Patents Represented by Attorney, Agent or Law Firm Thomas J. Dodd
  • Method for treating cancer having greater efficacy and reduced adverse effects
    Patent number: 6596320
    Abstract: A method of treating patients with cancer that involves administration of a combination regimen of a platinum agent, a taxane agent, and a formula I toxicity-reducing agent. The preferred order of administration is the formula I compound, followed by the platinum complex, followed by the taxane agent.
    Type: Grant
    Filed: January 11, 2002
    Date of Patent: July 22, 2003
    Assignee: BioNumerik Pharmaceuticals, Inc.
    Inventor: Frederick H. Hausheer
  • Method of treating atherosclerosis and complications resulting therefrom
    Patent number: 6525037
    Abstract: This invention relates to a method of treating patients afflicted with atherosclerosis or to prevent the development of atherosclerosis in patients assessed to be high risk of developing the disease. The method includes administering to a patient in need of treatment an effective amount of a thiol or reducible disulfide compound according to the formula set forth in the specification.
    Type: Grant
    Filed: February 25, 2000
    Date of Patent: February 25, 2003
    Assignee: BioNumerik Pharmaceuticals, Inc.
    Inventors: Frederick H. Hausheer, Seetharamulu Peddaiahgari
  • Process for synthesizing pharmaceutically active disulfide salts
    Patent number: 6504049
    Abstract: A process for synthesizing pharmaceutically active disulfides, particularly Dimesna and certain derivatives thereof. The process includes reacting an alkylene salt with a sulfurating reagent, then alkalizing the intermediate and flowing oxygen through the mixture to produce the final compound in high yield.
    Type: Grant
    Filed: April 30, 2002
    Date of Patent: January 7, 2003
    Assignee: BioNumerik Pharmaceuticals, Inc.
    Inventor: Harry Kochat
  • Method for reducing development of osteoporosis
    Patent number: 6468993
    Abstract: This invention relates to a method of treating patients afflicted with osteoporosis. The method includes administering to a patient in need of treatment an effective amount of a thiol or reducible disulfide compound according to the formula set forth in the specification.
    Type: Grant
    Filed: October 4, 1999
    Date of Patent: October 22, 2002
    Assignee: BioNumerik Pharmaceuticals, Inc.
    Inventor: Frederick H. Hausheer
  • Methods and formulations for reducing toxicity associated with diabetes treatments
    Patent number: 6468963
    Abstract: Formulations and methods for reducing the unwanted toxicity and complications associated with treatments for diabetes mellitus. The formulations include co-formulations of an anti-diabetic agent and a toxicity reducing agent of the formula described in the specification. The methods include administration of effective amounts of the anti-diabetic agent and the toxicity reducing agent to safely treat the diabetic patient.
    Type: Grant
    Filed: May 1, 2000
    Date of Patent: October 22, 2002
    Assignee: BioNumerik Pharmaceuticals, Inc.
    Inventors: Frederick H. Hausheer, Aulma Parker, Susan E. Hamilton
  • Method of treating snakebite and complications resulting therefrom
    Patent number: 6352979
    Abstract: This invention relates to a method of treating snakebite victims, especially those at risk from neurotoxic effects from snakebite or those already exhibiting symptoms of neurotoxicity. The method includes administering to a patient in need of treatment an effective amount of a thiol or reducible disulfide compound according to the formula set forth in the specification.
    Type: Grant
    Filed: August 20, 2001
    Date of Patent: March 5, 2002
    Inventor: Lucinda Lizcano
  • Method of treating inflammatory bowel disorders
    Patent number: 6291441
    Abstract: This invention relates to a method of treating patients suffering from the inflammatory bowel disorders. The method includes administering to a patient in need of treatment an effective amount of a thiol or reducible disulfide compound according to the formula set forth in the specification.
    Type: Grant
    Filed: September 27, 2000
    Date of Patent: September 18, 2001
    Inventors: Frederick H. Hausheer, Seetharamulu Peddaiahgari
  • Method of treating diabetic ophthalmopathy
    Patent number: 6274622
    Abstract: This invention relates to a method of treating patients afflicted with diabetic ophthalmopathy. The method includes administering to a patient in need of treatment an effective amount of a thiol or reducible disulfide compound according to the formula set forth in the specification.
    Type: Grant
    Filed: October 27, 1999
    Date of Patent: August 14, 2001
    Inventors: Frederick H. Hausheer, Aulma Parker, Seetharamulu Peddaiaghari
  • Method of inhibiting angiogenesis
    Patent number: 6255355
    Abstract: This invention relates to a method of treating patients in need of angiogenesis inhibition. The method includes administering to a patient in need of treatment an effective amount of a thiol or reducible disulfide compound according to the formula set forth in the specification.
    Type: Grant
    Filed: January 6, 2001
    Date of Patent: July 3, 2001
    Inventor: Seetharamulu Peddaiahgari
  • Method of treating diabetic angiopathy
    Patent number: 6251881
    Abstract: This invention relates to a method of treating patients afflicted with diabetic angiopathy. The method includes administering to a patient in need of treatment an effective amount of a thiol or reducible disulfide compound according to the formula set forth in the specification.
    Type: Grant
    Filed: October 21, 1999
    Date of Patent: June 26, 2001
    Inventors: Frederick H. Hausheer, Aulma Parker, Seetharamulu Peddaiaghari
  • Method of treating alcoholism and complications resulting therefrom
    Patent number: 6245815
    Abstract: This invention relates to a method of treating patients afflicted with alcoholism. The method includes administering to a patient in need of treatment an effective amount of a thiol or reducible disulfide compound according to the formula set forth in the specification.
