Abstract: A snare drum having an improved resonant, sensitive and harmonic sound. The snare drum comprises a head end, a snare end is substantially circular at its head end while being increasingly larger in transverse cross-sectional shape proceeding from the head end towards the snare end. An indentation adjacent the head end allows a drum skin to be positioned within a hoop and tightened to secure the skin and hoop without binding.
Abstract: The present invention provides for the first time an expeditious method to separate polyene macrolide antibiotics into their major components, through a general preparatory procedure employing high pressure liquid chromatography. The procedure allows for the first time a useable preparatory method for separating the polyene macrolide complexes derived from fermentation and cultivation of various organisms, into their major components. Substantially pure dermostatic A and dermostatic B can now be achieved as well as substantially pure mycoticin A and mycoticin B.
Abstract: A method for treating malaria which comprises to an afflicted host patient a therapeutically effective amount of a compound have the structure of formula I: ##STR1## wherein X is O or NH; R.sub.1 is H or two R.sub.1 groups on the same amidine group together represents --(CH.sub.2).sub.m --, wherein m=2, 3 or 4; R.sub.2 is H, NH.sub.2, Cl, NO.sub.2 ; R.sub.3 is H, CH.sub.3 or CH.sub.2 CH.sub.3 and n=2-6 or a pharmaceutically acceptable salt thereof provided that when X is O, both R.sub.2 and both R.sub.3 can not be H.
Type:
Grant
Filed:
September 5, 1991
Date of Patent:
April 27, 1993
Inventors:
Richard R. Tidwell, J. Dieter Geratz, James E. Hall, Dennis E. Kyle, Max Grogl, Kwasi A. Ohemeng
Abstract: This invention relates to a method for treating leishmaniasis which comprises administering to an afflicted host patient, a therapeutically effective amount of a compound having the following structure; ##STR1## wherein X is O or NH; R.sub.1 is H or two R.sub.1 of the same amidine group together represent --(CH.sub.2).sub.m -- wherein m=2, 3 or 4; R.sub.2 is H, NH.sub.2, OCH.sub.3, Cl or NO.sub.2 ; R.sub.3 is H, CH.sub.3 or CH.sub.2 CH.sub.3 and n=2-6 or a pharmaceutical acceptable salt thereof provided that X is O both R.sub.2 and both R.sub.3 cannot be H.
Type:
Grant
Filed:
April 6, 1989
Date of Patent:
April 13, 1993
Inventors:
Richard R. Tidwell, J. Dieter Geratz, James E. Hall, Dennis E. Kyle, Max Grogl, Kwasi A. Ohemeng
Abstract: The present invention provides a method for treating patients suffering from the acquired immunedeficiency syndrome (AIDS). The method comprises administering dermostatin, dermostatin A, dermostatin B or derivatives thereof, such as pharmaceutically acceptable esters, salts or complexes. The administration of the dermostatin or dermostatin A or dermostatin B should be done as soon as possible after the detection of the presence of the HIV virus which is believed to be responsible for the onset of AIDS. These polyene macrolide antibiotics have been found to be effective in improving the viability of lumphocyte cells infected with the HIV virus and in preventing the replication of the virus. The present invention also provides for the first time substantially pure dermostatin A and dermostatin B and an HPLC method for separation of dermostatin complex into those components in substantial purity.
Abstract: Salts of pentamidine, formulations containing such salts and the use of such salts of treatment or prophylaxis of pneumocystis carinii. Pentamidine gluconate and lactate has been discovered and found to have high water solubility while providing potentially less toxic alternatives to pentamidine isethionate, especially for aerosolized administration to patients suffering from acquired immunodeficiency syndrome, AIDS, or AIDS related complex, ARC.
Type:
Grant
Filed:
July 19, 1989
Date of Patent:
January 28, 1992
Assignee:
Fujisawa USA, Inc.
Inventors:
Sadanand Pai, Abu S. Alam, John N. Kapoor
Abstract: A vascular graft having a composite structure prepared by wrapping about the external surface of a tube having one or more layers of polytetrafluoroethylene or a polytetrafluoroethylene-elastomeric polymer blend, either alone or in combination, an elastic fiber, while maintaining the fiber under tension. The elastic fibers can be wound about the entire length of the tube while being maintained under the same of different degrees of tension. Furthermore, the elastic fibers may be wound about the tube under a higher degree of tension along locations adjacent the opposite ends the tubing.
Abstract: Nitroglycerin injection that is free of the customary organic solvents and has an extended shelf life of at least 1 year, consisting essentially of water, lactose, and nitroglycerin. Sodium chloride or dextrose may be added during manufacture or upon diluting with an infusion. Commercially safe manufacture and stable dispersion are assured by mixing lactose adsorbate, containing nitroglycerin, with water at high shear so that no nitroglycerin droplets coalesce. Stability is maintained by filtering and filling operations using nonreactive, nonleaching, nonadsorptive materials.
