Abstract: The present invention provides a method for treatment of hyporeactivity to interferon induction in interferon producing animals or animal cells which comprises administering a hyporeactive interferon stimulating prostaglandin (HIS-PG) to an interferon producing animal or animal cells having a hyporeactive (decreased) interferon response. Hyporeactive interferon stimulating prostaglandins (HIS-PG) refers to those prostaglandin-type compounds which are useful in alleviating the decreased ability of interferon producing animals or animal cells to produce interferon following administration of repeated doses of an interferon inducer or as a consequence of viral infection or neoplasia.

Abstract: Certain new 1-(substituted-hydrocarbyl)-di- and trihalopyrazoles have been synthesized. They possess herbicidal and plant growth regulatory activity. The hydrocarbyl group, i.e., alkylene or alkenylene group at the 1-nitrogen of the pyrazole nucleus has either a carboxyl group, an hydroxymethyl group, an hydroxymethyl lower-alkanoate group a carboxylic lower-alkyl ester group a cyano group or a carboxylic amide group. The new compounds are prepared and isolated by conventional chemical reactions and procedures. An improved reaction for making the new carboxylic acids is described. Weed control methods and compositions for herbicidal use are also described.

Abstract: Some new phosphinic acid derivatives of aminothio methylcarbamates have been synthesized and tested as pesticides. The new compounds are active against insects, mites, and nematodes. The N-[(phosphinyl)amino]thio- and N-[(phosphinothioyl)amino]thio- methylcarbamates are readily prepared by the general procedure of reacting a phosphinic acid amide with sulfur dichloride so as to obtain the corresponding N-(chlorothio)phosphinic acid amide which reactant will react with a methylcarbamate so as to produce the corresponding object compounds, the N-[phosphinyl)amino]thio- and N-[(phosphinothioyl)-amino]thio- methylcarbamates of this invention. Various formulations for pesticidal use are described along with appropriate rates of application.

Abstract: Novel pesticidal compounds of the formula: ##STR1## wherein R.sub.1 is lower alkyl of from 1 to 4 carbon atoms; R.sub.2 is hydrogen, halogen or lower alkyl of from 1 to 4 carbon atoms; R.sub.3 and R.sub.4 are the same or different and are hydrogen, alkyl of 1 to 8 carbon atoms, inclusive; haloalkyl, arylalkyl and ##STR2## WHEREIN ALKYL IS FROM 1 TO 4 CARBON ATOMS, CYCLOALKYL OF FROM 3 TO 6 CARBON ATOMS, ARYL AND R.sub.3 and R.sub.4 taken together are a member selected from the group piperidine, morpholine, pyrazole, tribromopyrazole, N-methylpiperazine, pyrrole, pyrrolidine, pyrrolidone.The compounds are combined with carriers to prepare compositions and are useful in controlling insect pests either as an insecticide or behavioral modifier and are particularly effective as miticides.

Abstract: There is disclosed concomitant systemic administration of certain prostaglandins of the PGE-type and PGA-type, for example, 16,16-dimethyl-PGE.sub.2 of 16,16-dimethyl-PGA.sub.2, and a prostaglandin synthetase inhibitor, for example, indomethacin, aspirin, or phenylbutazone, to mammals, including humans. Thereby the undesirable gastrointestinal effects of the synthetase inhibitor are reduced.

Abstract: Novel compounds of the formula: ##STR1## are disclosed with the corresponding hydrates and pharamceutically acceptable acid addition salts thereof, wherein R.sub.1 is halogen, lower alkyl, or trifluoromethyl; R.sub.2 is lower alkyl, substituted or unsubstituted phenyl or benzyl and R.sub.3 is hydrogen. The novel compounds are useful for the treatment of hypertension and anxiety in mammals, including humans.Disclosed also are compositions containing the novel compounds of the invention and methods of their use in the treatment of hypertension and anxiety.

Abstract: This invention relates to a novel process for purifying aqueous solutions which contain cholesterol oxidase. In particular, this invention relates to a process for removing nonionic surfactants from aqueous processing solutions containing cholesterol oxidase by extraction with a water-immiscible solvent.

Abstract: Compositions and methods for treating mastitis in milk animals which comprises administering by intramammary infusion an effective amount of an anti-mastitis medicament dispersed in a vehicle comprising an oil, a fatty acid ester and, optionally, a fatty acid salt.

Abstract: Alkyl 7-deoxy-7-.omega.-substituted alkylthio-.alpha.-thiolincos-aminides useful as intermediates for preparing anti-bacterially active 7-deoxy-7-.omega.-substituted alkylthiolincomycins are prepared by heating alkyl N-acyl-6,7-aziridino-6-deamino-7-deoxy-.alpha.-thiolincosaminides with an appropriate thiol in the presence of an anhydrous lower hydrocarbon carboxylic acid.BRIEF DESCRIPTION OF THE INVENTIONThis invention relates to methods for making alkyl (7R,S) 7-deoxy-7-.omega.-substituted alkylthio-.alpha.-thiolincosaminides of Formula I: ##STR1## wherein Alk is alkyl of not more than 4 carbon atoms, for example, methyl, ethyl, propyl, isopropyl, butyl, sec.- butyl, isobutyl, and tert.-butyl; R.sub.1 is hydrogen, methyl or ethyl; R.sub.2 is hydrogen, methyl or ethyl; R.sub.3 is hydrogen, methyl or ethyl; n is 0 or 1; and R is hydrogen, alkyl of 1 to 6 carbon atoms, inclusive, or aralkyl of 7 to 12 carbon atoms, inclusive.

Abstract: A method and therapeutic compositions for inducing interferon formation in vivo. To a host is administered an interferon inducer selected from the group consisting ofA. 1,5-bis[(3-morpholinopropyl)amino]anthraquinone,B. 1-[(2-aminoethyl)amino]-5-[[1-(hydroxymethyl)-propyl]amino]anthraquinone including primary -N-acylates, O-acylates, and O,primary-N-diacylates thereof, wherein the acylates are the acyl moiety of a carboxylic acid having from 2 to 18 carbon atoms, inclusive,C. 1,5-bis[[2-(diethylamino)ethyl]amino]anthraquinone,D. 1,5-bis[[3-(diethylamino)propyl]amino]anthraquinone,E. 1,5-bis[(3-piperidinopropyl)amino]anthraquinone.

Abstract: Pharmaceutical preparations in dosage forms and animal feeds (baits) consisting essentially of compatible, pharmaceutically acceptable carriers, oral and injectable, compounded with a sub-lethal, yet effective, amount of epichlorohydrin for inducing sterility in male mammals. Methods for preventing impregnation of females by male mammals which comprises administering systemically to male mammals a sterilizing amount of epichlorohydrin, also identified as .gamma.-epichlorohydrin.

Abstract: Pharmaceutical compositions of antibiotic U-44,590 and derivatives thereof which can be used to treat Gram-negative and Gram-positive bacterial and viral diseases in humans and animals.