Patents Represented by Attorney, Agent or Law Firm Thomas R. Savitsky
  • Penicillin V amidohydrolase gene from Fusarium oxysporum
    Patent number: 5516679
    Abstract: Nucleic acids coding for penicillin V amidohydrolase (PVA) from Fusarium oxysporum. Also, expression vectors, host cells and a method for production of PVA.
    Type: Grant
    Filed: December 23, 1994
    Date of Patent: May 14, 1996
    Assignee: Bristol-Myers Squibb Company
    Inventors: Shu-Jen Chiang, William V. Burnett, Jr., Sean M. Tonzi
  • Enzymatic acylation of 3-hydroxymethyl cephalosporins
    Patent number: 5512454
    Abstract: O-acylated cephalosporins are produced by reacting 3-hydroxymethylcephalosporins with an acyl donor containing at least three carbon atoms and an enzyme which is a Rodosporidium toruloides esterase, a wheat germ lipase, an Aspergillus niger lipase, an orange peel acetylesterase or a Bacillus subtilis esterase. A preferred enzyme is the esterase from Rodosporidium toruloides ATCC 10657. The enzyme can be used while in whole cells or in soluble or inmobilized form.
    Type: Grant
    Filed: February 3, 1994
    Date of Patent: April 30, 1996
    Assignee: Bristol-Myers Squibb Company
    Inventors: John J. Usher, Guna Romancik, Michael Politino, David A. Lowe
  • Calcium fortified beverages
    Patent number: 5500232
    Abstract: Calcium fortified acid beverages. The calcium source is a combination of calcium hydroxide and calcium glycerophosphate and the acidulant is a combination of citric acid and fumaric acid.
    Type: Grant
    Filed: October 6, 1994
    Date of Patent: March 19, 1996
    Assignee: Bristol-Myers Squibb Company
    Inventor: Kim R. Keating
  • Liquid vitamin formulations containing vitamin D esters
    Patent number: 5478816
    Abstract: Liquid vitamin formulation containing an ester of antirachitic vitamin D esterified at the 3 carbon position such as vitamin D.sub.3 palmitate, greater than 252 mg/ml water and at least about 100 mg/ml polyhydroxylated solvent such as glycerine. The formulations have improved taste and improved storage stability.
    Type: Grant
    Filed: July 2, 1993
    Date of Patent: December 26, 1995
    Assignee: Bristol-Myers Squibb Company
    Inventor: Mandar V. Shah
  • Partially hydrolyzed pectin in nutritional compositions
    Patent number: 5472952
    Abstract: The present invention concerns nutritionally complete food compositions which contain partially hydrolyzed pectin. The partially hydrolyzed pectin has a peak molecular weight less than unmodified pectin and greater than 3,300.
    Type: Grant
    Filed: March 18, 1993
    Date of Patent: December 5, 1995
    Assignee: Bristol-Myers Squibb Company
    Inventors: Carsten R. Smidt, John R. Euber
  • Process for preparing AZT
    Patent number: 5466787
    Abstract: A process for preparing AZT and comprising the steps of:a) reacting a 2'-halo-5'-protected pyrimidinyl 2'-deoxyribonucleoside having a 3'-sulfonyl group with tributyl tin hydride and catalytic amount of azobisisobutyronitrile in an ether, ester, or ketone solvent to yield a dehalogenated pyrimidinyl 2'-deoxyribonucleoside; followed byb) reacting said dehalogentated pyrimidinyl 2'-deoxynucleoside formed in step (a) with a base, a lithium salt, and an azide salt to yield a 5'-protected pyrimidinyl 3'-dideoxy-3'-azido-ribonucleoside; andc) deprotecting the nucleoside derivative of step (b) to yield 3'-dideoxy-3'-azidothymidine.
    Type: Grant
    Filed: November 15, 1993
    Date of Patent: November 14, 1995
    Assignee: Bristol-Myers Squibb Company
    Inventors: Bang-Chi Chen, Sandra L. Quinlan
  • Direct compression cholestyramine tablet and solvent-free coating therefor
    Patent number: 5455047
    Abstract: A directly compressed cholestyramine tablet with a solvent-free coating is disclosed. The inner core of the tablet is made up of cholestyramine agglomerates consisting of numerous small, irregularly-shaped, jagged-edged fragments having relatively few smooth or flat surfaces with a moisture content ranging from about 8 to 14 percent by weight. A process is also disclosed for preparing cholestyramine agglomerates of the invention. The solvent-free coating comprises from about 60 percent to about 95 percent by weight of stearic acid and from about 5 percent to about 40 percent of polyethylene glycol.
