Patents Represented by Attorney, Agent or Law Firm Thomas S. Deibert
  • gidB from Staphylococcus aureus
    Patent number: 6403334
    Abstract: The invention provides gidB polypeptides and DNA (RNA) encoding gidB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing gidB polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: December 16, 1998
    Date of Patent: June 11, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham p.l.c.
    Inventor: Howard Kallender
  • inFB
    Patent number: 6399343
    Abstract: The invention provides infB polypeptides and polynucleotides encoding infB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing in polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: May 19, 2000
    Date of Patent: June 4, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Sanjoy Biswas, James Raymond Brown, Martin Karl Russel Burnham, Alison Francis Chalker, Richard Lloyd Warren, Magdalena Zalacain, Chi Young So, Christopher M Traini, David John Holmes, Karen Anne Ingraham, Thomas B Mathie
  • PcrA helicase
    Patent number: 6391600
    Abstract: The invention provides PcrA Helicase polypeptides and polynucleotides encodi PcrA Helicase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing PcrA Helicase polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: November 9, 2000
    Date of Patent: May 21, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Damien McDevitt, Earl May, Annemarie St John, Stephanie Van Horn
  • Polynucleotides encoding peptide release factor, prfC (RF-3), a GTP-binding protein
    Patent number: 6372487
    Abstract: The invention provides prfC polypeptides and DNA (RNA) encoding prfC polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing prfC polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: May 20, 1999
    Date of Patent: April 16, 2002
    Assignee: SmithKline Beecham Corporation
    Inventor: Stewart C Pearson
  • fabG
    Patent number: 6365387
    Abstract: The invention provides fabG polypeptides and polynucleotides encoding fabG polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing fabG polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: May 17, 2000
    Date of Patent: April 2, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Jianzhong Huang, Damien McDevitt
  • YfiI pseudouridine synthase
    Patent number: 6361965
    Abstract: The invention provides YfiI pseudouridine synthase polypeptides and polynucleotides enconding YfiI pseudouridine synthase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing YfiI pseudouridine synthase polypeptides to screen for antibaterial compound.
    Type: Grant
    Filed: November 12, 1998
    Date of Patent: March 26, 2002
    Assignee: SmithKline Beecham Corporation
    Inventor: David J. Powell
  • IleS
    Patent number: 6361970
    Abstract: The invention provides ileS polypeptides and DNA (RNA) encoding ileS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ileS polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: August 12, 1999
    Date of Patent: March 26, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: James N. Brown, Elizabeth J Lawlor, Raymond W Reichard
  • M protein
    Patent number: 6358704
    Abstract: The invention provides M Protein polypeptides and DNA (RNA) encoding M Protein polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing M Protein polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: January 28, 1999
    Date of Patent: March 19, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham, PLC
    Inventors: Stephen Dudley Holmes, Martin Karl Russel Burnham
  • UDP-N-acetylenolpyruvylglucosamine reductase
    Patent number: 6355463
    Abstract: The invention provides MurB polypeptides and polynucleotides encoding MurB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing MurB polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: February 2, 2001
    Date of Patent: March 12, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Nicola Gail Wallis, Jason Craig Fedon, Leslie Marie Palmer, Lisa Kathleen Shilling
  • pskG
    Patent number: 6352840
    Abstract: The invention provides pskG polypeptides and polynucleotides encoding pskG polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pskG polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: February 1, 1999
    Date of Patent: March 5, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Michael Gwynn, Edwina Imogen Wilding
  • YsxC from Staphylococcus aureus
    Patent number: 6352843
    Abstract: The invention provides Staphylococcus aureus ysxC polypeptides and polynucleotides encoding Staphylococcus aureus ysxC polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ysxC polypeptides to screen for antibacterial compounds and for detecting Staphylococcus aureus.
    Type: Grant
    Filed: October 4, 1999
    Date of Patent: March 5, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Richard Lloyd Warren, Magdalena Zalacain
  • gidB
    Patent number: 6353093
    Abstract: The invention provides gidB polypeptides and polynucleotides encoding gidB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing gidB polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: August 31, 2000
    Date of Patent: March 5, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Martin K R Burnham, Howard Kallender, Anna Lisa Lenox, Judith Ward
  • MurD
    Patent number: 6350598
    Abstract: The invention provides MurD polypeptides and DNA (RNA) encoding MurD polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing MurD polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: April 13, 1999
    Date of Patent: February 26, 2002
    Assignee: SmithKline Beecham Corp.
    Inventors: Nicola Gail Wallis, Joanna Lynn Fueyo, Michael Arthur Lonetto
  • trmD
    Patent number: 6350600
    Abstract: The invention provides trmA methyl transferase (trmD) polypeptides and polynucleotides encoding trmD polypeptides and methods for producing such polypeptides by recominant techniques from strepococcus pneumoniae. Also provided are methods for utilizing polypepides to screen for antibacterial compounds.
    Type: Grant
    Filed: July 28, 2000
    Date of Patent: February 26, 2002
    Assignee: SmithKline Beecham Corp.
    Inventors: Sanjoy Biswas, James Raymond Brown, Chi Young So, Alison Francis Chalker, David John Holmes, Karen Anne Ingraham, Thomas B Mathie, Richard Lloyd Warren, Magdalena Zalacain
  • Fifty-four homologue (ffh) from streptococcus pneumoniae
    Patent number: 6350857
    Abstract: The invention provides ffh polypeptides and DNA (RNA) encoding ffh polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ffh polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: August 30, 1999
    Date of Patent: February 26, 2002
    Assignee: SmithKline Beecham Corp.
    Inventor: Michael Terence Black
  • Compounds
    Patent number: 6348328
    Abstract: This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the uses of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides and recombinant host cells transformed with the polynucleotides. This invention also relates to inhibiting the biosynthesis or action of such polynucleotides or polypeptides and to the use of such inhibitors in therapy.
    Type: Grant
    Filed: May 14, 1997
    Date of Patent: February 19, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc.
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Richard Oakley Nicholas, Robert King Stodola
  • Apt
    Patent number: 6348578
    Abstract: The invention provides apt polypeptides and DNA (RNA) encoding apt polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing apt polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: October 14, 1999
    Date of Patent: February 19, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Michael Arthur Lonetto, Richard Oakley Nicholas, James Raymond Brown, Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Robert King Stodola, Magdalena Zalacain
  • Compounds
    Patent number: 6348340
    Abstract: The invention provides histidine kinase polypeptides and DNA (RNA) encoding histidine kinase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing histidine kinase polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: December 22, 2000
    Date of Patent: February 19, 2002
    Assignee: SmithKline Beecham Corporation
    Inventor: Nicola Gail Wallis
  • Compounds
    Patent number: 6348342
    Abstract: The invention provides secA2 polypeptides and DNA (RNA) encoding secA2 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing secA2 polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: January 9, 2001
    Date of Patent: February 19, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Karen M O'Dwyer, Richard Warren, Caroline Perry
  • Prokaryotic polynucleotides polypeptides and their uses
    Patent number: 6348582
    Abstract: The invention provides novel polypeptides and polynucleotides encoding such polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: September 23, 1997
    Date of Patent: February 19, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Raymond Winfield Reichard, Richard O Nicholas, Martin Karl Russel Burnham, Julie M Pratt, Martin Rosenberg, Judith M Ward, Michael Arthur Lonetto