Patents Represented by Attorney, Agent or Law Firm The firm of Gordon W. Hueschen
  • Patent number: 5856356
    Abstract: The invention relates to the use of strontium salts and pharmaceutical compositions thereof for the treatment of arthrosis through stimulation of the synthesis of proteoglycans and type II collagen by chondrocytes.
    Type: Grant
    Filed: June 11, 1997
    Date of Patent: January 5, 1999
    Assignee: Adir et Compagnie
    Inventors: Yannis Tsouderos, Pascale Deloffre, Michel Wierzbicki
  • Patent number: 5853454
    Abstract: Mass flow gravity feed furnace charger apparatus includes (1) a charge-well cover having an aperture and (2) an essentially vertical conduit for forming a substantially vertically-oriented column of metal chips or scrap within and above the aperture, and (3) structure for bringing both (1) and (2) into position above a charge well. The conduit is rapidly moveable up and down to force the metal chips or scrap into molten metal in the charge well even when the dross level at the surface of the molten metal is considerable, so that the apparatus and corresponding method permit charging when gravity feed alone is not sufficient or sufficiently rapid. In a preferred embodiment, the conduit has an interior surface provided with gripping means to assist with the downward movement of metal chips or scrap into the molten metal in the charge well when the up and down motion of the conduit is in effect.
    Type: Grant
    Filed: August 28, 1996
    Date of Patent: December 29, 1998
    Assignee: Premelt Systems, Inc.
    Inventor: Larry D. Areaux
  • Patent number: 5854273
    Abstract: A compound of formula (I) ##STR1## in which: X and Y, which may be identical or different, represent hydrogen or halogen or alkyl, trihaloalkyl, alkoxy, hydroxyl, cyano, nitro, amino, alkylamino, or dialkylamino,Z represent a linear or branched C.sub.4 to C.sub.12 alkylene chain in which one or more --CH.sub.2 -- are optionally replaced by any one of the following atoms or groups: --NR--, --O--, --S--, --SO--, --SO.sub.2 --, or --CONH--,A forms, with two adjacent carbon atoms of the phenyl ring, a phenyl, naphthyl or tetrahydronaphthyl ring or a heterocycle, ##STR2## represents any one of the groups as defined in the description, its optical isomers and its addition salts with a pharmaceutically-acceptable acid or base, and medicinal products containing the same which are useful as anticancer agents.
    Type: Grant
    Filed: July 23, 1997
    Date of Patent: December 29, 1998
    Assignee: ADIR et Compagnie
    Inventors: Gilbert Lavielle, Patrick Hautefaye, Ghanem Atassi, Alain Pierre, Laurence Kraus-Berthier, Stephane Leonce
  • Patent number: 5849745
    Abstract: A compound of formula (I): ##STR1## In which: R.sub.1 represents linear or branched (C.sub.1 -C.sub.6) alkyl,X represents oxygen or sulfur,R.sub.2 represents optionally substituted alkyl, alkoxy, optionally substituted phenyl, optionally substituted cycloalkyl, 4-(2,3-dithiacyclopent-1-yl)butyl, pyridyl or optionally substituted amino or any one of the groups as defined in the description,R.sub.3 represents hydrogen or cycloalkyl, formyl, optionally substituted phenyl, pyridyl or optionally substituted alkyl,the isomers thereof, the addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal compounds containing them are useful for the treatment of chronic or cellular ischemia.
    Type: Grant
    Filed: December 15, 1997
    Date of Patent: December 15, 1998
    Assignee: ADIR et Compagnie
    Inventors: Michel Wierzbicki, Marie-Fran.cedilla.oise Boussard, Serge Labidalle, Daniel Guyot, Yves Rolland, Jean-Paul Tillement, Bernard Testa, Aime Crevat
  • Patent number: 5843945
    Abstract: The present patent application discloses compounds having formula (I) or a pharmaceutically acceptable salt thereof wherein R.sup.1 is hydrogen, alkyl or benzyl; X is O or NOR.sup.2, wherein R.sup.2 is hydrogen, alkyl or benzyl; Y is N--R.sup.4 wherein R.sup.4 is hydrogen, OH or alkyl; n is 0 or 1; R.sup.6 is phenyl, naphthyl, thienyl, pyridyl, all of which may be substituted one or more times with substituents selected from the group consisting of halogen, CF.sub.3, NO.sub.2, amino, alkyl, alkoxy and phenyl; A is a ring of five to seven atoms fused with the benzo ring at the positions marked a and b. The compounds are useful in the treatment of cerebrovascular disorders.
