Patents Represented by Attorney Stephen Venetianer

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  • Synthesis of intermediate compounds for 4-adyl-5-pyrimidine imidazole substituted derivatives
    Patent number: 6255491
    Abstract: The present invention relates to a method for synthesizing imidazole derivatives having 4-aryl, 5-pyrimidine heterocyclic rings using a cycloaddition reaction.
    Type: Grant
    Filed: January 20, 1999
    Date of Patent: July 3, 2001
    Assignee: SmithKline Beecham Corporation
    Inventor: Joseph Sisko
  • Stable, optically clear compositions
    Patent number: 6251441
    Abstract: Stable aqueous compositions of biologically active oils for the preparation of optically clear products for use in human or animal healthcare, for example beverages, are prepared.
    Type: Grant
    Filed: August 7, 1998
    Date of Patent: June 26, 2001
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Maarten Van Den Braak, Andrew Symonds, Michael Anthony Ford
  • Cycloalkyl substituted imidazoles
    Patent number: 6251914
    Abstract: Novel 1,4,5-substituted imidazole compounds and compositions for use in therapy.
    Type: Grant
    Filed: December 15, 1999
    Date of Patent: June 26, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry Leroy Adams, Jeffrey Charles Boehm, Ravi Shanker Garigipati, Margaret Sorenson
  • Substituted isoquinoline derivatives and their use as anticonvulsants
    Patent number: 6248754
    Abstract: The present invention relates to substituted isoquinoline derivatives and their use as anticonvulsants.
    Type: Grant
    Filed: June 15, 2000
    Date of Patent: June 19, 2001
    Assignee: SmithKline Beecham, p.l.c.
    Inventors: Steven Coulton, Roderick Alan Porter
  • Phenylacetyl-CoA ligase from penicillium chrysogenum
    Patent number: 6245524
    Abstract: A process for preparing an enzyme from Penicillium chrysogenum having Phenylacetate-Coenzyme A activity. DNA encoding for the enzyme is also provided and its use in the production of modified strains.
    Type: Grant
    Filed: February 11, 1998
    Date of Patent: June 12, 2001
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Linden Gledhill, Philip Andrew Greaves, John Patrick Griffin
  • Spherical pharmaceutical granules comprising microcrystalline cellulose and a process for their production
    Patent number: 6242008
    Abstract: A high speed agitation granulator method of preparing a substantially spherical granule for pharmaceutical use comprising a medicament for pharmaceutical use, wherein the medicament has an aqueous solubility of 0.01 to 0.30 g/ml, which method comprises introducing a mixture of medicament and excipients comprising at least 5% crystalline cellulose into the granulator and spraying on water or a mixture of ethanol and water as binder solution; a substantially spherical granule for pharmaceutical use comprising famciclovir and 5% or more crystalline cellulose, together with an optional coating; and a sachet containing a unit dose of famciclovir in the form of such granules.
    Type: Grant
    Filed: July 7, 1998
    Date of Patent: June 5, 2001
    Assignee: SmithKline Beecham Seiyaku K.K.
    Inventors: Hidero Akiyama, Zene Matsumoto, Takashi Ueno
  • Substituted bis-acridines and related compounds as CCR5 receptor ligands, anti-inflammatory agents and anti-viral agents
    Patent number: 6242459
    Abstract: This invention relates to substituted bis-acridines and related compounds which are ligands, in particular, antagonists of the CCR5 receptor. In addition, this invention relates to the treatment and prevention of disease states mediated by CCR5, including, but not limited to, asthma and atopic disorders, rheumatoid arthritis, atherosclerosis, psoriasis, auto immune diseases such as multiple sclerosis, and inflammatory bowel disease, all in mammals, by the use of substituted bis-acridines and related compounds which are CCR5 receptor antagonists. Also, since CCR5 is a co-receptor for the entry of HIV into cells, selective receptor ligands may be useful in the treatment of HIV infection.