Type:
Grant
Filed:
June 28, 1989
Date of Patent:
March 19, 1991
Assignee:
Fujisawa USA, Inc.
Inventors:
Abu s. Alam, Utpal G. Joshi, Jairaj U. Mehta, Fakrul A. A. Sayeed, John N. Kapoor
Abstract: Biologically compatible materials capable of being formed into implants, comprising layers of poly(tetrafluoroethylene) and mixtures of poly(tetrafluoroethylene) and elastomer, having excellent compliance, strength, elasticity and suturability are disclosed. The materials are preferably prepared as implants or vascular grafts by co-extruding a relatively thin luminal layer of poly(tetrafluoroethylene) having a distinct fibral nodal microstructure within a layer of a mixture of poly(tetrafluoroethylene) and elastomer to impart elasticity to the implant. A preferred embodiment comprises a radially asymmetric composite vascular graft having a luminal layer of poly(tetrafluoroethylene), a second layer of poly(tetrafluoroethylene)/elastomer mixture, a third layer of elastomer, and a fourth layer of a monomer fibrous elastomer matrix with each layer having a distinctive pore size, pore shape and porosity to promote tissue ingrowth and periprosthetic tissue anchoring.
Abstract: A new and distinct variety of Oriental hybrid lily cultivar characterized particularly by its medium height and large, semi-upright to outward facing flowers of rich magenta rose coloration carried on ascending pedicels forming a compact raceme, flowering profusely in late July under field conditions in northern California and western Oregon and having a vigorous growth habit.
Abstract: A new and distinct variety of Oriental hybrid lily characterized particularly by its very short stature and its large, outwardly and generally upwardly facing flowers having an unusual overall pattern of a generally red-purple color with a more peach-toned stripe along each tepal midrib, and being copiously marked over a major portion of its area with papillae of a dark spiraea red color, this plant also having a compact and vigorous growth habit with good strength and abundant foliage.
Abstract: A new and distinct lily cultivar of the Oriental hybrid type characterized by very large, pure white, bowl-shaped flowers having broad tepals of thick substance and borne as a compact raceme on strong, unusually thick stems and flowering profusely in midseason for Oriental lilies. This plant has abundant foliage, a vigorous growth habit, and is capable of being forced for potted plant cultivars.
Abstract: A new variety of Alstroemeria characterized by its very large blooms, the outer petals of which are distinguished by a mainly white coloration and having short, parallel streaks of a purplish color at each side of a short groove at the petal tip, the inner petals being more narrow in form and being mainly of a yellow coloration with the petal tips being white at their outer ends with a purplish blotch at the tip, the inner petals being further marked with short, deep purplish pencil stripes which spread outwardly from the base of the petals to the petal tips. This plant is further distinguished by its strong, vigorous and upright growth habit with the main stem reaching a height of about 180 cm., each stem bearing a raceme of many flowers at its upper portion and the flowers being produced profusely and continuously from spring through fall.
Abstract: A new hybrid Alstroemeria plant characterized by its very large flowers which have an overall red-purple coloration of its petals which is sharply offset by the bright yellow coloration in the lower body portion of the inside petals each of which is marked with short pencil stripes extending outwardly from the base of the inner petal to all of its margins except its apex portion; this plant being furthered distinguished by its strong, vigorous, upright growth with the main stems reaching a height of about 2.5 meters and the flowers being produced profusely and continuously the year around.
Abstract: A new variety of carnation plant particularly distinguished by the substantially white coloration of its medium sized blooms which are borne singly on relatively long stems of erect and rigid character, its vigorous and upright growth habit, abundant foliage, and its resistance to Fusarium oxysporum.
Type:
Grant
Filed:
June 9, 1986
Date of Patent:
June 21, 1988
Assignee:
Laboratoire de Physiologie Vegetale de la Londe
Abstract: A new carnation plant particularly distinguished by its spray of relatively small, Venetian Pink blossoms which are borne in a cluster on a strong, upright stem having an average length of about 6.5 cm. and blooming recurrently with a profuse production of flowers in the spring, midseason and fall periods but having a tendency to give fewer blooms in the fall season. This plant has a vigorous, upright growth habit with an abundant foliage production and reaching an average height of about 98 cm. at eight months, the plant also being tolerant to Fusarium oxysporum as observed I.N.R.A., Antibes, France.
Type:
Grant
Filed:
June 9, 1986
Date of Patent:
June 21, 1988
Assignee:
Laboratoire de Physiologie Vegetale de la Londe
Abstract: A new carnation cultivar having relatively large, bright red blooms which are produced profusely on relatively long, strong, upright stems, blooming recurrently in spring, midseason and fall on a plant having a vigorous, upright growth habit and moderately abundant foliage.
Type:
Grant
Filed:
June 9, 1986
Date of Patent:
June 21, 1988
Assignee:
Laboratoire de Physiologie Vegetale de la Londe