Patents Represented by Attorney, Agent or Law Firm Thomas D. Hoffman
  • Non-aqueous waterproof oil-based compositions and method of preparing same
    Patent number: 5047232
    Abstract: Non-aqueous waterproof oil-based topical compositions containing one or more water-in-oil emulsifiers having an HLB value of about 1 to about 7, e.g., sorbitan sesquioleate, and at least one cosmetic emollient, e.g., extra heavy mineral oil, as well as methods for making such compositions are disclosed. The waterproof compositions are particularly useful as vehicles for non-aqueous waterproof oil-based topical sunscreen compositions.
    Type: Grant
    Filed: September 29, 1986
    Date of Patent: September 10, 1991
    Assignee: Schering-Plough Healthcare Products, Inc.
    Inventor: Carl Kaplan
  • Tri- and tetra-substituted-oxetanes and tetrahydrofurans and intermediates thereof
    Patent number: 5039676
    Abstract: This invention relates to tri- and tetra-substituted-oxetanes, e.g. (.+-.)-cis- and (.+-.)-trans-2-[(4-(4-isopropylpiperazin-1-yl)phenoxy)methyl]-4-(2,4-dihal ophenyl)-4-[1H-1,2,4-triazol-1-yl)-methyl]oxetane and tri- and tetra-substituted-tetrahydrofurans, e.g. (.+-.)-cis- and (.+-.)-trans-1-[4-[[2-(2,4-dihalophenyl)tetrahydro-2-[(1H-azol-1-yl)methyl ]-5-furanylmethoxy]phenyl]-4-yl-1-substituted piperazine-3-one and related derivatives which exhibit antifungal and antiallergy activities, pharmaceutical composition thereof, methods of their use in treating or preventing susceptible fungal infections and allergic reactions in a host including warm-blooded animals such as humans.
    Type: Grant
    Filed: May 11, 1990
    Date of Patent: August 13, 1991
    Assignee: Schering Corporation
    Inventors: Anil K. Saksena, Viyyoor M. Girijavallabhan, Ashit K. Ganguly, Dinanath F. Rane
  • Pharmaceutical composition and method of treating psychoses
    Patent number: 5026731
    Abstract: A method of treating psychoses in a mammal which comprising administering to a mammal in need of such treating an antipsychotic effective amount of a compound represented by ##STR1## wherein R is a (C.sub.1 -C.sub.9) straight or branched chain alkyl group or a pharmaceutical composition thereof is disclosed.
    Type: Grant
    Filed: June 13, 1990
    Date of Patent: June 25, 1991
    Assignee: Schering Corporation
    Inventors: Vinod R. Hegde, Mahesh G. Patel
  • Actinomadura fulva subsp indica
    Patent number: 5024950
    Abstract: A macrolactam disaccharide isolated from an antimicrobial complex 530 produced in fermentation under controlled conditions using a biologically pure culture of the microorganism Actinomadura fulva subsp. indica ATCC 53714.
    Type: Grant
    Filed: January 3, 1990
    Date of Patent: June 18, 1991
    Assignee: Schering Corporation
    Inventor: Ann C Horan
  • Cup for dyeing eggs
    Patent number: 5009940
    Abstract: A shaped container having therein a water-soluble dyeing composition and a method of dyeing eggs using the shaped containers and a kit containing various shaped containers having therein different water-soluble dyeing compositions.
    Type: Grant
    Filed: May 24, 1989
    Date of Patent: April 23, 1991
    Assignee: Plough, Inc.
    Inventor: James E. McShane
  • Treatment of actinic keratoses with alpha.sub.2 interferon
    Patent number: 5002764
    Abstract: A method of treating actinic keratoses with alpha.sub.2 interferon is disclosed.
    Type: Grant
    Filed: August 22, 1989
    Date of Patent: March 26, 1991
    Assignee: Schering Corporation
    Inventors: Edwin A. Peets, Kenneth A. Smiles, Daniel J. Tanner
  • Sustained release oral suspensions
    Patent number: 4999189
    Abstract: Stable sustained release wax- and polymer-coated drug-ion exchange resin complexes especially useful in preparing oral suspensions are disclosed.
    Type: Grant
    Filed: November 14, 1988
    Date of Patent: March 12, 1991
    Assignee: Schering Corporation
    Inventors: Patricia W. Kogan, Edward M. Rudnic, Joel A. Sequeira, Imtiaz A. Chaudry
  • Preparation of (threo)-1-aryl-2-acylamido-3-fluoro-1-propanols
    Patent number: 4973750
    Abstract: A novel sequence of highly selective chemical reactions for conversion of 3-Aryl-2-propyn-1-ols into cis-1-Aryl-3-fluoro-1-propene and into D,L-(threo)-1-Aryl-2-acylamido-3-fluoro-1-propanols is disclosed. Preparation of D-(threo)-1-Aryl-2-acylamido-3-fluoro-1-propanol antibacterial agents including the D-(threo)-3-fluoro-3-deoxy derivatives of chloramphenicol and thiamphenicol is also disclosed.
