Patents Represented by Attorney Timothy G. Rothwell

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  • Substituted or unsubstituted 2-phenylbenzimidazoles as anti-obesity agents
    Patent number: 4212876
    Abstract: Certain substituted or unsubstituted 2-phenylbenzimidazoles, e.g., 1-methyl-2-phenylbenzimidazole, are useful as anti-obesity agents.
    Type: Grant
    Filed: June 21, 1978
    Date of Patent: July 15, 1980
    Assignee: Sandoz, Inc.
    Inventor: William J. Houlihan
  • Substituted 1-oxa-4-aza-2,6-disilacyclohexanes
    Patent number: 4208408
    Abstract: This disclosure describes novel compounds of the formula: ##STR1## where R.sub.1 and R.sub.2 each independently represent hydrogen, halo having an atomic weight of about 19 to 36, lower alkyl, lower alkoxy,trifluoromethyl or R.sub.1 is ##STR2## and R.sub.2 is hydrogen, whereinR.sub.7 and R.sub.8 are each independently hydrogen or lower alkyl andn is 0 or 1, andR.sub.3, R.sub.4, R.sub.5 and R.sub.6 each independently represent lower alkyl, which are useful as muscle relaxants.
    Type: Grant
    Filed: November 30, 1978
    Date of Patent: June 17, 1980
    Assignee: Sandoz, Inc.
    Inventor: Sandor Barcza
  • 5-Phenacyl-3-phenyl-4-isoxazole carboxamides
    Patent number: 4208532
    Abstract: Substituted hydroxy pyridones, e.g., 3-(.alpha.-iminobenzyl)-4-hydroxy-6-phenyl-1-methyl-2-(1H)-pyridone, are prepared by reducing corresponding isoxazolo[4,5-c]pyridin-4(5H)-ones and are useful as minor tranquilizers and sleep inducers.
    Type: Grant
    Filed: March 8, 1979
    Date of Patent: June 17, 1980
    Assignee: Sandoz, Inc.
    Inventor: Jeffrey Nadelson
  • Substituted 4-hydroxy pyridones
    Patent number: 4191827
    Abstract: This disclosure describes novel compounds of the formula: ##STR1## where R.sub.1 is straight chain lower alkyl or ##STR2## where R.sub.4 is hydrogen or halo having an atomic weight of about 19 to 36, andR.sub.2 is straight chain lower alkyl, andR.sub.3 is hydrogen or halo as defined above,which are useful as minor tranquilizers and muscle relaxants.
    Type: Grant
    Filed: September 18, 1978
    Date of Patent: March 4, 1980
    Assignee: Sandoz, Inc.
    Inventor: Jeffrey Nadelson
  • Tricyclo[2.2.1.0.sup.2,6 ]heptan-3-ones
    Patent number: 4190603
    Abstract: The present invention concerns a novel process for preparing derivatives useful in the production of prostaglandins.The present invention provides a process for the production of a compound of formula I ##STR1## wherein R.sub.1 is a protecting group which comprises hydrolysing a compound of formula II ##STR2## wherein R.sub.1 is as defined above andR.sub.2 is a leaving group,under acidic conditions.
    Type: Grant
    Filed: November 20, 1978
    Date of Patent: February 26, 1980
    Assignee: Sandoz Ltd.
    Inventor: Peter Funfschilling
  • Substituted hydroxy pyridones
    Patent number: 4179566
    Abstract: Substituted hydroxy pyridones, e.g., 3-(1-iminopropyl)-4-hydroxy-6-phenyl-1-methyl-2(1H)-pyridone, are prepared by reducing corresponding isoxazolo[4,5-c]pyridin-4(5H)-ones and are useful as minor tranquilizers, sleep inducers and neuroleptics.
    Type: Grant
    Filed: July 17, 1978
    Date of Patent: December 18, 1979
    Assignee: Sandoz, Inc.
    Inventor: Jeffrey Nadelson
  • Antibiotic S 31794/F-1
    Patent number: 4173629
    Abstract: This invention provides S 31794/F-1 which is a useful anti-mycotic for combatting Candida albicans infections.
