Patents Represented by Attorney, Agent or Law Firm Valeta Gregg
  • Fungal protein disulfide isomerase
    Patent number: 5879664
    Abstract: A fungal protein disulfide isomerase obtainable from fungal species belonging to Aspergillus, especially A. oryzae, or A. niger, is disclosed. Furthermore sequences for recombinant production of the protein disulfide isomerase are disclosed.
    Type: Grant
    Filed: December 11, 1995
    Date of Patent: March 9, 1999
    Assignee: Novo Nordisk A/S
    Inventor: Carsten Mailand Hjort
  • Processing plant material with xylanase
    Patent number: 5874274
    Abstract: The present invention relates to a process for reducing the viscosity of a plant material, which process comprises treating the plant material with a xylanase having i) a WSPS per mg protein added which is higher than 0,06, and/or ii) a WSPU per mg protein added which is higher than 15, and/or iii) a specific activity of more than 0,053 FVRU/mg protein. Further, the invention relates to use of a xylanase preparation for separating a plant material, such as wheat, into separate useful components as well as processes for such viscosity reduction or separation.
    Type: Grant
    Filed: September 23, 1996
    Date of Patent: February 23, 1999
    Assignee: Novo Nordisk A/S
    Inventors: Tina Sejersg.ang.ard Jakobsen, Hans Peter Heldt-Hansen, Lene Venke Kofod, Christian Lorentz Bagger, Anette Mullertz
  • Polypeptides having mutanase activity and nucleic acids encoding same
    Patent number: 5874275
    Abstract: The present invention relates to polypeptides having mutanase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing the polypeptides. The present invention further relates to oral cavity compositions and methods for degrading mutan.
    Type: Grant
    Filed: October 22, 1997
    Date of Patent: February 23, 1999
    Assignees: Novo Nordisk A/S, Novo Nordisk Biotech, Inc.
    Inventors: Randy M Berka, Stephan Christgau, Torben Halkier, Jeff Shuster, Claus Crone Fuglsang
  • Enzyme with endo-1,3(4)-.beta.- Glucanase activity
    Patent number: 5871966
    Abstract: A partial amino acid sequence of an endo-.beta.-1,4-glucanase obtainable by means of Aspergillus aculeatus is described, and also corresponding recombinant DNA sequences, vectors and transformed hosts. Use of the endo-.beta.- 1,4-glucanase or a pectinase preparation enriched with the endo-.beta.-1,4-glucanase for degradation or modification of plant cell walls is described.
    Type: Grant
    Filed: November 8, 1996
    Date of Patent: February 16, 1999
    Assignee: Novo Nordisk A/S
    Inventors: Lene Venke Kofod, Lene Nonboe Andersen, Markus Sakari Kauppinen, Stephan Christgau, Henrik Dalb.o slashed.ge, Hans Sejr Olsen, Jens Breinholt
  • Peptide derivatives
    Patent number: 5869602
    Abstract: The present invention relates to a pharmacologically active peptide hormone derivative in which the parent peptide hormone has been modified by introducing either a lipophilic substituent, W, in the N-terminal amino acid or a lipophilic substituent, Z, in the C-terminal amino acid of the parent peptide hormone or an analogue thereof, said lipophilic substituent having from 8 to 40 carbon atoms, has a protracted profile of action.
    Type: Grant
    Filed: May 23, 1995
    Date of Patent: February 9, 1999
    Assignee: Novo Nordisk A/S
    Inventors: Ib Jonassen, Svend Havelund, Per Hertz Hansen, Peter Kurtzhals, John Halstr.o slashed.m
  • Method for production of an acidified edible gel on milk basis
    Patent number: 5866180
    Abstract: The method for production of an acidified edible gel on milk basis comprises addition of transglutaminase to milk, followed by a heat treatment. Hereby a functionally and/or organoleptically satisfactory edible gel is obtained, which can be used as a yoghurt mousse or cheese.
    Type: Grant
    Filed: June 10, 1997
    Date of Patent: February 2, 1999
    Assignee: Novo Nordisk A/S
    Inventors: Gitte Budolfsen, Per Munk Nielsen
  • Cellobiose oxidase, and enzymatic agent and a process for treating paper pulp
    Patent number: 5866392
    Abstract: Enzyme exhibiting cellobiose oxidase activity, which enzyme has a relative activity of at least 70% at a pH of about 9 and a temperature of about 50.degree. C. An enzymatic agent comprising cellobiose oxidase and an endoglycanase and/or oxidoreductase. A process of bleaching paper pulp using cellobiose oxidase.
