Abstract: The invention relates to methods for treating or preventing acute and/or septic shock. The method comprises administering to patients in need thereof therapeutically effective amounts of a TNF binding protein and a Fas antigen. In a preferred embodiment, the TNF binding protein is sTNFR-I or sTNFR-II. The invention also relates to pharmaceutical compositions containing a TNF binding protein and a Fas antigen useful in such methods.

Abstract: This invention concerns a family of chimeric antibodies with high affinities to a high molecular weight, tumor-associated sialylated glycoprotein antigen (TAG-72) of human origin. These antibodies have (1) high affinity animal VH and VL sequences which mediate TAG-72 binding and (2) human CH and CL regions. They are thought to produce significantly fewer side-effects when administered to human patients by virtue of their human CH and CL antibody domains. The nucleotide and amino acid sequences of VH&agr;TAG VH, CC46 VH, CC49H, CC83 VH, and CC92 VH, and CC49L, CC83 VL, and CC92 VL idiotype sequences are disclosed, as well as in vivo methods of treatment and diagnostic assay using these chimeric antibodies.

Abstract: A pharmaceutical composition comprising (a) an effective amount of controlled release polymer and (b) an effective amount of a proteinaceous IL-1 inhibitor. The composition exhibits a therapeutic effect on inflammation and is useful for treating IL-1 mediated inflammatory diseases, particularly diseases of the joint.

Abstract: The present invention concerns the purification of keratinocyte growth factors.

Abstract: Based on extensive in vivo studies in animals, it has now been discovered that KGF stimulates proliferation, growth and differentiation in various cells of epithelial tissue, besides keratinocytes. This better understanding of the biological effects of KGF in vivo enables the use of this polypeptide as a therapeutic agent, suitably formulated in a pharmaceutical composition, for the specific treatment of disease states and medical conditions afflicting tissues and organs such as the dermal adnexae, the liver, the lung, and the gastrointestinal tract.

Abstract: A method and pharmaceutical compositions are described for the use of keratinocyte growth factor to treat diabetes mellitus in mammals.

Abstract: Based on extensive in vivo studies in animals, it has now been discovered that KGF stimulates proliferation, growth and differentiation in various cells of epithelial tissue, besides keratinocytes. This better understanding of the biological effects of KGF in vivo enables the use of this polypeptide as a therapeutic agent, suitably formulated in a pharmaceutical composition, for the specific treatment of disease states and medical conditions afflicting tissues and organs such as the dermal adnexae, the liver, the lung, and the gastrointestinal tract.

Abstract: Based on extensive in vivo studies in animals, it has now been discovered that KGF stimulates proliferation, growth and differentiation in various cells of epithelial tissue, besides keratinocytes. This better understanding of the biological effects of KGF in vivo enables the use of this polypeptide as a therapeutic agent, suitably formulated in a pharmaceutical composition, for the specific treatment of disease states and medical conditions afflicting tissues and organs such as the dermal adnexae, the liver, the lung, and the gastrointestinal tract.

Abstract: Dried proteins are stabilized against loss of biological activity in formulations by adding an reconstitution stabilizer upon rehydration of the dried protein. A kit for producing and a formulation produced by dissolving the dried composition in a solvent containing the reconstitution stabilizer is also described.

Abstract: An improved process for isolating A83543 factors from fermentation broth in which they are produced which comprises:a) adding an approximately equal volume of a water miscible, polar organic solvent to the fermentation broth, including the biomass thereof;b) separating the liquid phase of the resulting mixture from the biomass;c) adjusting the pH of the separated liquid phase to between about 7 and 13;d) applying the separated liquid phase directly to a column of nonfunctional, macroreticular polymer;e) eluting the A83543 components from the column with an aqueous solution of water miscible, polar organic solvent; andf) collecting the fractions containing A83543 components.

