Patents Represented by Attorney Scott J. Meyer

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  • Intermediates for 2-amino and azido derivatives of 1,5-iminosugars
    Patent number: 5334717
    Abstract: Novel derivatives of 1-deoxynojirimycin are disclosed which have amino or azido substituents at C-2 and/or C-3. These compounds are useful inhibitors of lentiviruses. Methods of chemical synthesis of these derivatives and intermediates therefor are also disclosed.
    Type: Grant
    Filed: January 8, 1993
    Date of Patent: August 2, 1994
    Assignee: G. D. Searle & Co.
    Inventors: Ish K. Khanna, Richard A. Mueller, Richard M. Weier
  • Prostate-derived mitogen
    Patent number: 5332669
    Abstract: A prostate-derived growth factor is disclosed which has a mol. wt. of about 28 kDa, an NH.sub.2 -terminal sequence substantially identical to the NH.sub.2 -terminal sequence of the 6 kDa mature rat EGF, potent mitogenic activity against NRK cells without additional carboxy terminal processing to the mature 6 kDa EGF molecular species, cross-reacts with antisera against rat EGF and its mitogenic activity is blocked by anti-EGF receptor antisera.
    Type: Grant
    Filed: May 24, 1989
    Date of Patent: July 26, 1994
    Assignee: The Jewish Hospital of St. Louis
    Inventor: Thomas F. Deuel
  • 2- and 3-sulfur derivatives of 1,5-iminosugars
    Patent number: 5331096
    Abstract: Novel derivatives of 1-deoxynojirimycin are disclosed which have thio or sulfinyl substituents at C-2 or C-3. These compounds are useful inhibitors of lentiviruses such as visna virus and human immunodeficiency virus. Methods of chemical synthesis of these derivatives and intermediates therefor are also disclosed.
    Type: Grant
    Filed: August 2, 1993
    Date of Patent: July 19, 1994
    Assignee: G. D. Searle & Co.
    Inventors: Francis J. Koszyk, Richard A. Mueller
  • Method for the treatment of pertussis with aminoguanidine
    Patent number: 5317040
    Abstract: A method for the treatment of pertussis is disclosed which comprises administering a selective inhibitor of inducible nitric oxide synthase, preferably aminoguanidine, to a mammalian host susceptible to pertussis in a small but effective amount for inhibiting the toxic effects of TCT released by Bordetella pertussis.
    Type: Grant
    Filed: January 26, 1993
    Date of Patent: May 31, 1994
    Assignee: Washington University
    Inventor: William E. Goldman
  • DNA transposon TN5SUPF in plasmid pBRG1310
    Patent number: 5316946
    Abstract: A small, novel transposon useful for mutagenesis and sequencing DNAs cloned in phage .lambda. is disclosed which comprises a transposon having at each terminus a segment of 19 nucleotides selected from the group consisting of the O-end and I-end sequences of Tn5, at least one restriction enzyme site positioned less that 20 nucleotides distant from each said terminal segment, and a supF amber-suppressor tRNA gene insert.
    Type: Grant
    Filed: January 22, 1990
    Date of Patent: May 31, 1994
    Assignee: Washington University
    Inventors: Suhas H. Phadnis, Henry V. Huang, Doulgas E. Berg
  • Antiviral compounds
    Patent number: 5310745
    Abstract: A method of inhibiting lentivirus is disclosed which comprises mammalian host susceptible to said lentivirus with a virally inhibitory effective amount of an O-acylated derivative of 1,5-dideoxy-1,5-imino-D-glucitol and their N-alkyl, N-acyl and N-aroyl derivatives in which from one to four of the free hydroxyl groups are O-acylated with carboxylic alkanoyl radicals selected from the group consisting of .omega.,.omega.,.omega.-trifluoroalkanoyl having from three to eight carbon atoms, carboxylic cycloalkanoyl groups having from four to eight carbon atoms and carboxylic acyclic alkanoyl groups having from two to ten carbon atoms, wherein the N-aroyl groups contain from 7 to 14 carbon atoms, the N-acyl groups contain from 4 to 8 carbon atoms and the N-alkyl groups contain from 1 to 14 carbon atoms.
    Type: Grant
    Filed: August 13, 1992
    Date of Patent: May 10, 1994
    Assignee: G. D. Searle & Co.
    Inventors: Richard A. Partis, Francis J. Koszyk, Richard A. Mueller
  • Heptitols
    Patent number: 5300659
    Abstract: Novel heptitol analogues of mannofuranose and their syntheses from .delta.-lactones of heptonic acids are disclosed. The novel heptitols are (A) 2,5-dideoxy-2,5-imino-D-glycero-D-talo-heptitol and (b) 1-amino-2,5-anhydro-1-deoxy-D-glycero-D-talo-heptitol. These novel heptitol compounds are useful inhibitors of glycosidases.