    Type: Grant
    Filed: June 24, 1996
    Date of Patent: February 2, 1999
    Assignee: Novo Nordisk A/S
    Inventors: Charlotte Schou, Martin Schulein, Thomas Vollmond
  • Enzyme preparation comprising a modified enzyme
    Patent number: 5866526
    Abstract: An enzyme preparation comprising a modified enzyme selected from the group consisting of an amylase, lipase, oxidorcductase, pectinace or hemicellulase, the modified enzyme having an improved performance due to an alkaline pI and/or increased surface activity obtained by chemical modification or amino acid substitution, is useful e.g., in detergents, in baking flour, in animal feed, in the manufacture of cellulosic fabrics and for the treatment of lignocellulosic fibers.
    Type: Grant
    Filed: May 2, 1996
    Date of Patent: February 2, 1999
    Assignee: Novo Nordisk A/S
    Inventors: Arne Agerlin Olsen, Allan Svendsen, Kim Borch, Henrik Lund, Marianne Thellersen, Peter Rosholm, Niels Munk
  • Process for producing cheese
    Patent number: 5863573
    Abstract: A process for producing cheese, in which an enzyme preparation comprising a specific protease is added to cheese milk in the course of the process.
    Type: Grant
    Filed: August 18, 1994
    Date of Patent: January 26, 1999
    Assignee: Novo Nordisk A/S
    Inventors: Claus Dambmann, Peter Budtz, Steen Bennike Mortensen
  • Host cell expressing reduced levels of a metalloprotease and methods using the host cell in protein production
    Patent number: 5861280
    Abstract: The present invention relates to novel host cells and to methods of producing proteins. More specifically the invention relates to a host cell useful for the expression of heterologous proteins, which host cell has been genetically modified in order to express significantly reduced levels of a metalloprotease. Moreover the invention relates to a method of producing a heterologous protein, which method comprises cultivating the host cell in a suitable growth medium, followed by recovery of the desired protein.
    Type: Grant
    Filed: August 27, 1997
    Date of Patent: January 19, 1999
    Assignee: Novo Nordisk A/S
    Inventor: Jan Lehmbeck
  • Use of heterocyclic compounds for the treatment of conditions caused by malfunctioning of the nicotinic cholinergic system
    Patent number: 5859004
    Abstract: This invention relates to the use of azabicyclic compounds for the treatment of diseases caused by malfunctioning of the nicotinic cholinergic system. These diseases treated include obesity, Parkinson's disease, anxiety, and ulcerative colitis.
    Type: Grant
    Filed: August 6, 1997
    Date of Patent: January 12, 1999
    Assignee: Novo Nordisk A/S
    Inventor: Preben Houlberg Olesen
  • Factor VII -binding reagent
    Patent number: 5859010
    Abstract: The invention relates to novel compounds that potentiate zinc ion inhibition of the activity of factor VIIa or tissue factor--factor VIIa complex having the formula Ia and Ib and pharmaceutical salts thereof as well as pharmaceutical compositions comprising said novel compounds. The invention is further related to the use of said compositions for inhibiting clotting activity, tissue factor activity and factor VIIa activity.
    Type: Grant
    Filed: June 23, 1997
    Date of Patent: January 12, 1999
    Assignee: Novo Nordisk A/S
    Inventors: Lars Christian Petersen, Ole Hvilsted Olsen, Stefan Lutz Richter, Palle Jakobsen
  • Enzyme with pectin lyase activity
    Patent number: 5858760
    Abstract: The nucleic acid sequence encoding a pectin lyase from Aspergillus aculeatus, CBS 101.43 and the corresponding amino acid sequence are disclosed. The nucleic acid is used to transform a host cell which is utilized in a method to make the pectin lyase. The catalytic properties and stability characteristics of the enzyme are reported. The enzyme is useful for the degradation of plant cell wall components.
    Type: Grant
    Filed: July 2, 1997
    Date of Patent: January 12, 1999
    Assignee: Novo Nordisk A/S
    Inventors: Henrik Dalb.o slashed.ge, Lene Venke Kofod, Markus Sakari Kauppinen, Lene Nonboe Andersen, Stephan Christgau, Hans Peter Heldt-Hansen
  • Lipases from hyphozyma
    Patent number: 5856163
    Abstract: A new species of the genus Hyphogyma is disclosed, as are new lipases obtainable therefrom, Also disclosed is a process for obtaining the enzymes.
