Patents Represented by Attorney, Agent or Law Firm Steven B. Kelber
  • Patent number: 8021833
    Abstract: The importance of interaction between TSG101 and Vps28 in the release of HIV-1 and other viruses is disclosed. Suppressing or interfering in this interaction may inhibit HIV-1 virion release from infected cells. Agents that modulate this interaction include antibodies that bind to Vps28, polypeptides that bind to Vps28, and nucleic acids that may be used in gene therapy to interfere with the expression of wild type Vps28. Administration of such agents in vitro for screening and diagnostic purposes, and in vivo for diagnostic and therapeutic purposes, is disclosed.
    Type: Grant
    Filed: February 12, 2004
    Date of Patent: September 20, 2011
    Assignees: Functional Genetics, Inc., Johns Hopkins University
    Inventors: Xiao-Fang Yu, Bindong Liu, Limin Li
  • Patent number: 7964708
    Abstract: The present invention provides antibodies that bind to the C-terminal region of TSG101. The invention also provides methods of using the TSG101 antibodies for the treatment of viral infections, including HIV and Ebola virus infection.
    Type: Grant
    Filed: November 15, 2007
    Date of Patent: June 21, 2011
    Inventors: Limin Li, Michael Kinch, Michael Goldblatt, Roxanne Duan
  • Patent number: 7452871
    Abstract: A modified alginate and/or modified pectin composition and method for preventing and/or treating diseases and/or conditions caused by circulating agents such as poisonous heavy metals, environmental toxins, calcium and cholesterol, is provided. The composition includes a modified alginate having a molecular weight of no more than 40,000 daltons and/or a modified pectin having a molecular weight of no more than 40,000 daltons. The method involves orally or intravenously administering the modified alginate and/or modified pectin composition, alone or with excipient.
    Type: Grant
    Filed: November 28, 2005
    Date of Patent: November 18, 2008
    Assignee: EcoNugenics, Inc.
    Inventor: Isaac Eliaz
  • Patent number: 7427468
    Abstract: The present invention provides methods of using antibodies that bind a TSG101 protein to inhibit or reduce viral production. The invention also provides methods of using the TSG101 antibodies for the treatment of viral infections, including HIV infection. The invention further provides methods of detecting viral infected cells using TSG101 antibodies.
    Type: Grant
    Filed: October 1, 2003
    Date of Patent: September 23, 2008
    Assignee: Functional Genetics, Inc.
    Inventor: Limin Li
  • Patent number: 6835816
    Abstract: TSG101 is a tumor susceptibility gene whose homozygous functional knock out in fibroblasts leads to transformation and the ability of these cells to form metastatic tumors in nude mice. The cellular transformation that results from inactivation of TSG101 is reversible by restoration of TSG101 function. Decreased expression of TSG101 is associated with the occurrence of certain human cancers, including breast carcinomas. The TSG101 nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as treatment of cancer, identification of cell type based on expression, and the like.
    Type: Grant
    Filed: March 12, 2001
    Date of Patent: December 28, 2004
    Assignee: The Board of Trustees of the Leland Stanford Jr. University
    Inventors: Stanley N. Cohen, Limin Li
  • Patent number: 6830868
    Abstract: A novel anthracene derivative useful as an additive to a radiation-sensitive resin composition is disclosed. The anthracene derivative has the following formula (1), wherein R1 groups individually represent a hydroxyl group or a monovalent organic group having 1-20 carbon atoms, n is an integer of 0-9, X is a single bond or a divalent organic group having 1-12 carbon atoms, and R2 represents a monovalent acid-dissociable group. The radiation-sensitive resin composition comprises the anthracene derivative of the formula (1), a resin insoluble or scarcely soluble in alkali, but becomes alkali soluble in the presence of an acid, and a photoacid generator. The composition is useful as a chemically-amplified resist for microfabrication utilizing deep ultraviolet rays, typified by a KrF excimer laser and ArF excimer laser.
