Patents Represented by Attorney Timothy G. Rothwell
  • Patent number: 4330555
    Abstract: The invention provides compounds of formula I, ##STR1## wherein R.sub.1 is hydrogen or alkyl(C.sub.1-10), andR.sub.2 is alkyl(C.sub.1-10),and physiologically acceptable and hydrolysable esters thereof, useful as anti-allergic agents.
    Type: Grant
    Filed: December 17, 1979
    Date of Patent: May 18, 1982
    Assignee: Sandoz Ltd.
    Inventor: Trevor G. Payne
  • Patent number: 4322526
    Abstract: Novel Cephalosporin C derivatives, their production and their use in isolating Cephalosporin C from culture filtrates for subsequent conversion of 7-aminocephalosporanic acid.
    Type: Grant
    Filed: December 29, 1980
    Date of Patent: March 30, 1982
    Assignee: Sandoz Ltd.
    Inventor: Gerd Ascher
  • Patent number: 4320133
    Abstract: The invention provides novel penicillins and cephalosporins of formula I, ##STR1## methods for their production and their anti-bacterial use.
    Type: Grant
    Filed: February 6, 1980
    Date of Patent: March 16, 1982
    Assignee: Sandoz Ltd.
    Inventors: Helmut Hamberger, Peter Stutz, Dieter Scholz, Hans Fliri
  • Patent number: 4315934
    Abstract: The analgesic use of compounds of formula I ##STR1## wherein R is hydrogen, acetyl or a group of formula IIR'--O--CO-- IIwherein R' is alkyl (C.sub.1-8); phenyl; phenyl substituted in the 4-position with halogen, alkoxy(C.sub.1-4) or alkyl(C.sub.1-4); phenylalkyl; or phenylalkyl in which the phenyl group is substituted in the 4-position with halogen, alkoxy(C.sub.1-4) or alkyl (C.sub.1-4).
    Type: Grant
    Filed: September 19, 1980
    Date of Patent: February 16, 1982
    Assignee: Sandoz Ltd.
    Inventor: Anne V. Christensen
  • Patent number: 4301290
    Abstract: Decahydro or octahydro-4-phenyl-cis-isoquinoline derivatives are useful as analgesics, anti-depressants, tranquilizers and sleep inducers.
    Type: Grant
    Filed: March 7, 1979
    Date of Patent: November 17, 1981
    Assignee: Sandoz Ltd.
    Inventors: Paul Pfaffli, Hartmut Hauth
  • Patent number: 4301170
    Abstract: This disclosure describes novel compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 each represent hydrogen, or ##STR2## and R.sub.3 is hydrogen or fluoro, andn is 1, 2 or 3, andprovided that one of R.sub.1 and R.sub.2 is other than hydrogen which are useful as anti-obesity agents.
    Type: Grant
    Filed: August 1, 1980
    Date of Patent: November 17, 1981
    Assignee: Sandoz, Inc.
    Inventor: William J. Houlihan
  • Patent number: 4285944
    Abstract: This disclosure describes novel compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 each independently represent hydrogen, halo having an atomic weight of about 19 to 36, lower alkyl, straight chain lower alkoxy, amino, nitro or trifluoromethyl, andR.sub.3 represents hydrogen or lower alkyl, andX represents ##STR2## which are useful as sleep inducers.
    Type: Grant
    Filed: April 10, 1980
    Date of Patent: August 25, 1981
    Assignee: Sandoz, Inc.
    Inventor: Gregory B. Bennett
  • Patent number: 4273780
    Abstract: The present invention provides anti-9,10-dihydro-4-(1-methyl-4-piperidylidene)-4H-benzo[4,5]-cyclohepta[1 ,2-b]thiophen-10(9H)-one oxime of formula ##STR1## useful for the treatment of allergic conditions.
    Type: Grant
    Filed: January 8, 1980
    Date of Patent: June 16, 1981
    Assignee: Sandoz Ltd.
    Inventors: Erwin Waldvogel, Jean-Michel Bastian, Gustav Schwarb
  • Patent number: 4273784
    Abstract: The present invention concerns prostaglandins having a cyclopropane ring in the 2,3 position.
    Type: Grant
    Filed: March 28, 1979
    Date of Patent: June 16, 1981
    Assignee: Sandoz Ltd.
    Inventor: Pietro Bollinger
  • Patent number: 4267321
    Abstract: Novel Cephalosporin C derivatives, their production and their use in isolating Cephalosporin C from culture filtrates for subsequent conversion to 7-aminocephalosporanic acid.
    Type: Grant
    Filed: January 22, 1980
    Date of Patent: May 12, 1981
    Assignee: Sandoz Ltd.
    Inventor: Gerd Ascher
  • Patent number: 4261895
    Abstract: The compounds of formula I ##STR1## wherein R is(a) hydrogen,(b) cycloalkyl of 3 to 7 carbon atoms,(c) alkyl of 2 to 5 carbon atoms monosubstituted by hydroxy, with the proviso that the hydroxyl radical is separated by at least 2 carbon atoms from the carbonylthio moiety to which R is bound,(d) phenyl or phenylalkyl of 7 to 11 carbon atoms, each monosubstituted or independently disubstituted in the phenyl ring by alkyl of 1 to 4 carbon atoms or halogen of atomic number of from 9 to 35, or phenyl or phenylalkyl of 7 to 11 carbon atoms, each monosubstituted or independently disubstituted or independently trisubstituted in the phenyl ring by alkoxy of 1 to 4 carbon atoms, or(e) furyl, benzo[b]furyl, thienyl, benzo[b]thienyl, pyridyl, quinolyl, isoquinolyl, 2- or 3-pyrrolyl or indolyl other than 1-indolyl,R.sub.1 and R.sub.
