Patents Represented by Attorney, Agent or Law Firm Thomas J. Dodd
  • Method of treating diabetic neuropathy
    Patent number: 6100247
    Abstract: This invention relates to a method of treating patients afflicted with diabetic neuropathy. The method includes administering to a patient in need of treatment an effective amount of a thiol or reducible disulfide compound according to the formula set forth in the specification.
    Type: Grant
    Filed: October 21, 1999
    Date of Patent: August 8, 2000
    Assignee: BioNumerik Pharmaceuticals, Inc.
    Inventors: Frederick H. Hausheer, Aulma Parker, Seetharamulu Peddaiaghari
  • Method of treating hangover
    Patent number: 6077838
    Abstract: This invention relates to a method of treating patients afflicted with hangover. The method includes administering to a patient in need of treatment an effective amount of a thiol or reducible disulfide compound according to the formula set forth in the specification.
    Type: Grant
    Filed: June 8, 1999
    Date of Patent: June 20, 2000
    Assignee: BioNumerik Pharmaceuticals, Inc.
    Inventor: Frederick Herman Hausheer
  • Method of reducing or reversing neuropathy
    Patent number: 6075053
    Abstract: This invention relates to a method of treating patients afflicted with peripheral neuropathy. The method includes administering to a patient in need of treatment an effective amount of a thiol or reducible disulfide compound according to the formula set forth in the specification.
    Type: Grant
    Filed: February 9, 1999
    Date of Patent: June 13, 2000
    Assignee: BioNumerik Pharmaceuticals, Inc.
    Inventor: Frederick Herman Hausheer
  • Formulations and methods of reducing toxicity of antineoplastic agents
    Patent number: 6066668
    Abstract: This invention provides for pharmaceutical formulations of compounds which are useful as protective agents when administered to patients also receiving antineoplastic drugs. The invention also includes methods of reducing the toxicity of various antineoplastic agents by administering an effective amount of the protective agent to a patient receiving one or more antineoplastic agents. The compounds useful as protective agents have either a sulfhydryl moiety or are reducible disulfides.
    Type: Grant
    Filed: January 6, 1999
    Date of Patent: May 23, 2000
    Assignee: BioNumerik Pharmaceuticals, Inc.
    Inventors: Frederick H. Hausheer, Thomas J. Dodd
  • Formulations and methods of reducing toxicity of antineoplastic agents
    Patent number: 6066645
    Abstract: This invention provides for pharmaceutical formulations of compounds which are useful as protective agents when administered to patients also receiving antineoplastic drugs. The invention also includes methods of reducing the toxicity of various antineoplastic agents by administering an effective amount of the protective agent to a patient receiving one or more antineoplastic agents. The compounds useful as protective agents have either a sulfhydryl moiety or are reducible disulfides.
    Type: Grant
    Filed: January 6, 1999
    Date of Patent: May 23, 2000
    Assignee: BioNumerik Pharmaceuticals, Inc.
    Inventors: Frederick H. Hausheer, Thomas J. Dodd
  • Highly lipophilic Camptothecin derivatives
    Patent number: 6057303
    Abstract: Derivatives of Camptothecin are disclosed, particularly derivatives having multiple substitutions at the `A`, `B` and `E` rings thereof. The novel compounds are useful in treating a wide variety of susceptible tumors and are potent inhibitors of Topoisomerase I.
    Type: Grant
    Filed: October 20, 1998
    Date of Patent: May 2, 2000
    Assignee: BioNumerik Pharmaceuticals, Inc.
    Inventors: Kochat Haridas, Frederick H. Hausheer
  • Formulations and methods of reducing toxicity of antineoplastic agents
    Patent number: 6057361
    Abstract: This invention provides for pharmaceutical formulations of compounds which are useful as protective agents when administered to patients also receiving antineoplastic drugs. The invention also includes methods of reducing the toxicity of various antineoplastic agents by administering an effective amount of the protective agent to a patient receiving one or more antineoplastic agents. The compounds useful as protective agents have either a sulfhydryl moiety or are reducible disulfides.
    Type: Grant
    Filed: January 6, 1999
    Date of Patent: May 2, 2000
    Assignee: BioNumerik Pharmaceuticals, Inc.
    Inventors: Frederick H. Hausheer, Thomas J. Dodd
  • Formulations and methods of reducing toxicity of antineoplastic agents
    Patent number: 6048849
    Abstract: This invention provides for pharmaceutical formulations of compounds which are useful as protective agents when administered to patients also receiving antineoplastic drugs. The invention also includes methods of reducing the toxicity of various antineoplastic agents by administering an effective amount of the protective agent to a patient receiving one or more antineoplastic agents. The compounds useful as protective agents have either a sulfhydryl moiety or are reducible disulfides.
