Patents Represented by Law Firm Sherman and Shalloway
  • Patent number: 6627611
    Abstract: C-glycoside derivatives are disclosed, which are represented by the following formula (I) and its pharmaceutical acceptable salt, and which are useful for the treatment and/or prevention of diabetes and hypoglycemia. wherein: with the provisos that R1 is H, OH, lower alkyl, O-lower alkyl or R2 is H, —COO-lower alkyl, R5 is —CH2OH, —CH2OCO2-lower alkyl, —CH2OSO3H, —COOH or —COONa; wherein: A is (with the provisos that X is oxygen atom, nitrogen atom or sulfur atom R3 is lower alkyl when m=0, and is lower alkyl, —OH or —O-lower alkyl when m=1, . . . means saturated or unsaturated carbon bond; m is 0 or 1; n is 0, 1 or 2; above mentioned-lower alkyl means C1-C5.) or a pharmaceutical acceptable salt.
    Type: Grant
    Filed: January 23, 2001
    Date of Patent: September 30, 2003
    Assignee: Kotobuki Pharmaceutical Co Ltd
    Inventors: Hiroshi Tomiyama, Yoshinori Kobayashi, Atsushi Noda, Akira Tomiyama, Tsuyoshi Tomiyama
  • Patent number: 6627727
    Abstract: Polyphenylene ether particles which contain fine powder in a small amount and are easy to handle at the time of molding, are obtained. A method for precipitating polyphenylene ether, which comprises adding a non-solvent for polyphenylene ether to a solution of polyphenylene ether in a good solvent for polyphenylene ether to precipitate polyphenylene ether continuously in a stirring vessel with a reciprocating stirrer, wherein the polyphenylene ether solution is dropped outside the working range of a stirring blade.
    Type: Grant
    Filed: December 26, 2001
    Date of Patent: September 30, 2003
    Assignee: Mitsubishi Gas Chemical Co
    Inventors: Kiyoshi Yoshida, Naoto Ohsaki, Hiroya Fujii
  • Patent number: 6624326
    Abstract: A novel method for preparing a heteropolyacid catalyst containing a heteropolyacid composed of molybdophosphoric acid and/or molybdovanadophosphoric acid, or a salt of the heteropolyacid, is provided. The method comprises preparing an aqueous solution or aqueous dispersion which (1) contains the nitrogen-containing heterocyclic compound, nitrate anions and ammonium ions, (2) the ammonium ion content not exceeding 1.7 mols per mol of the nitrate anion content, and (3) the ammonium ion content not exceeding 10 mols per 12 mols of the molybdenum atom content by mixing raw materials containing the catalyst-constituting elements with the nitrogen-containing heterocyclic compound in the presence of water, drying and calcining the same. This heteropolyacid catalyst excels over conventional catalysts in performance, life and strength.
    Type: Grant
    Filed: May 29, 2002
    Date of Patent: September 23, 2003
    Assignee: Nippon Shokubai Co., Ltd.
    Inventors: Hiroto Kasuga, Kaori Nakatani, Eiichi Shiraishi
  • Patent number: 6623858
    Abstract: The present invention relates to the metal oxide doped cerium oxide which has an excellent ultraviolet ray shielding effect and a transparency and whose catalytic activity is reduced. More in detail, relates to the metal oxide doped cerium oxide composed of cerium oxide in which metal ion having larger ion radius than that of Ce4+ and/or lower valence metal ion than Ce4+, such as Ca2+, Y3+, La3+, Nd3+, Eu3+, Tb3+, Sm3+, Mg2+, Sr2+, Ba2+, Ce3+ and so on are doped. Said metal oxide doped cerium oxide can be prepared at the temperature lower than 60° C. and in the condition of pH higher than 5 by reacting aqueous solution of cerium salt, aqueous solution of metal ion having larger ion radius than that of Ce4+ and/or lower valence metal ion than Ce4+ and alkali, then adding oxidizing agent.
    Type: Grant
    Filed: February 17, 2000
    Date of Patent: September 23, 2003
    Assignees: Kose Corporation, Nippon Inorganic Colour & Chemical Co. Ltd.