    Type: Grant
    Filed: December 22, 1994
    Date of Patent: January 5, 1999
    Assignee: Novo Nordisk A/S
    Inventors: Miyoko Hashida, Masanobu Abo, Yukiko Takamura, Ole Kirk, Torben Halkier, Sven Pedersen, Shamkant Anant Patkar, Mogens Trier Hansen
  • Dye transfer inhibition
    Patent number: 5855621
    Abstract: The transfer of a textile dye from a dyed fabric to another fabric during washing or rinsing is inhibited by adding an enzyme exhibiting peroxidase activity or an enzyme exhibiting a suitable oxidase activity to the wash liquor in which said fabrics are washed and/or rinsed. Peroxidase is produced extracellularly by some strains of Bacillus pumilus. The novel peroxidase preparation from B. pumilus is a microperoxidase, i.e. it contains hemopeptide as an active component. The preparation has improved stability at high temperature, at high pH and at high concentrations of hydrogen peroxide. It can be produced without undesired catalase activity.
    Type: Grant
    Filed: May 23, 1995
    Date of Patent: January 5, 1999
    Assignee: Novo Nordisk A/S
    Inventors: Ture Damhus, Ole Kirk, Gitte Pedersen, Manuel Garcia Venegas
  • Penicillium purpurogenum mutanases and nucleic acids encoding same
    Patent number: 5853702
    Abstract: The present invention relates to polypeptides having mutanase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing the polypeptides. The present invention further relates to oral cavity compositions and methods for degrading mutan.
    Type: Grant
    Filed: February 7, 1997
    Date of Patent: December 29, 1998
    Assignees: Novo Nordisk A/S, Novo Nordisk Biotech, Inc.
    Inventors: Randy M. Berka, Stephan Christgau, Torben Halkier, Jeff Shuster, Claus Crone Fuglsang
  • Peroxidase variants with improved hydrogen peroxide stability
    Patent number: 5851811
    Abstract: It has surprisingly been found that peroxidase variants with an improved stability towards hydrogen peroxide may be prepared by recombinant DNA techniques. Accordingly, the present invention relates to a peroxidase variant with improved hydrogen peroxide stability, characterized by insertion, deletion or substitution of one or more amino acid residues located in or near the substrate channel of the parent peroxidase, near the heme group of the parent peroxidase or at or near the active site of the parent peroxidase.
    Type: Grant
    Filed: November 1, 1994
    Date of Patent: December 22, 1998
    Assignee: Novo Nordisk A/S
    Inventors: Karen Gjesing Welinder, Morten Birket Andersen
  • Method for detecting glucagon-like peptide-1 antagonists and agonists
    Patent number: 5846747
    Abstract: The present invention relates to a recombinant glucagon-like peptide-1 (GLP-1) receptor, to a DNA construct which comprises a DNA sequence encoding a GLP-1 receptor, to methods of screening for antagonists of GLP-1 activity, and to the use of the GLP-1 receptor for screening for antagonists of GLP-1 activity.
    Type: Grant
    Filed: June 5, 1997
    Date of Patent: December 8, 1998
    Assignee: Novo Nordisk A/S
    Inventors: Bernard Thorens, Liselotte Bjerre Knudsen
  • Process for preparing a lignocellulose-based product, and product obtainable by the process
    Patent number: 5846788
    Abstract: A process for the manufacture of a lignocellulose-based product from a lignocellulosic material comprises treating the lignocellulosic material and a phenolic polysaccharide having substituents containing a phenolic hydroxy group with an enzyme capable of catalyzing the oxidation of phenolic groups in the presence of an oxidizing agent.
    Type: Grant
    Filed: December 3, 1996
    Date of Patent: December 8, 1998
    Assignee: Novo Nordisk A/S
    Inventors: Lars Saaby Pedersen, Claus Felby
  • Gene expression system
    Patent number: 5843702
    Abstract: The present invention relates to an expression system which comprises a phage-like bacteriocin("phibacin") or a mutant thereof, or a gene or mutant of a phibacin having a function in gene expression, such as a repressor gene, which is used to transform bacterial host for the producion of proteins, in particular in gram positive bacteria.
    Type: Grant
    Filed: May 25, 1994
    Date of Patent: December 1, 1998
    Assignee: Novo Nordisk A/S
    Inventors: David John McConnell, Kevin Martin Devine, Charles O'Kane