    Type: Grant
    Filed: June 14, 1993
    Date of Patent: April 5, 1994
    Assignee: Monsanto Company
    Inventors: George W. J. Fleet, Bryan G. Winchester
  • Immunosuppressive agents
    Patent number: 5294700
    Abstract: The disclosure describes novel immunosuppressive agents isolated from syncytiotrophoblast microvilli membranes by preparing a minutely subdivided and solubilized preparation of said membranes and isolating the unreduced N-linked oligosaccharides from an extract of said preparation.
    Type: Grant
    Filed: January 4, 1993
    Date of Patent: March 15, 1994
    Assignee: Monsanto Company
    Inventors: Peter D. Arkwright, Raymond A. Dwek, Christopher W. G. Redman, Graham A. W. Rook, thomas W. Rademacher
  • Tricyclic steroid analogs
    Patent number: 5292906
    Abstract: Novel tricyclic steroid analogs are disclosed which are 1H-benz[e]indene dodecahydro compounds that are useful for enhancing GABA-induced chloride currents at the GABA receptor/chloride ionophore complex and can be represented by the following structural formulas: ##STR1## wherein R.sub.1 =H or C.sub.1 -C.sub.4 alkyl or fluoroalkyl;R.sub.2 =H or C.sub.1 -C.sub.4 alkyl or fluoroalkyl, in which R.sub.1 and R.sub.2 can be the same or different;R.sub.3 =H or CH.sub.3 ;R.sub.4 =H or CH.sub.3, in which R.sub.3 and R.sub.4 can be the same or different;R.sub.5 =H;R.sub.6 =H;R.sub.5,R.sub.6 =.dbd.O(carbonyl);R.sub.7 =H;R.sub.8 =a hydrogen bond accepting group.R.sub.7,R.sub.8 =.dbd.O(carbonyl); andR'=an ester group.
    Type: Grant
    Filed: January 14, 1993
    Date of Patent: March 8, 1994
    Assignee: Washington University
    Inventors: Douglas F. Covey, Yuefei Hu, Charles F. Zorumski
  • Synthesis of 1,4-dideoxy-1,4-imino-L-arabinitol
    Patent number: 5286877
    Abstract: 1,4-Dideoxy-1,4-imino-L-arabinitol is chemically synthesized from D-lyxonolactone by formation of the pyrrolidine ring by joining the nitrogen between C-1 and C-4 and inversion of configuration at both C-2 and C-4, with the C-3 and C-5 hydroxyl groups being protected throughout the synthesis sequence by benzylidenation. The product is preferably isolated as the hydrochloride salt and is useful as an inhibitor of .alpha.-glucosidase and human immunodeficiency virus (HIV).
    Type: Grant
    Filed: February 1, 1993
    Date of Patent: February 15, 1994
    Assignee: G. D. Searle & Co.
    Inventors: James R. Behling, John R. Medich, Kevin A. Babiak, George W. J. Fleet
  • Method for producing synthetic N-linked glycoconjugates
    Patent number: 5280113
    Abstract: A method is disclosed for derivatizing oligosaccharides to form synthetic N-linked glycoconjugates by converting a glycosylamine derivative of the oligosaccharide to a haloacetylated derivative as an intermediate compound prior to formation of the synthetic N-linked glycoconjugate to thereby directly maintain the .beta.-anomeric configuration of said N-linked glycoconjugate.
    Type: Grant
    Filed: August 11, 1992
    Date of Patent: January 18, 1994
    Assignee: Monsanto Company
    Inventors: Thomas W. Rademacher, Ian D. Manger, Simon Wong, Raymond A. Dwek
  • Amebic glycoconjugate and monoclonal antibody
    Patent number: 5275935
    Abstract: An amebic glycoconjugate is disclosed that is recognized by an Entamoeba histolytica specific monoclonal antibody The glycoconjugate is isolated from the lysates of E. histolytica trophozoites, it is phosphorylated, lipid-containing, glycosylated, migrates as a polydisperse band on SDS-PAGE between about 65-200 kDa and is specifically recognized by monoclonal antibody CC 8.6, ATCC HB 11104.
    Type: Grant
    Filed: September 10, 1992
    Date of Patent: January 4, 1994
    Assignee: Washington University
    Inventors: Samuel L. Stanley, Jr., Ellen Li
  • Method of inhibiting microvascular thrombosis
    Patent number: 5276015
    Abstract: A method for reducing the thrombogenicity of microvascular anastomoses in a warm blooded mammal comprising administering to said mammal at the site of said microvascular anastomoses contemporaneously with microvascular reconstruction of a small but inhibitory effective amount of TFPI.
