Patents Represented by Attorney Sidney B. Williams, Jr.
  • Patent number: 4318790
    Abstract: Photochemical process for preparing N-demethyl-derivatives of nogalamycin.
    Type: Grant
    Filed: March 17, 1980
    Date of Patent: March 9, 1982
    Assignee: The Upjohn Company
    Inventor: Paul F. Wiley
  • Patent number: 4312868
    Abstract: Isothiochromans are described. The compounds possess hypotensive and antipsychotic properties; methods and compositions using them are described.
    Type: Grant
    Filed: May 15, 1979
    Date of Patent: January 26, 1982
    Assignee: The Upjohn Company
    Inventor: John M. McCall
  • Patent number: 4302452
    Abstract: Use of water soluble 21-polybasic esters of 1-dehydro-6.alpha.-methylhydrocortisone and their salts as an antiemetic.
    Type: Grant
    Filed: November 21, 1980
    Date of Patent: November 24, 1981
    Assignee: The Upjohn Company
    Inventor: Johnny M. Pittman, Jr.
  • Patent number: 4298744
    Abstract: Chemical process for preparing AT-125 and its analogs and intermediates used in the process.
    Type: Grant
    Filed: July 13, 1979
    Date of Patent: November 3, 1981
    Assignee: The Upjohn Company
    Inventors: Robert C. Kelly, Wendell Wierenga
  • Patent number: 4297285
    Abstract: New phosphinic acid derivatives of aminothio methylcarbamates. The new compounds are active against insects, mites and nematodes.
    Type: Grant
    Filed: July 31, 1980
    Date of Patent: October 27, 1981
    Assignee: The Upjohn Company
    Inventor: Stephen J. Nelson
  • Patent number: 4292256
    Abstract: New phosphinic acid derivatives of aminothio methylcarbamates. The new compounds are active against insects, mites and nematodes.
    Type: Grant
    Filed: January 25, 1980
    Date of Patent: September 29, 1981
    Assignee: The Upjohn Company
    Inventor: Stephen J. Nelson
  • Patent number: 4289757
    Abstract: A method of treating inflammation comprising topical administration to mammals suffering from an inflammatory condition not associated with amicrobial component, employing selected antibiotics as the anti-inflammatory agent.
    Type: Grant
    Filed: November 28, 1979
    Date of Patent: September 15, 1981
    Assignee: The Upjohn Company
    Inventor: E. Myles Glenn
  • Patent number: 4282152
    Abstract: Process for preparing intermediates of spectinomycin and analogs thereof. Also provides novel intermediates for making spectinomycin and analogs thereof.
    Type: Grant
    Filed: August 23, 1979
    Date of Patent: August 4, 1981
    Assignee: The Upjohn Company
    Inventor: David R. White
  • Patent number: 4279840
    Abstract: This invention pertains to novel phosphorus derivatives of aminothiocarbamic halides and prosesses for their preparation. The carbamic halides are readily prepared by two general procedures. In one procedure an appropriate N-(clorothio) phosphorus amide reactant is readily prepared by reacting the corresponding phosphorus amide with sulfur dichloride which reactant will react with N-methylcarbamoyl halide so as to produce the corresponding object compounds of this invention. In a different procedure the same compounds that are the object of this invention are prepared by reacting an appropriate corresponding phosphorus amide with an N-chlorothiemethylcarbamoyl halide reactant which reactant is readily prepared by reacting N-methylcarbamoyl halide with sulfur chloride. The novel compounds of this invention are intermediates for the preparation of pesticides.
    Type: Grant
    Filed: March 21, 1980
    Date of Patent: July 21, 1981
    Assignee: The Upjohn Company
    Inventor: Stephen J. Nelson
  • Patent number: 4275214
    Abstract: Analogs of tricholomic acids and process for preparing them.
    Type: Grant
    Filed: July 31, 1979
    Date of Patent: June 23, 1981
    Assignee: The Upjohn Company
    Inventors: Robert C. Kelly, Wendell Wierenga
  • Patent number: 4267117
    Abstract: A process for preparing 1.alpha.-hydroxylated calciferols is described. Intermediates used in the process are also provided.