    Type: Grant
    Filed: June 28, 1978
    Date of Patent: November 6, 1979
    Assignee: Sandoz Ltd.
    Inventors: Michael M. Dreyfuss, Hans Tscherter
  • Hydro-4-phenyl-benz[f]isoindoline compounds
    Patent number: 4171369
    Abstract: The present invention concerns novel hydro-4-phenyl-benz[f]isoindoline derivatives, of the formula ##STR1## wherein R is hydrogen or substituted or unsubstituted alkyl,R.sub.1 and R.sub.2 are hydrogen, halogen or alkyl, and eitherX and Y are hydrogen, orX and Y together are an additional bond,Useful as analgesics and antidepressants.
    Type: Grant
    Filed: March 17, 1975
    Date of Patent: October 16, 1979
    Assignee: Sandoz Ltd.
    Inventors: Roland Achini, Wolfgang Oppolzer, Emil Pfenninger
  • Process for the preparation of 1,3,3-trimethyl-2-oxabicyclo[2,2,2]octan-6-ones
    Patent number: 4170599
    Abstract: 1,3,3-Trimethyl-2-oxabicyclo[2,2,2]octan-6-ones are prepared by first epoxidizing .alpha.-terpineol with a peracid and thereafter oxidizing the resulting product with an appropriate oxidizing agent.
    Type: Grant
    Filed: June 19, 1978
    Date of Patent: October 9, 1979
    Assignee: Sandoz, Inc.
    Inventor: Gregory B. Bennett
  • Substituted hydroxy pyridones
    Patent number: 4170705
    Abstract: Substituted hydroxy pyridones, e.g., 3-(.alpha.-N-methyliminobenzyl)-4-hydroxy-6-phenyl-1-methyl-2(1H)-pyridone , are prepared by reacting a corresponding substituted hydroxy pyridone carbonyl with an alkyl amine, and are useful as minor tranquilizers, sleep inducers, muscle relaxants, and neuroleptics.
    Type: Grant
    Filed: July 17, 1978
    Date of Patent: October 9, 1979
    Assignee: Sandoz, Inc.
    Inventor: Jeffrey Nadelson
  • Benz[f]isoindoline compounds
    Patent number: 4164583
    Abstract: The present invention provides benz[f]isoindolines, useful in the treatment of aggression, a process for their preparation and compositions containing these compounds.
    Type: Grant
    Filed: June 22, 1978
    Date of Patent: August 14, 1979
    Assignee: Sandoz Ltd.
    Inventors: Roland Achini, Wolfgang Oppolzer, Emil Pfenninger
  • Isoxazole-4-carboxamides as tranquilizers, sleep-inducers and muscle relaxants
    Patent number: 4163057
    Abstract: Compounds of the formula ##STR1## where R.sub.1 is hydrogen or lower alkyl, andR.sub.2 is hydrogen or straight chain lower alkyl, andR.sub.3 is hydrogen, fluoro, chloro, lower alkoxy, lower alkyl or trifluoromethyl, andN is 1, 2, 3, and 4,Which are useful as minor tranquilizers, sleep inducers and muscle relaxants.
    Type: Grant
    Filed: December 27, 1977
    Date of Patent: July 31, 1979
    Assignee: Sandoz, Inc.
    Inventor: Jeffrey Nadelson
  • Substituted hydroxy pyridones
    Patent number: 4158735
    Abstract: Substituted hydroxy pyridones, e.g., 3-(.alpha.-iminobenzyl)-4-hydroxy-6-phenyl-1-methyl-2(1H)-pyridone, are prepared by reducing corresponding isoxazolo[4,5-c]pyridin-4(5H)-ones and are useful as minor tranquilizers and sleep inducers.
    Type: Grant
    Filed: May 1, 1978
    Date of Patent: June 19, 1979
    Assignee: Sandoz, Inc.