    Inventors: Sinryo Yabe, Kota Tofukuji, Shigeyoshi Momose, Sakae Yoshida, Kazuyuki Tahira, Tsugio Sato
  • Patent number: 6620570
    Abstract: An electrophotographic method which uses a single-layer organic photosensitive material drum having a single organic photosensitive layer of a thickness of not smaller than 25 &mgr;m formed on an electrically conducting blank tube with a surface roughness Ra of not larger than 0.6 &mgr;m and rotates the photosensitive material drum at a peripheral speed of not smaller than 400 mm/sec, in order to execute an image-forming processing that includes electric charging, exposure to image-bearing light, developing, transfer, cleaning by a blade and removal of electric charge. Though the photosensitive material drum rotates at a high speed and a large frictional force is exerted on the cleaning blade, damage to the blade is effectively suppressed, and image is stably formed for extended periods of time without permitting the cleaning to become defective.
    Type: Grant
    Filed: February 2, 2001
    Date of Patent: September 16, 2003
    Assignee: Kyocera-Mita Corporation
    Inventors: Keizo Kimoto, Nobuyuki Kashiwagi, Hiroshi Shiomi
  • Patent number: 6620493
    Abstract: A reflection-reducing film formed by being applied onto the surface of a substrate having light transmitting property, and including a base layer formed on the surface of said substrate and a surface layer formed on the upper side of said base layer, wherein: said base layer has a thickness of from 50 to 200 nm; and said surface layer is formed of a hydrolyzed product of a silane compound represented by the following formula (I), Rn—Si(X)4-n  (I)  wherein R is a substituted or unsubstituted alkyl group or an alkenyl group, X is a hydrolyzable group, and n is a number of 1 or 2, a metal chelate compound and a silica sol, and has a thickness of from 50 to 200 nm. The reflection-reducing film is easily formed on a light-transmitting substrate by applying a multi-layer coating thereon, and exhibits an excellent liquid resistance.
    Type: Grant
    Filed: March 6, 2001
    Date of Patent: September 16, 2003
    Assignee: Fukuvi Chemcial Industry Co Ltd
    Inventors: Hiroaki Hasegawa, Masahiro Saitou, Munetake Tajima, Hirokazu Hasimoto
  • Patent number: 6616868
    Abstract: A method of producing an optically molded product of a thermoplastic resin by injection compression molding, the method comprising the steps of: (1) expanding the volume of a cavity more than the volume of the optically molded product of interest; (2) injecting a molten thermoplastic resin into the cavity through an injection cylinder; (3) compressing the expanded cavity to a prescribed thickness of the molded product; (4) returning an excess of the thermoplastic resin produced by the compression into the injection cylinder; and (5) keeping the molten thermoplastic resin in the cavity until the molded product of interest is formed. The present invention makes it possible to produce an optically molded product (for example, a spectacle lens) free from a weld line and excellent in surface accuracy using a metal mold having a simple structure industrially advantageously.
    Type: Grant
    Filed: October 19, 2000
    Date of Patent: September 9, 2003
    Assignee: Teijin Chemicals, Ltd.
    Inventors: Kiyohito Gotoh, Hiromi Ichioka
  • Patent number: 6616937
    Abstract: An improved cosmetic composition comprises at least one cosmetically effective ingredient and water, where at least a potion of the water has been replaced by a distillate of a green plant juice. The distillate is obtained from a green plant juice, produced by squeezing green plants, by evaporation of the green plant juice to cause a concentration increase of the green plant juice.
    Type: Grant
    Filed: May 17, 2002
    Date of Patent: September 9, 2003
    Inventor: Takahiko Amano
  • Patent number: 6613925
    Abstract: Here is provided a process of preparing an O-alkyl-N-cyanoacetimidate from cyanamide and an orthoacetic acid ester on an industrial scale and in a high yield using an inexpensive apparatus. In preparing an O-alkyl-N-cyanoacetimidate by reaction of an orthoacetic acid ester with cyanamide, the start of the reaction is made in the presence of an alkaline catalyst.
    Type: Grant
    Filed: March 7, 2001
    Date of Patent: September 2, 2003
    Assignee: Nippon Carbide Kogyo K.K.
    Inventors: Takehiko Yoshie, Hidenori Nitta, Youichi Fukunishi
  • Patent number: 6602816
    Abstract: Activated regular-shaped clay particles forming macropores therein, preserving fine structure of the dioctahedral smectite clay minerals, and having particle diameters controlled to lie within a range in which they exhibit excellent filtering property. The invention further provides method of producing activated regular-shaped clay particles comprising the steps of adjusting the particle size of the dioctahedral smectite clay minerals to possess a volume-based median diameter (D50) of from 1 to 10 &mgr;m as found by a laser diffraction method, mixing an acid-soluble or acid-decomposing inorganic compound to the milled product thereof, granulating the mixture into regular particles having a volume-based median diameter (D50) of from 10 to 60 &mgr;m as found by a laser diffraction method, and treating the regular-shaped particles with an acid while maintaining the particle shapes.
