Patents Represented by Attorney, Agent or Law Firm Thomas S. Deibert
  • GbpA
    Patent number: 6320036
    Abstract: The invention provides gbpA polypeptides and DNA (RNA) encoding gbpA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing gbpA polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: May 13, 1999
    Date of Patent: November 20, 2001
    Assignee: SmithKline Beecham Corp.
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Raymond Winfield Reichard, Richard Oakley Nicholas, Martin Karl Russel Burnham, Julie M Pratt, Martin Rosenberg, Judith M Ward, Michael Arthur Lonetto, Patrick Vernon Warren
  • Respiratory nitrate reductase alpha subunit
    Patent number: 6316237
    Abstract: The invention provides respiratory nitrate reductase alpha subunit polypeptides and polynucleotides encoding respiratory nitrate reductase alpha subunit polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing respiratory nitrate reductase alpha subunit polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: May 26, 2000
    Date of Patent: November 13, 2001
    Assignee: SmithKline Beecham Corp.
    Inventors: Thomas B Mathie, Christopher M Traini, Stephanie Van Horn, Richard L Warren
  • ThdF
    Patent number: 6316211
    Abstract: The invention provides thdF polynucleotides encoding thdF polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing thdF polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: January 26, 2000
    Date of Patent: November 13, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Sanjoy Biswas, Martin K R Burnham, Stephanie Van Horn, Magdalena Zalacain
  • Yfil pseudouridine synthase
    Patent number: 6312932
    Abstract: The invention provides YfiI pseudouridine synthase polypeptides and polynucleotides encoding YfiI pseudouridine synthase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing YfiI pseudouridine synthase polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: March 24, 2000
    Date of Patent: November 6, 2001
    Assignee: SmithKline Beecham Corporation
    Inventor: David J. Powell
  • DbpB
    Patent number: 6313270
    Abstract: The invention provides dbpB polypeptides and DNA (RNA) encoding dbpB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing dbpB polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: July 12, 1999
    Date of Patent: November 6, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Jianzhong Huang, Damien McDevitt, Christopher M Traini, Min Wang
  • MurC from Streptococcus pneumoniae
    Patent number: 6310193
    Abstract: The invention provides MurC polypeptides and DNA (RNA) encoding MurC polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing MurC polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: September 30, 1997
    Date of Patent: October 30, 2001
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Michael Arthur Lonetto, Richard O Nicholas, Robert King Stodola, Nicola Gail Wallis
  • SigB
    Patent number: 6310192
    Abstract: SigB polypeptides and DNA (RNA) encoding such SigB and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such SigB for the treatment of infection, particularly bacterial infections. Antagonists against such SigB and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of SigB nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding SigB operon and for detecting the polypeptide in a host.
    Type: Grant
    Filed: September 26, 1997
    Date of Patent: October 30, 2001
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham PLC
    Inventors: Andrew P Fosberry, Elizabeth J Lawlor, Richard O Nicholas
  • 6-phosphogluconate dehydrogenase
    Patent number: 6309866
    Abstract: The invention provides 6-phosphogluconate dehydrogenase polypeptides and polynucleotides encoding 6-phosphogluconate dehydrogenase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing 6-phosphogluconate dehydrogenase polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: May 31, 2000
    Date of Patent: October 30, 2001
    Assignee: SmithKline Beecham Corporation
    Inventor: Richard Lloyd Warren
  • Def
    Patent number: 6307022
    Abstract: The invention provides def polypeptides and DNA (RNA) encoding def polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing def polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: June 29, 1999
    Date of Patent: October 23, 2001
    Inventor: Michael Arthur Lonetto
  • Polynucleotides encoding mevalonate kinase from Streptococcus pneumoniae
    Patent number: 6306633
    Abstract: The invention provides mevalonate kinase (hereinafter “MVK”) polypeptides and polynucleotides from Streptococcus pneumoniae encoding mvk polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing mvk polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: February 1, 1999
    Date of Patent: October 23, 2001
    Assignees: SmithKline Beecham Corporation, Public Health Research Institute
    Inventors: Edwina Imogen Wilding, Michael Gwynn, Mihai-Serban Iordanescu
