Abstract: New imidazoquinazoline compounds having the general formula ##STR1## wherein A together with the .alpha.-marked carbon atom and the .beta.-marked nitrogen atom is one of the groups ##STR2## wherein R.sup.4, R.sup.5, R.sup.6 and R.sup.7 independently are hydrogen, halogen C.sub.1-6 -alkyl, aryl or aralkylR.sup.1 is ##STR3## cyano or CO.sub.2 R.sup.8, wherein R.sup.8 is hydrogen, C.sub.1-6 -alkyl or C.sub.3-7 -cycloalkyl, trifluoromethyl or C.sub.1-6 -alkoxymethyl,R.sup.2 and R.sup.3 independently are hydrogen, halogen, CN, C.sub.1-6 -alkyl, C.sub.2-6 -alkenyl, C.sub.2-6 -alkynyl, trifluoromethyl, C.sub.1-6 -alkoxy, dialkylaminoalkoxy, aralkoxy, aryloxy which may be substituted with halogen or alkoxy, a cyclic amino group, or NR.sup.9 R.sup.10, wherein R.sup.9 and R.sup.10 independently are hydrogen or C.sub.1-6 -alkyl.

Abstract: Heterocyclic dihydroxyquinoxaline compounds having the formula ##STR1## wherein R.sup.1 is hydroxy, alkoxy, aryloxy, aralkyloxy, cycloalkylalkoxy, cycloalkoxy, or acyloxy;R.sup.5 and R.sup.6 together form a further fused ring, which is substituted with hydrogen, halogen or CN, and R.sup.7 and R.sup.8 independently are hydrogen, NO.sub.2, halogen, CN, SO.sub.2 NR'R', SO.sub.2 R', CF.sub.3, or OR', wherein R' is hydrogen or C.sub.1-4 -alkyl; orR.sup.7 and R.sup.8 together form a further fused ring, which is substituted with hydrogen, halogen or CN, and R.sup.5 and r.sup.6 independently are hydrogen, NO.sub.2, halogen, CN, SO.sub.2 NR'R', SO.sub.2 R', CF.sub.3, or OR', wherein R' is hydrogen or C.sub.1-4 -alkyl.The invention also relates to a method of preparing the compounds, pharmaceutical compositions thereof, and their use.

Abstract: Novel 2, 3, 4, 5-tetrahydro-1H-3-benzazepines, which in the 7-position have a methoxymethyloxy group, in the 8-position hydrogen, halogen, or a nitro group and in the 5-position have an optionally substituted phenyl ortho-fused ring-system, with interesting effects on the central nervous system.

Abstract: Novel combinations of lipase and protease show better lipase stability in detergent solution than prior-art combinations. The lipase is derived from Pseudomonas. The protease can be a Fusarium protease, Subtilisin Novo or certain variants of the latter.

Abstract: Novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which an ether group forms part of the N-substituent, the compounds thus having the general formula I ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and each represents phenyl, 2-thienyl or 3-thienyl, 2-pyrrolyl or 3-pyrrolyl, substituted with one or more substituents selected among the following atoms or groups: hydrogen, halogen, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkoxy or cyano; R.sup.3 and R.sup.4 each represents hydrogen or together represent a bond; m is 1 or 2 and n is 1 when m is 1 and n is 0 when m is 2; R.sup.5 and R.sup.6 each represents hydrogen or may--when m is 2--together represent a bond, and R.sup.7 is OH or C.sub.1 -C.sub.8 -alkoxy, p is 0 or 1 or 2, q is 0 or 1 or 2, R.sup.8 is H and C.sub.1 -C.sub.4 -alkyl, are potent inhibitors of GABA uptake from the synaptic cleft.

Abstract: A diaphragm valve (2) comprising valve seats (11, 12) describing a sector of a sphere providing a complete closure of the inlet (13) and the outlet (14), when the diaphragm (16) assumes the shape of a spherical segment. The valve permits easy and complete cleaning and sterilization and is especially suited for sampling.

Abstract: Heterocyclic dihydroxyquinoxaline compounds having the formula ##STR1## wherein R.sup.1 is hydroxy, alkoxy, aryloxy, aralkyloxy, cycloalkylalkoxy, cycloalkoxy, or acyloxy; andR.sup.5, R.sup.6, R.sup.7 and R.sup.8 independently are hydrogen, NO.sub.2, halogen CN, SO.sub.2 NR'R', SO.sub.2 R', CF.sub.3, or OR', wherein R' is hydrogen or C.sub.1-4 -alkyl;The invention also relates to a method of preparing the compounds, pharmaceutical compositions thereof, and their use.The compounds are useful in the treatment of indications caused by hyperactivity of the excitatory neurotransmitters, particularly the quisqualate receptors, and especially as neuroleptics.

Abstract: The present invention relates to therapeutically active piperidine compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful as stimulants of the cognitive function of the forebrain and hippocampus of mammals and especially in the treatment of Alzheimer's disease.

