Abstract: Derivatives of .alpha.,.beta.-unsaturated ketones having anticonvulsant activity and methods of their preparation from heterocyclic phosphonium salts and acyclic phosphoranes are disclosed.

Abstract: The present invention relates to bis(4-demethoxydaunorubicin)dihydrazone of the formula ##STR1## wherein R.sub.1 and R.sub.2 represent hydrogen or alkyl having from 1 to 4 carbon atoms and X represents(a) alkylene having from 3 to 20 carbon atoms and optionally substituted by one or more hydroxy and/or primary amino groups, or(b) alkylene optionally interrupted by one or more secondary amino groups, the total number of carbon and nitrogen atoms in the resultant chain being 3 to 20and to pharmacologically acceptable salts thereof which are potent inhibitors of neoplastic disease and are also useful as antiviral agents.

Abstract: N-Adamantane-substituted tetrapeptide amides and the pharmacologically acceptable salts thereof are disclosed herein. These compounds are analogs of enkephalin wherein the methionine or leucine of position 5 has been substituted by an adamantyl amide and the glycine of position 2 has been substituted by various amino acid residues. Optionally the tyrosine of position 1 and the phenylalanine of position 4 may be substituted by various amino acid residues. These compounds exhibit agonist activity at opiate receptor sites and are useful as analgesics.

Abstract: 1-(Diarylmethyl)-4-piperidinamine and derivatives thereof of the formula ##STR1## or a non-toxic pharmocologically acceptable acid addition salt thereof; wherein Ar, Ar.sup.1 and Ar.sup.2 independently are phenyl, phenyl substituted with up to five halogens, alkyl radicals of 1 to 7 carbon atoms or alkoxy radicals of 1 to 7 carbon atoms, 3,4-(methylenedioxy)phenyl or pyridyl optionally substituted with up to four alkyl radicals of 1 to 7 carbon atoms; and R and R.sup.1 are each hydrogen or together form a double bond between the nitrogen and carbon atoms to which they are attached are disclosed. These compounds are useful because of their anti-convulsant and anti-ulcer activity.

Abstract: An animal feed supplement in a solid, weather resistant block form and method of making is disclosed. The molasses based feed supplement block, intended for consumption primarily by ruminant animals, although not limited thereto, contains ferrous sulfate as a blocking agent. The feed supplement also comprises a water absorbent clay, a phosphorous source and finely ground magnesium oxide as well as an edible fat or oil in sufficient quantities to set into a solid block when admixed with the blocking agent. A preferred block composition is prepared by a method which comprises admixing the molasses, water, phosphate source and water absorbent clay under high speed shearing action for an effective amount of time to disperse the clay, admixing edible fat and dispersing it in the mixture and then admixing ferrous sulfate and finely ground magnesium oxide to obtain a nutrient mixture. The mixture is then poured into molds or packages and solidifies to form a hard block.

Abstract: Soy polysaccharides, which are substantially high molecular weight cell wall structural components of soybean cotyledons, are mixed with a therapeutically-active substance and the mixture is made into a tablet by conventional means such as wet or dry granulation or direct compression procedures. The tablets obtained by this method have sufficient hardness and highly beneficial disintegration properties.

Abstract: Meat from mollusks, especially clam and oyster meat, and isolated soy protein fibers are integrally bound by parboiling the meat, buffering the fibers, and mixing the two under agitation followed by forming and cooking.

Abstract: A uniquely palatable horse feed is prepared by employing certain prescribed amounts of citric acid in the feed.

Abstract: An animal feed supplement in a solid, weather resistant block form and method of making is disclosed. The molasses based feed supplement block, intended for consumption primarily by ruminant animals, although not limited thereto, contains ferrous sulfate as a blocking agent. The feed supplement also comprises a water absorbent clay, a phosphorous source and magnesium oxide as well as an edible fat or oil in sufficient quantities to set into a solid block form in less than one hour at room temperature when admixed with the blocking agent. A preferred block composition is prepared by a method which comprises admixing the molasses, water, phosphorous source and water absorbing clay under high speed shearing action for an effective amount of time to disperse the clay, admixing edible fat and dispersing it in the mixture and then admixing ferrous sulfate and magnesium oxide to obtain a viscous nutrient mixture that thickens quickly.

