Patents Represented by Attorney Vedder Price P.C.
  • Patent number: 8349557
    Abstract: Transmembrane V-ATPase proton pump complexes regulate pH of extracellular space or intracellular compartments of cells. V-ATPase complexes are ubiquitous in cells across species. A human orthologue of yeast vma21, LOC203547 (VMA21), is likely involved in the assembly of the V-ATPase. Hypomorphic mutations of VMA21 are identified from XMEA patients. Methods to diagnose and/or distinguish between different forms of vacuolar or vacuolated myopathy in an individual or patient are provided based either on the sequence of the VMA21 gene and/or the level and/or activity of the V-ATPase complex. Compositions of the present invention may comprise DNA, RNA, or protein molecules corresponding to all or a portion of VMA21 and including one or more of the mutations in VMA21 identified. Cultured cells or cell lines having one or more mutations in the VMA21 gene derived from patients having a form of vacuolar or vacuolated myopathy are provided.
    Type: Grant
    Filed: June 3, 2009
    Date of Patent: January 8, 2013
    Assignee: The Hospital for Sick Children
    Inventor: Berge A. Minassian
  • Patent number: 8338153
    Abstract: A method of producing hexose oxidase by recombinant DNA technology, recombinant hexose oxidase and the use of such enzyme, in particular in the manufacturing of food products such as doughs and dairy products, animal feed, pharmaceuticals, cosmetics, dental care products and in the manufacturing of lactones. Suitable sources of DNA coding for the enzyme are marine algal species including Chondrus crispus, Iridophycus flaccidum and Euthora cristata. In useful embodiments, the recombinant hexose oxidase is produced by Pichia pastoris, Saccharomyces cerevisiae or E. coli.
    Type: Grant
    Filed: June 29, 2010
    Date of Patent: December 25, 2012
    Assignee: DuPont Nutrition Biosciences APS
    Inventors: Peter Stougaard, Ole Cai Hansen
  • Patent number: 8322112
    Abstract: A multi-piece interconnected body for use in at least structural support and/or in creating internal cavities for an improved strength-to-weight ratio in a variety of structures is nestable prior to its assembly and use. When assembled, the device preferably forms a generally spherical and hollow body, with (1) one or more ribs or similar structural support network associated with and/or integrally formed in the body; (2) at least one latch mechanism to help hold the pieces in a desired assembled relationship with each other; and (3) a hinge or other interconnecting element that facilitates nesting and/or stacking of a plurality of the bodies with each other prior to assembly, association of the multiple parts of each body with each other prior to assembly, and ready repositioning of those parts into a desired assembled position.
    Type: Grant
    Filed: January 28, 2010
    Date of Patent: December 4, 2012
    Assignee: Ropak Corporation
    Inventor: Frano Luburic
  • Patent number: 8318925
    Abstract: Small interfering RNAs (siRNAs) or small hairpin RNA (shRNAs) and compositions comprising same are provided that specifically target human cyclophilin A (CyPA) to effectively inhibit Hepatitis C (HCV) infection in a cell. Such siRNA and shRNAs may have a length of from about 19 to about 29 contiguous nucleotides corresponding to a specific region of human cyclophilin A (CyPA) cDNA of from about nucleotide 155 to about nucleotide 183 having particular potency against CyPA and HCV. Such siRNA and shRNAs may be formulated as naked compositions or as pharmaceutical compositions. DNA polynucleotides, plasmids, and viral or non-viral vectors are also provided that encode siRNA or shRNA molecules, which may be delivered directly to cells or in combination with known delivery agents, such as lipids, polymers, encapsulated lipid particles, such as liposomes. Methods for treating, managing inhibiting, preventing, etc., HCV infection using such siRNA and shRNAs and compositions comprising same are also provided.
