Patents Represented by Attorney Stephen Venetianer

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  • Monohydrate of cis-lithium-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]cyclohexanecarboxylate
    Patent number: 6699903
    Abstract: This invention provides a means for preparing a monohydrate of the lithium salt of cis 4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]cyclohexanecarboxylate which is a novel composition of matter.
    Type: Grant
    Filed: July 22, 2002
    Date of Patent: March 2, 2004
    Assignee: SmithKline Beecham Corporation
    Inventor: Kevin Scott Webb
  • Peptide-based gemini compounds
    Patent number: 6693167
    Abstract: New peptide-based Gemini compounds comprising two linked chains (a) each having: (1) a positively charged hydrophilic head, Q1 or Q2 formed from one or more amino acids and/or amines, (2) a central portion, P1 or P2, having a polypeptide backbone, and (3) a hydrophobic tail, R1 or R2, the central sections of each chain being linked together by bridge Y through residues in P1 and P2, are disclosed. Methods for their preparation and uses are also disclosed. Such uses include transfection of polynucleotides into cells in vivo.
    Type: Grant
    Filed: June 8, 2000
    Date of Patent: February 17, 2004
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Patrick Camilleri, Andreas Kremer, Simon Quentyn John Rice
  • Osp a proteins of Borrelia burgdorferi subgroups, encoding genes and vaccines
    Patent number: 6676942
    Abstract: The invention related to novel Borrelia, and OspA antigens derived therefrom. These antigens show little homology with know OspA's and are therefore useful as vaccine and diagnostic reagents. Multicomponent vaccines based on OspA's from different Borrelia groups are also disclosed.
    Type: Grant
    Filed: April 1, 1999
    Date of Patent: January 13, 2004
    Assignees: SmithKline Beecham Biologicals (s.a.), Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V., Deutsches Krebs Forschungszentrum Stiftung des Offentlichen Rechts
    Inventors: Yves Lobet, Markus Simon, Ulrich Schaible, Reinhard Wallich, Michael Kramer
  • Method for treating COPD
    Patent number: 6670394
    Abstract: This invention relates to a method for the prophylaxis of or for treating COPD by administering a PDE4 inhibitor which has a defined therapeutic ratio.
    Type: Grant
    Filed: August 31, 2001
    Date of Patent: December 30, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: Siegfried B. Christensen, IV, Mary S. Barnette, Theodore J. Torphy
  • Thrombopoietin mimetics
    Patent number: 6670387
    Abstract: Non-peptide TPO mimetics are disclosed, as well as a method of treating thrombocytopenia, in a mammal, including a human, in need thereof, which comprises administering to such mammal an effective amount of a selected hydroxy-1-azo-naphthalene derivative.
    Type: Grant
    Filed: June 14, 2001
    Date of Patent: December 30, 2003
    Assignees: SmithKline Beecham Corporation, Ligand Pharmaceuticals
    Inventors: Juan I. Luengo, Kevin J. Duffy, Stephen G. Miller
  • Modified release pharmaceutical formulation comprising amoxycillin
    Patent number: 6660299
    Abstract: Bacterial infections may be treated using a high dosage regimen of amoxycillin. Preferably, the dosage is provided by a bilayer tablet.
    Type: Grant
    Filed: July 24, 2001
    Date of Patent: December 9, 2003
    Assignee: Beecham Pharmaceuticals Limited
    Inventors: Creighton P. Conley, John A. Roush, Kevin H. Storm
  • Vaccine against Mumps containing a Jeryl-Lynn virus strain
    Patent number: 6656476
    Abstract: A new mumps vaccine is presented, comprising a homogeneous pure isolate derived from the Jeryl-Lynn strain of mumps virus.
    Type: Grant
    Filed: August 7, 2002
    Date of Patent: December 2, 2003
    Assignee: SmithKline Beecham Biologicals (S.A.)
    Inventors: Nigel Maurice Harford, Brigitte Desiree Alberte Colau, Jean Didelez
  • Compounds
    Patent number: 6649619
    Abstract: Pyrimidone compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in treating atheroscelerosis.
    Type: Grant
    Filed: February 3, 2003
    Date of Patent: November 18, 2003
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Deirdre Mary Bernadette Hickey, Robert John Ife, Colin Andrew Leach, Ivan Leo Pinto, Stephen Allan Smith, Steven James Stanway
  • Thrombopoietin mimetics
    Patent number: 6642265
    Abstract: Invented are non-peptide TPO mimetics. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.
    Type: Grant
    Filed: March 8, 2002
    Date of Patent: November 4, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: Juan I. Luengo, Kevin J. Duffy
  • G-CSF mimetics
    Patent number: 6630470
    Abstract: Invented are G-CSF mimetics. Also invented are selected octacyclic compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds as G-CSF mimetics. Also invented are novel processes used in preparing these compounds.