    Type: Grant
    Filed: March 13, 2001
    Date of Patent: August 5, 2003
    Assignee: Mizusawa Industrial Chemicals Ltd
    Inventors: Masashi Hatano, Hitoshi Yamamoto, Daisuke Kuse
  • Patent number: 6596358
    Abstract: The present invention is to provide a thermally sensitive recording type adhesive label possessing a thermally sensitive recording layer on a substrate, and an adhesive layer and a release paper on the reverse side of the substrate, wherein said substrate is a neutral paper containing a wet strength reinforcing agent and further containing 5-20 wt. % of a filler to the total weight of pulp.
    Type: Grant
    Filed: August 24, 2000
    Date of Patent: July 22, 2003
    Assignee: Nippon Paper Industries Co Ltd
    Inventors: Tastuhiko Sakamoto, Yoshihide Kimura, Naomi Sumikawa, Hidenori Ogawa
  • Patent number: 6596137
    Abstract: A bipolar membrane which exhibits a low water dissociation voltage for an extended period of time under a high current density condition, and a high current efficiency, without developing blister. The bipolar membrane comprises a cation-exchange membrane and an anion-exchange membrane which are joined together, wherein ion-exchange resin particles having ions exchanged with ions of a metal of an atomic number 20 to 90, such as titanium, zirconium, tin, iron, ruthenium or palladium, or with complex ions of said metal are existing on the junction interface between the cation-exchange membrane and the anion-exchange membrane.
    Type: Grant
    Filed: December 17, 2001
    Date of Patent: July 22, 2003
    Assignee: Tokoyama Corporation
    Inventors: Satoshi Nago, Fumio Hanada
  • Patent number: 6589496
    Abstract: A metal oxide doped cerium oxide has an excellent ultraviolet ray shielding effect and transparency and reduced catalytic activity. The doping mextal oxide is an oxide of a metal ion having larger ion radius than that of Ce4+ and/or lower valence metal ion than Ce4+, such as Ca2+, Y3+, La3+, Nd3+, Eu3+, Tb3+, Sm3+, Mg2+, Sr2+, Ba2+, Ce3+. The metal oxide doped cerium is prepared by reacting aqueous solution of cerium salt, aqueous solution of metal ion having larger ion radius than that of Ce4+ and/or lower valence metal ion than Ce4+ and alkali at a temperature lower than 60° C. and at pH higher than 5. An oxidizing agent may be present together with the alkali or added subsequently. Resin compositions or cosmetic compositions blended with the metal oxide doped cerium oxide have improved ultraviolet shielding effect without spoiling transparency in the visible ray region.
    Type: Grant
    Filed: May 31, 2001
    Date of Patent: July 8, 2003
    Assignee: Nippon Dewho Co., Ltd.
    Inventors: Sinryo Yabe, Kota Tofukuji, Shigeyoshi Momose, Sakae Yoshida, Kazuyuki Tahira, Tsugio Sato
  • Patent number: 6590043
    Abstract: The present invention provides a polymer obtained by polymerizing a mixture composed of a methacrylic ester monomer having an electron-donating group bonded to a specific site of its ester-forming residue (its alcohol moiety) and optionally a lactone or lactide, while using an alkali metal alcoholate as a polymerization initiator. Moreover, it also provides a process for preparing the polymer and polymer micelles formed from the polymer. Since the polymer has a functional group corresponding to the polymerization initiator and the aforesaid electron-donating groups (functional groups), it can perform a great variety of functions by taking advantage of these functional groups.
    Type: Grant
    Filed: December 21, 1999
    Date of Patent: July 8, 2003
    Assignee: Nano Carrier Co., Ltd.
    Inventors: Yukio Nagasaki, Masao Kato, Kazunori Kataoka, Yasuo Sato, Atsushi Harada, Daisuke Wakebayashi
  • Patent number: 6583086
    Abstract: A thermally sensitive recording medium that contains a compound represented by general formula (1) as a color developer, and a compound represented by general formula (2) or general formula (3) as a sensitizer. The said thermally sensitive recording medium has sufficient color developing sensitivity with lower impressive energy, and has good image preservability of recorded part, good resistance to humid and heat resistance of background white paper part. In the formulae, R1 represents a hydrogen atom, a methyl group or a chlorine atom, R2 and R3 represents a methyl group, an alkoxy group or an allyloxy group, m and n represents an integer of 1-5, R4 represents an alkyl group, an alkoxy group of carbon number 1-6 or an electron withdrawing group and o represents an integer of 0-2.