    Type: Grant
    Filed: March 6, 2003
    Date of Patent: December 14, 2004
    Assignee: JSR Corporation
    Inventors: Tomoki Nagai, Tsutomu Shimokawa
  • Patent number: 6832176
    Abstract: A tracking system and method automatically tracks time spent by end users in different applications on the end users' computers while performing tasks. The time keeping application is integrated with at least some of the applications on the end user computers. This integration allows the time keeping application to detect and track events, such as the opening and closing of files, that signify a change in the task being performed by the end users by receiving messages directly from the other applications being used by the end user. The time keeping software may automatically suggest a categorization for the task based on at least one criteria.
    Type: Grant
    Filed: August 26, 2002
    Date of Patent: December 14, 2004
    Assignee: XI Software
    Inventors: Karen Wynne Hartigan, Samuel Wolfram Hunter, Dennis Evgenievick Loukonine, Brien Francis Morgan, Omid E. Kia
  • Patent number: 6824110
    Abstract: A method and system for automatically activating a train warning device that uses a positioning system such as a global positioning system (GPS) receiver or an inertial navigation system (INS) to determine the train's position. The system further includes a database containing locations of grade crossings and other locations at which a train is required to give a warning signal and what regulations govern activation of the warning device at such locations.
    Type: Grant
    Filed: July 16, 2003
    Date of Patent: November 30, 2004
    Assignee: Quantum Engineering, Inc.
    Inventors: Mark Edward Kane, James Francis Shockley, Harrison Thomas Hickenlooper
  • Patent number: 6825324
    Abstract: The protein tyrosine kinase receptors, designated Rse and HPTK6, have been purified from human and/or murine cell tissues. Rse and HPTK6 have been cloned from a cDNA library of a human liver carcinoma cell line (i.e., Hep 3B) using PCR amplification. Provided herein are nucleic acid sequences encoding Rse and HPTK6 useful as diagnostics and in the recombinant preparation of Rse and HPTK6. Rse and HPTK6 are used in the preparation and purification of antibodies thereto and in diagnostic assays.
    Type: Grant
    Filed: December 30, 1998
    Date of Patent: November 30, 2004
    Assignee: Genentech, Inc.
    Inventors: Kevin P. Baker, Will F. Baron
  • Patent number: 6820762
    Abstract: A rib suitable for use with a storage tank has a “Y” cross sectional shape including a trunk section and branches. Each of the branches includes a substantially flat upper surface for positioning adjacent to a tank wall. The branches together with the tank wall define an annular space which may be used as part of an annular space in a multiple wall tank. The rib preferably includes a high modulus material such as graphite or steel. The high modulus material may be present in the trunk, branches, or both.
    Type: Grant
    Filed: January 7, 2002
    Date of Patent: November 23, 2004
    Assignee: Xerxes Corporation
    Inventor: Robin L. Berg, Sr.
  • Patent number: 6821705
    Abstract: A radiation-sensitive resin composition comprising (A) a compound of the following formula (1), (R1, R2, and R3 is hydrogen, hydroxyl group, or monovalent organic group and R4 is monovalent acid-dissociable group), (B) an alkali insoluble or scarcely soluble resin comprising a recurring unit of the following formula (2), (R5 is hydrogen or monovalent organic group, R′ hydrogen or methyl, n 1-3, m 0-3) and a recurring unit containing acid-dissociable group, and (C) a photoacid generator. The resin composition is useful as a chemically amplified resist, exhibits high sensitivity, resolution, radiation transmittance, and surface smoothness, and is free from the problem of partial insolublization during overexposure.
