Abstract: A fixed permanent pattern is used for identifying a magnetic recording medium and a high security against forgery or modification is obtained by a magnetic recording medium including a non-magnetic support and at least two magnetic layers formed on said support, characterized in that at least one of said at least two magnetic layers contains magnetic particles having a coercive force of 4,000 Oe or less dispersed in a binder and has a non-rewritable fixed signal which has been recorded by magnetic field generated by a signal recorded on one or more other magnetic layers under the influence of an orientation magnetic field.

Abstract: A cholesterol-cordycepin conjugate having the formula ##STR1## wherein: n is an integer from 1 to 8; R.sub.1 is selected from the group of consisting of T, T' and Y; T is ##STR2## T' is ##STR3## where x is an integer from 1 to 18; Y is ##STR4## where m is zero, 1, 2, or 3; each R.sub.2 is independently selected from the group consisting of oxygen and sulfur; each R.sub.3 is independently selected from the group consisting of hydrogen and hydroxyl; R.sub.4 is selected from the group consisting of hydrogen, hydroxyl and T or T'; R.sub.5 is selected from the group consisting of hydrogen, hydroxyl and T or T'; provided that all R.sub.1, R.sub.4 and R.sub.5 may not be T or T'; at least one R.sub.3 is hydrogen or R.sub.4 is hydrogen; and at least one of R.sub.1, R.sub.4 and R.sub.5 must be T or T'; or a water soluble salt thereof. The compounds possess increased antiviral activity and/or metabolic stability.

Abstract: A homogeneous polyolefinic blend and a preparation process thereof, are provided wherein the blend comprises polyolefin and a polymer which has a barrier property to organic liquid and vapor permeability. The barrier property is improved through the inclusion of mixed compatibilizing substances comprising an alkylcarboxyl-substituted polymer and reactive low molecular weight compounds. The compatibilizing substances are included by the means of ordinary processing equipment. The polymer with the barrier property having low organic liquid and vapor permeability is distributed as a multitude of thin, wide, disc-like layers in a polyolefin phase. The compatibilizing substances minimize the interfacial energy between the two polymers to adhere them together.

Abstract: This invention provides methods and apparatuses for determining the non-true condition of a damaged metal wheel such as the wheel's radial runout, its lateral runout, and the length of its damaged zone. The invention provides for the use of components which rigidly hold the wheel in a fixture, which apply heat to the wheel in a controlled manner so as to raise the temperature of the wheel to its somewhat softened state, and which apply a suitable force to the damaged zone while the wheel is in its, or while it is being heated, to its somewhat softened state. This force is applied to the heated wheel until the radial runout of the damaged zone is reduced to a first predetermined limit. The invention also provides for the use of components which rotate the wheel between at least a pair of oppositely-positioned contacting and compressing rollers. This compression action occurs after the wheel has been heated to its, or while it is being heated to its, somewhat softened state.

Abstract: A novel multi-unit ribozyme is provided which is capable of selectively cleaving the mRNA transcript of a hybrid oncogene resulting from a chromosomal translocation. Specialized delivery vehicles such as liposomes, and growth factor conjugates for cellular uptake by receptor-mediated endocytosis, are also described. The multi-unit ribozyme is used for the treatment of neoplasms characterized by expression of the oncogene. In one embodiment, a multi-unit ribozyme is provided which cleaves the mRNA transcript of Philadelphia chromosome-positive cells, thereby blocking production of the tumorigenic p210.sup.bcr-abl fusion protein.

Abstract: A lightweight plastic cervical collar includes a one-piece injected molded body, of a flexibility and length sufficient to enable the body to be wrapped around the neck of a wearer. One or more absorbent compressible foam strips are attached to an inner side of the body. A front section of the body defining part of a front collar half includes a generally T-shape integrally molded chin support. Upper edge portions of the body are made flexible by the provision of elongated openings and integral hinges formed by molded grooves extending generally longitudinally in the body. A first fabric-strip fastener is adhered to the front body section near one free end while a second, matably configured flexible fabric-strip is extended from the free end of the rear body section to join the adjoining collar ends together. Where the molded body extends around a tracheal opening, transverse reinforcement ridges are molded in the body to prevent collapse.

