissue plasminogen activator from normal human colon cells
    Patent number: 4751084
    Abstract: Glycosylated plasminogen activator (t-PA) having a glycosylation pattern significantly different than exhibited by t-PA from Bowes melanoma cells is obtained from cultured normal human colon fibroblast cells (CCD-18Co).
    Type: Grant
    Filed: November 12, 1986
    Date of Patent: June 14, 1988
    Assignee: Monsanto Company
    Inventors: Joseph Feder, William R. Tolbert, Thomas W. Rademacher, Raj B. Parekh, Raymond A. Dwek
  • Method of enhancing the bioactivity of atrial peptides
    Patent number: 4740499
    Abstract: A method of prolonging or enhancing the bioactivity of atrial peptides is disclosed in which thiorphan or kelatorphan is administered contemporaneously with the administration of the atrial peptide.
    Type: Grant
    Filed: July 28, 1986
    Date of Patent: April 26, 1988
    Assignee: Monsanto Company
    Inventor: Gillian M. Olins
  • Novel substrate peptides
    Patent number: 4740588
    Abstract: A peptide substrate for myristoylating enzymes is disclosed having an amino acid sequence selected from the group consisting of the following sequences or a physiologically acceptable amide or salt derivative thereof: ##STR1## wherein R=Ala, Asn, Gln or Ser;S=Ala, Arg, Gln, Glu, Phe or Ser;T=Ala or Lys;W=Ala or Ser;X=Ala, Tyr, or Lys;Y=Arg or Pro; andZ=Arg, Leu or Lys.
    Type: Grant
    Filed: October 29, 1986
    Date of Patent: April 26, 1988
    Assignee: Washington University
    Inventors: Steven P. Adams, Dwight A. Towler, Luis Glaser
  • Isolation of unreduced oligosaccharides
    Patent number: 4736022
    Abstract: A preparative scale method for the isolation of unreduced oligosaccharides of glycoproteins and glycohormone having a N-linked oligosaccharide structure is disclosed. The method employs hydrazinolysis of the glycoprotein or glycohormone under reaction conditions to cause cleavage at the N-linked sites, producing a mixture having as a major component a de-N-acetylated hydrazone derivative of the oligosaccharides, followed by N-acylation of the hydrazone derivative, acid-catalysis of the hydrazone derivative to produce unreduced oligosaccharides, and subjecting the resulting unreduced oligosaccharides to cellulose column chromatography to remove contaminants and to recover the unreduced oligosaccharides.
    Type: Grant
    Filed: November 12, 1986
    Date of Patent: April 5, 1988
    Assignee: Monsanto Company
    Inventors: Thomas W. Rademacher, Raymond A. Dwek