    Type: Grant
    Filed: February 25, 2011
    Date of Patent: November 27, 2012
    Assignee: Florida State University Research Foundation
    Inventor: Hengli Tang
  • Patent number: 8287559
    Abstract: A surgical clip (5) is provided for clipping a tubular structure (9) in vivo to ligate the tubular structure. The clip comprises first and second clip portions (6, 7). A hinge portion (8) is provided connecting the clip portions together and to enable the clip portions to be hinged together from an open clip condition to a closed clip condition thereby to ligate a tubular structure placed between the clip portions. A lock is provided for locking the clip portions together in the closed clip condition. In the closed clip condition the clip has a substantially smooth external profile, for example including blunt ends (21), so as to reduce the possibility of the clip (in use) eroding surrounding tissue structures.
    Type: Grant
    Filed: January 21, 2004
    Date of Patent: October 16, 2012
    Assignee: UCL Business PLC
    Inventors: Stephen George Edward Barker, Simon John Hollingsworth
  • Patent number: 8283446
    Abstract: A T cell receptor (TCR) having the property of binding to EVDPIGHLY HLA-A1 complex and comprising a specified wild type TCR which has specific mutations in the TCR alpha variable domain and/or the TCR beta variable domain to increase affinity. Such TCRs are useful for adoptive therapy.
    Type: Grant
    Filed: August 4, 2010
    Date of Patent: October 9, 2012
    Assignee: Immunocore Limited
    Inventors: Bent Karsten Jakobsen, Nathaniel Ross Liddy
  • Patent number: 8278062
    Abstract: A method of producing one or more of a carbohydrate ester, a protein ester, a protein subunit ester or a hydroxyl acid ester, which method comprises admixing an acyl donor, an acyl acceptor and water to produce a high water environment comprising 5-98% water, wherein said acyl donor is a lipid substrate selected from one or more of the group consisting of a phospholipid, a lysophospholipid, a triacylglyceride, a diglyceride, a glycolipid or a lysoglycolipid and said acyl acceptor is selected from one ore more of the group consisting of a carbohydrate, a protein, a protein subunit, or a hydroxyl acid; and contacting the admixture with a lipid acyltransferase, such that said lipid acyl transferase catalyses one or both of the following reactions: alcoholysis or transesterification.
    Type: Grant
    Filed: March 9, 2009
    Date of Patent: October 2, 2012
    Assignee: DuPont Nutrition Biosciences ApS
    Inventors: Arno De Kreij, Susan Mampusti Madrid, Jørn Dalgaard Mikkelsen, Jørn Borch Søe
  • Patent number: 8276893
    Abstract: An elastomer-containing rod end isolator. The isolator includes a handle for connection to a load and inner and outer members. The outer member is a pocket and the inner member is spherical or nearly so. The pocket and the inner member are concentric and the inner member has two continuous exterior legs extending in a circular path. An elastomer fills most of the space between members.
    Type: Grant
    Filed: June 18, 2010
    Date of Patent: October 2, 2012
    Assignee: SKF USA Inc.
    Inventor: S. Gregory Martin
  • Patent number: 8276222
    Abstract: A patient transfer kit including an inflatable mattress, alternatively with a rigid top board with a patient restraint system on which a patient can be placed, when patient immobilization is required. A portable cart is included with a chamber for storage of a plurality of mattresses. The cart also has a gas/air blower and power supply system for powering the blower. The power system includes provision for drawing power from line AC/DC, and has a rechargeable battery and charger for maintaining the battery by connecting the supply to the line AC/DC. The mattress has a perforated bottom surface for exit of air to provide an air cushion, and is constructed with a white top surface and a dark bottom surface for optimum recognition of contamination, and identification of the bottom surface which must be placed downward. The cart is coated with an antimicrobial substance to minimize the risk of contaminants.
    Type: Grant
    Filed: October 3, 2006
    Date of Patent: October 2, 2012
    Assignee: Smart Medical Technology, Inc.
