Patents Represented by Attorney Stephen Venetianer
  • Patent number: 6835712
    Abstract: Spermine:peptide-based surfactant compounds are disclosed. The compounds are based on a spermine backbone with peptide groups and optionally hydrocarbyl groups linked thereto. Uses of the spermine:peptide-based surfactant compounds and methods for their production are also disclosed.
    Type: Grant
    Filed: July 19, 2002
    Date of Patent: December 28, 2004
    Assignees: SmithKline Beecham p.l.c., Cambridge University Technical Services Ltd.
    Inventors: Patrick Camilleri, Philippe Guedat, Anthony John Kirby, Andreas Kremer
  • Patent number: 6818655
    Abstract: The present invention relates to quinolines, pharmaceutical compositions containing them and their use as antagonists of urotensin II.
    Type: Grant
    Filed: July 25, 2003
    Date of Patent: November 16, 2004
    Assignee: SmithKline Beecham Corporation
    Inventors: Dashyant Dhanak, Steven D. Knight, Gregory L. Warren
  • Patent number: 6783773
    Abstract: Bacterial infections may be treated using a high dosage regimen of amoxicillin and potassium clavulanate. Preferably, the dosage is provided by a bilayer tablet.
    Type: Grant
    Filed: October 5, 2001
    Date of Patent: August 31, 2004
    Assignee: Beecham Pharmaceuticals (Pte) Limited
    Inventors: Kevin H. Storm, Creighton P. Conley, John A. Roush
  • Patent number: 6774127
    Abstract: Novel pyridyl and pyrimidinyl substituted pyrazole and pyrazoline compounds and compositions for use in therapy.
    Type: Grant
    Filed: February 19, 2003
    Date of Patent: August 10, 2004
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry L. Adams, Timothy Gallagher, Irennegbe Kelly Osifo
  • Patent number: 6770657
    Abstract: The invention relates to novel isoquinolines and their use as anticonvulsant and in the treatment of a variety of disorders.
    Type: Grant
    Filed: September 11, 2002
    Date of Patent: August 3, 2004
    Assignee: Smithkline Beecham p.l.c.
    Inventors: John David Harling, Mervyn Thompson
  • Patent number: 6762192
    Abstract: Compounds of formula (I) and pharmaceutically acceptable salts and solvates: where R1 is hydrogen, C1-6 alkyl (optionally substituted by hydroxy or C1-4alkoxy), phenyl-C1-4alkyl-, C1-6alkenyl, C1-6alkynyl; R2 is hydrogen or up to three substituents selected from halogen, NO2, CN, N3, CF3O—, CF3S—, CF3CO—, C1-6alkyl, C1-6alkenyl, C1-6alkynyl, C1-6perfluoroalkyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-4alkyl-, C1-6alkylO—, C1-6alkylCO—, C3-6cycloalkylO—, C3-6cycloalkylCO—, C3-6cycloalkyl-C1-4alkylO—, C3-6cycloalkyl-C1-4alkylCO—, phenyl, phenoxy, benzyloxy, benzoyl, phenyl-C1-4alkyl-, C1-6alkylS—, C1-6alkylSO2—, (C1-4alkyl)2NSO2—, (C1-4alkyl)NHSO2—, (C1-4alkyl)2NCO—, (C1-4alkyl)NHCO— or CONH2; or —NR5R6 where R5 is hydrogen or C1-4 alkyl, and R6 is hydrogen, C1-4alkyl, formyl, —CO2C1-4alkyl or —COC1-4alkyl; or two R2 groups together form a carbocyclic ring that is saturated or unsaturated.
    Type: Grant
    Filed: May 23, 2002
    Date of Patent: July 13, 2004
    Assignee: SmithKline Beechum p.l.c.
    Inventors: John David Harling, Frank Peter Harrington, Mervyn Thompson
  • Patent number: 6759410
    Abstract: The present invention relates to 4,4-disubstituted-3,4-dihydro-2(1H)-quinazolines of formula (1), or stereoisomeric forms, stereoisomeric mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of HIV reverse transcriptase, and to pharmaceutical compositions and diagnostic kits comprising the same, and methods of using the same for treating viral infection or as an assay standard or reagent.
    Type: Grant
    Filed: May 10, 2002
    Date of Patent: July 6, 2004
    Assignee: SmithLine Beecham Corporation
    Inventors: Jerry L. Adams, Michael J. Bower, Ralph Hall, Don Edgar Griswold, David C. Underwood
  • Patent number: 6756040
    Abstract: The invention relates to a vaccine formulation for the prevention of Haemophilus Influenzae Type B (Hib) infections and where the antigen is adsorbed onto aluminum phosphate. The invention also relates to a multivalent vaccines, that is a vaccine for the amelioration or treatment of more than one disease states. The present invention also relates to the production and use of such vaccines in medicine.
    Type: Grant
    Filed: May 23, 2002
    Date of Patent: June 29, 2004
    Assignee: SmithKline Beecham Biologicals s.a.
    Inventors: Julien Peetermans, Pierre Hauser
  • Patent number: 6756057
    Abstract: Bacterial infections may be treated using a high dosage regimen of amoxicillin and potassium clavulanate. Preferably, the dosage is provided by a bilayer tablet.
