Abstract: The invention relates to novel hemoglobin compositions, particularly novel recombinant mutant hemoglobin compositions, which eliminate or substantially reduce 1) the creation of heart lesions, 2) gastrointestinal discomfort, 3) pressor effects, and 4) endotoxin hypersensitivity associated with the administration of extracellular hemoglobin compositions in various therapeutic applications. Applications described include treatments for anemia, head injury, hemorrhage or hypovolemia, ischemia, cachexia, sickle cell crisis and stroke; enhancing cancer treatments; stimulating hematopoiesis; improving repair of physically damaged tissues; alleviating cardiogenic shock; and shock resuscitation.

Abstract: The present invention relates, inter alia, to methodologies for the synthesis, screening and characterization of organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention provide for the combinatorial synthesis, screening and characterization of libraries of supported and unsupported organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention can be applied to the preparation and screening of large numbers of organometallic compounds which can be used not only as catalysts (e.g., homogeneous catalysts), but also as additives and therapeutic agents.

Abstract: A locomotive monitoring system defines several mutually exclusive operating states for a locomotive. The amount of time the locomotive operates in each state is preferably determined and recorded. This recorded information can then be evaluated with a view towards improving locomotive operations. For example, a plurality of mutually exclusive idle states can be defined and monitored to determine how long a locomotive idles under certain conditions instead of automatically shutting down for the purpose of conserving fuel. In this manner, the sources of lost fuel savings can be readily identified, quantified and addressed. An event log is also provided for chronicling certain operating events of interest over time, such as those relating to the starting, stopping and/or idling of the locomotive's engine.

Abstract: Method of and apparatus for feeding string involving entraining the string around two godet rolls and driving one or both rolls in the direction for feeding the string forward. The string entrained around the rolls is tensioned by retarding the string upstream from the rolls with a gas flow and by accelerating the string downstream from the rolls with a gas flow.

Abstract: A mine ventilation structure with a deck made up of panels of inverted channel shape modified to be of relatively light weight yet strong.

Abstract: A cyclone separator includes a housing generally symmetric about its central longitudinal axis and an inlet for introduction of a fluid containing dispersed substances. An outlet for the cleaned fluid includes a tube through the bottom wall of the housing having an axis coaxial with the longitudinal axis. An outlet for the dispersed substances has the shape of an annular channel in the bottom wall disposed adjacent the tube and adjacent a rotation axis of the fluid whereat high-density substances settle.

Abstract: Apparatus having automated loading 15, nailing 22, and stacking 24 areas for wood components, wall panels or wall components is described. The apparatus includes a control panel 14 that allows automated selection 94 of the type of sub-component to be handled, the speed 98 at which the nailing and stacking operation is executed, the compression rate 100 in which the operation is executed and provides automated feedback 106 of the progress of the operation. A guide track 30, stationary 26 and powered 28 compression members and side conveyer belts 16 that work in conjunction with upper 18 and side 20 rollers allow for positioning, clamping, and movement of the raw material 70 into the nailing stage 22 of the operation. The rollers allow for the nailing process 22 before being moved to the stacking system 24.

Abstract: This invention is directed to a novel process for the preparation of a silicon wafer comprising a surface having an epitaxial layer deposited thereon. In one embodiment, an epitaxial layer is deposited onto a surface of a silicon wafer. The wafer is also heated to a temperature of at least about 1175° C. This heat treatment begins either during or after the epitaxial deposition. Following the heat treatment, the heated wafer is cooled for a period of time at a rate of at least about 10° C./sec while (a) the temperature of the wafer is greater than about 1000° C., and (b) the wafer is not in contact with a susceptor. In this process, the epitaxial deposition, heating, and cooling are conducted in the same reactor chamber.

Abstract: A crystal puller and method for growing monocrystalline silicon ingots includes first and second electrical resistance heaters in the crystal puller in longitudinal, closely spaced relationship with each other to radiate heat toward the ingot as the ingot is pulled upward within the housing. In one embodiment, the first heater is powered when the ingot is pulled upward to a first axial position above the surface of the molten silicon and the second heater is powered when the ingot is pulled upward to a second axial position above the first axial position. In another embodiment the first and second heaters are powered until the ingot is separated from the molten silicon and then the heating power output of the first and second heaters is reduced to substantially increase the cooling rate at which the ingot is cooled. An adapter mounting the heaters may also be provided for adapting existing crystal pullers to incorporate the heaters.

Abstract: The present invention is generally directed to a process for preparing polyoxometalates having amine-derived substituents attached thereto. In a first embodiment, the process comprises contacting a polyoxometalate and an amine in the presence of a diimide. The present invention is further directed to novel functionalized polyoxometalates prepared by the present process.

Abstract: Taxanes having a heterosubstituted acetate substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.

Abstract: Taxanes having a carbonate substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.

Abstract: The present invention provides a treatment for angiogenic diseases, including solid tumors. The treatment consists of administering therapeutically active dosages of FC101, resulting in a reduction in endothelial cell proliferation and inhibition of new blood vessel formation. FC101 can also be used as a lead compound to develop other pharmacologically-active compounds, by adding or substituting different functional groups for those already present on the FC101 molecule.

Abstract: Method of and apparatus for applying withdrawal strings to tampon pledgets wherein string is pneumatically looped around a pledget, the ends of the loop are knotted, and the knotted loop is driven through a hole in the pledget.

Abstract: A weight-based, multiple filler filling machine has a simplified wiring arrangement. The filling machine fills a plurality of bottles with a predetermined amount in weight of an article through associated ones of a plurality of valves. The weight of the article placed in each of the bottles is measured by a load cell. An arithmetic unit is mounted on the surface of or inside each load cell for determining the weight level of the article as measured by that load cell and controlling the associated valve in accordance with the determined weight level.

Abstract: A method of inhibiting the production of exoproteins from Gram positive bacteria, such as harmful proteins produced by Staphylococcus species, is described. The method is particularly useful for inhibiting the production of TSST-1, alpha-toxin and/or enterotoxins A, B and C from S. aureus bacteria. The method may be based on exposing Gram positive bacteria to alkyl polyglycoside incorporated into an absorbent product. Alternatively, the methods can include causing Gram positive bacteria to come into contact with the alkyl polyglycoside in other forms, e.g., when formulated with a pharmaceutically acceptable carrier or incorporated in or on a non-absorbent substrate. Typically, the alkyl polyglycoside has an HLB of at least about 10 and an alkyl group with an average of 8 to 14 carbon atoms.

Abstract: A sheet including a substrate having on one face a multiplicity of tangible signalers for signaling the wearer on occurrence of urination. The substrate has urine-soluble matter on the face establishing a non-signaling condition of the tangible signalers. The urine-soluble matter is dissolved by the urine on urination enabling signaling by the tangible signalers.

Abstract: Composition for topical administration comprising (a) a corticosteroid, (b) a drying agent, and (c) a broad spectrum anti-fungal agent that treats both dermatophytes and yeast.