    Type: Grant
    Filed: June 14, 1979
    Date of Patent: May 12, 1981
    Assignee: The Upjohn Company
    Inventor: William G. Salmond
  • Patent number: 4256898
    Abstract: Chemical process for preparing AT-125 and its analogs and intermediates used in the process.
    Type: Grant
    Filed: July 31, 1979
    Date of Patent: March 17, 1981
    Assignee: The Upjohn Company
    Inventors: Robert C. Kelly, Wendell Wierenga
  • Patent number: 4254095
    Abstract: A kit and method for the radioimmunoassay (RIA) for erythropoietin. Also, a method for purifying erythropoietin and purified labelled erythropoietin-conjugate for use as a tracer in the RIA.
    Type: Grant
    Filed: April 27, 1978
    Date of Patent: March 3, 1981
    Assignee: Research Corporation
    Inventors: James W. Fisher, Arvind B. Rege
  • Patent number: 4254142
    Abstract: Norbornyl thio- and dithiocarbanilic acid are described. The compounds possess immunoregulatory activity. Also provided are compositions containing and methods of using them.
    Type: Grant
    Filed: August 8, 1979
    Date of Patent: March 3, 1981
    Assignee: The Upjohn Company
    Inventors: David J. Anderson, Barbara E. Loughman
  • Patent number: 4251526
    Abstract: Novel 2-Benzothiepins, having substituents in the 1-position heretofore unknown, are described. The compounds possess hypotensive and antipsychotic properties; methods and compositions using them are described.
    Type: Grant
    Filed: May 15, 1979
    Date of Patent: February 17, 1981
    Inventor: John M. McCall
  • Patent number: 4250175
    Abstract: Isochromans, isothiochromans, 2-benzoxepins and 2-benzothiepins are described. The compounds possess hypotensive and antipsychotic properties; methods and compositions using them are described.
    Type: Grant
    Filed: September 5, 1979
    Date of Patent: February 10, 1981
    Inventor: John M. McCall
  • Patent number: 4250181
    Abstract: Isochromans, isothiochromans, 2-benzoxepins and 2-benzothiepins are described. The compounds possess hypotensive and antipsychotic properties; methods and compositions using them are described.
    Type: Grant
    Filed: September 5, 1979
    Date of Patent: February 10, 1981
    Assignee: The Upjohn Company
    Inventor: John M. McCall
  • Patent number: 4247553
    Abstract: Isochromans, isothiochromans, 2-benzoxepins and 2-benzothiepins are described. The compounds possess hypotensive and antipsychotic properties; methods and compositions using them are described.
    Type: Grant
    Filed: September 5, 1979
    Date of Patent: January 27, 1981
    Assignee: The Upjohn Company
    Inventor: John M. McCall
  • Patent number: 4234521
    Abstract: This invention pertains to novel phosphorus derivatives of aminothiocarbamic halides and processes for their preparation. The carbamic halides are readily prepared by two general procedures. In one procedure an appropriate N-(chlorothio)phosphorus amide reactant is readily prepared by reacting the corresponding phosphorus amide with sulfur dichloride which reactant will react with N-methylcarbamoyl halide so as to produce the corresponding object compounds of this invention. In a different procedure the same compounds that are the object of this invention are prepared by reacting an appropriate corresponding phosphorus amide with an N-chlorothiomethylcarbamoyl halide reactant which reactant is readily prepared by reacting N-methylcarbamoyl halide with sulfur chloride. The novel compounds of this invention are intermediates for the preparation of pesticides.
    Type: Grant
    Filed: June 1, 1979
    Date of Patent: November 18, 1980
    Assignee: The Upjohn Company
    Inventor: Stephen J. Nelson
  • Patent number: 4232164
    Abstract: Process for the purification of L-(.alpha.S,5S)-.alpha.-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125). Also provided are AT-125 analogs prepared in the process.
    Type: Grant
    Filed: June 23, 1978
    Date of Patent: November 4, 1980
    Assignee: The Upjohn Company
    Inventor: David G. Martin