  • Pth
    Patent number: 6303771
    Abstract: The invention provides pth polypeptides and polynucleotides encoding pth polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pth polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: May 18, 1998
    Date of Patent: October 16, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Sanjoy Biswas, James Raymond Brown, Christine Debouck, Deborah Dee Jaworski, Elizabeth Jane Lawlor, Jeffrey Mooney, Lisa Kathleen Shilling, Min Wang, Richard Lloyd Warren, Magdalena Zalacain, Yi Yi Zhong, John Peter Throup, Karen Anne Ingraham, Alison Frances Chalker, David John Holmes, Christopher Michael Traini
  • LicC
    Patent number: 6303571
    Abstract: The invention provides licC polypeptides and polynucleotides encoding licC polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing licC polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: March 17, 2000
    Date of Patent: October 16, 2001
    Inventor: Michael Arthur Lonetto
  • Compounds
    Patent number: 6303124
    Abstract: The invention provides lysS polypeptides and DNA (RNA) encoding lysS polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing lysS polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: January 13, 2000
    Date of Patent: October 16, 2001
    Assignee: SmithKline Beecham Corporation
    Inventor: Elizabeth Jane Lawlor
  • Tarf
    Patent number: 6299883
    Abstract: The invention provides tarF polypeptides and DNA (RNA) encoding tarF polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tarF polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: January 28, 1999
    Date of Patent: October 9, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Alison Frances Chalker, Stephanie Van Horn, Andrew Peter Fosberry, Michael Ovari
  • Signal peptidase polypeptides of Staphylococcus aureus
    Patent number: 6300097
    Abstract: spsB polypeptides and DNA (RNA) encoding such spsB and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such spsB for the treatment of infection, particularly bacterial infections. Antagonists against such spsB and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of spsB nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding spsB and for detecting the polypeptide in a host.
    Type: Grant
    Filed: June 25, 1999
    Date of Patent: October 9, 2001
    Assignee: SmithKline Beecham PLC
    Inventors: Michael T. Black, Karen M. O'Dwyer
  • Cell surface protein compounds
    Patent number: 6299880
    Abstract: Novel cell surface protein polypeptides and DNA (RNA) encoding such novel cell surface protein and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such novel cell surface protein for the treatment of infection, particularly bacterial infections. Antagonists against such novel cell surface protein and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of novel cell surface protein nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding cell surface protein family and for detecting the polypeptide in a host.
    Type: Grant
    Filed: August 4, 1999
    Date of Patent: October 9, 2001
    Assignee: SmithKline Beecham PLC
    Inventors: John Edward Hodgson, Martin Karl Russell Burnham
  • Polynucleotides encoding a novel ABC transporter
    Patent number: 6300094
    Abstract: The invention provides Novel ABC transporter polypeptides and polynucleotides encoding Novel ABC transporter polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Novel ABC transporter polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: December 18, 1997
    Date of Patent: October 9, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Richard Lloyd Warren, Christopher Michael Traini
  • Stretococcal ERS
    Patent number: 6300119
    Abstract: The invention provides gluS polypeptides and DNA (RNA) encoding gluS polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing gluS polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: March 19, 1999
    Date of Patent: October 9, 2001
    Inventors: Deborah D. Jaworski, Elizabeth J. Lawlor, Min Wang
  • Amps from Streptococcus pneumoniae
    Patent number: 6297039
    Abstract: The invention provides ampS polypeptides and DNA (RNA) encoding ampS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ampS polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: December 4, 1998
    Date of Patent: October 2, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Magdalena Zalacain, James Raymond Brown
  • Integral membrane proteins of Staphylococcus aureus
    Patent number: 6296851
    Abstract: The invention provides integral membrane protein polypeptides and DNA (RNA) encoding integral membrane protein polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing integral membrane protein polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: February 23, 1999
    Date of Patent: October 2, 2001
    Assignee: SmithKline Beecham Corporation
    Inventor: Richard Lloyd Warren