Abstract: New fermentation products A83543L, A83543M, and A83543N, N-demethyl derivatives thereof, and salts thereof, are useful for the control of insects. A83543PsaL1 is useful for the preparation of A83543 components. Methods for making A83543J, A83543L, A83543M, and A83543N by culture of Saccharopolyspora spinosa NRRL 18719 or NRRL 18720 are provided. Insecticidal and ectoparasiticidal compositions containing A83543L, A83543M, A83543N, and N-demethyl derivatives thereof are also provided.

Abstract: An apparatus and method are taught for the acceleration of a propellable matter at selected target matter.

Abstract: A functionalized polymeric composition, said polymeric composition comprising a first phase and a second phase. The first phase comprises a first copolymer of a monovinylidene monomer and a comonomer selected to have at least one reactive epoxide functionality. The second phase is dispersed with the first phase. The second phase comprises a copolymer of an olefin monomer and one or more ethylenically unsaturated monomers copolymerizable with the olefin monomer wherein at least one of the ethylenically unsaturated monomers copolymerizable with the olefin monomer comprises a reactive functionality capable of reacting with one or more of the reactive epoxide functionalities of the first copolymer.

Abstract: A polymeric polyblend comprising a vinylidene chloride interpolymer and a thermoplastic graft copolymer.

Abstract: The present invention concerns a polymeric composition formed from a vinylidene chloride interpolymer; an olefinic wax and oil and, in one embodiment, a salt of an acid; and in another embodiment, a polyolefin containing up to a minor amount of oxygen, said polyolefin being capable of lowering the frictional coefficient and the mechanical energy to extrude of the polymeric composition.

Abstract: An article for the storage of food products, the body of the article comprising multilayers of different thermoplastic resins which together provide excellent water vapor and gas barrier properties to preserve the food product while in its packaged state. The article contains at least one skin layer, one barrier layer, and a tie layer interposed between each skin layer and the barrier layer. The tie layer contains a graft copolymer formed from a polymerizable mixture comprising a monomer mixture and a preformed polymer which is capable of imbibing the monomer mixture. The preformed polymer is allowed to contact the monomer mixture for a length of time and at a temperature such that enough of the monomer mixture is imbibed therein, and then the polymerizable mixture is polymerized.

Abstract: A polymeric blend composition comprising a vinylidene chloride interpolymer, a copolymer of a monovinylidene aromatic monomer and methyl methacrylate, and, optionally, a polymer formed from one or more monovinylidene aromatic monomers. The polymeric blend compositions of the present invention have been found to possess excellent impact strength and sufficient melt strength and rigidity to be thermoformable.

Abstract: The present invention is a polymeric composition with improved extrudability comprising a vinylidene chloride interpolymer and a Group IIA alkaline-earth hydroxyphosphate, which is incorporated with the vinylidene chloride interpolymer by advance addition, polymer slurry addition or, finally, by dry blending addition. The Group IIA alkaline-earth hydroxyphosphate will be present in an amount of between about 0.01 to about 5 weight percent, said weight percents being based on the total weight of the polymeric composition.

Abstract: Material is supplied to a mold by direct application of gas pressure to a liquid material. A method for the shaping of at least two different synthetic resinous materials by providing a predetermined quantity of up to about 100 cm.sup.3 of a first material in a first material reservoir and a second material in a second material reservoir, the first and second material reservoirs each being in communication with a discharge line having a sufficiently narrow inner diameter such that each reactive quantity may, when propelled by sufficient gas pressure, be propelled in plug flow and each discharge line being in communication with a mold; introducing into each of the first and second gas reservoirs a predetermined volume of a gas at predetermined gas pressures sufficient to propel each quantity of material as turbulently flowing plug into the mold.

Abstract: A nonwoven fibrous batt which is formed by a dry process. The batt is formed by contacting any suitable fiber with an interpolymer of vinylidene chloride and an alkyl acrylate or an alkyl methacrylate. The batt may be formed into a variety of articles.