Abstract: Oligonucleotides are provided having a nucleotide sequence complementary to at least a portion of the mRNA transcript of the STK-1 gene. These "antisense" oligonucleotides are hybridizable to the STK-1 mRNA transcript. Such oligonucleotides are useful in treating neoplastic diseases characterized by activation of STK-1 gene expression. The oligonucleotides are also useful as bone marrow purging agents in the treatment of leukemia and metastasized neoplasms.

Abstract: Antisense oligonucleotides specific for the vav proto-oncogene inhibit the proliferation of malignant, but not normal, myeloid cells. The oligonucleotides are therefore useful in the treatment of leukemias, in particular, as bone marrow purging agents. The vav antisense oligonucleotides also selectively inhibit the formation of erythroid cell colonies without effect on megakaryocyte and granulocyte/macrophage colony formation. The oligonucleotides are therefore useful in treating disorders characterized by an elevated hematocrit due to overproduction of erythrocytes.

Abstract: An actuating mechanism for a vehicle parking brake mounted in a vehicle consisting of the following elements. An actuator that is pivotally-mounted for movement between a first and second position. An elongate output member connected to a vehicle parking brake that is slidably mounted in the mounting structure. This elongate output member moves in a brake-applying direction in response to the movement of the actuator from the first to second position. A driver that alternates states between an uncoupled and coupled position in relation to the output member, in response to the movement of the actuator from the first to second position, respectively. A releasable holder that restrains the output member against reverse movement during movement of the actuator from second to first position, and a release mechanism for disengaging the releasable holder from the output member.

Abstract: A continuous non-catalytic process for the manufacture of 1,1-dichloro-1-fluoroethane/1-chloro-1,1-difluoroethane mixtures from 1,1-dichloro-1-fluoroethane is provided. Hydrogen fluoride and 1,1,1-trichloroethane are continuously feed a molar ratio of from about 3.0 to about 5.2 to form a liquid phase hydrofluorination reaction mixture. Vapor phase reaction product is continuously withdrawn from the reaction zone, and hydrogen fluoride is continuously selectively refluxed back to the reaction mixture. 1,1,1-Trichloroethane utilization approaches 100% , with selectivity for 1,1-dichloro-1-fluoroethane between 15% and 85%, based upon the amount of 1,1-dichloro-1-fluoroethane and 1-chloro-1,1-difluoroethane contained in the gaseous reaction product.

Abstract: The surgical tool is used in conjunction with a direct contact laser that is powered through a small diameter laser power tube. In one embodiment, the tool includes a bendable, rigid tube having a lumen sufficiently larger than the laser power tube such that upon application of an axial, inboard directed force, the laser power tube is axially compressed within the lumen of the bendable tube. The contact laser tip, located at the end of the power tube, is powered by a laser core which is retained within the lumen of the laser power tube. The laser core is flooded by irrigation and cooling fluid flowing through the laser power tube. This fluid is ejected or emitted from the distal end of the laser power tube immediately behind the laser contact tip. In one embodiment, the bendable tube includes a handle and a bendable, rigid nozzle made of plastic. A longitudinally actuated suction control valve is disposed in the handle.

Abstract: A container, such as the type having a base portion, and an upper neck portion, a shoulder portion between the neck and base portion and a removable closure applied to the neck portion in a sealed relation therewith, is provided with an anti-counterfeit multi-layer label construction. The multi-layer construction includes a label which is adhesively applied to the back side of a container. A printed indicia is provided on the front side of the label so as to be readable by the customer upon removal of an overlying sleeve which is placed over the label. The sleeve is in the form of a protective film which is heat shrunk into a conforming, sealed relationship around the container and which covers at least a portion of the label. A release coat is provided over the underlying printing. A background coat is provided over the release coat so as to cover the underlying printing. Top indicia is provided on the background coat with a varnish thereon.