    Inventor: Jeffrey Nadelson
  • Substituted isoxazolo compounds
    Patent number: 4154928
    Abstract: An improved process for the preparation of substituted isoxazolo[4,5-c]pyridin-4(5H)-ones which are either useful as intermediates in the preparation of compounds having pharmaceutical activity or as hypolipidemic agents which comprises cyclizing a corresponding 5-(2-amino-2-phenyl- or substituted phenyl-ethenyl)-3-substituted-N-alkyl isoxazole-4-carboxamide under acidic conditions.
    Type: Grant
    Filed: June 19, 1978
    Date of Patent: May 15, 1979
    Assignee: Sandoz, Inc.
    Inventors: Max Denzer, Joseph A. Smith
  • Benz[g]isoquinolines and use thereof
    Patent number: 4150136
    Abstract: The present invention provides novel compounds of the formula, ##STR1## wherein R.sub.1 is hydrogen, halogen, alkyl or alkoxy; R.sub.2 may, for example, be hydrogen, alkyl, alkenyl, alkinyl or phenylalkyl, the phenyl ring of which may be mono-substituted with halogen, alkyl or alkoxy; and R.sub.3 is hydrogen, alkyl, thienyl, phenyl or phenyl which may be mono- or di-substituted with halogen, alkyl, alkoxy or alkylthio, useful, for example, as anti-depressants and analgesics.
    Type: Grant
    Filed: June 30, 1977
    Date of Patent: April 17, 1979
    Assignee: Sandoz Ltd.
    Inventor: Jean-Michel Bastian
  • 2-Oxabicyclo[3.2.1]octan-3-ones
    Patent number: 4148807
    Abstract: The present invention concerns a novel process for preparing derivatives useful in the production of prostaglandins.The present invention provides a process for the production of a compound of formula I ##STR1## wherein R.sub.1 is a protecting group which comprises hydrolyzing a compound of formula II ##STR2## wherein R.sub.1 is as defined above and R.sub.2 is a leaving group, under acidic conditions.
    Type: Grant
    Filed: December 2, 1977
    Date of Patent: April 10, 1979
    Assignee: Sandoz Ltd.
    Inventor: Peter Funfschilling
  • Derivatives of oxaminic acids and esters
    Patent number: 4148916
    Abstract: The invention provides oxaminic acids and esters thereof, useful for the treatment of allergic conditions, a process for the preparation of said compounds and pharmaceutical compositions containing these compounds.
    Type: Grant
    Filed: June 22, 1978
    Date of Patent: April 10, 1979
    Assignee: Sandoz Ltd.
    Inventor: Trevor G. Payne
  • Substituted imidazo[5,1-a]isoquinolines
    Patent number: 4143143
    Abstract: Compounds of formula I, ##STR1## wherein either R.sub.1 is hydroxy or alkoxy of 1 to 4 carbon atoms, and R.sub.2 is hydrogen, hydroxy or alkoxy of 1 to 4 carbon atoms,Or R.sub.1 and R.sub.2, together, are methylenedioxy,R.sub.3 is hydrogen or alkyl of 1 to 4 carbon atoms, andR.sub.4 is phenyl or phenyl substituted by 1, 2 or 3 substituents independently chosen from halogen, hydroxy, nitro or alkyl(C.sub.1-4) haloalkyl(C.sub.1-4), or alkoxy (C.sub.1-4),are useful as anti-arrhythmic agents.
    Type: Grant
    Filed: September 23, 1977
    Date of Patent: March 6, 1979
    Assignee: Sandoz Ltd.
    Inventor: Max-Peter Seiler
  • 2-Aminomethylene-5-hydroxy-N-alkyl-3-oxo-amides
    Patent number: 4136114
    Abstract: 2-Aminomethylene-5-hydroxy-N-alkyl-3-oxo-amides.
    Type: Grant
    Filed: August 5, 1977
    Date of Patent: January 23, 1979
    Assignee: Sandoz, Inc.
    Inventor: Jeffrey Nadelson
  • Compartmented condiment dispenser
    Patent number: D253508
    Type: Grant
    Filed: June 8, 1977
    Date of Patent: November 27, 1979
    Assignee: John L. Sutton
    Inventor: John L. Sutton