    Type: Grant
    Filed: July 2, 1999
    Date of Patent: June 5, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: William E. Bondinell, Valerie A. Reader, Thomas Wen Fu Ku
  • Vitronectin receptor antagonist
    Patent number: 6239138
    Abstract: Compounds of the formula (I): are vitronectin receptor antagonists useful in the treatment of osteoporosis.
    Type: Grant
    Filed: December 8, 1999
    Date of Patent: May 29, 2001
    Assignee: SmithKline Beecham Corporation
    Inventor: Thomas W. Ku
  • Synthesis for 4-aryl-5-pyrimidine imidazole substituted derivatives
    Patent number: 6239279
    Abstract: The present invention relates to a novel method for synthesizing imidazole derivatives having 4-aryl, 5-pyrimidine heterocyclic rings using a novel cycloaddition reaction.
    Type: Grant
    Filed: December 16, 1998
    Date of Patent: May 29, 2001
    Assignee: SmithKline Beecham Corporation
    Inventor: Joseph Sisko
  • Indole derivatives as 5-HT receptor antagonist
    Patent number: 6235758
    Abstract: A compound of formula (I) or a salt thereof: wherein: P1 is pyridiyl; P2 is phenyl; A is a bond or a chain of 1 to 5 atoms optionally substituted by C1-6 alkyl; R1 and R2 groups are each independently hydrogen, C1-6alkyl optionally substituted by NR12R13, C2-6alkenyl, C2-6alkynyl, cyano, halogen, CF3, NR12R13, CHO, OCF3, COR14, CH2OR14 or OR14 where R12, R13 and R14 are independently hydrogen or C1-6alkyl; n and m are independently 0, 1 or 2; R3 is hydrogen or C1-6 alkyl; R4 is a group of formula (i): in which: R6 and R7 are independently hydrogen, C1-6 alkyl optionally substituted by one or more fluorine atoms, C1-6alkylthio, C1-6alkoxy or halogen.
    Type: Grant
    Filed: July 23, 1999
    Date of Patent: May 22, 2001
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Laramie Mary Gaster, Paul Adrian Wyman, Keith Raymond Mulholland, David Thomas Davies, David Malcolm Duckworth, Ian Thomson Forbes, Graham Elgin Jones
  • Treatment for CNS injuries
    Patent number: 6235760
    Abstract: The present invention is directed to the use of 2,4,5-trisubstituted imidazole compounds and compositions in the treatment of CNS injuries to the brain.
    Type: Grant
    Filed: September 17, 1998
    Date of Patent: May 22, 2001
    Assignee: SmithKline Beecham Corporation
    Inventor: Giora Z. Feuerstein
  • Process for the fermentative preparation of clavam derivatives whereby the levels of ammonia and urea in the fermentation medium are kept low
    Patent number: 6235506
    Abstract: Improved methods for the preparation of clavams by fermentation of a clavam-producing organism in a suitable medium wherein the ammonium levels are kept low so as to avoid repression of enzymes, particularly urease, are disclosed.
    Type: Grant
    Filed: September 29, 1999
    Date of Patent: May 22, 2001
    Assignee: SmithKline Beecham, p.l.c.
    Inventors: Brian Peter Valentine, Paul Alan Jeffkins, William Henry Holms, David Michael Mousdale
  • Protease inhibitors
    Patent number: 6232342
    Abstract: The present invention provides compounds which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease, hypercalcemia of malignancy; and metabolic bone disease, comprising inhibiting and bone loss or excessive cartilage or matrix degradation by administering to a patient in need thereof a compound of the present invention.
    Type: Grant
    Filed: June 11, 1999
    Date of Patent: May 15, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Thomas Joseph Carr, Renee Louise Desjarlais, Timothy Francis Gallagher, Stacie Marie Halbert, Hye-Ja Oh, Scott Kevin Thompson, Daniel Frank Veber, Dennis Shinji Yamashita, Jack Hwekwo Yen
  • Skin wash compositions comprising triclocarban and surfactants
    Patent number: 6224886
    Abstract: The compositions of the present invention are useful for the topical delivery of a wide variety of active ingredients. These compositions are particularly useful for treating conditions such as acne and its attendant skin lesions, blemishes, and other imperfections. These compositions are nonirritating to the skin and also provide skin feel benefits. These compositions can be in the form of leave-on products and products that are rinsed or wiped from the skin after use.
