Patents Represented by Attorney, Agent or Law Firm Thomas D. Webster
  • Screen for inhibitors of fungal IPC synthase
    Patent number: 5976866
    Abstract: This invention provides novel fungal strains altered in IPC synthase production, and a method for screening for inhibitors of fungal IPC synthase using whole cells.
    Type: Grant
    Filed: April 9, 1997
    Date of Patent: November 2, 1999
    Assignee: Eli Lilly and Company
    Inventors: Steven Alan Heidler, Jeffrey Alan Radding, Debra Ann Young
  • Streptococcus pneumoniae gene sequence FtsY
    Patent number: 5958730
    Abstract: The invention provides isolated nucleic acid compounds encoding FtsY of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said protein.
    Type: Grant
    Filed: December 8, 1997
    Date of Patent: September 28, 1999
    Assignee: Eli Lilly and Company
    Inventors: Paul Luther Skatrud, Robert Brown Peery, Q May Wang, Paul Robert Rosteck, Jr., Michele Louise Young Bellido
  • Biosynthetic gene muri from Streptococcus pneumoniae
    Patent number: 5948645
    Abstract: The invention provides isolated nucleic acid compounds encoding the stem peptide biosynthetic gene murI of Streptococcus pneumoniae. Also provided are vectors and transformed heterologous host cells for expressing the MurI enzyme product and a method for identifying compounds that inhibit stem peptide biosynthesis.
    Type: Grant
    Filed: December 4, 1996
    Date of Patent: September 7, 1999
    Assignee: Eli Lilly and Company
    Inventors: Jo Ann Hoskins, Franklin Harpold Norris, Pamela Kay Rockey, Paul Robert Rosteck, Jr., Paul Luther Skatrud, Patti Jean Treadway, Michele Louise Young Bellido, Chyun-Yeh Earnest Wu
  • Multiple drug resistance gene ATRC of aspergillus nidulans
    Patent number: 5945324
    Abstract: The invention provides isolated nucleic acid compounds encoding a multiple drug resistance protein of Aspergillus nidulans. Vectors and transformed host cells comprising the multiple drug resistance-encoding DNA of Aspergillus nidulans atrC are also provided. The invention further provides assays which utilize these transformed host cells.
    Type: Grant
    Filed: December 23, 1997
    Date of Patent: August 31, 1999
    Assignee: Eli Lilly and Company
    Inventors: Paul Luther Skatrud, Maarten A. de Waard, Alan C. Andrade, Robert Brown Peery
  • Glucosltransferase gene GTFE from amycolatopsis orientalis
    Patent number: 5932464
    Abstract: The invention provides isolated nucleic acid compounds encoding a glycosyltransferase enzyme of Amycolatopsis orientalis. Also provided are vectors carrying genes that encode the enzyme, transformed heterologous host cells for expressing the enzyme, and methods for producing glycopeptide compounds using the cloned genes that encode the enzyme.
    Type: Grant
    Filed: July 21, 1998
    Date of Patent: August 3, 1999
    Assignee: Eli Lilly and Company
    Inventors: Richard H. Baltz, Patricia J. Solenberg, Patti J. Treadway
  • Multiple drug resistance gene atrD of Aspergillus nidulans
    Patent number: 5928898
    Abstract: The invention provides isolated nucleic acid compounds encoding a multiple drug resistance protein of Aspergillus nidulans. Vectors and transformed host cells comprising the multiple drug resistance-encoding DNA of Aspergillus nidulans atrD are also provided. The invention further provides assays which utilize these transformed host cells.
    Type: Grant
    Filed: December 23, 1997
    Date of Patent: July 27, 1999
    Assignee: Eli Lilly and Company
    Inventors: Paul Luther Skatrud, Maarten A. de Waard, Alan C. Andrade, Robert Brown Peery
  • Monofunctional glycosyltransferase gene of Staphylococcus aureus
    Patent number: 5922540
    Abstract: The invention provides isolated nucleic acid compounds encoding a novel MTG of Staphylococcus aureus. Also provided are vectors and transformed heterologous host cells for expressing the MTG and a method for identifying compounds that bind and/or inhibit the enzymatic activity of the MTG.