    Type: Grant
    Filed: January 6, 1999
    Date of Patent: April 11, 2000
    Assignee: BioNumerik Pharmaceuticals, Inc.
    Inventors: Frederick H. Hausheer, Thomas J. Dodd
  • Formulations and methods of reducing toxicity of antineoplastic agents
    Patent number: 6046234
    Abstract: This invention provides for pharmaceutical formulations of compounds which are useful as protective agents when administered to patients also receiving antineoplastic drugs. The invention also includes methods of reducing the toxicity of various antineoplastic agents by administering an effective amount of the protective agent to a patient receiving one or more antineoplastic agents. The compounds useful as protective agents have either a sulfhydryl moiety or are reducible disulfides.
    Type: Grant
    Filed: January 6, 1999
    Date of Patent: April 4, 2000
    Assignee: BioNumerik Pharmaceuticals, Inc.
    Inventors: Frederick H. Hausheer, Thomas J. Dodd
  • Formulations and methods of reducing toxicity of antineoplastic agents
    Patent number: 6046159
    Abstract: This invention provides for pharmaceutical formulations of compounds which are useful as protective agents when administered to patients also receiving antineoplastic drugs. The invention also includes methods of reducing the toxicity of various antineoplastic agents by administering an effective amount of the protective agent to a patient receiving one or more antineoplastic agents. The compounds useful as protective agents have either a sulfhydryl moiety or are reducible disulfides.
    Type: Grant
    Filed: January 6, 1999
    Date of Patent: April 4, 2000
    Assignee: BioNumerik Pharmaceuticals, Inc.
    Inventors: Frederick H. Hausheer, Thomas J. Dodd
  • Formulations and methods of reducing toxicity of antineoplastic agents
    Patent number: 6043249
    Abstract: This invention provides for pharmaceutical formulations of compounds which are useful as protective agents when administered to patients also receiving antineoplastic drugs. The invention also includes methods of reducing the toxicity of various antineoplastic agents by administering an effective amount of the protective agent to a patient receiving one or more antineoplastic agents. The compounds useful as protective agents have either a sulfhydryl moiety or are reducible disulfides.
    Type: Grant
    Filed: January 6, 1999
    Date of Patent: March 28, 2000
    Assignee: BioNumerik Pharmaceuticals, Inc.
    Inventors: Frederick H. Hausheer, Thomas J. Dodd
  • Method of treating diabetic cardiomyopathy
    Patent number: 6043274
    Abstract: This invention relates to a method of treating patients afflicted with diabetic cardiomyopathy. The method includes administering to a patient in need of treatment an effective amount of a thiol or reducible disulfide compound according to the formula set forth in the specification.
    Type: Grant
    Filed: October 21, 1999
    Date of Patent: March 28, 2000
    Assignee: BioNumerik Pharmaceuticals, Inc.
    Inventors: Frederick H. Hausheer, Aulma Parker, Seetharamulu Peddaiahgari
  • Pharmaceutical formulations of taxanes
    Patent number: 6040330
    Abstract: A pharmaceutical formulation of a taxane antineoplastic agent, particularly paclitaxel or docetaxel or a pharmaceutically acceptable salt thereof, and N-methylpyrrolidin-2-one (NMP). The formulation may include other excipients and/or diluents, and is suitable for administration to patients with cancer.
    Type: Grant
    Filed: January 8, 1999
    Date of Patent: March 21, 2000
    Assignee: BioNumerik Pharmaceuticals, Inc.
    Inventors: Fredrick H. Hausheer, Dhanabalan Murali, Peddaiahgari Seetharamulu
  • Formulations and methods of reducing toxicity of antineoplastic agents
    Patent number: 6040294
    Abstract: This invention provides for pharmaceutical formulations of compounds which are useful as protective agents when administered to patients also receiving antineoplastic drugs. The invention also includes methods of reducing the toxicity of various antineoplastic agents by administering an effective amount of the protective agent to a patient receiving one or more antineoplastic agents. The compounds useful as protective agents have either a sulfhydryl moiety or are reducible disulfides.
    Type: Grant
    Filed: January 6, 1999
    Date of Patent: March 21, 2000
    Assignee: BioNumerik Pharmaceuticals, Inc.