    Type: Grant
    Filed: April 26, 2002
    Date of Patent: November 23, 2004
    Assignee: JSR Corporation
    Inventors: Tomoki Nagai, Jun Numata, Eiichi Kobayashi, Tsutomu Shimokawa
  • Patent number: 6815304
    Abstract: Silicon carbide bipolar junction transistors having an overgrown base layer are provided. The bipolar junction transistors can be made with a very thin (e.g., 0.3 &mgr;m or less) base layer while still possessing adequate peripheral base resistance values. Self aligning manufacturing techniques for making the silicon carbide bipolar junction transistors are also provided. Using these techniques, the spacing between emitter and base contacts on the device can be reduced. The silicon carbide bipolar junction transistors can also be provided with edge termination structures such as guard rings to increase the blocking capabilities of the device.
    Type: Grant
    Filed: February 22, 2002
    Date of Patent: November 9, 2004
    Assignee: SemiSouth Laboratories, LLC
    Inventors: Igor Sankin, Janna B. Dufrene
  • Patent number: 6809191
    Abstract: The present invention relates to improved methods for the treatment or prevention of disease with gene therapy or vaccines comprising host optimized GM-CSF nucleic acid sequences. More particularly, the invention provides methods for codon optimized GM-CSF with enhanced expression and adjuvant activity ex vivo and in vivo. The present invention also provides for methods of optimizing homologous gene expression ex vivo and in vitro or in transgenic animals.
    Type: Grant
    Filed: July 3, 2002
    Date of Patent: October 26, 2004
    Assignee: Vaxim, Inc.
    Inventors: Jian-Tai Qiu, Wan-Ching Lai, Yong Liang Chu, Frank Q. Li
  • Patent number: 6809821
    Abstract: The present invention relates to a mass-flow sensor that measures the mass flow of conveyed reflective materials, such as cotton, in a stream of air or non-opaque fluid. In particular, the mass-flow sensor of the present invention may be used with a GPS receiver as a cotton yield monitor when mounted on a cotton harvester. It can also be used to measure mass flow of the various cotton component streams in a cotton gin. The mass flow measurements may be made non-intrusively and in real time. The present invention also relates to a method for measuring mass flow using the mass-flow sensor of the present invention.
    Type: Grant
    Filed: March 2, 2001
    Date of Patent: October 26, 2004
    Assignee: Mississippi State University
    Inventors: J. Alex Thomasson, Ruixiu Sui
  • Patent number: 6805134
    Abstract: Tobaccos are cured in a manner so as to provide tobaccos having extremely low tobacco specific nitrosamine (TSNA) contents. Harvested Virginia tobacco is subjected to flue-curing so as to provide flue-cured tobacco. During the curing processing steps, contact of the tobacco with nitric oxide gases, such as those produced as combustion products of propane burning heating units, is avoided. Tobacco in curing barns is not subjected to direct-fire curing techniques, but rather, heat for tobacco curing can be provided by heat exchange or electrical heating methods.
    Type: Grant
    Filed: December 12, 2000
    Date of Patent: October 19, 2004
    Assignee: R. J. Reynolds Tobacco Company
    Inventor: David McCray Peele
  • Patent number: 6806081
    Abstract: The present invention relates to methods and organisms for concentrating and recovering metals and minerals from aqueous media. In the inventive method, a eucaryotic aquatic organism capable of concentrating a metal or mineral is contacted an aqueous medium containing the metal or mineral, in order to concentrate the metal or mineral in the organism. Following concentration, the metal or mineral accumulated by the organism may be recovered. Sponges are very preferable organisms for isolating metals, e.g, gold and silver, from seawater.
    Type: Grant
    Filed: March 20, 2001
    Date of Patent: October 19, 2004
    Inventors: John Shannon, John R. Huffman
  • Patent number: 6803330
    Abstract: A method of nitriding a gate oxide layer by annealing a preformed oxide layer with nitric oxide (NO) gas is disclosed. The nitridation process can be carried out at lower temperatures and pressures than a conventional nitrous oxide anneal while still achieving acceptable levels of nitridation. The nitridation process can be conducted at atmospheric or sub-atmospheric pressures. As a result, the nitridation process can be used to form nitrided gate oxide layers in-situ in a CVD furnace. The nitrided gate oxide layer can optionally be reoxidized in a second oxidation step after the nitridation step. A gate electrode layer (e.g., boron doped polysilicon) can then be deposited on top of the nitrided gate oxide layer or on top of the reoxidized and nitrided gate oxide layer.