    Type: Grant
    Filed: October 15, 1997
    Date of Patent: December 1, 1998
    Assignee: NeuroSearch A/S
    Inventors: Frank Watjen, Jorgen Drejer
  • Patent number: 5843947
    Abstract: A compound selected from those of formula (I): ##STR1## where m is equal to 0 or 1 and Het, A, X, R,R.sub.1, R.sub.2, R.sub.3, R.sub.4 and the ring ##STR2## are defined in the description, and a medicinal product comprising the same for treating an inflammatory disorder.
    Type: Grant
    Filed: March 26, 1997
    Date of Patent: December 1, 1998
    Assignee: Adir et Compagnie
    Inventors: Jean-Michel Robert, Odile Rideau, Sylvie Robert-Piessard, Jacqueline Courant, Guillaume Le Baut, Daniel-Henri Caignard, Pierre Renard, Gerard Adam
  • Patent number: 5843986
    Abstract: A compound selected from those of formula (I): ##STR1## in which A, Y, R.sup.1, R.sup.2 and R.sup.3 are as defined in the description, and a medicinal product containing the same useful for treating a mammal afflicted with a disorder of the melatoninergic system.
    Type: Grant
    Filed: October 19, 1995
    Date of Patent: December 1, 1998
    Assignee: Adir et Compagnie
    Inventors: Daniel Lesieur, Patrick Depreux, Veronique Leclerc, Hamid Ait Mansour, Philippe Delagrance, Pierre Renard
  • Patent number: 5814622
    Abstract: Compound of formula (I) ##STR1## in which: R.sub.1 and R.sub.2, which are identical or different, represent hydrogen or alkyl or alternatively R.sub.1 and R.sub.2 form, with the carbon atom which bears them, cycloalkyl,R.sub.3 represents hydrogen or alkyl, phenyl or benzyl,R.sub.4 represents:optionally substituted amino, optionally substituted amindino, optionally substituted guanidino, optionally substituted isothioureido, optionally substituted iminomethylamino, mercapto substituted with heterocyclic, or heterocyclic,R.sub.5 and R.sub.6 each represent hydrogen or alkyl, or ##STR2## forms a boronic ester of pinanediol, m represents an integer such that 0.ltoreq.m.ltoreq.6,n represents an integer such that 1.ltoreq.n.ltoreq.6,A represents any one of the following groups:* optionally substituted bicycloalkyl (C.sub.5 -C.sub.10)phenyl,* or a group of formula: ##STR3## A.sub.1 represents --CO--, --CS--, --SO.sub.
    Type: Grant
    Filed: February 27, 1997
    Date of Patent: September 29, 1998
    Assignee: Adir et Compagnie
    Inventors: Guillaume de Nanteuil, Philippe Gloanec, Christine Lila, Bernard Portevin, Tony Verbeuren, Alain Rupin, Serge Simonet
  • Patent number: 5806532
    Abstract: A self-ejecting cigar core or plug cutter having a cylindrical barrel, a slidable cylindrical cutting tube inside the barrel, and a solid cylindrical core member inside the cutting tube, the cutting tube extending rearwardly and being secured to a knob, a spring normally biasing the cutting tube rearwardly so that its forward cutting edge is normally inside the barrel, and an L-slot on opposite sides of the cutting tube, with a pin extending through the slot and through the inner core and being secured at both ends in the barrel, whereby pushing in and turning the knob compresses the spring and forces the forward cutting edge of the cutting tube out of the forward edge of the barrel for cutting a plug out of a cigar, and whereby turning of the knob in the opposite direction releases the forward spring bias and permits the cutting tube to retract into its normal position inside the barrel, the plug cut from the cigar being ejected from the cutting tube by the inner core within the cutting tube upon retraction
    Type: Grant
    Filed: September 11, 1997
    Date of Patent: September 15, 1998
    Inventor: Kurt I. Kuenzel
  • Patent number: 5807882
    Abstract: A compound of formula (I): ##STR1## in which R.sup.1, R.sup.2, X and Y are as defined in the description, the isomers thereof and the addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same are useful in the treatment of certain cancers.