    Type: Grant
    Filed: April 15, 2000
    Date of Patent: June 12, 2001
    Assignee: BioNumerik Pharmaceuticals, Inc.
    Inventor: Seetharamulu Peddaiahgari
  • Method of treating acetaminophen overdose
    Patent number: 6225295
    Abstract: A method of treating patients suffering from acetaminophen overdose is disclosed. The method comprises administering to a patient in need of treatment an effective amount of a thiol or reducible disulfide compound according to the formula set forth in the specification.
    Type: Grant
    Filed: September 27, 2000
    Date of Patent: May 1, 2001
    Inventors: Frederick H. Hausheer, Seetharamulu Peddaiahgari
  • Process for preparing camptothecin
    Patent number: 6218540
    Abstract: A process for preparing the anti-cancer drug camptothecin (CPT) and certain derivatives thereof. The process includes the reacting of three base reagents and a five-step process for synthesizing optically pure CPT in high overall yield from inexpensive starting materials.
    Type: Grant
    Filed: May 4, 1999
    Date of Patent: April 17, 2001
    Assignee: BioNumerik Pharmaceuticals, Inc.
    Inventors: Marco Ciufolini, Frank Roschangar
  • Method of treating septic shock
    Patent number: 6197831
    Abstract: This invention relates to a method of treating patients afflicted with septic shock. The method includes administering to a patient in need of treatment an effective amount of a thiol or reducible disulfide compound according to the formula set forth in the specification.
    Type: Grant
    Filed: February 9, 1999
    Date of Patent: March 6, 2001
    Assignee: BioNumerik Pharmaceuticals, Inc.
    Inventor: Frederick Herman Hausheer
  • Highly lipophilic camptothecin derivatives
    Patent number: 6194579
    Abstract: Novel compounds, formulations and methods of treating patients with cancer are provided for in this invention. The compounds are derivatives of camptothecin, and specifically relate to compounds having novel substitutions at the C-7 position of the camptothecin scaffold B-ring. The formula I compounds are highly lipophilic, lactone stable, do not require metabolic activation, and are potent antineoplastic compounds.
    Type: Grant
    Filed: December 23, 1999
    Date of Patent: February 27, 2001
    Assignee: BioNumerik Pharmaceuticals, Inc.
    Inventor: Frederick H. Hausheer
  • Method for treating heavy metal poisoning
    Patent number: 6177411
    Abstract: This invention relates to a method of treating patients afflicted with heavy metal poisoning. The method includes administering to a patient in need of treatment an antidotal amount of a thiol or reducible disulfide compound according to the formula set forth in the specification.
    Type: Grant
    Filed: February 9, 1999
    Date of Patent: January 23, 2001
    Assignee: BioNumerik Pharmaceuticals, Inc.
    Inventor: Frederick Herman Hausheer
  • Method of treating acute renal failure
    Patent number: 6172119
    Abstract: This invention relates to a method of treating patients afflicted with acute renal failure. The method includes administering to a patient in need of treatment an effective amount of a thiol or reducible disulfide compound according to the formula set forth in the specification.
    Type: Grant
    Filed: February 9, 1999
    Date of Patent: January 9, 2001
    Assignee: BioNumerik Pharmaceuticals, Inc.
    Inventor: Frederick Herman Hausheer
  • Highly lipophilic camptothecin derivatives
    Patent number: 6169080
    Abstract: This invention relates to novel derivatives of camptothecin, and will, particularly to derivatives having a substitution at the C-7 position, or at one of the C-9, C-10, C-11 or C-12 positions, or to disubstituted derivatives having a first substitution at C-7 and a second at one of C-9, C-10, C-11 or C-12. The invention also includes methods of using the compounds as Topoisomerase I inhibitors to treat patients with cancer. The invention also includes pharmaceutical formulations which consist of the novel compounds in solution or suspension with one or more pharmaceutical excipients or dilutes.
    Type: Grant
    Filed: February 11, 1998
    Date of Patent: January 2, 2001
    Assignee: BioNumerik Pharmaceuticals, Inc.
    Inventors: Frederick H. Hausheer, Kochat Haridas, P. Seetharamulu, Dasharatha G. Reddy, Shijie Yao, Pavankumar N.V. Petluru, Dhanabalan Murali
  • Mercaptans and disulfides
    Patent number: 6160167
    Abstract: This invention relates to novel compositions of matter which either terminate in a sulfhydryl moiety or are disulfides. The compounds also include a terminal sulfonate or phosphonate moiety, and have many uses, such as toxicity reducing agents when administered with many antineoplastic agents.
    Type: Grant
    Filed: September 1, 1998
    Date of Patent: December 12, 2000
    Assignee: BioNumerik Pharmaceuticals, Inc.
    Inventors: Frederick H. Hausheer, Kochat Haridas, Qiuli Huang
  • Method for reducing development of free radical induced malignancies
    Patent number: 6143796
    Abstract: This invention relates to a method of treating patients at risk of developing a free radical induced malignancy. The method includes administering an effective amount of a thiol or reducible disulfide compound according to the formula set forth in the specification to a patient at risk.
    Type: Grant
    Filed: September 2, 1999
    Date of Patent: November 7, 2000
    Assignee: BioNumerik Pharmaceuticals, Inc.
    Inventor: Frederick H. Hausheer