    Type: Grant
    Filed: January 23, 1989
    Date of Patent: November 27, 1990
    Assignee: Schering Corporation
    Inventors: Tattanahali L. Nagabhushan, Stuart W. McCombie
  • Fruity flavored nasal decongestant composition
    Patent number: 4970240
    Abstract: An aqueous, flavored, topical, nasal decongestant composition containing an amount of oxymetazoline or a pharmaceutically acceptable salt thereof, e.g., oxymetazoline HCl sufficient to effect nasal decongestion and an amount of a fruity flavor e.g. cherry flavor, sufficient to mask the medicinal after-taste of the composition, together with an aqueous carrier.
    Type: Grant
    Filed: October 18, 1989
    Date of Patent: November 13, 1990
    Assignee: Schering Corporation
    Inventor: James R. Kielley
  • Apparatus for dyeing eggs
    Patent number: 4967687
    Abstract: A shaped container of a size suitable having an insert having a face coated with a dry water-soluble dyeing composition and a method of dyeing eggs using said shaped containers and a kit containing various shaped containers, each having therein different dry water-soluble dyeing compositions.
    Type: Grant
    Filed: December 8, 1988
    Date of Patent: November 6, 1990
    Assignee: Plough, Inc.
    Inventor: James E. McShane
  • Non-cariogenic confections
    Patent number: 4963359
    Abstract: A non-cariogenic confectionery base free of cellulosics and graining compounds containing hydrogenated starch hydrolysates e.g. Lycasin 85%, more than 10 to about 50% by weight of at least one edible oil, fat, wax or mixtures thereof and an emulsifying amount of at least one emulsifier and a method of making same are disclosed. A non-cariogenic confectionery composition containing said confectionery base in homogeneous admixture with a semi-solid matrix containing various ingredients and optionally at least one medicament is also disclosed.
    Type: Grant
    Filed: January 30, 1989
    Date of Patent: October 16, 1990
    Assignee: Plough, Inc.
    Inventors: Joseph Haslwanter, Walter G. Chambliss
  • 3-O-glycosyl 16-membered macrolide antibacterials and related derivatives
    Patent number: 4962146
    Abstract: 3-O-Glycosyl derivatives of 16-membered macrolides such as O-.alpha.-L-cladinosyl-(1.fwdarw.3)-12,13-dehydro-12,13-deoxorosaramicin, 2", 4",4'"-tri-O-acetyl-O-(4'-O-phenoxyacetyl-.alpha.-L-cladinosyl)-(1.fwdarw. 3)-desmyconsin and pharmaceutically acceptable acid addition salts thereof useful as antibacterials are disclosed.
    Type: Grant
    Filed: October 14, 1988
    Date of Patent: October 9, 1990
    Assignee: Schering Corporation
    Inventors: Alan K. Mallams, Randall R. Rossman, Olga Sarre, Viyyoor M. Girijavallabhan, Ashit K. Ganguly
  • Treatment of genital warts with a combination of liquid nitrogen and recombinant DNA human alpha interferon
    Patent number: 4959210
    Abstract: Condylomata Acuminata infections (anogenital warts) are treated in infected patients by administering liquid nitrogen and immediately thereafter beginning administering recombinant DNA human alpha interferon thrice a week for three weeks.The interferon exemplified is recombinant DNA human interferon alfa-2b in which 1.0.times.10.sup.6 International Units are administered by injection to each lesion.The liquid nitrogen is the cryosurgical agent exemplified and it is topically administered to each lesion by conventional means.
    Type: Grant
    Filed: November 1, 1988
    Date of Patent: September 25, 1990
    Assignee: Schering Corporation
    Inventors: Kenneth A. Smiles, Edwin A. Peets, Daniel J. Tanner
  • Antifungal triacetylenic dioxolone from Microbispora sp. SCC 1438, ATCC 53620
    Patent number: 4956383
    Abstract: The novel triacetylenic dioxolone antifungal compound of this invention is isolated from the EV-22 complex of this invention which is elaborated by the microorganism Microbispora sp. SCC 1438, ATCC 53620.