    Type: Grant
    Filed: June 9, 2000
    Date of Patent: June 24, 2003
    Assignee: Nippon Paper Industries Co. Ltd.
    Inventors: Seiki Yoneshige, Tomoyuki Nakano, Reiji Ohashi
  • Patent number: 6583316
    Abstract: Improved catalysts for use in vapor phase oxidation of at least one compound selected from the group consisting of propylene, isobutylene, t-butanol and methyl-t-butyl ether with molecular oxygen or a molecular oxygen-containing gas to produce the corresponding unsaturated aldehyde and unsaturated carboxylic acid are provided. The improved catalysts are compositions comprising (A) a complex oxide containing as essential components molybdenum, bismuth and iron, which is known per se as a catalyst for said reaction and (B) a complex oxide containing cerium and zirconium as the essential components. When the improved catalysts are used, the production operation of unsaturated aldehyde and unsaturated carboxylic acid can be continued stably for over prolonged period.
    Type: Grant
    Filed: May 11, 2000
    Date of Patent: June 24, 2003
    Assignee: Nippon Shokubai Co., Ltd.
    Inventors: Hideo Onodera, Michio Tanimoto
  • Patent number: 6579828
    Abstract: A multi chromatic thermally sensitive recording medium comprising, a higher temperature color developing layer containing dye precursor and an organic color developer that reacts with said dye precursor and develops color by heating, and at least one lower temperature color developing layer that develops different color from that of said higher temperature color developing layer and develops color by lower temperature than the color developing temperature of said higher temperature color developing layer laminated in order on a substrate, wherein an organic color developer contained in said higher temperature color developing layer contains said diphenylsulfone bridgeable type compound represented by general formula (1) and/or said 3-{[(phenylamine)carbonyl]amino}benzenesulfoneamide compound represented by general formula (2), wherein, X and Y can be different and indicates a saturate or an unsaturated liner or grafted hydrocarbon group of carbon number 1 to 12 which can
    Type: Grant
    Filed: October 10, 2000
    Date of Patent: June 17, 2003
    Assignee: Nippon Paper Industries Co. LTD
    Inventors: Kaoru Hamada, Tadakazu Fukuchi, Yoshimi Midorikawa, Yoshihide Kimura
  • Patent number: 6572860
    Abstract: Peptide constructs chemically synthesized to contain a Herpes Simplex Virus specific antigenic peptide, such as, the 322-332 peptide (H1) from the ICP27 protein of Herpes Simplex Virus (HSV-1) and a peptide from a T cell binding ligand (TCBL), such as &bgr;-2M (aa 35-50), which elicits a TH1-like response in vitro tests in mice, were protective against challenge with HSV.
    Type: Grant
    Filed: March 30, 2000
    Date of Patent: June 3, 2003
    Assignee: CEL-SCI Corporation
    Inventors: Daniel H. Zimmerman, Kenneth S. Rosenthal
  • Patent number: 6572802
    Abstract: A novel process for creating aesthetically pleasing multicolor designs and patterns in cast materials, particularly cementitious materials, which may be used to imitate natural stone in appearance. The process includes the steps of preparing multiple colors of the casting material, geometrically loading these colors in a three dimensional array in a holding container according to formulas corresponding to particular patterns to be created, placing the geometrically loaded colors into a mold by means which include pouring, extruding and spraying, consolidating the mixtures in the mold and allowing them to set, and removing the cast structure from the mold followed by polishing and sealing if required. A removable matrix in the holding container provides the ability to reliably repeat patterns according to the loading formulas.
    Type: Grant
    Filed: June 14, 2000
    Date of Patent: June 3, 2003
    Assignee: The Spectrastone Co. International, Inc.
    Inventor: Mark Austin
  • Patent number: 6572541
    Abstract: Retractor system to be used in surgery comprising an assistance nipple with a base plate and an adhesive patch underneath for attachment to the patient's skin or a surgical sheet, and a retractor for retracting outwardly and fastening the edges of an incision and capable of releasably fastening to the nipple, and a surgical sheet having a large opening corresponding to the surgical site with a plurality of holes surrounding the large opening through which assistance nipples may protrude. In an alternative embodiment, a ring having a plurality of nipples and adhesive to secure the ring to the patient's skin surrounding a surgical site is provided to hold a plurality of retractors.
    Type: Grant
    Filed: March 29, 2000
    Date of Patent: June 3, 2003
    Assignee: Pular Medica AS
    Inventor: Alf Petersvik