    Inventors: Frederick H. Hausheer, Thomas J. Dodd
  • Formulations and methods of reducing toxicity of antineoplastic agents
    Patent number: 6040312
    Abstract: This invention provides for pharmaceutical formulations of compounds which are useful as protective agents when administered to patients also receiving antineoplastic drugs. The invention also includes methods of reducing the toxicity of various antineoplastic agents by administering an effective amount of the protective agent to a patient receiving one or more antineoplastic agents. The compounds useful as protective agents have either a sulfhydryl moiety or are reducible disulfides.
    Type: Grant
    Filed: January 5, 1999
    Date of Patent: March 21, 2000
    Assignee: BioNumerik Pharmaceuticals, Inc.
    Inventors: Frederick H. Hausheer, Thomas J. Dodd
  • Formulations and methods of reducing toxicity of antineoplastic agents
    Patent number: 6040304
    Abstract: This invention provides for pharmaceutical formulations of compounds which are useful as protective agents when administered to patients also receiving antineoplastic drugs. The invention also includes methods of reducing the toxicity of various antineoplastic agents by administering an effective amount of the protective agent to a patient receiving one or more antineoplastic agents. The compounds useful as protective agents have either a sulfhydryl moiety or are reducible disulfides.
    Type: Grant
    Filed: January 6, 1999
    Date of Patent: March 21, 2000
    Assignee: BioNumerik Pharmaceuticals, Inc.
    Inventors: Frederick H. Hausheer, Thomas J. Dodd
  • Reducing toxic effects of carboplatin using dithioethers
    Patent number: 6037336
    Abstract: To reduce the toxic effect of carboplatin, particularly myelosuppression and emesis, a dithioether having the formula R.sub.1 -(CH.sub.2).sub.n --S--S--(CH.sub.2).sub.m --R.sub.2 (I) wherein:each of R.sub.1 and R.sub.2 individually is SO.sub.3 H or PO.sub.3 H.sub.2 ; andeach of m and n is individually 1, 2, 3 or 4;or a pharmaceutically acceptable salt thereof, preferably disodium 2,2'-dithiobis(ethane sulfonate) (dimesna), is administered in combination with carboplatin to a patient, at substantially the same time or sequentially, whereby the dithioether and the carboplatin become co-present in the blood of the patient. Compositions comprising carboplatin and the dithioether are included in the invention.
    Type: Grant
    Filed: May 10, 1999
    Date of Patent: March 14, 2000
    Assignee: BioNumerik Pharmaceuticals, Inc.
    Inventors: Frederick H. Hausheer, Kochat Haridas, Dhanabalan Murali, Seetharamulu Peddaiahgari, Dasharatha G. Reddy
  • Method for treating glycol poisoning
    Patent number: 6034126
    Abstract: This invention relates to a method of treating patients afflicted with glycol poisoning. The method includes administering to a patient in need of treatment an antidotal amount of a thiol or reducible disulfide compound according to the formula set forth in the specification.
    Type: Grant
    Filed: May 24, 1999
    Date of Patent: March 7, 2000
    Assignee: BioNumerik Pharmaceuticals, Inc.
    Inventor: Frederick Herman Hausheer
  • Method of treating diabetic nephropathy
    Patent number: 6031006
    Abstract: This invention relates to a method of treating patients afflicted with diabetic nephropathy. The method includes administering to a patient in need of treatment an effective amount of a thiol or reducible disulfide compound according to the formula set forth in the specification.
    Type: Grant
    Filed: October 21, 1999
    Date of Patent: February 29, 2000
    Assignee: BioNumerik Pharmaceuticals, Inc.
    Inventors: Frederick H. Hausheer, Aulma Parker, Seetharamulu Peddaiaghari
  • Highly lipophilic camptothecin derivatives
    Patent number: 6028078
    Abstract: Novel compounds, formulations and methods of treating patients with cancer are provided for in this invention. The compounds are derivatives of camptothecin, and specifically relate to compounds having novel substitutions at the C-7 position of the camptothecin scaffold B-ring. The formula I compounds are highly lipophilic, lactone stable, do not require metabolic activation, and are potent antineoplastic compounds.
    Type: Grant
    Filed: October 26, 1998
    Date of Patent: February 22, 2000
    Assignee: BioNumerik Pharmaceuticals, Inc.
    Inventors: Frederick H. Hausheer, Pavankumar N. V. Petluru, Dasharatha Reddy, Dhanabalan Murali, Kochat Haridas, Peddaiahgari Seetharamulu, Shijie Yao