    Type: Grant
    Filed: December 15, 1998
    Date of Patent: May 1, 2001
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Lynda Rosemary Charlton, Juliet Teresa McGillycuddy
  • Multi-reactor synthesizer and method for combinatorial chemistry
    Patent number: 6224832
    Abstract: Solid phase combinatorial synthesis is carried out in a multi-reactor synthesizer comprising an array of separate reactor cells (1-9) containing a solid reaction support medium (26). Subsets of the reactor cells (1-9) are interconnected with one another in a desired pattern, and, in a first reaction step, reagents (A, B, C) are circulated through the subsets. After the first reaction step is completed, the reactor cells (1-9) are rearranged into a new configuration of the subsets, and the same, or other, reagents (A, B, C) are circulated through the new subsets. The process can be repeated to produce large numbers of compounds differing from one another.
    Type: Grant
    Filed: November 20, 1998
    Date of Patent: May 1, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Michael Lee Moore, Dennis Shinji Yamashita
  • Beta-lactam inhibitors of CoA-IT
    Patent number: 6221860
    Abstract: This invention relates to methods for treating diseases or disorders mediated by lipid inflammatory mediators, arachidonic acid, its metabolites and/or platelet activating factor (PAF), which method comprises administration to a mammal in need thereof of an effective Coenzyme A independent transacylase (CoA-IT) inhibiting amount of a triphenylmethylazetidinone. This invention also relates to a method of treating or reducing inflammation in a mammal in need thereof, which comprises administering to said mammal an effective amount of a triphenylmethylazetidinone.
    Type: Grant
    Filed: November 8, 1999
    Date of Patent: April 24, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: William E. Bondinell, James David Winkler
  • Process of preparing 2-thiopyrimidine aldehyde
    Patent number: 6222036
    Abstract: Novel 1,4,5-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.
    Type: Grant
    Filed: February 11, 2000
    Date of Patent: April 24, 2001
    Assignee: SmithKline Beecham Corporation
    Inventor: Zhi-Qiang Peng
  • Method of promoting smoking cessation
    Patent number: 6218421
    Abstract: A method for promoting smoking cessation, which method comprises administrating an effective, non-toxic amount of ropinirole or a pharmaceutically acceptable salt or solvate thereof to a human in need thereof. Said ropinirole is preferably administered orally or transdermally. Also provided is a medicament for use in smoking cessation that comprises ropinirole. Said medicament may be a tablet for oral use or a transdermal patch containing ropinirole.
    Type: Grant
    Filed: July 1, 1999
    Date of Patent: April 17, 2001
    Assignee: SmithKline Beecham p.l.c.
    Inventor: Stephen Eldon King
  • Process for making pyridyl and pyrimidine substituted imidazole compounds
    Patent number: 6218537
    Abstract: 1,4,5,-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.
    Type: Grant
    Filed: May 13, 1998
    Date of Patent: April 17, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry Leroy Adams, Timothy Francis Gallagher, Joseph Sisko, Irennegbe Kelly Osifo, Jeffrey Charles Boehm
  • Use of a combination of amoxycillin and clavulanate in the manufacture of a medicament for the treatment drug-resistant Streptococcus pneumoniae
    Patent number: 6214359
    Abstract: Infections potentially caused by DRSP may be treated by a method, which comprises administering to an adult or older child patient a pharmaceutical formulation comprising from 800 to 1100 mg amoxycillin and from 100 to 150 mg clavulanate in a weight ratio between 6:1 and 10:1 inclusive, in combination with a pharmaceutically acceptable carrier or excipient, three times a day (tid).
    Type: Grant
    Filed: November 5, 1999
    Date of Patent: April 10, 2001
    Assignee: SmithKline Beecham p.l.c.
    Inventor: Richard Peregrine Bax