    Type: Grant
    Filed: November 20, 2000
    Date of Patent: October 7, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: Juan I Luengo, Kevin J Duffy
  • Vaccines
    Patent number: 6623739
    Abstract: The present invention provides vaccine compositions comprising an oil-in-water emulsion optionally with 3 De-O-acylated monophosphoryl lipid A and QS21. The vaccine compositions are potent inducers of a range of immune responses.
    Type: Grant
    Filed: February 24, 2000
    Date of Patent: September 23, 2003
    Assignee: SmithKline Beecham Biologicals s.a.
    Inventors: Patricia Marie Momin, Nathalie Marie-Josephe Garcon
  • Process and intermediates for making 4-cyanosubstituted cyclohexanoic acids
    Patent number: 6624323
    Abstract: Herein is provided a process for preparing substituted cyclohexanoic acids of formula (I), where Ra is a carbon-containing group optionally linked by oxygen, sulfur or nitrogen to the phenyl ring and j is 1-5; and one of R and R* is hydrogen and the other is C(O)OH.
    Type: Grant
    Filed: March 14, 2002
    Date of Patent: September 23, 2003
    Assignee: SmithKline Beecham Corporation
    Inventor: Jose J. Conde
  • Endothelin receptor antagonists
    Patent number: 6620826
    Abstract: Novel N-phenyl imidazole derivatives, pharmaceutical compositions containing these compounds and their use as endothelin receptor antagonists are described.
    Type: Grant
    Filed: January 29, 2003
    Date of Patent: September 16, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: John Duncan Elliott, Joseph Weinstock, Jia-Ning Xiang
  • Hepatitis vaccines containing 3-0-deacylated monophoshoryl lipid A
    Patent number: 6620414
    Abstract: A vaccine formulation for the treatment or prophylaxis of hepatitis, especially hepatitis B, infections is provided comprising the hepatitis antigen and a suitable carrier such as alum in combination with 3-O-deacylated monophosphoryl lipid A. Combination vaccines including the vaccine formulation are also described.
    Type: Grant
    Filed: August 21, 2001
    Date of Patent: September 16, 2003
    Assignee: SmithKline Beecham Biologicals (s.a.)
    Inventors: Nathalie Marie-Josephe Claude Garcon-Johnson, Pierre Hauser, Clothilde Thiriart, Pierre Voet
  • Lipstatin derivative-soluble fiber tablets
    Patent number: 6607749
    Abstract: The present invention relates to a novel pharmaceutical composition and process for preparing swallowable rapidly disintegrating methylcellulose and lipstatin derivatives together in combination with a suitable diluent and excipients.
    Type: Grant
    Filed: March 6, 2001
    Date of Patent: August 19, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: Bruce P. Daggy, Kenneth G. Mandel
  • 6-(substituted methylene) penems and intermediates
    Patent number: 6600035
    Abstract: Compounds of formula (I) in which: R1 is hydrogen or an organic substituent group; R2 is a fused bicyclic heterocyclic ring system of general formula (a) wherein R4 and R5 are independently hydrogen or one or more substituents replacing hydrogen atoms in the ring system shown; m is 2 or 3; p is 0, 1 or 2; and R3 is hydrogen, a salt-forming cation or an ester-forming group; and the symbol ═/═ indicates that the double bond may be in either the E or Z configuration.
    Type: Grant
    Filed: May 24, 1995
    Date of Patent: July 29, 2003
    Assignee: SMithKline Beecham p.l.c.
    Inventors: Nigel John Perryman Broom, Frank Peter Harrington
  • Substituted triazole compounds
    Patent number: 6599910
    Abstract: Novel substitued triazole compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors.
    Type: Grant
    Filed: June 11, 2001
    Date of Patent: July 29, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry L. Adams, Dennis Lee
  • Protease inhibitors
    Patent number: 6596715
    Abstract: This invention relates to the compound of Formula (I): or a pharmaceutically acceptable salt, hydrate or solvate thereof, which is an inhibitor of cysteine proteases, particularly cathepsin K, and is useful in the treatment of diseases in which inhibition of bone loss or of cartilage degradation is a factor.
    Type: Grant
    Filed: May 6, 2002
    Date of Patent: July 22, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: Robert W. Marquis, Jr., Daniel Frank Veber
  • Nitrosation process
    Patent number: 6596869
    Abstract: A process for preparing compounds of formula (I), by nitrosating compounds of formula (II), compounds of formula (I) having pharmaceutical activity.
    Type: Grant
    Filed: May 30, 2002
    Date of Patent: July 22, 2003
    Assignee: SmithKline Beecham plc
    Inventors: Mark Jason Hughes, John Kitteringham
  • Capsule
    Patent number: D481456
    Type: Grant
    Filed: July 29, 2002
    Date of Patent: October 28, 2003
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Stephen Mark McAllister, Brian Hewitt