    Type: Grant
    Filed: June 13, 2003
    Date of Patent: June 29, 2004
    Assignee: Beecham Pharmaceuticals (pte) Limited
    Inventors: Kevin H. Storm, Creighton P. Conley, John A. Roush
  • Patent number: 6750227
    Abstract: The use of [R-(Z)]-&agr;-(methoxyimino)-&agr;-(1-azabicyclo[2.2.2]oct-3-yl)acetonitrile or a pharmaceutically acceptable salt thereof for the treatment of neuropsychiatric symptoms in patients with Alzheimer's Disease is disclosed.
    Type: Grant
    Filed: February 21, 2003
    Date of Patent: June 15, 2004
    Assignees: SmithKline Beecham Corporation, SimthKline Beecham p.l.c.
    Inventors: Frank Brown, James P. Mc Cafferty, Eve Naomi Cedar
  • Patent number: 6747030
    Abstract: Piperazine derivatives of formula(1), processes for their preparation, pharmaceutical compositions containing them in the treatment of CNS and other disorders and in their use in therapy as 5-HT1B antagonists are disclosed herein.
    Type: Grant
    Filed: March 25, 2002
    Date of Patent: June 8, 2004
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Howard Marshall, Mervyn Thompson, Paul Adrian Wyman
  • Patent number: 6746692
    Abstract: Bacterial infections may be treated using a high dosage regimen of amoxycillin and potassium clavulanate. Preferably, the dosage is provided by a bilayer tablet.
    Type: Grant
    Filed: April 4, 2002
    Date of Patent: June 8, 2004
    Assignee: Beecham Pharmaceuticals (Pte) Limited
    Inventors: Creighton P. Conley, John A. Roush, Kevin H. Storm
  • Patent number: 6740765
    Abstract: This invention relates to a method for preparing 4-substituted-4-cyanocyclohexane carboxylates by forming the cyclohexane ring by treating a &agr;,&agr;-bis(2-haloethyl)-4-benzeneacetonitrile with a dialkyl malonate and decarboxylating the resulting diester.
    Type: Grant
    Filed: April 2, 2002
    Date of Patent: May 25, 2004
    Assignee: SmithKline Beecham Corporation
    Inventors: Ann M. Diederich, Ann Marie Eldridge, Robert J. Mills, Vance J. Novack
  • Patent number: 6730683
    Abstract: Novel 1,4,5-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.
    Type: Grant
    Filed: June 10, 2002
    Date of Patent: May 4, 2004
    Assignee: SmithKline Beecham Corporation
    Inventors: Timothy Francis Gallagher, Jeffrey Charles Boehm, Jerry Leroy Adams
  • Patent number: 6726908
    Abstract: This invention relates to pharmaceutical formulations comprising amoxycillin and a salt clavulanic acid in a ratio of 14:1.
    Type: Grant
    Filed: October 27, 1997
    Date of Patent: April 27, 2004
    Assignee: SmithKline Beecham p.l.c.
    Inventor: Daniel Joseph Burch
  • Patent number: 6720345
    Abstract: Compounds of formula (I), particularly a compound of formula (Ia), are non-peptide TPO mimetics, useful in the treatment of thrombocytopenia.
    Type: Grant
    Filed: May 3, 2002
    Date of Patent: April 13, 2004
    Assignee: SmithKline Beecham Corporation
    Inventors: Juan I. Luengo, Kevin J. Duffy, Antony N. Shaw
  • Patent number: 6716985
    Abstract: Compounds of structure (1) are obtained by reduction of compounds of the structures: Compounds of structure (1), especially where Z is a hydrogen atom or a 3,4-methylenedioxyphenyl group, are important intermediates for inter alia paroxetine.
    Type: Grant
    Filed: May 3, 2002
    Date of Patent: April 6, 2004
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Victor Withold Jacewicz, Marvin Sungwhan Yu, Evgeny Shapiro
  • Patent number: 6713509
    Abstract: This invention relates to a controlled or sustained release formulation designed to deliver a PDE4 inhibitor for treating an inflammatory disease such as asthma or COPD and the like.
    Type: Grant
    Filed: August 22, 2001
    Date of Patent: March 30, 2004
    Assignee: SmithKline Beecham Corporation
    Inventors: Patrick G. Faulkner, Jaime J. Lucca, Thomas J. Wrzosek
  • Patent number: 6709859
    Abstract: DNA sequences obtained from S. clavuligerus ATCC 27064, recombinant vectors incorporating such sequences and hosts transformed with such vectors are disclosed. The DNA comprises one or more genes coding for one or more enzymes involved in the biosynthesis of penicillin and cephalosporin &bgr;-lactams and such enzymes are expressed by hosts into which the recombinant vectors are transformed. The DNA and the enzymes encoded thereby have utility in the preparation of penicillins and cephalosporins, both known and novel, possessing pharmacological, especially antimicrobial, activity.
    Type: Grant
    Filed: January 10, 2000
    Date of Patent: March 23, 2004
    Assignee: Beecham Group p.l.c.
    Inventors: Martin Karl Rossel Burnham, Ian David Normansell, John Edward Hodgson
  • Patent number: D493518
    Type: Grant
    Filed: November 26, 2002
    Date of Patent: July 27, 2004
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Stephen Mark McAllister, Brian Hewitt