Abstract: Compositions for treating, reducing, ameliorating, or preventing infections comprise a fluoroquinolone having Formulae I-VIII and an additional anti-infective agent. Methods for treating, reducing, ameliorating, or preventing such infection use such compositions. Such compositions and methods can be effective against mixed types of pathogens including certain antibiotic-resistant microbial pathogens found in such infections.
Type:
Grant
Filed:
April 3, 2012
Date of Patent:
December 18, 2012
Assignee:
Bausch & Lomb Incorporated
Inventors:
Praveen Tyle, Erning Xia, Hongna Wang, Susan E. Norton, Pramod Kumar Gupta, Keith W. Ward, Lynne Brunner
Abstract: A process of preparing a quinolone carboxylic acid or its derivatives having Formula I, Ia, Ib, or IV, as shown herein, comprises using a starting quinolone that already has one or more desired substituents at one or more particular positions on the quinolone ring and preserving the orientation of such substituents throughout the synthesis. The present process comprises fewer steps than prior-art processes. The present process also can include a simple separation of a desired enantiomer of the quinolone carboxylic acid or its derivatives from the enantiomeric mixture. Pharmaceutical compositions comprising fluoroquinolones prepared by the present process can be used effectively against a variety of microbial pathogens.
Type:
Grant
Filed:
September 17, 2009
Date of Patent:
August 28, 2012
Assignee:
Bausch & Lomb Incorporated
Inventors:
Arthur E. Harms, Ramakrishnan Arul, Anil K. Soni
Abstract: A process of preparing a quinolone carboxylic acid or its derivatives having Formula I, Ia, or IV, as shown herein, comprises using a starting quinolone that already has one or more desired substituents at one or more particular positions on the quinolone ring and preserving the orientation of such substituents throughout the synthesis. The present process comprises fewer steps than prior-art processes. The present process also can include a simple separation of a desired enantiomer of the quinolone carboxylic acid or its derivatives from the enantiomeric mixture. Pharmaceutical compositions comprising fluoroquinolones prepared by the present process can be used effectively against a variety of microbial pathogens.
Abstract: Compositions for treating, reducing, ameliorating, or preventing infections comprise a fluoroquinolone having Formulae I-VIII and an additional anti-infective agent. Methods for treating, reducing, ameliorating, or preventing such infection use such compositions. Such compositions and methods can be effective against mixed types of pathogens including certain antibiotic-resistant microbial pathogens found in such infections.
Type:
Grant
Filed:
May 6, 2008
Date of Patent:
May 8, 2012
Assignee:
Bausch & Lomb Incorporated
Inventors:
Praveen Tyle, Erning Xia, Honga Wang, Susan E. Norton, Pramod Kumar Gupta, Keith W. Ward, Lynne Brunner
Abstract: The present invention is directed to a composition for treating dry eye comprising, in one embodiment, carboxymethylcellulose and a polyol. Such compositions have been found to alleviate the symptoms of dry eye and remain in the eye for a long period of time.
Type:
Grant
Filed:
March 28, 2006
Date of Patent:
February 14, 2012
Assignee:
Bausch & Lomb Incorporated
Inventors:
Erning Xia, Joseph Salamone, X. Michael Liu
Abstract: A brimonidine (5-bromo-6-(2-imidazolidinylideneamino)quinoxaline) pamoate polymorph exhibits characteristics disclosed herein. The brimonidine pamoate polymorph is included in a composition, device, or implant for use in the treatment or control of elevated intraocular pressure or in the neuroprotection of components of a neurological tissue to prevent progressive degeneration of such components. In particular, such a composition, device, or implant can be used to provide neuroprotection to cells and components of the optic nerve system.
Type:
Grant
Filed:
October 23, 2009
Date of Patent:
October 11, 2011
Assignee:
Bausch & Lomb Incorporated
Inventors:
Hongna Wang, Stephen R. Davio, Gregory L. McIntire, Michael Hall, Shazad Suchit, Jon Summersett, Brent Whitehead
Abstract: The present invention includes a method of treating inflammation of the eye comprising administering to an eye of a patient suffering from inflammation of the eye, a composition comprising an aqueous solution of alginate having a minimum of about 50% mannuronate residues based upon the total number of saccharide monomeric units.
Abstract: A process of preparing a quinolone carboxylic acid or its derivatives having Formula I, Ia, or IV, as shown herein, comprises using a starting quinolone that already has one or more desired substituents at one or more particular positions on the quinolone ring and preserving the orientation of such substituents throughout the synthesis. The present process comprises fewer steps than prior-art processes. The present process also can include a simple separation of a desired enantiomer of the quinolone carboxylic acid or its derivatives from the enantiomeric mixture. Pharmaceutical compositions comprising fluoroquinolones prepared by the present process can be used effectively against a variety of microbial pathogens.
Abstract: Polymerized drug delivery devices are described. Additionally, methods are described for producing and for using polymerized particles for use as drug delivery devices.
Type:
Grant
Filed:
September 15, 2004
Date of Patent:
February 24, 2009
Assignee:
Bausch & Lomb Incorporated
Inventors:
Adrian T. Raiche, Joseph C. Salamone, Jeffrey Linhardt
Abstract: Optically transparent, relatively high refractive index polymeric compositions and ophthalmic devices such as intraocular lenses, contact lenses and corneal inlays made therefrom are described herein. The preferred polymeric compositions are produced through the polymerization of one or more siloxysilane monomers or the copolymerization of one or more siloxysilane monomers with one or more aromatic or non-aromatic non-siloxy monomers, hydrophobic monomers or hydrophilic monomers.