    Type: Grant
    Filed: March 18, 1992
    Date of Patent: January 4, 1994
    Assignee: Washington University
    Inventors: Roger K. Khouri, Tze-Chein Wun
  • 2- and 3- amino azido derivatives of 1,5-iminosugars
    Patent number: 5270468
    Abstract: Novel derivatives of 1-deoxynojirimycin are disclosed which have amino or azido substituents at C-2 and/or C-3. These compounds are useful inhibitors of lentiviruses. Methods of chemical synthesis of these derivatives and intermediates therefor are also disclosed.
    Type: Grant
    Filed: January 8, 1993
    Date of Patent: December 14, 1993
    Assignee: G. D. Searle & Co.
    Inventors: Ish K. Khanna, Richard A. Mueller, Richard M. Weier, Michael A. Stealey
  • 2- and 3-sulfur derivatives of 1,5-iminosugars
    Patent number: 5268482
    Abstract: Novel derivatives of 1-deoxynojirimycin are disclosed which have thio or sulfinyl substituents at C-2 or C-3. These compounds are useful inhibitors of lentiviruses such as visna virus and human immunodeficiency virus. Methods of chemical synthesis of these derivatives and intermediates therefor are also disclosed.
    Type: Grant
    Filed: September 9, 1992
    Date of Patent: December 7, 1993
    Assignee: G. D. Searle & Co.
    Inventors: Francis J. Koszyk, Richard A. Mueller
  • 2-substituted tertiary carbinol derivatives of deoxynojirimycin
    Patent number: 5258518
    Abstract: 2-Substituted tertiary carbinol derivatives of deoxynojirimycin are disclosed having the formula ##STR1## wherein R.sub.4 =an alkyl, vinyl, alkenyl, alkynyl, aryl, aralkyl, alkenylalkyl, alkylnylalkyl or CH.sub.2 Y substituent having from about 1 to 10 carbon atoms;Y=OR', SR', NR'R', or N.sub.3 ;R=H or CH.sub.3 ; andR=H or an alkyl, aralkyl, alkenylalkyl, alkynylalkyl, aralkenyl, aralkynyl or hydroxyalkyl substituent, having from about 1 to 18 carbon atoms, provided that no carbon unsaturated bond is directly attached to nitrogen.These compounds have useful antiviral activity as demonstrated against lentivirus.
    Type: Grant
    Filed: April 1, 1992
    Date of Patent: November 2, 1993
    Assignee: G. D. Searle & Co.
    Inventors: Ish K. Khanna, Richard A. Mueller, Richard M. Weier
  • Pyrrolidin-3,4-diol derivatives of heptitols and preparation thereof
    Patent number: 5250703
    Abstract: Novel heptitol analogues of mannofuranose and their syntheses from .delta.-lactones of heptonic acids are disclosed. The novel heptitols are (A) 2,5-dideoxy-2,5-imino-D-glycero-D-talo-heptitol and (b) 1-amino-2,5-anhydro-1-deoxy-D-glycero-D-talo-heptitol. These novel heptitol compounds are useful inhibitors of glycosidases.
    Type: Grant
    Filed: September 29, 1992
    Date of Patent: October 5, 1993
    Assignee: Monsanto Company
    Inventors: George W. J. Fleet, Bryan G. Winchester
  • Synthesis of nojirimycin derivatives
    Patent number: 5248779
    Abstract: Nojirimycin .delta.-lactam and deoxynojirimycin are each synthesized from 5,6-anhydro-3-O-benzyl-1,2-O-isopropylidene-L-idofuranose as a divergent intermediate by a method which comprises formation of the piperidine ring by connection of nitrogen between C-1 and C-5 with inversion of configuration at C-5 to form nojirimycin .delta.-lactam or between C-2 and C-6 with inversion of configuration at C-2.
    Type: Grant
    Filed: September 24, 1992
    Date of Patent: September 28, 1993
    Assignee: Monsanto Company
    Inventor: George W. J. Fleet
  • Method of inhibiting nitric oxide formation
    Patent number: 5246970
    Abstract: A method is disclosed for inhibiting nitric oxide formation in a warm blooded mammal which comprises administering to said mammal an effective nitric oxide inhibitory amount of aminoguanidine.
    Type: Grant
    Filed: June 30, 1992
    Date of Patent: September 21, 1993
    Assignee: Washington University
    Inventors: Joseph R. Williamson, John A. Corbett, Michael L. McDaniel, Ronald G. Tilton
  • Method of inhibiting nitric oxide formation
    Patent number: 5246971
    Abstract: A method is disclosed for inhibiting nitric oxide formation in a warm blooded mammal which comprises administering to said mammal an effective nitric oxide inhibitory amount of methylguanidine or dimethylguanidine.
    Type: Grant
    Filed: February 28, 1992
    Date of Patent: September 21, 1993
    Assignee: Washington University
    Inventors: Joseph R. Williamson, John A. Corbett, Michael L. McDaniel, Ronald G. Tilton