Abstract: A bubbler for solid metal-organic precursors is described. The bubbler includes a bubbler body, a carrier gas feed tube, an exhaust tube, a compressing plate and a pair of porous thin plates. A carrier gas is fed into a mass of metal-organic precursors through a feed tube which is connected with the bottom of the bubbler body. The exhaust tube is set away from the mass of metal-organic precursors and drains the carrier gas passing through the precursors. The compressing plate has many holes and is movable up and down along the wall of the bubbler body so that it may be positioned according to the amount of the precursors. The upper porous thin plate is located between the exhaust tube and the compressing plate, and the lower porous thin plate is located above the leading end of the feed tube, giving support to the mass of the metal-organic precursors. That is, the precursors are placed on the lower porous thin plate and there is a room between the lower porous thin plate and the bottom of the bubbler body.

Abstract: A method is provided for producing superconducting Josephson devices using a chemical etching solution which comprises forming a mask on a predetermined portion of a MgO substrate, and immersing the MgO substrate having the mask in an aqueous acid solution in which the volume ratio of phosphoric acid to sulfuric acid is approximately 10:1 or more, so as to form a step at the boundary between the masked region and the unmasked region.

Abstract: The amount of breathable liquid eliminated from a mammal through volatilization in the lungs and/or through skin transpiration is detected by measuring the amount of saturation of the expiratory gas by vapors or the breathable liquid. Instantaneous saturation values are employed to gauge the amount of interaction in the lungs between the breathable liquid and respiratory gas flowing therein and to control selected feedback operations to maintain the maximum possible amount of interaction therebetween. The saturation level of expiratory gas is also employed to optimize operating parameters or a system for recovering the breathable liquid from the expiratory gas, directly from the patient, or from a gas or liquid ventilator. The saturation level or expiratory gas is also employed to perform functional residual capacity studies and to correct for errors in conventional functional residual capacity measurements performed while a patient undergoes partial liquid ventilation.

Abstract: The present invention relates to the discovery of novel polymorph form of an active pharmaceutical agent and the process for its preparation. More specifically, the present invention relates to the preparation of a novel polymorph form of terazosin hydrochloride, a well known anti-hypertensive agent.

Abstract: A heart massager for substernal heart massage is disclosed. The heart massager has a heart-contacting member having a surface which is at least partially concave for contacting the heart, cushioning on the surface of the contact member, and a handle attached to the heart-contacting member for manually manipulating the massager. The partially concave surface allows the heart-contacting member to conform to the shape of the heart. The handle is substantially upright with respect to the surface of the heart-contacting member. The handle is significantly offset from a central portion of the heart-contacting member in the region where it attaches to the member. The cushioning covers substantially the entire surface of the heart-contacting member so as to form a solid surface.

Abstract: A process is disclosed for producing feedstocks for manufacturing high quality lube base oil utilizing unconverted oil, which is produced from a fuels hydrocracker unit. The first step of the process is the distillation of an atmospheric residue under vacuum in a first vacuum distillation unit to produce a vacuum gas oil. The vacuum gas oil is then hydrotreated in a first reaction unit to remove impurities and produce a treated vacuum gas oil. The treated vacuum gas oil is then subjected to hydrocracking in a second reaction unit to yield light hydrocarbons. The light hydrocarbons are then subjected to a series of fractional distillations to separate light oil products and an unconverted oil. All or a fraction of the unconverted oil is fed to a second vacuum distillation unit to produce feedstocks of high quality lube base oil and a remaining portion. The remaining portion and, optionally, a fraction of the unconverted oil is recycled from the second vacuum distillation unit to the second reaction unit.