Abstract: Novel substituted 2,3-diphenyl-1,2-dihydroquinoxalines are useful for promoting growth and improving feed conversion efficiencies in meat-producing animals. In addition, the novel compounds are useful for controlling coccidiosis in poultry.
Type:
Grant
Filed:
October 21, 1988
Date of Patent:
December 12, 1989
Assignee:
International Minerals & Chemical Corp.
Inventors:
Kurt G. R. Sundelin, Joseph P. Salanitro, Susan Stackhouse
Abstract: Substituted resorcyclic acid esters having the structural formula: ##STR1## wherein R.sub.1 and R.sub.2, which may be the same or different, are H, X, or COX, where X is an alkyl group having from 1-6 carbon atoms; and R.sub.3 is an alkyl group having from 1-12 carbon atoms are synthesized and used as housefly chemosterilants which reduce housefly fecundity.
Abstract: A microorganism of the genus Pseudomonas (ATCC 53716) metablizes cinnamate to produce acetophenone in a receoverable quantity upon fermentation in an aqueous nutrient medium containing cinnamate as a carbon source and, optionally, assimilable sources of nitrogen and inorganic substances.
Abstract: A process for purifying lysocellin which comprises mixing lysocellin solids with sufficient halogen acid to convert fatty acid ester salt impurities into water-soluble metal halogen salts and water-insoluble free fatty acids and to convert lysocellin salts into water-soluble metal halogen salts and water-insoluble lysocellin acid, separating the halogen salts from the lysocellin acid and fatty acid solids, mixing the lysocellin acid and fatty acid solids with sufficient caustic reagent to convert free fatty acids into water-soluble alkali metal salts and to convert lysocellin acid into a water-insoluble alkali metal lysocellin salts, and separating the water-soluble fatty acid alkali metal salts from the alkali metal lysocellin solids.
Abstract: Apparatus for typically delivering a measured quantity of liquid to a small animal comprising:a spray nozzle for producing an atomized stream of liquid;a syringe in fluid communication with the spray nozzle for delivering a measured quantity of the liquid from a liquid source to the spray nozzle;means for actuating the syringe to deliver the measured quantity of liquid activated by a compressed air signal from a compressed air source;means for regulating the compressed air signal to deliver to the spray nozzle a portion of the compressed air signal for atomizing the measured quantity of liquid; andmeans for transmitting the compressed air signal simultaneously to the actuating means and to the regulating means.
Abstract: A composition for synergistically increasing milk fat production in ruminants comprising (1) pellets which comprise an antacid selected from the group consisting of sodium and magnesium antacids and an electrolyte selected from the group consisting of potassium, sodium, and chlorine containing electrolytes, said pellets containing potassium, sodium, and chlorine in a weight ratio of from about 1.5 to about 1.8 parts of potassium and from about 1.2 to about 1.5 parts of chlorine per part of sodium, said potassium being present in sufficient amount to provide from about 0.8 to about 1 weight parts of potassium per weight part of any magnesium present and (2) sodium bicarbonate.
Abstract: Estriol is administered to ruminants in dosages from about 0.01-4.0 mg/ruminant/day to promote growth and increase feed utilization efficiency.
Type:
Grant
Filed:
February 27, 1987
Date of Patent:
July 25, 1989
Assignee:
International Minerals & Chemical Corp.
Inventors:
Martin J. Jacobs, John Katzenellenbogen
Abstract: Compounds having the formula: ##STR1## wherein R.sub.1 is hydrogen, or an alkyl from about 1 to about 3 carbon atoms; R.sub.2 is hydrogen, or an alkyl from about 1 to about 18 carbon atoms; R.sub.3 is keto, or hydroxyl; and R.sub.4 is hydrogen, an alkyl from about 1 to about 4 carbon atoms, hydroxyl, or amino are synthesized and administered to animals as anabolic agents.
Abstract: Crystallization of trimethylolethane from supersaturated aqueous solutions is inhibited in the presence of effective amounts of methanol and formic acid as crystallization inhibitors.