    Type: Grant
    Filed: June 15, 1994
    Date of Patent: October 3, 1995
    Assignee: Bristol-Myers Squibb Company
    Inventors: Robert J. Bequette, Bruce A. Bonenberger, Claude E. Gallian, John R. Reckelhoff
  • Nutritional compositions containing vitamin D esters
    Patent number: 5422127
    Abstract: The present invention is directed to nutritional compositions at an acidic to mid pH containing a vitamin D ester, an amino acid source, a carbohydrate source and a certain amount of a lipid source. The compositions have improved vitamin D stability upon storage.
    Type: Grant
    Filed: December 21, 1992
    Date of Patent: June 6, 1995
    Assignee: Bristol-Myers Squibb Company
    Inventors: David G. Dube, John R. Euber, James W. Hansen, Andrew C. Mosier, Jr., Joseph L. Napoli, Jr., Gwen G. Richardson
  • Pradimic acids, amides, and novel pradimicin derivatives
    Patent number: 5414073
    Abstract: The present invention relates to intermediates, pradimic acids and pradimic acid amides of the formula (II) ##STR1## wherein R is OH or NH.sub.2 ; R.sup.1 is hydrogen or a group of the formula ##STR2## with the proviso that when R is OH, R.sup.1 is not hydrogen; Y is OH or NR.sup.2 R.sup.3 ; R.sup.2 is hydrogen or methyl; R.sup.3 is hydrogen, C.sub.1-5 alkyl, or an amino protecting group; R.sup.4 is hydrogen, hydroxy protecting group, or .beta.-D-xylosyl. The invention relates also to novel processes for the preparation of pradimic acids and pradimic acid amides, as well as novel pradimicin derivatives prepared therefrom.
    Type: Grant
    Filed: August 3, 1994
    Date of Patent: May 9, 1995
    Assignee: Bristol-Myers Squibb
    Inventors: Satsuki Okuyama, Takaaki Okita, Hajime Kamachi
  • Milk protein partial hydrolysate and infant formula containing same
    Patent number: 5405637
    Abstract: Disclosed is a milk protein partial hydrolysate prepared by enzymatic hydrolysis and infant formula prepared therefrom. The hydrolysate has reduced antigenicity and is prepared from a mixture of whey protein and casein wherein the degree of hydrolysis is between 4 and 10%.
    Type: Grant
    Filed: June 30, 1993
    Date of Patent: April 11, 1995
    Assignee: Bristol-Myers Squibb Company
    Inventors: Sarah B. Martinez, H. Lee Leary, Jr., Debra J. Nichols
  • Stereoselective reduction of ketones
    Patent number: 5391495
    Abstract: The present invention concerns a process for the stereoselective enzymatic reduction of keto group-containing compounds such as N-(4-(2-chloroacetyl)phenyl)methanesulfonamido to form the corresponding hydroxyl-group containing compound. The process is selective for the D(+) enantiomer and is catalyzed by enzymes such as oxido-reductase or dehydrogense, or by microorganisms such as Hansenula, Rhodococcus, or Norcardia species.
    Type: Grant
    Filed: October 27, 1993
    Date of Patent: February 21, 1995
    Assignee: Bristol-Myers Squibb Company
    Inventors: Ramesh N. Patel, Amit Banerjee, Clyde G. McNamee, Laszlo J. Szarka
  • Direct compression cholestyramine tablet and solvent-free coating thereof
    Patent number: 5372823
    Abstract: A directly compressed cholestyramine tablet with a solvent-free coating is disclosed. The inner core of the tablet is made up of cholestyramine agglomerates consisting of numerous small, irregularly-shaped, jagged-edged fragments having relatively few smooth or flat surfaces with a moisture content ranging from about 8 to 14 percent by weight. A process is also disclosed for preparing cholestyramine agglomerates of the invention. The solvent-free coating comprises from about 60 percent to about 95 percent by weight of stearic acid and from about 5 percent to about 40 percent of polyethylene glycol.
    Type: Grant
    Filed: October 22, 1992
    Date of Patent: December 13, 1994
    Assignee: Bristol-Myers Squibb Company
    Inventors: Robert J. Bequette, Bruce A. Bonenberger, Claude E. Gallian, John R. Reckelhoff
  • Pradimicin compounds
    Patent number: 5338728
    Abstract: Disclosed are novel pradimicin compounds which possess antifungal activity and, preferably, improved water solubility. The compounds of the invention are prepared by modifying the 4'-amino or 4'-alkylamino moieties of known pradimicin compounds.