    Inventor: James E. Patrick
  • Patent number: 8277807
    Abstract: The invention provides combinations comprising (or consisting essentially of) one or more ancillary compound(s) and a compound of the formula (I): or salts, tautomers, solvates and N-oxides thereof; wherein R1 is hydroxy or hydrogen; R2 is hydroxy; methoxy or hydrogen; provided that at least one of R1 and R2 is hydroxy; R3 is selected from hydrogen; halogen; cyano; optionally substituted C1-5 hydrocarbyl and optionally substituted C1-5 hydrocarbyloxy; R4 is selected from hydrogen; a group —(O)n—R7 where n is 0 or 1 and R7 is an optionally substituted acyclic C1-5 hydrocarbyl group or a monocyclic carbocyclic or heterocyclic group having 3 to 7 ring members; halogen; cyano; hydroxy; amino; and optionally substituted mono- or di-C1-5 hydrocarbyl-amino; or R3 and R4 together form a monocyclic carbocyclic or heterocyclic ring of 5 to 7 ring members; and NR5R6 forms an optionally substituted bicyclic heterocyclic group having 8 to 12 ring members of which up to 5 ring members are heteroatoms selected from oxyg
    Type: Grant
    Filed: October 12, 2007
    Date of Patent: October 2, 2012
    Assignee: Astex Therapeutics Limited
    Inventors: Neil James Gallagher, John Francis Lyons, Neil Thomas Thompson, Stephen Murray Yule, Christopher William Murray
  • Patent number: 8273659
    Abstract: Surface processing in which the area to be processed is restricted to a predetermined pattern, can be achieved by: (a) providing a layer of a first reagent over a region of the surface to be processed which at least covers an area of the predetermined pattern; (b) providing one or more further reagents which are further reagents required for the processing of the surface; and (c) applying at least one of the further reagents over the region to be processed according to the predetermined pattern; such that the first reagent acts with the one or more of the further reagents to process the surface only in the area of the predetermined pattern. The process is particularly applicable to etching where an etchant having two or more components is used. In that case at least a first etchant component is applied over the surface and at least one further etchant component is applied in the predetermined pattern.
    Type: Grant
    Filed: July 30, 2010
    Date of Patent: September 25, 2012
    Assignee: Newsouth Innovations PTY Limited
    Inventors: Alison Joan Lennon, Stuart Ross Wenham, Anita Wing Yi Ho-Baillie
  • Patent number: 8269807
    Abstract: The present invention generally relates to an electrostatic coating apparatus for spraying a stream of particles onto a medium, and in particular to an apparatus equipped with a powder coating suspension device such as a multivolume chamber, or a air stream creation device. What is also contemplated is the use of a plurality of variable openings in the enclosure, used in conjunction with a plurality of conductors, to dispose a stream of particles onto a moving medium in successive layers. In yet another embodiment, the stream of particles is directed in a directional electrical field created by electrodes placed adjacent to directional shields. The present disclosure relates to an in-line industrial device able to coat paint, starch, thermoplastic materials, or any other powder material onto a medium by successively controlling a plurality of parameters.
    Type: Grant
    Filed: November 25, 2009
    Date of Patent: September 18, 2012
    Inventor: Robert J. McShane
  • Patent number: 8259152
    Abstract: A Video Call Distributor, including systems and methods, for distributing high quality real time video calls over an IP Packet-Based Wide Area Network and for routing those calls based on an ability to communicate and leverage existing routing rules and logic of a call management system, such as a traditional PBX-based.
    Type: Grant
    Filed: December 21, 2007
    Date of Patent: September 4, 2012
    Assignee: Glowpoint, Inc.
    Inventors: Andreas Eriksson, Ahsan Cheema, Stuart Morris, Ella Promislovskaya, Lou Chiorazzi, Cesar Manriquez
  • Patent number: 8256959
    Abstract: A fastener strip, such as would be used in a reclosable container, comprises a sealing member having a plurality of sealing portions configured to engage complementary sealing portions of a complementary fastener strip. At least one sealing portion comprises one or more finger members extending therefrom. The at least one finger member, by engaging a complementary sealing portion of a complementary fastener strip, provides an additional degree of sealing, particularly when the fastener strips are in a partially engaged condition. A slider comprises top and side walls and inwardly facing flanges, preferably at lower ends of the side walls. The inwardly facing flanges define a gap having dimensions such that the sealing members of the opposing fastener strips, and particularly the sealing portion having the at least one finger member and its complementary sealing portion, are urged together to provide an additional degree of sealing, yet not completely interlocking, engagement.