Abstract: An animal feed supplement in a solid, weather resistant block form and method of making is disclosed. The molasses based feed supplement block, intended for consumption primarily by ruminant animals, although not limited thereto, contains magnesium oxide as a blocking agent. The feed supplement also comprises a water absorbent clay, a phosphorous source and an edible fat or oil in sufficient quantities to set into a solid block in a relatively short period of time at ambient temperatures. A preferred block composition is prepared by a method which comprises admixing the molasses, water, phosphorous source and water absorbing clay under high speed shearing action for an effective amount of time to disperse the clay, admixing edible fat and dispersing it in the mixture and then admixing magnesium oxide to obtain a viscous nutrient mixture that thickens quickly. The mixture is then poured into molds or packages and solidifies to form a hard depackagable block.

Abstract: A method of preventing iron deficiency anemia in baby pigs and an animal feed supplement containing an iron source is disclosed. The molasses based feed supplement block, intended for consumption primarily by baby pigs, contains fat as a major energy source to aid in weight gain and an effective amount of a nutritional iron source to inhibit anemia in baby pigs. The animal feed supplement may also contain ferrous sulfate to aid in the setting of the supplement in block form.

Abstract: Lemon oil at extremely low levels is found to greatly enhance the palatability of even an extruded horse ration.

Abstract: A method of preparing stable high moisture food products such as pet food products is disclosed which enables nutritious farinaceous-proteinaceous food materials to be preserved in a stable, nutritious and wholesome form without refrigeration or resorting to canning and autoclaving techniques. The preserved materials may be packaged in transparent, flexible containers and stored under ambient conditions for periods of a year or more. The method involves impregnating the materials with a preservative such as succinic acid, pyruvic acid, or fumaric acid, forming the materials, and packaging the formed food product.

Abstract: A process for the recovery of protein from vegetable protein material is disclosed which involves differential settling and separation of protein bodies and cellular debris from the material by hydrocyclone separation. The process includes the steps of grinding vegetable protein material to a particle size range of less than about 40 microns, preferably less than about 10 microns followed by admixing the ground material with an aqueous suspension medium having a pH of 4.5, separating the protein bodies from the non-proteinaceous material by hydrocyclone separation into underflow and overflow streams, the underflow stream substantially containing intact protein bodies, the overflow stream substantially containing cellular debris and recovering the solids from both streams. The underflow stream which is separated from the aqueous suspension medium provides protein concentration of at least 68% by weight.

Abstract: A method of producing a dry, extruded feed for carnivorous animals containing a large amount of proteinaceous materials, a minor amount of farinaceous materials and up to about 24% fat by weight is disclosed. More specifically, a hard dry high fat feed having excellent particle integrity is extruded under conditions of elevated temperature and pressure without the use of materials to selectively bind the fat to the other food ingredients.

Abstract: A protein-based snack food product and its method of manufacture are disclosed. The process negates the need for carbohydrate, starch or farinaceous ingredients in the product formulation. Yet the product will expand or puff and will maintain its structural integrity during deep fat frying.

Abstract: A system for treating dry protein material in brine solutions comprises a tank for receiving the protein material and brine solution a container having a screened bottom end an agitator inserted through its open upper end for creating a vortex mixing action in the brine solution in which the container is immersed in the brine holding tank.

Abstract: Effective amounts of sulfur in swine feeds will limit feed intake. More particularly, the use of at least about 0.25% sulfur in the feed will negate the need for hand feeding and will accordingly allow the swine to be self-fed.

Abstract: A method of completely removing the volatiles in the headspace area of cans, bottles and other sealed containers which comprises inserting first and second penetrating means into the headspace of the sealed container without prematurely releasing the vacuum of the sealed container, passing a carrier gas into the headspace of the sealed container through said first penetrating means and removing the carrier gas and headspace volatiles from the sealed container through said second penetrating means for analysis.

Abstract: This invention relates primarily to innovations in methods of feeding laying hens wherein the hens' nutrient reserves and specialized nutritious feeds are utilized so that a uniform rate of egg production can be maintained at substantial economic savings. More specifically, it concerns a feeding program wherein laying hens are fed a ration with vitamins, minerals and a specific low total crude protein for an effective amount of time to reduce the hens' nutrient reserves without reducing their rate of lay and total feed efficiency. The hens are then fed a ration adequate in total crude protein, vitamins and minerals for the remaining feeding time to replenish the nutrient reserves in an efficient manner while maintaining optimum egg production and other performance characteristics.