    Type: Grant
    Filed: December 20, 1996
    Date of Patent: July 13, 1999
    Assignee: Eli Lilly and Company
    Inventors: Jo Ann Hoskins, Stanley R. Jaskunas, Jr., Robert B. Peery, Paul L. Skatrud
  • Potentiation of ?.sup.3 H! 2-(2-benzofuranyl)-2-imidazoline (BFI) binding sites in human tissue by tranylcypromine (TCP)
    Patent number: 5914235
    Abstract: The present invention relates to a process for discovering compounds that modulate novel I.sub.2 binding sites (e.g. BFI binding sites) in human tissue, as well as a process for identifying TCP-like compounds that potentiate BFI binding.
    Type: Grant
    Filed: September 25, 1997
    Date of Patent: June 22, 1999
    Assignee: Eli Lilly and Company
    Inventors: Mitchell Irvin Steinberg, Sally Ann Wiest
  • Streptococcus pneumoniae gene sequence HI1648
    Patent number: 5910580
    Abstract: The invention provides isolated nucleic acid compounds encoding HI1648 of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said protein.
    Type: Grant
    Filed: December 8, 1997
    Date of Patent: June 8, 1999
    Assignee: Eli Lilly and Company
    Inventors: Paul Luther Skatrud, Robert Brown Peery, Patti Jean Treadway
  • Glucosyltransferase gene GTFE from amycolatopsis orientalis
    Patent number: 5871983
    Abstract: The invention provides isolated nucleic acid compounds encoding a glycosyltransferase enzyme of Amycolatopsis orientalis. Also provided are vectors carrying genes that encode said enzyme, transformed heterologous host cells for expressing said enzyme, and methods for producing glycopeptide compounds using the cloned genes that encode said enzyme.
    Type: Grant
    Filed: September 5, 1997
    Date of Patent: February 16, 1999
    Assignee: Eli Lilly and Company
    Inventors: Richard H. Baltz, Patricia J. Solenberg, Patti J. Treadway
  • Biosynthetic gene murD from streptococcus pneumoniae
    Patent number: 5834270
    Abstract: The invention provides isolated nucleic acid compounds encoding the murD stem peptide biosynthetic gene of Streptococcus pneumoniae. Also provided are vectors and transformed heterologous host cells for expressing the MurD enzyme product and a method for identifying compounds that inhibit stem peptide biosynthesis.
    Type: Grant
    Filed: April 14, 1997
    Date of Patent: November 10, 1998
    Assignee: Eli Lilly and Company
    Inventors: Jo Ann Hoskins, Robert Brown Peery, Paul Luther Skatrud, Chyun-Yeh Earnest Wu
  • Monoclonal antibodies to human influx peptide transporter
    Patent number: 5824510
    Abstract: Monoclonal antibodies which react with the human influx peptide transporter are provided. The human influx peptide transporter-reactive antibodies are useful in the purification of influx peptide transporter and in immunoassays to identify agents taken up into the cell by the human influx peptide transporter mechanism. The monoclonal antibodies are also useful for the detection and treatment of carcinomas derived from the gastrointestinal tract and pancreatic duct.
    Type: Grant
    Filed: December 1, 1994
    Date of Patent: October 20, 1998
    Assignee: Eli Lilly and Company
    Inventors: Stuart W. Bright, Anne H. Dantzig, Linda B. Tabas, J. Richard Sportsman
  • Glycosyltransferase gene gtfD from amycolatopsis orientalis
    Patent number: 5821098
    Abstract: The invention provides isolated nucleic acid compounds encoding the glycosyltransferase protein GtfD of Amycolatopsis orientalis. Also provided are vectors carrying the gtfD gene, transformed heterologous host cells for expressing the GtfD protein, and methods for producing glycopeptide compounds using the cloned gtfD gene.
    Type: Grant
    Filed: September 5, 1997
    Date of Patent: October 13, 1998
    Assignee: Eli Lilly and Company
    Inventors: Richard H. Baltz, Patricia J. Solenberg
  • Peptidoglycan biosynthetic gene murE from Streptococcus pneumoniae
    Patent number: 5821096
    Abstract: The invention provides isolated nucleic acid compounds encoding the murE stem peptide biosynthetic gene of Streptococcus pneuinoniae. Also provided are vectors and transformed heterologous host cells for expressing the murE enzyme product and a method for identifying compounds that inhibit stem peptide biosynthesis.