    Type: Grant
    Filed: October 23, 1978
    Date of Patent: April 14, 1981
    Assignee: Sandoz Ltd.
    Inventor: Erik Wiskott
  • Patent number: 4259523
    Abstract: This invention provides new mono-deuterated prostaglandins having prolonged uterotonic activity.
    Type: Grant
    Filed: May 11, 1979
    Date of Patent: March 31, 1981
    Assignee: Sandoz Ltd.
    Inventors: Pietro Bollingen, Manfred Krieger
  • Patent number: 4252817
    Abstract: This invention provides new compounds of the formula, ##STR1## wherein R.sub.1 is alkyl of 1 to 10 carbon atoms, cycloalkyl of 3 to 8 carbon atoms or phenyl,R.sub.2 is hydrogen or lower alkyl, andR.sub.3 is halogen, nitro, lower alkyl, methylthio, hydroxy, lower alkoxy, acyloxy or acylamino, with the proviso that when R.sub.3 is in the 5 position, and R.sub.1 and R.sub.3 are identical and signify a straight alkyl chain of 1 to 5 carbon atoms, R.sub.2 is lower alkyl,useful as anti-phlogistics.
    Type: Grant
    Filed: May 11, 1979
    Date of Patent: February 24, 1981
    Assignee: Sandoz Ltd.
    Inventors: Annemarie Closse, Walter Haefliger, Daniel Hauser
  • Patent number: 4249001
    Abstract: Prostanoic acid ergolinylalkyl-esters, -thioesters and -amides have interesting prostaglandin-like activity, especially blood pressure lowering activity.
    Type: Grant
    Filed: July 9, 1979
    Date of Patent: February 3, 1981
    Assignee: Sandoz Ltd.
    Inventor: Roland Wenger
  • Patent number: 4238616
    Abstract: Substituted hydroxy pyridones, e.g., 3-(.alpha.-iminobenzyl)-4-hydroxy-6-phenyl-1-methyl-2(1H)-pyridone, are prepared by reducing corresponding isoxazolo[4,5-c]pyridin-4(5H)-ones and are useful as minor tranquilizers and sleep inducers.
    Type: Grant
    Filed: November 19, 1979
    Date of Patent: December 9, 1980
    Assignee: Sandoz, Inc.
    Inventor: Jeffrey Nadelson
  • Patent number: 4235907
    Abstract: This invention provides compounds of formula ##STR1## wherein R.sub.1 is hydrogen, alkyl, alkenyl or alkynyl, the multiple bond of which is not adjacent to the nitrogen atom,R.sub.2 is, for example, hydrogen, alkyl, alkoxy, hydroxy or halogen, andR.sub.3 is hydrogen, halogen, hydroxyl, alkyl or alkoxy,useful, for example, in the treatment of allergic asthma.
    Type: Grant
    Filed: April 6, 1979
    Date of Patent: November 25, 1980
    Assignee: Sandoz Ltd.
    Inventor: Emil Pfenninger
  • Patent number: 4228280
    Abstract: This disclosure describes novel compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 each independently represent hydrogen, halo having an atomic weight of about 19 to 36, lower alkyl, straight chain lower alkoxy, amino, nitro or trifluoromethyl, andX represents ##STR2## which are useful as minor tranquilizers and sleep inducers.
    Type: Grant
    Filed: May 16, 1979
    Date of Patent: October 14, 1980
    Assignee: Sandoz, Inc.
    Inventor: Gregory B. Bennett
  • Patent number: 4224317
    Abstract: This disclosure describes compounds of the formula ##STR1## wherein R.sub.1 represents ##STR2## and R.sub.2, R.sub.3, R.sub.4 and R.sub.5 each independently represent lower alkyl having 1 to 2 carbon atoms, andn is 1 or 2,which are useful as muscle-relaxant agents.
    Type: Grant
    Filed: August 27, 1979
    Date of Patent: September 23, 1980
    Assignee: Sandoz, Inc.
    Inventor: Sandor Barcza
  • Patent number: 4219560
    Abstract: This disclosure describes novel compounds of the formula: ##STR1## where A is --CH.sub.2 OH or ##STR2## wherein R.sub.4 and R.sub.5 each independently represent hydrogen or lower alkyl having 1 to 2 carbon atoms or together with N represent ##STR3## and, R.sub.1 is hydrogen or lower alkyl having 1 to 2 carbon atoms, andR.sub.2 and R.sub.3 each independently represent hydrogen, chloro, fluoro, methyl, methoxy or together, represent methylenedioxy, andn is 1 or 2, provided that one of R.sub.2 and R.sub.3 is other than hydrogen which are useful as hypolipidemic agents.
    Type: Grant
    Filed: April 17, 1978
    Date of Patent: August 26, 1980
    Assignee: Sandoz, Inc.
    Inventor: William J. Houlihan
  • Patent number: 4216206
    Abstract: Antibiotics active against gram positive bacteria are produced from Microellobosporia brunea nov. Sp. King 1977.
    Type: Grant
    Filed: January 19, 1979
    Date of Patent: August 5, 1980
    Assignee: Sandoz Ltd.
    Inventors: Camilla Keller-Juslen, Hamilton D. King