Abstract: A zinc complex of lysocellin is provided. The complex acts as a coccidiostat and growth-promoting agent when administered to poultry.

Abstract: Ring-opened resorcyclic acid lactone derivatives of the formla ##STR1## wherein X is ethylene or ethenylene; Y and Z, which may be the same or different, are methylene, hydroxymethylene or carbonyl; R.sub.1 is hydrogen or lower alkyl of from 1 to about 6 carbon atoms; R.sub.2, R.sub.3, R.sub.4 and R.sub.5, which may be the same or different, are hydrogen, hydroxyl, halogen, nitro, amino or a radical selected from the group consisting of --R', --OR', --COOR' and --OCOR' wherein R' is lower alkyl of from 1 to about 6 carbon atoms, lower cycloalkyl of from 3 to about 8 carbon atom, alkenyl of from 2 to about 6 carbon atoms, substituted or unsubstituted aryl of from 6 to about 8 carbon atoms, or substituted or unsubstituted aralkyl wherein the alkyl portion contains from 1 to about 6 carbon atoms and the aryl portion contains from 6 to about 8 carbon atoms. These compounds are useful as growth-promotants in food-producing animals.

Abstract: Polyether antibiotic material is liberated from agglomerates containing a lipid material and the polyether antibiotic material by separating the polyether antibiotic from the lipid through formation of an acid salt of the lipid and a desired acid salt of the polyether antibiotic. The agglomerates can be formed during fermentation or produced by adding lipids afterwards.

Abstract: A method for preventing conception in mammals which includes administering to the mammals a composition containing (1) free LHRH or its analog and (2) an immunogenic conjugate between LHRH or its analog and a carrier protein. Free LHRH or its analog acts to prevent conception in the mammal during the period from administration to about 6 weeks; the immunogenic conjugate acts to prevent conception during the period from about 6 weeks after administration until the LHRH antibodies formed in response to the conjugate are metabolized, generally about 0.5-2 years.

Abstract: A method of producing pure and dense amorphous fused synthetic silica. Silica of desired purity is wet pelletized or agglomerated to form particles having an average particle size of between about 5 and 2500 microns. These particles are calcined to volatilize impurities and increase density to at least about 0.9 g/cm.sup.3. Calcined particles are classified by size or reduced in size if desired or needed by grinding in such a way that the purity of the product is maintained.

Abstract: The proteins somatotropin and prolactin are administered to animals in amounts of from about 0.1-24 mg/animal/day to stimulate the immune system by increasing the production of macrophages and augmenting the oxidative metabolism of macrophages. The activated macrophages combat infectious disease causing agents such as viruses, bacteria, fungi, protozoa, helminths, and the like and thus are effective in preventing and treating diseases caused by those agents.

Abstract: A method of producing a high purity silica powder which can be fused to form transparent, bubble-free particles. An ammonium fluosilicate solution is purified preliminarily by removing colloidal-sized silica onto which impurities in the solution have been adsorbed. The high purity powder is produced by ammoniation of an unsaturated aqueous solution of ammonium fluosilicate. Silica powder produced is filtered, washed, and dried before fusion. Additional pre-fusion treatments such as washing, hydrothermal leaching, calcination, and a combination thereof, may be utilized to ensure that the concentration of volatile material is low.

Abstract: Porcine prolactin (pPRL) is administered to poultry in dosages of from about 1-500 ug/kg/day, preferably 10-100 ug/kg/day, to promote growth by improving the rate of weight gain and/or increasing feed utilization efficiency.

Abstract: Somatotropin is administered to food producing animals in the finishing stage of growth to increase fertility by increasing embryonic survival and litter size during the reproductive stage of growth.

Abstract: A device for the continuous administration of a diffusible agent having a relatively rapid rate of diffusion and a diffusible agent having a relatively show rate of diffusion comprises:a wall, formed at least in part by a porous membrane, which surrounds and defines a reservoir, the reservoir comprising:(a) a compartment which comprises the agent having the relatively slow rate of diffusion, wherein said compartment is in direct contact with the porous membrane part of the wall and(b) at least one compartment which comprises the agent having the relatively rapid rate of diffusion, wherein said compartment is not in direct contact with the porous membrane part of the wall and is separated from the compartment comprising the agent having the relatively slow rate of diffusion by a porous partition, such that when said device is exposed to said fluid medium, said agents will diffuse through the porous membrane part of said wall at a substantially steady rate for a prolonged period of time.