    Type: Grant
    Filed: March 17, 1997
    Date of Patent: October 13, 1998
    Assignee: Eli Lilly and Company
    Inventors: Robert Brown Peery, Paul Luther Skatrud
  • Glycosyltransferase gene GtfC from Amycolatopsis orientalis
    Patent number: 5821097
    Abstract: The invention provides isolated nucleic acid compounds encoding the glycosyltransferase protein GtfC of Amycolatopsis orientalis. Also provided are vectors carrying the gtfC gene, transformed heterologous host cells for expressing the GtfC protein, and methods for producing glycopeptide compounds using the cloned gtfC gene.
    Type: Grant
    Filed: September 5, 1997
    Date of Patent: October 13, 1998
    Assignee: Eli Lilly and Company
    Inventors: Richard H. Baltz, Patricia J. Solenberg
  • Glycosyltransferase gene gtfb from Amycolatopsis orientalis
    Patent number: 5821100
    Abstract: The invention provides isolated nucleic acid compounds encoding the glycosyltransferase protein GtfB of Amycolatopsis orientalis. Also provided are vectors carrying the gtfB gene, transformed heterologous host cells for expressing the GtfB protein, and methods for producing glycopeptide compounds using the cloned gtfB gene.
    Type: Grant
    Filed: September 5, 1997
    Date of Patent: October 13, 1998
    Assignee: Eli Lilly and Company
    Inventors: Richard H. Baltz, Patricia J. Solenberg
  • Glycosyltransferase gene GtfA from Amycolatopsis orientalis
    Patent number: 5821099
    Abstract: The invention provides isolated nucleic acid compounds encoding the glycosyltransferase protein GtfA of Amycolatopsis orientalis. Also provided are vectors carrying the gtfA gene, transformed heterologous host cells for expressing the GtfA protein, and methods for producing glycopeptide compounds using the cloned gtfA gene.
    Type: Grant
    Filed: September 5, 1997
    Date of Patent: October 13, 1998
    Assignee: Eli Lilly and Company
    Inventors: Richard H. Baltz, Patricia J. Solenberg
  • Biosynthetic gene murg from streptococcus pneumoniae
    Patent number: 5821335
    Abstract: The invention provides isolated nucleic acid compounds encoding the stem peptide biosynthetic gene murG of Streptococcus pneumoniae. Also provided are vectors and transformed heterologous host cells for expressing the MurG enzyme product and a method for identifying compounds that inhibit stem peptide biosynthesis.
    Type: Grant
    Filed: November 19, 1996
    Date of Patent: October 13, 1998
    Assignee: Eli Lilly and Company
    Inventors: Jo Ann Hoskins, Paul Luther Skatrud, Robert Brown Peery
  • DNA encoding a novel penicillin binding protein from streptococcus pneumoniae
    Patent number: 5789202
    Abstract: The invention provides isolated nucleic acid compounds encoding a novel high molecular weight PBP of Streptococcus pneumoniae. Also provided are vectors and transformed heterologous host cells for expressing the PBP and a method for identifying compounds that bind and/or inhibit the enzymatic activity of the PBP.
    Type: Grant
    Filed: October 17, 1996
    Date of Patent: August 4, 1998
    Assignee: Eli Lilly and Company
    Inventors: Jo Ann Hoskins, S. Richard Jaskunas, Jr., Pamela K. Rockey, Paul R. Rosteck, Jr., Franklin H. Norris
  • Biosynthetic gene DD1 from Streptococcus pneumoniae
    Patent number: 5776733
    Abstract: The invention provides isolated nucleic acid compounds encoding the stem peptide biosynthetic gene ddl of Streptococcus pneumoniae. Also provided are vectors and transformed heterologous host cells for expressing the DDL enzyme product and a method for identifying compounds that inhibit stem peptide biosynthesis.
    Type: Grant
    Filed: July 25, 1996
    Date of Patent: July 7, 1998
    Assignee: Eli Lilly and Company
    Inventors: Paul L. Skatrud, Robert B. Peery