    Type: Grant
    Filed: November 7, 1997
    Date of Patent: September 15, 1998
    Assignee: Adir et Compagnie
    Inventors: Gerard Coudert, Siham Khatib, Pascale Moreau, Daniel-Henri Caignard, Pierre Renard, Ghanem Atassi, Alain Pierre
  • Patent number: 5792789
    Abstract: Acids and esters of diosmetin of formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6 and R.sub.7 are as defined in the description, and the physiologically tolerable salts thereof.The said compounds can be used as medicaments in the treatment of chronic venous insufficiency and any other disorder involving hyperpermeability and/or inflammation.
    Type: Grant
    Filed: April 25, 1997
    Date of Patent: August 11, 1998
    Assignee: Adir et Compagnie
    Inventors: Michel Wierzbicki, Marie-Francoise Boussard, Tony Verbeuren, Marie-Odile Vallez
  • Patent number: 5789412
    Abstract: Novel 5HT receptor antagonists of general formula (I) ##STR1## in which Ar.sub.1 and Ar.sub.2 are aromatic residues, X is O, NH, CH.sub.2 O, or CH.sub.2 NH, and R.sub.1 is hydrogen or linear or branched alkyl comprising 1-6 carbon atoms, as well as their salts, hydrates, solvates, and physiologically-acceptable bioprecursors for their therapeutic use, their geometric and optical isomers, and their mixtures in all proportions and in racemic form, methods for the preparation of these novel antagonists, and their use in the treatment of a living animal and pharmaceutical compositions comprising them.
    Type: Grant
    Filed: January 20, 1997
    Date of Patent: August 4, 1998
    Assignee: Pierre Fabre Medicament
    Inventors: Serge Halazy, Catherine Jorand, Peter Pauwels
  • Patent number: 5786330
    Abstract: The invention relates to the compounds of formula (I) (SEQ ID NO: I:H-phe-A.sub.1 -Arg-Pro-(Gly).sub.4 -Asn-Gly-Asp-Phe-Glu-Abo-Ile-Pro-Glu-Glu-A.sub.2 -Leu-glu-OH(I)in which A.sub.1 and A.sub.2 are as defined in the description. Medicinal products containing the same are useful as anticoagulants.
    Type: Grant
    Filed: April 2, 1996
    Date of Patent: July 28, 1998
    Assignee: Adir et Compagnie
    Inventors: Jean-Luc Fauchere, Christophe Thurieau, Tony Verbeuren, Alain Rupin, Serge Simonet
  • Patent number: 5780512
    Abstract: The invention relates to a compounds selected from these of formula (I): ##STR1## in which: R.sub.1, R.sub.2, R.sub.3 and A are as defined in the description, and a medicinal product containing the same useful for treating a melatoninergic disorder.
    Type: Grant
    Filed: March 26, 1997
    Date of Patent: July 14, 1998
    Assignee: Adir et Compagnie
    Inventors: Daniel Lesieur, Eric Fourmaintraux, Patrick Depreux, Philippe Delagrange, Pierre Renard, Beatrice Guardiola-Lemaitre
  • Patent number: 5780493
    Abstract: The present patent application discloses compounds having formula (I) or a pharmaceutically acceptable salt thereof wherein R.sup.1 is hydrogen, alkyl or benzyl; X is O or NOR.sup.2, wherein R.sup.2 is hydrogen, alkyl or benzyl; Y is N--R.sup.4 wherein R.sup.4 is hydrogen, OH or alkyl; n is 0 or 1; R.sup.6 is phenyl, naphthyl, thienyl, pyridyl, all of which may be substituted one or more times with substituents selected from the group consisting of halogen; CF.sub.3, NO.sub.2, amino, alkyl, alkoxy and phenyl; A is a ring of five to seven atoms fused with the benzo ring at the positions marked a and b. The compounds are useful in the treatment of cerebrovascular disorders for example.