Abstract: High purity fused silica particles are made by heating relatively low density silica flour in a high temperature flame. The silica flour feed rate, flame temperature, and collection zone temperature are adjusted to produce an aggregate of surface-bonded fused silica particles. The aggregate is shaped like a honeycomb and can be ground autogenously without introducing impurities into the final product.

Abstract: Novel substituted 2,3-diphenyl-1,2-dihydroquinoxalines are useful for promoting growth and improving feed conversion efficiencies in meat-producing animals. In addition, the novel compounds are useful for controlling coccidiosis in poultry.

Abstract: A method for recovering a recombinant protein from a protein solution containing high molecular weight contaminating proteins by directly adding Group IIA metal salts to the solution in amounts sufficient to selectively precipitate the high molecular weight protein contaminants is disclosed.The high molecular weight precipitates are removed and the solution is further processed to remove low molecular weight contaminating proteins and other non-protein contaminants. The recombinant protein is subsequently recovered and further processed to produce a protein composition suitable for its intended use.

Abstract: The known immunostimulants FK-565 and IL-2 are administered to animals in conjunction to synergistically stimulate the immune system.

Abstract: A process for promoting growth and feed efficiency in food producing animals is provided by administering to such animals, growth promoting amounts of certain forms of lysocellin, including the free acid and physiologically-acceptable salts thereof.Metal complexes of lysocellin can be prepared by adding the appropriate soluble metal salts to a fermentation beer containing lysocellin to thereby form an insoluble, recoverable biomass containing the desired growth-promoting metal salt complex of lysocellin for use in the process herein.

Abstract: A pelletized feed supplement is supplied which effectively increases productivity of animals fed high acid producing diets. The pelletized feed supplement can also be used to neutralize stomach acid of humans and to maintain a proper electrolyte balance. A method is taught of producing the pelletized feed supplement which results in a buffering agent which is dissolved gradually, and has a high buffering capacity.

Abstract: 6' Carbamate esters of zearalanol and its derivatives are used to promote growth in ruminants. The compounds have the structural formula: ##STR1## wherein R.sub.1 and R.sub.2, which may be the same or different, are H, X, or COX, where X is an alkyl group having from 1-6 carbon atoms; and R is NH-Y, where Y is an alkyl group having from 1-6 carbon atoms or a five-membered or six-membered ring; N(C.sub.n H.sub.2n+1).sub.2, where n is an integer from 1 to 6; or a five-membered or six-membered heterocyclic ring having one N heteroatom and up to one other heteroatom selected from the group consisting of N, S, and O heteroatoms.

Abstract: A device for the continuous administration of a beneficial agent to a living being at a substantially steady rate which comprises:(a) a body fluid-contacting layer which comprises a dispersion of an agent which is substantially soluble in the body fluid and a solid matrix material, said matrix material comprising a polymer which is substantially insoluble in said body fluid, and(b) a non-body fluid-contacting layer which comprises said beneficial agent,wherein said body fluid-contacting layer is compression molded to said non-body fluid contacting layer.

Abstract: Crystalline lysocellin compositions, and method of making them. These compounds are useful for promoting growth and feed efficiency in food producing mammals by administering growth promoting amounts of the compounds to such mammals. In particular, the crystalline free acid and the crystalline zinc, copper and manganese of lysocellin can be made according to the disclosed methods.

Abstract: A method for preparing a dried protein product, such that the bioactivity and potential for solubility of the protein are substantially maintained when said product is administered to a living being and contacted with body fluids of said being, which comprises:(a) forming an aqueous solution comprising a mixture of said protein and an ionic detergent and(b) drying said protein-detergent mixture, wherein a sufficient amount of detergent is mixed with said protein in step (a) to substantially fully coat said protein.