Abstract: The present invention provides compounds which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease; hypercalcemia of malignancy; and metabolic bone disease, comprising inhibiting said bone loss or excessive cartilage or matrix degradation by administering to a patient in need thereof a compound of the present invention.

Abstract: 1,4,5-substituted imidazole compounds and compositions for use in therapy.

Abstract: A toothbrush in which the head comprises a substantially rigid base region adjoining the toothbrush neck and extending from the base end of the head to a resilient flexible link situated between the base end and the tip end, and a tip region extending from the tip end of the head to the link region, both the base region and tip region being bristle bearing, the tip region being flexibly and resiliently linked at the link region to the base region, and between the base end of the head and the neck there is a resilient flexible link.

Abstract: Acidic oral compositions having reduced tooth erosion characteristics, especially acid beverages such as fruit juice drink concentrates, or oral healthcare products such as mouthwashes, are prepared by adding a calcium compound to the acid composition so that the mol ratio of calcium to acid ranges from 0.3 to 0.8, and the pH of the composition, if necessary after adjustment with an alkali, is from 3.5 to 4.5.

Abstract: Compounds of formula (I) are inhibitors of the bacterial enzyme S aureus methionyl tRNA synthetase and are of use in treating bacterial infections.

Abstract: The present invention relates to a swallow tablet or capsule formulation comprising paracetamol, sodium bicarbonate, and at least one pharmaceutically acceptable excipient.

Abstract: This invention relates to the novel pyrazole compounds of Formula (I), and pharmaceutical compositions comprising a compound of formula (I) and a pharmaceutically acceptable diluent or carrier. This invention also relates to a method of inhibiting cytokines by a compound of formula (I) and the treatment of cytokines mediated diseases, in mammals, by administration of said compound.

Abstract: The present invention provides a method for obtaining expression of a mixed hepatitis B surface antigen particle, e.g., a particle of mixed polypeptide composition, in yeast. Also disclosed is a method for obtaining multimeric structures presenting two or more polypeptides by expression in yeast as fusion proteins with the S antigen of HBsAg.

Abstract: A display for a flexible head toothbrush includes a first representation of a first bristled portion of a toothbrush head and a second representation of a second bristled portion of a toothbrush head. The first representation is interconnected with the second representation by a mechanical linkage. The mechanical linkage provides oscillatory pivotal movement of the second representation with respect to the first representation. The mechanical linkage is preferably an electromagnet motor, such as a self-starting swinging apparatus, powered by a solar cell. The second representation preferably depicts a tip end of the toothbrush head, while the first representation depicts a remaining portion of the toothbrush head. The display may also include a third representation of at least a portion of a toothbrush handle extending from the first representation. Further, the display may include a support having shelves that hold actual toothbrushes.

Abstract: This invention relates to a new monoargininyl salt form of the endothelin receptor antagonist (E)-3-[1-n-Butyl-5-[2-(2-carboxyphenyl)methoxy-4-chlorophenyl]-1H-pyrazol-4-yl]-2-[(5-methoxy-2,3-dihydrobenzofuran-6-yl)methyl]-prop-2-enoic acid.

Abstract: A process for the preparation of a metal salt of clavulanic acid which comprises the reaction between an organic amine salt of clavulanic acid and a metal salt precursor compound, the reaction taking place in a liquid medium which comprises a liquid florinated and/or chlorinated hydrocarbon.

Abstract: Pharmaceutical formulations for oral administration, comprising a matrix which comprises a &bgr;-lactam antibiotic, a &bgr;-lactamase inhibitor, and granules in a delayed release form dispersed within the matrix which comprise a &bgr;-lactam antibiotic and a &bgr;-lactamase inhibitor.

Abstract: A denture adhesive base composition consisting essentially of polyvinyl pyrrolidone and ethylene oxide polymer. A denture adhesive composition including this base composition is also provided with other optional adhesive components. Also is provided a method for formulating a novel denture adhesive base composition consisting essentially of polyvinyl pyrrolidone and ethylene oxide polymer.

Abstract: Bacterial infections may be treated using a high dosage regimen of amoxycillin. Preferably, the dosage is provided by a bilayer tablet.

Abstract: This invention relates to a process for preparing eprosartan.

Abstract: Rapamycin derivatives; pharmaceutical compositions comprising such rapamycin derivatives and pharmaceutically acceptable carriers or diluents; and methods of using such derivatives to inhibit pathogenic fungi growth, inhibit immunosuppression or treat carcinogenic tumors are disclosed.