Patents Represented by Attorney Scott J. Meyer

Find this attorney in the Justia Lawyer Directory

  • Fatty acid analogs and prodrugs
    Patent number: 5672769
    Abstract: Novel derivatives of fatty acid analogs that have from one to three heteroatoms in the fatty acid moiety which can be oxygen, sulfur or nitrogen, are disclosed in which the carboxy-terminus has been modified to form various amides, esters, ketones, alcohols, alcohol esters and nitriles thereof.These compounds are useful as substrates for N-myristoyltransferase (NMT) and/or its acyl coenzyme, and as anti-viral and anti-fungal agents or pro-drugs of such agents. Illustrative of the disclosed compounds are fatty acid amino acid analogs of the structure ##STR1## in which X is the ethyl or t-butyl ester of an amino acid such as Gly, L-Ala, L-Ile, L-Phe, L-Trp, L-Thr or an amide such as NHCH.sub.2 C.sub.6 H.sub.5 or NH(CH.sub.2).sub.2 C.sub.6 H.sub.5.
    Type: Grant
    Filed: November 4, 1996
    Date of Patent: September 30, 1997
    Assignee: G. D. Searle & Co.
    Inventors: Sean T. Nugent, Richard A. Mueller
  • Fatty acid analogs and prodrugs
    Patent number: 5670650
    Abstract: Novel derivatives of fatty acid analogs that have from one to three heteroatoms in the fatty acid moiety which can be oxygen, sulfur or nitrogen, are disclosed in which the carboxy-terminus has been modified to form various amides, esters, ketones, alcohols, alcohol esters and nitriles thereof.These compounds are useful as substrates for N-myristoyltransferase (NMT) and/or its acyl coenzyme, and as anti-viral and anti-fungal agents or pro-drugs of such agents. Illustrative of the disclosed compounds are fatty acid amino acid analogs of the structure ##STR1## in which X is the ethyl or t-butyl ester of an amino acid such as Gly, L-Ala, L-Ile, L-Phe, L-Trp, L-Thr or an amide such as NHCH.sub.2 C.sub.6 H.sub.5 or NH(CH.sub.2).sub.2 C.sub.6 H.sub.5.
    Type: Grant
    Filed: November 4, 1996
    Date of Patent: September 23, 1997
    Assignee: G. D. Searle & Co.
    Inventors: Sean T. Nugent, Richard A. Mueller
  • 2-chloro and 2-bromo derivatives of 1,5-iminosugars
    Patent number: 5663342
    Abstract: Novel 2-chloro and 2-bromo derivatives of 1,5-iminosugars are disclosed, especially such derivatives of 1,5-dideoxy-1,5-imino-D-glucitol. These compounds are useful inhibitors of glucosidase enzymes and also are useful as antiviral agents and as intermediates for the synthesis of other enzyme inhibitors and antiviral compounds.
    Type: Grant
    Filed: June 14, 1996
    Date of Patent: September 2, 1997
    Assignee: G. D. Searle & Co.
    Inventors: Thomas E. Barta, Richard A. Mueller
  • Method of inhibiting glycolipid synthesis
    Patent number: 5656641
    Abstract: A method is disclosed for inhibiting the biosynthesis of glycolipids in cells capable of producing glycolipids comprising subjecting said cells to a glycolipid inhibitory effective amount of an N-alkyl derivative of 1,5-dideoxy-1,5-imino-D-glucitol in which said alkyl contains from 2-8 carbon atoms.
    Type: Grant
    Filed: February 24, 1995
    Date of Patent: August 12, 1997
    Assignee: Monsanto Company
    Inventors: Frances M. Platt, Gabrielle R. Neises, Raymond A. Dwek, Terry D. Butters
  • 2-substituted tertiary carbinol derivatives of 1,5-iminosugars
    Patent number: 5639882
    Abstract: Novel 2-alkyl carbinol derivatives of deoxynojirimycin (DNJ) and the chemical synthesis of these derivatives and intermediates therefor from DNJ and their method of inhibiting lentiviruses are disclosed.
    Type: Grant
    Filed: June 5, 1996
    Date of Patent: June 17, 1997
    Assignee: G. D. Searle & Co.
    Inventors: Ish K. Khanna, Richard A. Mueller, Richard M. Weier
  • 2-substituted tertiary carbinol derivatives of 1, 5-iminosugars
    Patent number: 5637707
    Abstract: Novel 2-alkyl carbinol derivatives of deoxynojirimycin (DNJ) and the chemical synthesis of these derivatives and intermediates therefor from DNJ and their method of inhibiting lentiviruses are disclosed.