Abstract: The present invention relates to therapeutically active piperidine compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful as stimulants of the cognitive function of the forebrain and hippocampus of mammals and especially in the treatment of Alzheimer's disease, severe painful conditions and glaucoma.

Abstract: This invention relates to contraceptive devices. More particularly, this invention relates to novel contraceptive devices for males and females which provide immunological barriers to the spread of sexually transmitted diseases along with related methods to prevent the spread of these diseases.

Abstract: The invention relates to 4-pyridone-3-carboxylic acid derivatives, a process for the preparation thereof and pharmaceutical compositions containing same. The 4-pyridone-3-carboxylic acid derivatives are useful as antibacterial agents and/or as agents having a stimulating activity on the central nervous system.

Abstract: A method for the extraction of intact recombinant human immune interferon with guanidine-HCl is disclosed. This method permits the purification to homogenity of intact recombinant human immune interferon.

Abstract: Disclosed herein are methods and means of microbially preparing novel human hybrid leukocyte interferons, useful in the treatment of viral and neoplastic diseases, by DNA recombination of parental interferon genes, taking advantage of common restriction endonuclease cleavage sites therein and in carrier expression plasmids.

Abstract: A method for producing monomeric interferons from oligomeric interferons, for preventing formation of oligomeric interferon from monomeric interferon, and for increasing the yield of monomeric interferon upon purification of interferon is described. The method employs a redox reagent to treat the interferon sample.

Abstract: A convenient, self-contained, disposable device suitable for the rapid identification of microorganisms, having capability for simultaneously carrying out a multiplicity of analytical determinations. The device comprises a disc-shaped arrangement defining a multiplicity of satellite testing chambers each of which is connected to a centrally defined chamber. The central chamber is provided with a movable sleeve or piston arrangement. Liquid sample is received in the central chamber and the sleeve is manipulated to provide samples uniformly and simultaneously to each of the satellite testing chambers without resorting to external means, such as positive or a negative pressurization or centrifugal force. Also disclosed are unique disc-shaped optically transparent support films which are coated on one or both sides with analytical substrates or reagents which are predispensed to the satellite testing chambers.

Abstract: A method, solid-state culture support and culture solution are disclosed which enables successful in vitro culturing of differentiated cells, with significant retention of their differentiated character. Through the use of extra-cellular matrix fibers, specifically derived from connective tissue, as culture substrates, the method also discloses the isolation of the connective tissue fibers and their preparation as a culture substrate. This method provides significantly higher survival and attachment rates, and often significantly improved growth properties for in vitro cultures of differentiated cells, especially epithelial, over the current methods for culturing these cells.This method also significantly enables certain differentiated cells to retain much of their normal enzymatic activities.Furthermore, this method enables certain differentiated cells to retain to a high degree, their ability to secrete substances, such as hormones.

Abstract: A backgammon game is disclosed which accomodates simultaneously two to four players at 10 pieces, men or stones per player, and which gameboard is comprised of four quadrents or tables with seven playing points per table. The 10 pieces in a set are similarly colored, and each set is of a color different from each other set. All the points in a particular quadrant are similarly colored, and the color of the points in each particular quadrant differ from the color in each other quadrant. The color of the points in each quadrant corresponds to the color of the pieces in one of the sets. The backgammon game permits multiple play by four players without a cumbersome board structure and without an unwieldly number of stones per player.

Abstract: A method is disclosed herein for the treatment of parasitic diseases in animals such as birds and mammals, more specifically, in vivo and in vitro treatments of malaria, chagas disease and sleeping sickness with a compound comprising a unit of the formula:R.sub.1 --[--O--C.tbd.N]wherein the N may be single, double or triple bonded with respect to C, wherein R.sub.1 is one selected from the group consisting of alkali metals, ammonium and low molecular weight organo groups selected from the group consisting of alkyl, aryl, aroalkyl and allyl groups, whereby said parasitic infection is either reduced in severity or entirely eliminated. The compounds may comprise isocyanates, cyanate salts and carbamylphosphates.

Abstract: A place mat is disclosed which comprises a paper sheet and a composition coating comprising a blend of water, a water soluable salt, a wax and a polymeric material which both coats and impregnates the paper sheet, whereby said sheet is rendered substantially hydrophobic and it and items placed on it are rendered substantially slip resistant when resting on a tray or table which may be subject to sudden movement. The non-slip place mat is particularly useful for airline serving trays.

Abstract: Antiglobulin control cells are disclosed wherein reagent human red blood cells are coated with univalent antibody fragments. These control cells provide a high degree of specifity in determining the presence of active anti-human sera, which specifity is lacking in conventional Coombs control cells. The evaluation results of the reactivity tests may be performed in the present manner, but the positive hemagglutination provides assurance of anti-human sera activity as opposed to other agglutinating activity, such as protein that might be present.