Type:
Grant
Filed:
January 21, 2005
Date of Patent:
November 21, 2006
Assignee:
Bausch & Lomb Incorporated
Inventors:
Joseph C. Salamone, Jay F. Kunzler, Richard M. Ozark, David E. Seelye
Abstract: Optically transparent, relatively high refractive index polymeric compositions and ophthalmic devices such as intraocular lenses, contact lenses and corneal inlays made therefrom are described herein. The preferred polymeric compositions are produced through the polymerization of one or more aromatic-based silyl monomers or the copolymerization of one or more aromatic-based silyl monomers with one or more aromatic or non-aromatic non-siloxy-based monomers, hydrophobic monomers or hydrophilic monomers.
Type:
Grant
Filed:
May 18, 2004
Date of Patent:
November 7, 2006
Assignee:
Bausch & Lomb Incorporated
Inventors:
Joseph C. Salamone, Jay F. Kunzler, Richard M. Ozark, David E. Seelye, David P. Vanderbilt
Abstract: Relatively high refractive index polymeric compositions and ophthalmic devices such as for example intraocular lenses and corneal inlays made therefrom are described herein. The preferred polymeric compositions are produced through the copolymerization of one or more aromatic-substituted polysiloxane prepolymers with one or more aromatic monomers, alkylated monomers or hydrophilic monomers.
Abstract: Relatively high refractive index polymeric compositions and ophthalmic devices such as for example intraocular lenses and corneal inlays made therefrom are described herein. The preferred polymeric compositions are produced through the copolymerization of one or more aromatic-substituted polysiloxane prepolymers with one or more aromatic monomers, alkylated monomers or hydrophilic monomers.
Abstract: Optically transparent, relatively high refractive index polymeric compositions and ophthalmic devices such as intraocular lenses, contact lenses and corneal inlays made therefrom are described herein. The preferred polymeric compositions are produced through the polymerization of one or more siloxysilane monomers or the copolymerization of one or more siloxysilane monomers with one or more aromatic or non-aromatic non-siloxy monomers, hydrophobic monomers or hydrophilic monomers.
Type:
Grant
Filed:
January 21, 2005
Date of Patent:
September 5, 2006
Assignee:
Bausch & Lomb Incorporated
Inventors:
Joseph C. Salamone, Jay F. Kunzler, Richard M. Ozark, David E. Seelye
Abstract: Novel azo-based reactive yellow dyes and a process for manufacturing and using ocular devices having blue light absorption properties. Intraocular lenses so produced block blue light from reaching the retina of an eye implanted with the IOL. By blocking blue light from reaching the retina, the IOL thereby prevents potential damage to the retina.
Abstract: Optically transparent, relatively high refractive index polymeric compositions and ophthalmic devices such as intraocular lenses, contact lenses and corneal inlays made therefrom are described herein. The preferred polymeric compositions are produced through the polymerization of one or more siloxysilane monomers or the copolymerization of one or more siloxysilane monomers with one or more aromatic or non-aromatic non-siloxy monomers, hydrophobic monomers or hydrophilic monomers.
Type:
Grant
Filed:
January 21, 2005
Date of Patent:
August 15, 2006
Assignee:
Bausch & Lomb Incorporated
Inventors:
Joseph C. Salamone, Jay F. Kunzler, Richard M. Ozark, David E. Seelye
Abstract: Surface modified medical devices such as intraocular lens implants formed from one or more functional group-containing materials using reactive, hydrophilic polymers for the purpose of reducing or eliminating lens epithelial cell growth thereon, reducing or eliminating silicone oil absorption upon subsequent surgical exposure and/or reducing or eliminating implantation inserter friction is provided herein. Additionally, a method of making and using surface modified intraocular lens implants is provided.
Type:
Grant
Filed:
June 28, 2002
Date of Patent:
August 1, 2006
Assignee:
Bausch & Lomb Incorporated
Inventors:
Paul L. Valint, Jr., Joseph A. McGee, Wenyan Yan, Joseph C. Salamone, Daniel M. Ammon, Jr., Jay F. Kunzler
Abstract: Relatively high refractive index polymeric compositions and ophthalmic devices such as for example intraocular lenses and corneal inlays made therefrom are described herein. The preferred polymeric compositions are produced through the copolymerization of one or more aromatic-substituted polysiloxane prepolymers with one or more aromatic monomers, alkylated monomers or hydrophilic monomers.
Abstract: A process for producing silicone-containing prepolymers capable of absorbing blue light for use in the production of relatively high refractive index polymeric compositions is described herein. Polymeric compositions so produced are useful in the production of ophthalmic devices such as for example intraocular lenses and corneal inlays.
Abstract: Optically transparent, relatively high refractive index polymeric compositions and ophthalmic devices such as intraocular lenses, corneal inlays and contact lenses made therefrom are described herein. The preferred polymeric compositions are produced through the polymerization of one or more aromatic-based siloxane macromonomers or the copolymerization of one or more aromatic-based siloxane macromonomers with one or more non-siloxy aromatic-based monomers, non-aromatic-based hydrophobic monomers or non-aromatic-based hydrophilic monomers.
Type:
Grant
Filed:
September 18, 2003
Date of Patent:
April 4, 2006
Assignee:
Bausch & Lomb Incorporated
Inventors:
Joseph C. Salamone, Jay F. Kunzler, Richard M. Ozark, David E. Seelye