    Type: Grant
    Filed: October 16, 1997
    Date of Patent: July 14, 1998
    Assignee: NeuroSearch A/S
    Inventors: Frank Watjen, Jorgen Drejer
  • Patent number: 5780474
    Abstract: Compounds of formula: ##STR1## wherein: A, m, n, E and Y are as defined in the description, the optical isomers thereof and the physiologically-tolerable salts thereof.These compounds, their optical isomers and their physiologically-tolerable salts, can be used as medicaments in the treatment of psychotic disorders, anxio-depressive disorders, and aggressiveness.
    Type: Grant
    Filed: June 3, 1997
    Date of Patent: July 14, 1998
    Assignee: Adir et Compagnie
    Inventors: Jean-Louis Peglion, Mark Millan, Mauricette Brocco, Valerie Audinot
  • Patent number: 5776935
    Abstract: Pyridyl-phtalazin diones having the following formula: ##STR1## wherein R1 and R2 are selected from the group consisting of hydrogen, halogen, and methoxy or wherein R1 and R2 together form methylenedioxy, and pharmaceutically-acceptable salts thereof, and pharmaceutical compositions containing an effective glycine.sub.B antagonistic amount thereof, are useful in combatting neurological disorders associated with excitotoxicity and malfunctioning of glutamatergic neurotransmission in a living animal, including a human, in need thereof.
    Type: Grant
    Filed: July 25, 1996
    Date of Patent: July 7, 1998
    Assignee: Merz & Co. GmbH & Co.
    Inventors: Wojciech Danysz, Markus Gold, Ivars Kalvinsh, Christopher Graham Raphael Parsons, Irene Piskunova, Eugene Rozhkov
  • Patent number: 5776949
    Abstract: A compound of formula (I): ##STR1## in which: R.sub.1, R.sub.2, R.sub.3, which are identical or different, represent hydrogen, halogen, alkyl, nitro, cyano, aminosulfonyl, imidazolyl, or pyrrolyl, or alternatively, when two of them are situated on adjacent carbons, may form with the carbon atoms to which they are attached a benzene ring on C.sub.3 -C.sub.7 cyloalkylR.sub.4 represents hydroxyl, alkoxy, phenoxy, or amino,their isomers as well as their addition salts with a pharmaceutically-acceptable base, and medicinal products containing the same which are useful as inhibitors of the the pathological phenomena linked to hyperactivation of the neurotransmission pathways by the excitatory amino acids.
    Type: Grant
    Filed: July 10, 1997
    Date of Patent: July 7, 1998
    Assignee: Adir et Compagnie
    Inventors: Alex Cordi, Patrice Desos, Jean Lepagnol, Philippe Morain, Pierre Lestage
  • Patent number: 5776986
    Abstract: A retinal-containing cosmetic skin-care composition comprising an oil-in-water emulsion stabilized by BHT and a method for preparing same.
    Type: Grant
    Filed: September 20, 1996
    Date of Patent: July 7, 1998
    Assignee: Pierre Fabre Dermo-Cosmetique
    Inventors: Emmanuelle Couval, Nicole Peyrot, Nathalie Firmino, Henri Jammes, Valerie Clairand
  • Patent number: 5773075
    Abstract: Principal components of paprika, red pepper, pungent chili, or other plants of the genus Capsicum containing carotenoid pigments are simultaneously extracted and concentrated with an edible solvent in a series of mixing and high temperature and pressure mechanical pressing steps using edible solvent and a countercurrent extraction procedure. The extract containing the carotenoid pigments may be hydrated and then centrifuged to remove fine particulate solids and gums. A solution having several times the concentration of the carotenoid pigments and other flavor and aroma components of the starting raw material is obtained. The residual press solids may be cooled and hydrated following the last pressing operation.
    Type: Grant
    Filed: December 13, 1996
    Date of Patent: June 30, 1998
    Assignee: Kalamazoo Holdings, Inc.
    Inventor: George N. Todd