    Type: Grant
    Filed: August 14, 1992
    Date of Patent: August 16, 1994
    Assignee: Bristol-Myers Squibb
    Inventors: Hajime Kamachi, Minoru Hirano, Shinji Masuyoshi
  • Megestrol acetate formulation
    Patent number: 5338732
    Abstract: The present invention relates to a novel oral pharmaceutical composition of micronized megestrol acetate at a concentration of 15 to 150 mg/mL comprising polysorbate at a concentration of 0.005% to 0.015% weight/volume and polyethylene glycol at a concentration of 5-30% weight/volume which composition forms a stable flocculated suspension in water. The invention further comprises the micronized megestrol acetate formulation described above with added preservatives, buffers, sweeteners and flavoring agents.
    Type: Grant
    Filed: May 13, 1992
    Date of Patent: August 16, 1994
    Assignee: Bristol-Myers Squibb Company
    Inventors: Anne E. Atzinger, Robert J. Bequette, Robert E. Davis
  • Compounds produced by a strain of Streptomyces exfoliatus
    Patent number: 5332574
    Abstract: Disclosed are active compounds BU-4726G-A and BU-4726G-B which contain a quinone chromophore and hydroquinone chromophore, respectively. The compounds are produced by fermentation of Streptomyces exfoliatus AA4510. The compounds possess antimicrobial, and K.sub.ATP channel blocking activities.
    Type: Grant
    Filed: February 11, 1993
    Date of Patent: July 26, 1994
    Assignee: Bristol-Myers Squibb Company
    Inventors: Koko Sugawara, Koji Tomita, Michael R. Kozlowski, Yosuke Sawada
  • Pradimic acids, amides, and pradimicin derivatives
    Patent number: 5326867
    Abstract: The present invention relates to intermediates, pradimic acids and pradimic acid amides of the formula (II) ##STR1## wherein R is OH or NH.sub.2 ; R.sup.1 is hydrogen or a group of the formula ##STR2## with the proviso that when R is OH, R.sup.1 is not hydrogen; Y is OH or NR.sup.2 R.sup.3 ; R.sup.2 is hydrogen or methyl; R.sup.3 is hydrogen, C.sub.1-5 alkyl, or an amino protecting group; R.sup.4 is hydrogen, hydroxy protecting group, or .beta.-D-xylosyl. The invention relates also to novel processes for the preparation of pradimic acids and pradimic acid amides, as well as novel pradimicin derivatives prepared therefrom.
    Type: Grant
    Filed: July 16, 1992
    Date of Patent: July 5, 1994
    Assignee: Bristol-Myers Squibb Company
    Inventors: Satsuki Okuyama, Takaaki Okita, Hajime Kamachi
  • Solid-form additive systems dispersible in aqueous media
    Patent number: 5300256
    Abstract: Solid form additive systems which are dispersible in aqueous media are disclosed, as are methods for preparing such additive systems and methods for dispersing such additive systems in aqueous media. Also disclosed are methods for applying additives to polymeric particles and the polymeric particles treated by such methods.
    Type: Grant
    Filed: October 5, 1992
    Date of Patent: April 5, 1994
    Assignee: Eastman Chemical Company
    Inventor: Mahendra K. Sharma
  • Compound produced by a strain of microtetraspora having antibacterial and neuritogenic activity
    Patent number: 5266588
    Abstract: Disclosed is a novel compound, designated BU-4514N, which is produced by cultivation of a novel strain of Microtetraspora, designated species T689-92. The novel compound possesses antibacterial and neuritogenic properties.
    Type: Grant
    Filed: September 25, 1992
    Date of Patent: November 30, 1993
    Assignee: Bristol-Myers Squibb Company
    Inventors: Soichiro Toda, Takashi Tsuno, Satoshi Yamamoto, Toshifumi Hasegawa, Osamu Tenmyo, Mary P. Rosser
  • Tetraamides and method for improving feed utilization
    Patent number: 5208034
    Abstract: Disclosed are novel tetraamide compounds and intermediates therefor which are useful in methods for improving feed conversion and/or weight gain in animals such as chickens.
    Type: Grant
    Filed: August 25, 1992
    Date of Patent: May 4, 1993
    Assignee: Eastman Kodak Company
    Inventors: David C. Herting, Alan W. White
  • Bottle
    Patent number: D360582
    Type: Grant
    Filed: April 21, 1994
    Date of Patent: July 25, 1995
    Assignee: Bristol-Myers Squibb Company
    Inventors: Billy D. McDonald, Donald D. Cochran