    Type: Grant
    Filed: June 5, 1996
    Date of Patent: June 10, 1997
    Assignee: G. D. Searle & Co.
    Inventors: Ish K. Khanna, Richard A. Mueller, Richard M. Weier
  • Receptor for cell-binding domain of thrombospondins
    Patent number: 5627265
    Abstract: A 52 kDa protein is disclosed, which is a receptor for the cell-binding peptide sequences of the cell-binding domain (CBD) of thrombospondin 1 (TS1), namely the 4N1s and 7N3 peptide sequences as well as the 4N1K and 4NK peptides.
    Type: Grant
    Filed: November 30, 1994
    Date of Patent: May 6, 1997
    Assignee: Washington University
    Inventors: William A. Frazier, Ai-Guo Gao
  • 2-chloro and 2-bromo derivatives of 1,5-iminosugars
    Patent number: 5612480
    Abstract: Novel 2-chloro and 2-bromo derivatives of 1,5-iminosugars are disclosed, especially such derivatives of 1,5-dideoxy-1,5-imino-D-glucitol. These compounds are useful inhibitors of glucosidase enzymes and also are useful as antiviral agents and as intermediates for the synthesis of other enzyme inhibitors and antiviral compounds.
    Type: Grant
    Filed: March 6, 1995
    Date of Patent: March 18, 1997
    Assignee: G. D. Searle & Co.
    Inventors: Thomas E. Barta, Richard A. Mueller
  • Fatty acid analogs and prodrugs
    Patent number: 5599947
    Abstract: Novel derivatives of fatty acid analogs that have from one to three heteroatoms in the fatty acid moiety which can be oxygen, sulfur or nitrogen, are disclosed in which the carboxy-terminus has been modified to form various amides, esters, ketones, alcohols, alcohol esters and nitriles thereof.These compounds are useful as substrates for N-myristoyltransferase (NMT) and/or its acyl coenzyme, and as anti-viral and anti-fungal agents or pro-drugs of such agents. Illustrative of the disclosed compounds are fatty acid amino acid analogs of the structure ##STR1## in which X is the ethyl or t-butyl ester of an amino acid such as Gly, L--Ala, L--Ile, L--Phe, L--Trp, L--Thr or an amide such as NHCH.sub.2 C.sub.6 H.sub.5 or NH(CH.sub.2).sub.2 C.sub.6 H.sub.
    Type: Grant
    Filed: March 24, 1995
    Date of Patent: February 4, 1997
    Assignee: G. D. Searle & Co.
    Inventors: Sean T. Nugent, Richard A. Mueller
  • 2-chloro and 2-bromo derivatives of 1,5-iminosugars
    Patent number: 5595981
    Abstract: Novel 2-chloro and 2-bromo derivatives of 1,5-iminosugars are disclosed, especially such derivatives of 1,5-dideoxy-1,5-imino-D-glucitol. These compounds are useful inhibitors of glucosidase enzymes and also are useful as antiviral agents and as intermediates for the synthesis of other enzyme inhibitors and antiviral compounds.
    Type: Grant
    Filed: March 6, 1995
    Date of Patent: January 21, 1997
    Assignee: G.D. Searle & Co.
    Inventors: Thomas E. Barta, Richard A. Mueller
  • Deoxygalactonojirimycin derivatives
    Patent number: 5580884
    Abstract: Novel N-alkyl derivatives of deoxygalactonojirimycin are provided in which said alkyl contains from 3-6 carbon atoms. These novel compounds are useful for selectively inhibiting glycolipid synthesis.
    Type: Grant
    Filed: March 1, 1995
    Date of Patent: December 3, 1996
    Assignee: Monsanto Company
    Inventors: Frances M. Platt, Gabrielle R. Neises, Raymond A. Dwek, Terry D. Butters
  • Method of N-acylating peptide and proteins with diheteroatom substituted analogs of myristic acid
    Patent number: 5571689
    Abstract: A method for acylating peptides and proteins with the CoA-ester of diheteroatom substituted C.sub.13 to C.sub.14 myristic acid analogs catalyzed by N-myristoyltransferase is presented. In the analogs, two non-adjacent methylene groups, which are normally at positions 3-13, are replaced with oxygen or sulfur atoms.
    Type: Grant
    Filed: March 28, 1994
    Date of Patent: November 5, 1996
    Assignee: Washington University
    Inventors: Robert O. Heuckeroth, Steven P. Adams, Jeffrey I. Gordon, George W. Gokel
  • B preparation of 2- and 3- azido derivates of 1,5-iminosugars
    Patent number: 5550243
    Abstract: Novel derivatives of 1-deoxynojirimycin are disclosed which have amino or azido substituents at C-2 and/or C-3. These compounds are useful inhibitors of lentiviruses. Methods of chemical synthesis of these derivatives and intermediates therefor are also disclosed.