    Type: Grant
    Filed: June 14, 2006
    Date of Patent: September 4, 2012
    Assignee: Global Packaging Solutions Limited
    Inventors: Jonathan Hui, Mark Branson
  • Patent number: 8256640
    Abstract: A container includes: a base; one or more sidewalls integrally formed with and extending upwardly from the base, wherein the sidewalls surround an internal cavity and wherein one or more of the sidewalls include a reinforcing web of increased wall thickness; and an upper edge on the sidewalls defining a top opening.
    Type: Grant
    Filed: August 19, 2008
    Date of Patent: September 4, 2012
    Assignee: Ropak Corporation
    Inventors: Frano Luburic, Joshua Dana Urban, Ralph G. Perkins
  • Patent number: 8256677
    Abstract: A holographic read only memory card which can be coupled to and read by a card reader to which electronic read only memory cards can also be coupled to and read by the card reader is disclosed. The holographic read only memory card comprises: a housing having a compartment for receiving a holographic storage medium; a holographic storage medium having stored thereon holographic data; and optionally a an electronics panel member having an electronic memory component which can be read by the card reader when the holographic read only memory card is coupled to the electronic card reader. The housing comprises one or more card locating members to thereby repeatedly position the holographic read only memory card each time the holographic read only memory card is coupled to the electronic card reader so that the holographic data can be read.
    Type: Grant
    Filed: April 11, 2008
    Date of Patent: September 4, 2012
    Assignees: InPhase Technologies, Inc., Nintendo Co., Ltd.
    Inventors: Rodney C. Harris, Hiroshi Kamada, Motofumi Yoshino
  • Patent number: 8254418
    Abstract: An apparatus comprising: a processor for determining if a laser is operating in a single-mode state and for determining the degree to which one of one or more tunable parameters for the laser must be adjusted so that laser operates in a single-mode state if not operating in a single-mode state, wherein the one or more tunable parameters include the following parameters: the laser current and the wavelength of the output light. The apparatus may include a laser and/or a holographic storage medium. Also provided is a method for determining if a laser is operating in a single-mode state and for determining the degree to which one of one or more tunable parameters for the laser must be adjusted so that laser operates in a single-mode state if not operating in a single-mode state.
    Type: Grant
    Filed: September 18, 2009
    Date of Patent: August 28, 2012
    Assignee: InPhase Technologies, Inc.
    Inventors: Paul C. Smith, Jason R. Ensher, Paul A. Morrison, Keith W. Malang, Roger Shepherd, William G. Creech
  • Patent number: 8240098
    Abstract: A molding profile assembly has a first and second molding profile. The first molding profile, whose upper surface is to form the upper surface of the molding profile assembly, has a groove formed into an under-surface of a first arm and a groove formed into a foot perpendicular to the arm. The second molding profile has first and second tabs which fit snugly into the first and second grooves of the first molding profile, respectively, interlocking the first and second molding profiles together. The molding profiles do not require scraping, stripping or other permanent alteration in order to be assembled together.
    Type: Grant
    Filed: September 19, 2007
    Date of Patent: August 14, 2012
    Assignee: Faus Group, Inc.
    Inventor: Jose Francisco Gómez Insa
  • Patent number: D667567
    Type: Grant
    Filed: May 4, 2012
    Date of Patent: September 18, 2012
    Assignee: Ropak Corporation
    Inventors: Frano Luburic, David W. MacDonald
  • Patent number: D673453
    Type: Grant
    Filed: October 18, 2010
    Date of Patent: January 1, 2013
    Assignee: Ropak Corporation
    Inventor: Frano Luburic