    Type: Grant
    Filed: October 12, 2001
    Date of Patent: October 12, 2004
    Assignee: Cypress Semiconductor Corporation
    Inventors: Krishnaswamy Ramkumar, Sundar Narayanan
  • Patent number: 6800414
    Abstract: A radiation-sensitive resin composition comprising an acid-labile group-containing resin and a photoacid generator is disclosed. The resin has a structure of the formula (1), wherein R1 represents a hydrogen atom, a monovalent acid-labile group, an alkyl group having 1-6 carbon atoms which does not have an acid-labile group, or an alkylcarbonyl group having 2-7 carbon atoms which does not have an acid-labile group, X1 represents a linear or branched fluorinated alkyl group having 1-4 carbon atoms, and R2 represents a hydrogen atom, a linear or branched alkyl group having 1-10 carbon atoms, or a linear or branched fluorinated alkyl group having 1-10 carbon atoms. The resin composition exhibits high transmittance of radiation, high sensitivity, resolution, and pattern shape, and is useful as a chemically amplified resist in producing semiconductors at a high yield.
    Type: Grant
    Filed: June 14, 2001
    Date of Patent: October 5, 2004
    Assignee: JSR Corporation
    Inventors: Yukio Nishimura, Noboru Yamahara, Masafumi Yamamoto, Toru Kajita, Tsutomu Shimokawa, Hiroshi Ito
  • Patent number: 6800419
    Abstract: A radiation-sensitive resin composition comprising: (A) an alkali insoluble or scarcely alkali-soluble resin having an acid-dissociable protecting group of the following formula [I], wherein R1 groups are monovalent alicyclic hydrocarbon groups or alkyl groups, provided that at least one of the R1 groups is the monovalent alicyclic hydrocarbon group, or any two of the R1 groups and the carbon atom form a divalent alicyclic hydrocarbon group, (B) a photoacid generator, and (C) propylene glycol monomethyl ether acetate, &ggr;-butyrolactone, and cyclohexanone as solvents. The resin composition is useful as a chemically-amplified resist for microfabrication utilizing deep ultraviolet rays and exhibits excellent film thickness uniformity and storage stability.
    Type: Grant
    Filed: February 21, 2003
    Date of Patent: October 5, 2004
    Assignee: JSR Corporation
    Inventors: Akimasa Soyano, Hiroyuki Ishii, Hidemitsu Ishida, Motoyuki Shima, Yukio Nishimura
  • Patent number: 6800445
    Abstract: Methods for detecting G-protein coupled receptor (GPCR) activity; methods for assaying GPCR activity; and methods for screening for GPCR ligands, G-protein-coupled receptor kinase (GRK) activity, and compounds that interact with components of the GPCR regulatory process are described. Included are methods for expanding ICAST technologies for assaying GPCR activity with applications for ligand fishing, and agonist or antagonist screening. These methods include: engineering seronine/threonine phosphorylation sites into known or orphan GPCR open reading frames in order to increase the affinity of arrestin for the activated form of the GPCR or to increase the reside time of arrestin on the activated GPCR; engineering mutant arrestin proteins that bind to activated GPCRs in the absence of G-protein coupled receptor kinases which may be limiting; and engineering mutant super arrestin proteins that have an increased affinity for activated GPCRs with or without phosphorylation.
    Type: Grant
    Filed: January 16, 2001
    Date of Patent: October 5, 2004
    Assignee: Applera Corporation
    Inventors: Michelle A. J. Palmer, Melissa Gee, Bonnie Tillotson, Xiao-jia Chang