    Type: Grant
    Filed: March 6, 1995
    Date of Patent: August 27, 1996
    Assignee: G. D. Searle & Co.
    Inventors: Ish K. Khanna, Richard A. Mueller, Richard M. Weier
  • 2-substituted tertiary carbinol derivatives of 1,5-iminosugars
    Patent number: 5530132
    Abstract: Novel 2-alkyl carbino1 derivatives of deoxynojirimycin (DNJ) and the chemical synthesis of these derivatives and intermediates therefor from DNJ and their method of inhibiting lentiviruses are disclosed.
    Type: Grant
    Filed: July 8, 1994
    Date of Patent: June 25, 1996
    Assignee: G. D. Searle & Co.
    Inventors: Ish K. Khanna, Richard A. Mueller, Richard M. Weier
  • Method of inhibiting glycolipid synthesis
    Patent number: 5525616
    Abstract: A method is disclosed for inhibiting the biosynthesis of glycolipids in cells capable of producing glycolipids comprising subjecting said cells to a glycolipid inhibitory effective amount of an N-alkyl derivative of 1,5-dideoxy-1,5-imino-D-glucitol in which said alkyl contains from 2-8 carbon atoms.
    Type: Grant
    Filed: May 12, 1995
    Date of Patent: June 11, 1996
    Assignee: Monsanto Company
    Inventors: Frances M. Platt, Gabrielle R. Neises, Raymond A. Dwek, Terry D. Butters
  • 2-substituted tertiary carbinol derivatives of 1,5-iminosugars
    Patent number: 5523406
    Abstract: Novel 2-alkyl carbinol derivatives of deoxynojirimycin (DNJ) and the chemical synthesis of these derivatives and intermediates therefor from DNJ and their method of inhibiting lentiviruses are disclosed.
    Type: Grant
    Filed: August 23, 1994
    Date of Patent: June 4, 1996
    Assignee: G. D. Searle & Co.
    Inventors: Ish K. Khanna, Richard A. Mueller, Richard M. Weier
  • Method for treatment of arterial stenosis
    Patent number: 5521191
    Abstract: A method is disclosed for treatment of arterial stenosis which comprises administering to a warm-blooded mammal following balloon angioplasty a small but effective amount of zaprinast sufficient to inhibit intimal hyperplasia in said mammal.
    Type: Grant
    Filed: October 17, 1994
    Date of Patent: May 28, 1996
    Assignee: Washington University
    Inventor: James E. Greenwald
  • Method of blocking the SEC receptor
    Patent number: 5514653
    Abstract: A method is disclosed for blocking the SEC receptor and also inhibiting the neurotoxic effects of amyloid-.beta. protein by treating SEC receptor-bearing cells with a synthetic inhibitor peptide, e.g. peptide PB145.
    Type: Grant
    Filed: September 9, 1994
    Date of Patent: May 7, 1996
    Assignee: Washington University
    Inventor: David H. Perlmutter
  • Method for protein N-myristoylation
    Patent number: 5504008
    Abstract: There is disclosed a method for providing for the coexpression of N-myristoyltransferase and a protein substrate for said N-myristoyltransferase in E. coli comprising introducing into E. coli a dual plasmid system comprising (A) the isopropyl-.beta.-D-thiogalactopyranoside-inducible tac promoter, the g10-L ribosome binding site, a NMT gene, the kanamycin resistance gene and the p15A origin of replication in operable sequence and (B) the recA promoter, the g10-L ribosome binding site, a mammalian gene, the ampicillin resistance gene and the Col E1 origin of replication in operable sequence. This allows production of mammalian N-myristoylproteins or proteins containing covalently linked analogs of myristate with altered physical-chemical properties.
    Type: Grant
    Filed: July 13, 1994
    Date of Patent: April 2, 1996
    Assignee: Washington University
    Inventors: Robert J. Duronio, Peter O. Olins, Jeffrey I. Gordon
  • 2-substituted tertiary carbinol derivatives of 1,5-iminosugars
    Patent number: 5502193
    Abstract: Novel 2-alkyl carbinol derivatives of deoxynojirimycin (DNJ) and the chemical synthesis of these derivatives and intermediates therefor from DNJ and their method of inhibiting lentiviruses are disclosed.
    Type: Grant
    Filed: January 19, 1994
    Date of Patent: March 26, 1996
    Assignee: G. D. Searle & Co.
    Inventors: Ish K. Khanna, Richard A. Mueller, Richard M. Weier