Abstract: The Resorcylic Acid Lactone (RAL) derivatives zearalenone, zearalanone, zearalene, zearalane, zearalenol, zearalanol, and dideoxyzearalane are administered to vertebrates to non-specifically stimulate the immune system.
Type:
Grant
Filed:
July 3, 1986
Date of Patent:
June 27, 1989
Assignee:
International Minerals & Chemical Corp.
Inventors:
Martin J. Jacobs, Carl K. Edwards, III, Paula Myers-Keith
Abstract: The proteins somatotropin and prolactin are administered to animals in amounts of from about 0.1-24 mg/animal/day to stimulate the immune system by increasing the production of macrophages and augmenting the oxidative metabolism of macrophages. The activated macrophages combat infectious disease causing agents such as viruses, bacteria, fungi, protozoa, helminths, and the like and thus are effective in preventing and treating diseases caused by those agents.
Abstract: A novel strain of attenuated infectious bursal disease virus VR2161, an infectious bursal disease vaccine containing the attenuated infectious bursal disease virus strain, and a method for controlling infectious bursal disease in poultry are disclosed.
Abstract: Growth hormones are admixed with various stabilizers to provide for the decreased formation of insolubles and preservation of the soluble bioactivity of the growth hormone in aqueous environments. Examples of such stabilizers include certain polyols, amino acids, polymers of amino acids having a charged side group at physiological PH, and choline salts.
Type:
Grant
Filed:
May 16, 1986
Date of Patent:
March 28, 1989
Assignee:
International Minerals & Chemical Corp.
Inventors:
Edwin J. Hamilton, Jr., Bruce D. Burleigh
Abstract: Guanidine hydrochloride (GCl) is used to remove excess sodium dodecyl sulfate (SDS) from SDS-solubilized protein solutions, and particularly from SDS-solubilized inclusion body solutions, GCl is added to the solution containing SDS to induce the formation of a GCl-SDS complex (GDS) which, when allowed to precipitate, can easily be removed by centrifugation, filtration, or other suitable means.
Abstract: Human Growth Hormone-Releasing Factor (hGRF) analogs having the sequence [X.sup.3, Y.sup.8, Z.sup.25, Nle.sup.27 ]-hGRF(1-A)--B, wherein X, Y, and Z are selected from the group consisting of Asn and Asp, A has a value from 29-44, and B is NH.sub.2 or OH are synthesized and administered to animals to stimulate the release of Growth Hormone (GH).
Abstract: This invention relates to a method for purifying and concentrating biologically active growth hormone to produce growth hormone in a form suitable for incorporation into a controlled release device (or system). A buffered solution of purified recombinant growth hormone is dialyzed against a buffered solution until the salt level is reduced to less than 5% and then lyophilized.
Abstract: A method for controlling helmintic parasites in animals which comprises administering alone or in combination at least one Resorcylic Acid Lactone (RAL) compound selected from the group consisting of zearalenone, zearalanone, zearalene, zearalane, zearalenol, zearalanol, and dideoxyzearalane to the animal. The RAL compounds are administered to animals infected with or susceptible to infection by helmintic parasites to control the parasite population.
Abstract: Two different ionic forms of somatomedin C (pI 6.4-7.0 and pI 8.3-8.6) are separated and isolated by applying an aqueous solution of somatomedin C to a strong cation-exchange column, eluting the somatomedin C from the column by applying a salt concentration gradient at constant pH and recovering the two ionic forms in different eluant fractions.
Abstract: Porcine serum albumin stabilizes porcine growth hormone, and provided for sustained release of porcine growth hormone in implant devices for swine.
Abstract: Purification and solubilization of proteins produced in transformant microorganisms as insoluble, biologically inactive inclusion bodies is effected by solubilizing the inclusion bodies in SDS; treating the SDS-protein solution with urea; removing the SDS and purifying the protein by chromatography on an anion-exchange resin having cationic groups attached to a polysaccharide support; and dialyzing the solution obtained from the anion-exchange resin to remove urea, thereby allowing the protein to fold into its native conformation. The solution thus obtained can be activated by removing soluble protein aggregates via ultrafiltration or chromatography on a weak anion-exchange column.