    Type: Grant
    Filed: August 25, 1987
    Date of Patent: September 11, 1990
    Assignee: Schering Corporation
    Inventors: Mahesh G. Patel, Ann C. Horan, Joseph A. Marquez, J. Allan Waitz
  • Non-aqueous high SPF sunscreen oils
    Patent number: 4940574
    Abstract: Non-aqueous sunscreen oils having a high SPF value and containing a volatile oil such as a volatile silicone oil, an emollient containing esters of straight and branched chain C.sub.10 -C.sub.16 alcohols and C.sub.4 -C.sub.20 mono- or dicarboxylic acids such as tridecyl stearate and an ester of a straight or branched-chain C.sub.10 -C.sub.16 alcohol and a tri(loweralkyl) substituted benzoic acid such as tridecyl trimellitate, esters of branched-chain C.sub.5 -C.sub.10 glycols and C.sub.4 -C.sub.20 mono- and dicarboxylic acid such as the diester of neopentyl glycol and decanoic acid and the diester of neopentyl glycol and octanoic acid and a sunscreening effective amount of at least two UV-B type sunscreens and at least one UV-A type sunscreen.
    Type: Grant
    Filed: December 22, 1988
    Date of Patent: July 10, 1990
    Assignee: Plough, Inc.
    Inventor: Carl Kaplan
  • Compositions and methods of decorating firm-rinded fruit
    Patent number: 4919954
    Abstract: A method of decorating the outside surface of a firm-rinded fruit of vines of the genus Cucurbita e.g. a pumpkin with a non-toxic, peelable film of predetermined design which comprises applying to the outer surface of said fruit at least one homogeneous film-forming composition containing a film-forming amount of a non-toxic polyvinyl alcohol polymer, a plasticizer, a volatile solvent ethanol and an amount of a colorant or a mixture of colorants sufficient to mask the color of said fruit, and allowing the solvent to evaporate thereby forming a non-toxic, peelable film of predetermined design on the surface of said fruit.
    Type: Grant
    Filed: December 20, 1988
    Date of Patent: April 24, 1990
    Assignee: Plough, Inc.
    Inventor: James E. McShane
  • Antimicrobial compound isolated from Actinomadura fulva subsp indica
    Patent number: 4904644
    Abstract: A macrolactam disaccharide isolated from an antimicrobial complex 530 produced in fermentation under controlled conditions using a biologically pure culture of the microorganism Actinomadura fulva subsp. indica ATCC 53714.
    Type: Grant
    Filed: August 3, 1988
    Date of Patent: February 27, 1990
    Assignee: Schering Corporation
    Inventors: Vinod R. Hedge, Ann C. Horan, Arthur H. King, Frank A. Gentile, Mahesh G. Patel, Gerald H. Wagman
  • Moveable display rack assembly
    Patent number: 4898283
    Abstract: A movable display assembly for use with a fixed display wall includes a stationary base positioned horizontally in front of and at the lower end of the fixed display wall; a pair of spaced apart parallel tracks extending parallel to the fixed display wall and mounted on the stationary base; a trolley movably mounted on the tracks, each trolley including a plurality of rollers which ride within the tracks and thereby movably support the trolley therealong; an inverted substantially U-shaped rack formed from a tubular member for supporting a plurality of articles thereon, the rack including a lower end fixedly supported on the trolley and an upper free end, with a transparent pegboard supported by the rack for supporting the plurality of articles thereon.
    Type: Grant
    Filed: September 6, 1988
    Date of Patent: February 6, 1990
    Assignee: Plough, Inc.
    Inventor: Ted Kingsford
  • Process, composition and apparatus for cleaning venetian blinds
    Patent number: 4897122
    Abstract: A mobile vehicle containing apparatus and process for on-site cleaning of venetian blinds, and an aqueous spray solution, process and apparatus for eliminating water spots from the washed and rinsed venetian blinds are described.
    Type: Grant
    Filed: March 21, 1988
    Date of Patent: January 30, 1990
    Inventors: A. Charles Schreiber, Robert W. Schreiber
  • Method of treating gynecomastia
    Patent number: 4895715
    Abstract: A method of treating gynecomastia in noncastrated patients being treated with an antiandrogen for androgen-dependent diseases such as benign prostatic hypertrophy, who are in need of such treating comprising administering to such patients therapeutically effective amounts of an antiandrogen, e.g., flutamide, in association with an antiestrogen, e.g., Tamoxifen, or an aromatase inhibitor such as 4-hydroxyadrostenedione is disclosed.
    Type: Grant
    Filed: May 9, 1989
    Date of Patent: January 23, 1990
    Assignee: Schering Corporation
    Inventors: Rudolph Neri, Robert J. Spiegel