Abstract: A dispenser for dispensing metered amounts of a viscous material includes a rigid tube which defines a compartment for the material, a discharge passage at one end of the tube, a push button activated and reciprocatingly movable rod which moves back and forth between two positions in the tube, and a sealing plunger which moves step-wise on the rod, from the push button end to the discharge end. Each activation of the push button expels a metered amount of the viscous material. The plunger is formed of a short inner tube section which makes sealing contact with the rod, an outer tube section which is in sealing contact with the interior surface of the tube and a radially extending, ring-shaped, rib which connects the two sealing tubes to one another. In a preferred embodiment, the radial cross-section of the plunger exhibits and H-shape. A metallic gripper is secured to the plunger and has a free end which is inclined toward the rod.

Abstract: Azetidinones represented by the formula ##STR1## are prepared by a multistep process from L-(-)-theonine via an epoxyamide.

Abstract: Novel compounds including 1-aryl-1-(1H-imidazol-1-ylmethyl)-1,3-dihydroisobenzofurans such as 1-(4-chlorophenyl)-1-(1H-imidazol-1-ylmethyl)-1,3-dihydroisobenzofuran, and 1-aryl-1-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dihydroisobenzofurans are disclosed. The corresponding benzo[c]thiophenes, isochromans, and isothiochromans and antifungal pharmaceutical compositions containing same, and methods of using said pharmaceutical compositions to elicit an antifungal response in warm blooded animals having a susceptible antifungal infection are also disclosed.

Abstract: A multi-step stereospecific process for preparing (3S,4R,5R)-1-(allyloxycarbonyl)-methyl-3-(1-hydroxyethyl)-4-beta-naphthoxy thi ocarbonylthio-2-azetidinone, stereoisomers thereof or hydroxy protected analogs thereof from anhydropenicillin. The azetidinones are intermediates useful for producing penems which are a known group or antibacterial compounds. The process involves protecting the hydroxy group of anhydropenicillin with a readily removable hydroxy protecting group, then reacting the resulting compound by treatment with oxygen and cuprous chloride in methanol, followed by reaction with ozone to produce a hydroxy protected dithiobis azetidinone and convert the methylidene groups originally in the 2-position of anhydropenicillin and in the bis-compound, to a (methoxycarbonyl)-carbonyl group. The resulting compound is converted to the unprotected dithiobis compound by reaction with ammonium hydroxide, then allyliodoacetate followed by an acid.

Abstract: A lipstick composition comprising a gloss-enhancing amount i.e. about 0.5 to about 8 weight percent of isohexadecane in a conventional lipstick formulation is disclosed.

Abstract: Liquid makeup compositions containing an oil-absorbing effective amount of distarch phosphate in an alcohol-free e.g. ethanol-free-liquid makeup formulation which may be anhydrous, an oil-in-water emulsion or a water-in-oil emulsion.

Abstract: A shaped container having therein a water-soluble dyeing composition and a method of dyeing eggs using the shaped containers and a kit containing various shaped containers having therein different water-soluble dyeing compositions.

Abstract: The disclosed invention is compounds represented by the formulaZ--X--Q--Y--W, IZ--X--Q--Y--W'--Y--Q--X--Z IIand pharmaceutically acceptable acid addition salts and quarternary amine salts thereof, whereinZ is phenyl, naphthyl or adamantyl; substituted phenyl wherein the substituents are one or more of halogen, lower alkoxy, phenoxy, nitrile, nitro, phenylsulfonyl, methylsulfonyl, isoxazol-2-yl, lower alkanoyl, benzoyl, lower alkoxycarbonyl, lower alkyl, loweralkylthio, phenyl, phenylaminothiocarbonyl, or lower alkylaminothiocarbonyl; 5 or 6 membered unsubstituted or substituted heterocyclic ring containing at least one nitrogen and one carbon in the ring, wherein the substituents are one or more of carboxyl, hydroxymethyl, loweralkyl, loweralkylcarbonyl or aryl lower alkyl; or tertiary butyl;X and Y are each independently a bond, -O-, ##STR1## Q is a divalent substituted or unsubstituted straight or branched chain lower alkanediyl, -lower alkanedinyl- cycloalkanediyl- lower alkanediyl-, lower alkendiyl, lower

Abstract: There are disclosed novel di- and tri-O-acetyl-23-O-demycinosyl-4"-O-iso-valeryltylosins and the pharmaceutically acceptable salts thereof, which have improved activity as antibacterials and provide higher blood levels than other tylosin derived compounds. These compounds have the following structural formula ##STR1## wherein R is acetyl or hydrogen and z is for example O or ##STR2##Processes for selectively deacylating the 2' and 4"-positions of 3,2',4",4'"-tetra-O-acyltylosin or 2',4",4'"-tri-O-acyltylosin and for the selective acylation of 2',4"-di-O-acyltylosin and 2',4",4'"-tri-O-acyltylosin are also disclosed.

Abstract: Radiation sensitive human cancers are treated with combined interferon and radiation therapy.

Abstract: A loose make-up powder container with a brush inserted into a powder reservoir a short distance but not far enough to reach the powder therein. The brush is loaded by inserting the container, then righting it. The amount of powder loaded on the brush is a function of the area of the brush extending into the reservoir.

Abstract: A multistep process is disclosed for preparing azetidinone intermediates used in the making penems and carbapenems wherein intermediates containing ##STR1## R' is independently hydrogen or 1, 2 or 3 of lower alkyl or lower alkoxy, preferably hydrogen, wherein R" is methyl, ethyl, a phenyl or alkyl, preferably ethyl, as a readily removable nitrogen protecting group are made.

Abstract: A sensor circuit on a face of a ceramic substrate providing reliable continuous monitoring of fluid pressure in a closed chamber, said circuit being used in combination with a wiper arm having two or more contacting points that passes over and maintains continuous electrical contact with conductor contact pads of the circuit and converts the position of the contacting points of the wiper arm to predetermined resistance values which are converted into fluid pressures in a closed chamber, for example, to record the oil pressure in an automobile crankcase.

Abstract: Processes for the production of 6-hydroxyethyl-2-substituted thio penem-3-carboxylates are disclosed as well as novel penems.

Abstract: 12,13-Oxo derivatives of 16-membered macrolides such as tylosin and 23-O-demycinosyltylosin useful as antibacterials are disclosed.

Abstract: There is disclosed antibacterial compounds represented by the formula ##STR1## and pharmaceutically acceptable salts or pharmaceutically acceptable esters thereof,wherein:X represents oxygen, sulfur, ##STR2## wherein R is hydrogen, loweralkyl, acetate or methoxycarbonyl; Y is cis, trans or mixtures thereof and is selected from hydroxy, lower alkoxy, aminocarbamoyloxy, methoxycarbonylamino, lower alkylcarbonyloxy, lower alkylcarbonylamino and loweralkylsulfonylamino; andthe wavy lines indicate cis, trans or mixtures thereof.

Abstract: There are disclosed compositions and methods for treating tumors and viruses in humans by administering a combination of gamma interferon and delta-4 alpha-2 (Bgl II-1)/(Bgl II) alpha-1 hybrid interferon, preferably by injection.

Abstract: The invention relates to an antifungal compound of the following structural formula ##STR1## which is isolated from the AFC complex elaborated by the microorganism Actinomadura sp: nov SCC 1838, ATCC 53656.